The Experts below are selected from a list of 4611 Experts worldwide ranked by ideXlab platform

Timothy F. Jamison - One of the best experts on this subject based on the ideXlab platform.

  • Continuous Flow Total Synthesis of Rufinamide
    Organic Process Research & Development, 2014
    Co-Authors: Ping Zhang, M. Grace Russell, Timothy F. Jamison
    Abstract:

    Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of organic azide intermediates. Continuous flow synthesis provides the opportunity to synthesize and consume the energetic organoazides, without accumulation thereof. In this report, we described a continuous synthesis of the antiseizure medication rufinamide. This route is convergent and features Copper Tubing reactor-catalyzed cycloaddition reaction. Each of the three chemical steps enjoys significant benefits and has several advantages by being conducted in flow. The total average residence time of the synthesis is approximately 11 min, and rufinamide is obtained in 92% overall yield.

  • Continuous Flow Total Synthesis of Rufinamide
    2014
    Co-Authors: Ping Zhang, Grace M. Russell, Timothy F. Jamison
    Abstract:

    Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of organic azide intermediates. Continuous flow synthesis provides the opportunity to synthesize and consume the energetic organoazides, without accumulation thereof. In this report, we described a continuous synthesis of the antiseizure medication rufinamide. This route is convergent and features Copper Tubing reactor-catalyzed cycloaddition reaction. Each of the three chemical steps enjoys significant benefits and has several advantages by being conducted in flow. The total average residence time of the synthesis is approximately 11 min, and rufinamide is obtained in 92% overall yield

  • Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing.
    ChemInform, 2011
    Co-Authors: Yun Zhang, Timothy F. Jamison, Sejal Patel, Nello Mainolfi
    Abstract:

    A commercially available Copper tube flow reactor (CTFR) effects Ullmann condensations, Sonogashira couplings, and decarboxylation reactions without added metals, ligands, or reagents in greater than 90% yield in most cases examined.

  • Continuous flow coupling and decarboxylation reactions promoted by Copper Tubing.
    Organic letters, 2010
    Co-Authors: Yun Zhang, Timothy F. Jamison, Sejal Patel, Nello Mainolfi
    Abstract:

    A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available Copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

Ping Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Continuous Flow Total Synthesis of Rufinamide
    Organic Process Research & Development, 2014
    Co-Authors: Ping Zhang, M. Grace Russell, Timothy F. Jamison
    Abstract:

    Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of organic azide intermediates. Continuous flow synthesis provides the opportunity to synthesize and consume the energetic organoazides, without accumulation thereof. In this report, we described a continuous synthesis of the antiseizure medication rufinamide. This route is convergent and features Copper Tubing reactor-catalyzed cycloaddition reaction. Each of the three chemical steps enjoys significant benefits and has several advantages by being conducted in flow. The total average residence time of the synthesis is approximately 11 min, and rufinamide is obtained in 92% overall yield.

  • Continuous Flow Total Synthesis of Rufinamide
    2014
    Co-Authors: Ping Zhang, Grace M. Russell, Timothy F. Jamison
    Abstract:

    Small molecules bearing 1,2,3-triazole functionalities are important intermediates and pharmaceuticals. Common methods to access the triazole moiety generally require the generation and isolation of organic azide intermediates. Continuous flow synthesis provides the opportunity to synthesize and consume the energetic organoazides, without accumulation thereof. In this report, we described a continuous synthesis of the antiseizure medication rufinamide. This route is convergent and features Copper Tubing reactor-catalyzed cycloaddition reaction. Each of the three chemical steps enjoys significant benefits and has several advantages by being conducted in flow. The total average residence time of the synthesis is approximately 11 min, and rufinamide is obtained in 92% overall yield

V.s. Vigneswaran - One of the best experts on this subject based on the ideXlab platform.

Holger Schmidt - One of the best experts on this subject based on the ideXlab platform.

  • Temperature and wall coating dependence of alkali vapor transport speed in micron-scale capillaries
    Journal of Vacuum Science & Technology A: Vacuum Surfaces and Films, 2017
    Co-Authors: Matthieu Giraud-carrier, Trevor K. Decker, Aaron R. Hawkins, Jennifer A. Black, Soren Almquist, Joshua S. Mcclellan, Linsey Bennett, Holger Schmidt
    Abstract:

