The Experts below are selected from a list of 19533 Experts worldwide ranked by ideXlab platform
Pralay Das - One of the best experts on this subject based on the ideXlab platform.
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a solid supported palladium 0 nano microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
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A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale Suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
Arun K. Shil - One of the best experts on this subject based on the ideXlab platform.
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a solid supported palladium 0 nano microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
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A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale Suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
Nitul Ranjan Guha - One of the best experts on this subject based on the ideXlab platform.
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a solid supported palladium 0 nano microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
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A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale Suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
Dharminder Sharma - One of the best experts on this subject based on the ideXlab platform.
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a solid supported palladium 0 nano microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
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A solid supported palladium(0) nano/microparticle catalyzed ultrasound induced Continuous Flow Technique for large scale Suzuki reactions
RSC Advances, 2013Co-Authors: Arun K. Shil, Nitul Ranjan Guha, Dharminder Sharma, Pralay DasAbstract:An ultrasound-induced Continuous Flow Technique was developed for the solid supported palladium(0) nano/microparticle (SS-Pd) catalyzed Suzuki cross coupling reaction of haloarenes (chloro, bromo and iodo) with phenyl boronic acid on a gram scale. An externally conjugated reservoir was fitted for easy operation of the reaction in water under mild basic conditions. The SS-Pd catalyst was found to be very stable in aqueous media, easily separable and recyclable up to five runs without significant loss of activity. Furthermore, the scaling of the well known Suzuki reaction up to 5 g scale under mild ultrasonic irradiation can be of industrial interest in the future.
Bernhard Lendl - One of the best experts on this subject based on the ideXlab platform.
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Time-resolved mid-IR spectroscopy of (bio)chemical reactions in solution utilizing a new generation of Continuous-Flow micro-mixers
Analytical and Bioanalytical Chemistry, 2011Co-Authors: Christoph Wagner, Wolfgang Buchegger, Martin Kraft, Michael J. Vellekoop, Bernhard LendlAbstract:A specially designed micro-mixer made of silicon, calcium fluoride, and silicone with an optical transmission path of 8 μm has been used for mid-IR spectroscopy monitoring of mixing-induced chemical reactions in the low millisecond time regime. The basic principle of the proposed Continuous-Flow Technique is to mix two liquids introduced in two times two alternatingly stacked layers through diffusion at the entrance of a 200 μm wide, 1 cm long micro-fluidic channel also serving as measurement area. By using this special, dedicated arrangement, diffusion lengths and hence the mixing times can be significantly shortened and the overall performance improved in comparison to previous systems and alternative methods. Measurements were carried out in transmission mode using an Fourier transform infrared (FTIR) microscope, recording spectra with spot sizes of 180 × 100 μm^2 each at defined spots along this channel. Each of these spots corresponds to a specific reaction time: moving the measurement spot towards the entry yields shorter reaction times, moving it towards the channel’s end gives longer reaction times. This principle is generic in nature and provides a solution for accurate, chemically induced triggering of reactions requiring the mixing of two liquid reagents or reagent solutions. A typical experiment thus yields up to 85 time-coded data points, covering a time span from 1 to 80 ms at a total reagent consumption of only about 125 μL. Using the fast neutralization reaction of acetic acid with sodium hydroxide as a model, the time required for 90% mixing was determined to be around 4 ms. Additionally, first experiments on ubiquitin changing its secondary structure from native to “A-state” were carried out, illustrating the potential for time-resolved measurements of proteins in aqueous solutions. Figure
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Time-resolved mid-IR spectroscopy of (bio)chemical reactions in solution utilizing a new generation of Continuous-Flow micro-mixers
Analytical and Bioanalytical Chemistry, 2011Co-Authors: Christoph Wagner, Wolfgang Buchegger, Martin Kraft, Michael J. Vellekoop, Bernhard LendlAbstract:A specially designed micro-mixer made of silicon, calcium fluoride, and silicone with an optical transmission path of 8 μm has been used for mid-IR spectroscopy monitoring of mixing-induced chemical reactions in the low millisecond time regime. The basic principle of the proposed Continuous-Flow Technique is to mix two liquids introduced in two times two alternatingly stacked layers through diffusion at the entrance of a 200 μm wide, 1 cm long micro-fluidic channel also serving as measurement area. By using this special, dedicated arrangement, diffusion lengths and hence the mixing times can be significantly shortened and the overall performance improved in comparison to previous systems and alternative methods. Measurements were carried out in transmission mode using an Fourier transform infrared (FTIR) microscope, recording spectra with spot sizes of 180 × 100 μm2 each at defined spots along this channel. Each of these spots corresponds to a specific reaction time: moving the measurement spot towards the entry yields shorter reaction times, moving it towards the channel’s end gives longer reaction times. This principle is generic in nature and provides a solution for accurate, chemically induced triggering of reactions requiring the mixing of two liquid reagents or reagent solutions. A typical experiment thus yields up to 85 time-coded data points, covering a time span from 1 to 80 ms at a total reagent consumption of only about 125 μL. Using the fast neutralization reaction of acetic acid with sodium hydroxide as a model, the time required for 90% mixing was determined to be around 4 ms. Additionally, first experiments on ubiquitin changing its secondary structure from native to “A-state” were carried out, illustrating the potential for time-resolved measurements of proteins in aqueous solutions.