The Experts below are selected from a list of 21726 Experts worldwide ranked by ideXlab platform
Haeil Park - One of the best experts on this subject based on the ideXlab platform.
-
stereoselective protection free asymmetric total synthesis of chamuvarinin a potent anticancer and antitrypanosomal agent substrate Controlled construction of the adjacently linked oxatricyclic core by internal alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.
-
Stereoselective Protection-Free Asymmetric Total Synthesis of (+)-Chamuvarinin, a Potent Anticancer and Antitrypanosomal Agent: Substrate-Controlled Construction of the Adjacently Linked Oxatricyclic Core by Internal Alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.
Christophe M. Thomas - One of the best experts on this subject based on the ideXlab platform.
-
Single-Site Cobalt and Zinc Catalysts for the Ring-Opening Polymerization of Lactide
European Polymer Journal, 2019Co-Authors: Paul Marin, Mathieu J.-l. Tschan, Pierre Haquette, Thierry Roisnel, Iker Del Rosal, Laurent Maron, Christophe M. ThomasAbstract:Abstract Novel zinc(II) and cobalt(II) complexes containing tripodal mono(phenolate) ligands have been synthesized and characterized. The resulting mononuclear complexes act as efficient initiators in the polymerization of rac-lactide to provide the corresponding biodegradable poly(lactic acid). Most of these polymerizations proceeded in a Controlled Fashion, giving polymers with narrow polydispersities and experimental molecular weights in good agreement with calculated values.
-
Single-site cobalt and zinc catalysts for the ring-opening polymerization of lactide
European Polymer Journal, 2019Co-Authors: Paul Marin, Mathieu J.-l. Tschan, Pierre Haquette, Thierry Roisnel, Iker Del Rosal, Laurent Maron, Christophe M. ThomasAbstract:Novel zinc(II) and cobalt(II) complexes containing tripodal mono(phenolate) ligands have been synthesized and characterized. The resulting mononuclear complexes act as efficient initiators in the polymerization of rac-lactide to provide the corresponding biodegradable poly(lactic acid). Most of these polymerizations proceeded in a Controlled Fashion, giving polymers with narrow polydispersities and experimental molecular weights in good agreement with calculated values. © 2019 Elsevier Ltd
Mallesham Samala - One of the best experts on this subject based on the ideXlab platform.
-
stereoselective protection free asymmetric total synthesis of chamuvarinin a potent anticancer and antitrypanosomal agent substrate Controlled construction of the adjacently linked oxatricyclic core by internal alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.
-
Stereoselective Protection-Free Asymmetric Total Synthesis of (+)-Chamuvarinin, a Potent Anticancer and Antitrypanosomal Agent: Substrate-Controlled Construction of the Adjacently Linked Oxatricyclic Core by Internal Alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.
Paul Marin - One of the best experts on this subject based on the ideXlab platform.
-
Single-Site Cobalt and Zinc Catalysts for the Ring-Opening Polymerization of Lactide
European Polymer Journal, 2019Co-Authors: Paul Marin, Mathieu J.-l. Tschan, Pierre Haquette, Thierry Roisnel, Iker Del Rosal, Laurent Maron, Christophe M. ThomasAbstract:Abstract Novel zinc(II) and cobalt(II) complexes containing tripodal mono(phenolate) ligands have been synthesized and characterized. The resulting mononuclear complexes act as efficient initiators in the polymerization of rac-lactide to provide the corresponding biodegradable poly(lactic acid). Most of these polymerizations proceeded in a Controlled Fashion, giving polymers with narrow polydispersities and experimental molecular weights in good agreement with calculated values.
-
Single-site cobalt and zinc catalysts for the ring-opening polymerization of lactide
European Polymer Journal, 2019Co-Authors: Paul Marin, Mathieu J.-l. Tschan, Pierre Haquette, Thierry Roisnel, Iker Del Rosal, Laurent Maron, Christophe M. ThomasAbstract:Novel zinc(II) and cobalt(II) complexes containing tripodal mono(phenolate) ligands have been synthesized and characterized. The resulting mononuclear complexes act as efficient initiators in the polymerization of rac-lactide to provide the corresponding biodegradable poly(lactic acid). Most of these polymerizations proceeded in a Controlled Fashion, giving polymers with narrow polydispersities and experimental molecular weights in good agreement with calculated values. © 2019 Elsevier Ltd
Suresh Mandava - One of the best experts on this subject based on the ideXlab platform.
-
stereoselective protection free asymmetric total synthesis of chamuvarinin a potent anticancer and antitrypanosomal agent substrate Controlled construction of the adjacently linked oxatricyclic core by internal alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.
-
Stereoselective Protection-Free Asymmetric Total Synthesis of (+)-Chamuvarinin, a Potent Anticancer and Antitrypanosomal Agent: Substrate-Controlled Construction of the Adjacently Linked Oxatricyclic Core by Internal Alkylation
Organic Letters, 2018Co-Authors: Mallesham Samala, Thien Nhan Lu, Suresh Mandava, Jungjoong Hwang, Ganganna Bogonda, Haeil ParkAbstract:A stereoselective protection-free asymmetric total synthesis of (+)-chamuvarinin (1), a potent anticancer and antitrypanosomal agent, has been accomplished. The adjacently linked [bis(tetrahydrofuran)]tetrahydropyran (THF–THF–THP) core of this natural product with seven stereogenic centers was constructed in a completely substrate-Controlled Fashion. The inter-ring stereochemistry (threo,threo,threo) of the oxatricyclic core was established in a stereoselective Fashion by a chelation-Controlled Keck allylation, whereas the intraring cis or trans relative stereochemistry was Controlled by a stereoselective internal alkylation.