    The impact of storage temperature and wall coatings on alkali vapor transport through micron-scale glass capillaries is analyzed. Glass microbore Tubing, chromatography vials, and Copper Tubing are assembled into closed atomic spectroscopy units with varying capillary lengths and inner diameters. Such devices serve as valuable test models for integrated atomic spectroscopy platforms that rely on hollow-core optical waveguides for chip-scale implementation of quantum coherence phenomena such as slow and stopped light. The inside surface of the systems are coated with dimethyldichlorosilane (DMDCS) after which the system is loaded with rubidium vapor and hermetically sealed. The loaded units are stored in a tube furnace at elevated temperatures and tested daily for absorption over several weeks. Both a wall coating of DMDCS and higher storage temperature increases the transport speed of Rb vapor. The limits and implications of these results are discussed and compared to an expected theoretical model. Suggestions for increasing transport speed are given.The impact of storage temperature and wall coatings on alkali vapor transport through micron-scale glass capillaries is analyzed. Glass microbore Tubing, chromatography vials, and Copper Tubing are assembled into closed atomic spectroscopy units with varying capillary lengths and inner diameters. Such devices serve as valuable test models for integrated atomic spectroscopy platforms that rely on hollow-core optical waveguides for chip-scale implementation of quantum coherence phenomena such as slow and stopped light. The inside surface of the systems are coated with dimethyldichlorosilane (DMDCS) after which the system is loaded with rubidium vapor and hermetically sealed. The loaded units are stored in a tube furnace at elevated temperatures and tested daily for absorption over several weeks. Both a wall coating of DMDCS and higher storage temperature increases the transport speed of Rb vapor. The limits and implications of these results are discussed and compared to an expected theoretical model. Sugges...

  • Nondiffusive rubidium vapor transport in confined glass channels
    Journal of Vacuum Science & Technology A: Vacuum Surfaces and Films, 2016
    Co-Authors: Matthieu Giraud-carrier, Cameron Hill, Trevor K. Decker, Aaron R. Hawkins, Jennifer A. Black, Soren Almquist, Holger Schmidt
    Abstract:

    Rubidium vapor transport through micron-scale capillaries is analyzed. A testing platform is assembled out of Copper Tubing, glass chromatography vials, and glass microbore capillary Tubing. The system is loaded with rubidium vapor and hermetically sealed under a vacuum of

Stuart W Baur - One of the best experts on this subject based on the ideXlab platform.

  • Performance comparison of modular photovoltaic-thermal solar panels
    2011 IEEE Green Technologies Conference Green 2011, 2011
    Co-Authors: Nicole C. Annis, Stuart W Baur
    Abstract:

    The purpose of this experiment was to create a modular photovoltaic-thermal panel, which would be easily implemented and maintained. Three different prototype panels were tested simultaneously. The system was fixed at the optimal angle of 37.95° for the local area (Rolla, Missouri).The first two panels (Panel A & B) consisted of a highly conductive thermal sheeting and different sized Copper Tubing. The third panel (Panel C) consisted of Copper Tubing with an aluminum fin. Thermal images were used to verify the heat transfer across the panels and compare with the standard photovoltaic panel. The thermal efficiencies of panels A, B and C at 0.5 gallon per minute were 33.6%, 26.4% and 28.7%, respectively. Based on the thermal efficiency of Panel A three similar PVT panels were connected in series. Panels A1-3 at 0.5, 1.0 and 1.5 gpm had thermal gain plus electrical output equivalents of 931.9, 1281.2 and 1496.8 watts.

  • EXPERIMENTAL AND MODELING COMPARISON OF MODULAR PHOTOVOLTAIC-THERMAL SOLAR PANELS
    ASME 2011 5th International Conference on Energy Sustainability Parts A B and C, 2011
    Co-Authors: Nicole C. Annis, Stuart W Baur
    Abstract:

    The scope of the project included two steps. Step one was to create three prototype photovoltaic-thermal panels and test them. Step two was to model all photovoltaic-thermal panels using TRNSYS 16. The three different photovoltaic-thermal panels were tested simultaneously using the same inlet water source. The first two panels (Panel A & B) consisted of a highly conductive thermal sheeting and different sized Copper Tubing. The third panel (Panel C) consisted of Copper Tubing with an aluminum fin. Thermal images were used to verify the heat transfer across the panels and compare the amount of heat radiating off the back of the photovoltaic-thermal panels versus the standard photovoltaic panel. The purpose of this experiment was to create a modular photovoltaic-thermal panel, which would be easily implemented and maintained by the average consumer. A TRNSYS model was created for each photovoltaic-thermal panel to gather approximate year-round efficiency. The thermal efficiencies of photovoltaic-thermal panels A, B and C at 1.9 lpm (0.5 gpm) were 33.6%, 26.4% and 28.7%, respectively. Panels A, B and C at 1.9 lpm (0.5 gpm) had thermal gain plus electrical output equivalents of 394.0, 363.2 and 422.9 watts, respectively. The TRNSYS models of the prototype photovoltaic-thermal (Panels A, B and C) proved to be a poor representation of the actual texted panels.Copyright © 2011 by ASME