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Rasik B Vajpayee - One of the best experts on this subject based on the ideXlab platform.

  • comparison of amniotic membrane transplantation and umbilical Cord Serum in acute ocular chemical burns a randomized controlled trial
    American Journal of Ophthalmology, 2016
    Co-Authors: Namrata Sharma, Thirumurthy Velpandian, Divya Singh, Prafulla K Maharana, Alka Kriplani, Ravindra Mohan Pandey, Rasik B Vajpayee
    Abstract:

    Purpose To compare the efficacy of topical umbilical Cord Serum drops (UCS) and amniotic membrane transplantation (AMT) in acute ocular chemical burns. Design Randomized controlled trial. Methods setting: Tertiary care hospital. study population: Forty-five eyes with acute chemical burns of grade III, IV, and V (Dua's classification) presenting within the first week of injury were randomized into 3 groups (15 each). Patients with perforation/impending corneal perforation were excluded from the study. intervention: Groups 1, 2, and 3 received UCS with medical therapy (MT), AMT with MT, and MT alone, respectively. main outcome measure: Time to complete epithelialization. Results The mean time to complete epithelialization was 56.7 ± 14.9, 22.0 ± 10.2, and 22.9 ± 10.1 days in MT, AMT, and UCS groups, respectively, with a significant difference between MT and AMT ( P  = .001) and between MT and UCS ( P  = .001), but not between UCS and AMT ( P  = .9). Improvement in pain score was better with UCS than AMT ( P value: .012, .002, and .012 on days 7, 14, and 21, respectively). Corneal clarity was better in the UCS group at 21 ( P  = .008) and 30 days ( P  = .002), but not at 3 months ( P  = .9). By month 3, visual outcome, symblepharon, tear film status, and lid abnormalities were comparable between the 3 groups. Conclusions UCS and AMT, as an adjuvant to standard medical therapy in acute chemical injury, are equally efficacious. UCS has the advantage of faster improvement in corneal clarity, better pain control, and avoidance of surgery in an inflamed eye.

  • comparison of umbilical Cord Serum and amniotic membrane transplantation in acute ocular chemical burns
    British Journal of Ophthalmology, 2015
    Co-Authors: Namrata Sharma, Shiv Shankar Lathi, Sri Vatsa Sehra, Tushar Agarwal, Rajesh Sinha, Jeewan S Titiyal, Thirumurthy Velpandian, Radhika Tandon, Rasik B Vajpayee
    Abstract:

    Purpose To compare the efficacy of umbilical Cord Serum (UCS) with amniotic membrane transplantation (AMT) in cases of acute ocular chemical burns. Methods In a retrospective, interventional, comparative case series, 55 eyes with grades III, IV and V chemical burns (Dua9s classification) who presented within 3 weeks of injury were evaluated. Patients were treated with conventional medical (CM group, 20 eyes) management alone or combined with either UCS (UCS group, 17 eyes) or AMT (AMT group, 18 eyes). The parameters evaluated were time to epithelialisation, epithelial defect diameter, epithelial defect area, corneal clarity, tear break-up time (TBUT), Schirmer test and best-corrected vision. Results UCS and AMT groups showed early epithelialisation as compared with the CM group (Kaplan–Meier analysis=0.01). Mean time for healing of epithelial defect was 57.7±29.3, 27.4±19.0, 41.1±28.9 days in the CM, UCS and AMT groups, respectively (p=0.02). Mean TBUT at the last follow-up was 8.6±0.7, 10.3±1.1, 9.4±1.2 s in the CM, UCS and AMT groups, respectively (p=0.02). The mean Schirmer value at the last follow-up was 13.7±1.0, 16.9±3.0 and 13.2±1.5 mm in the CM, UCS and AMT groups, respectively (p=0.01). The visual outcomes and the occurrence of corneal vascularisation, symblepheron, ectropion and entropion were comparable in between the groups. Conclusions Our study suggests that the UCS therapy may be a better alternative to AMT in acute moderate to severe (grades III, IV and V) ocular chemical burns, as it avoids surgical manoeuvre in already inflamed eyes.

  • evaluation of umbilical Cord Serum therapy in acute ocular chemical burns
    Investigative Ophthalmology & Visual Science, 2011
    Co-Authors: Namrata Sharma, Jeewan S Titiyal, Thirumurthy Velpandian, Radhika Tandon, Rasik B Vajpayee, Manik Goel
    Abstract:

    PURPOSE To evaluate the role of umbilical Cord Serum therapy in cases of acute ocular chemical burns. METHODS In a double-blind prospective randomized controlled clinical study, 33 eyes of 32 patients with acute ocular chemical burns of grade III, IV, and V severity were randomized into three groups: umbilical Cord Serum (n = 12), autologous Serum (n = 11), and artificial tears (0.5% HPMC+0.3% glycerin; n = 10). In addition, all eyes received standard medical therapy. The parameters evaluated were pain score, size, and area of epithelial defect, extent of limbal ischemia, corneal clarity, and symblepharon formation. The patients were followed up at day 1, 3, 7, 14, and 21 and at the end of months 1, 2, and 3. RESULTS Mean time to complete epithelialization was 21.16 ± 26.81, 56.6 ± 35.5, and 40.13 ± 35.79 days in Cord Serum, autologous Serum, and artificial tears groups respectively (P = 0.02). By day 21, the mean percentage decrease in epithelial defect diameter was 94.63 ± 11.99 with Cord Serum compared with 53.17 ± 34.81 and 64.22 ± 42.43 with autologous Serum and artificial tears, respectively (P = 0.01). By month 3, the extent of limbal ischemia with Cord Serum showed a mean percentage decrease of 73.43 ± 25.51 compared with 35.64 ± 25.60 and 43.71 ± 28.71 with autologous Serum and artificial tears, respectively (P = 0.008). More patients had clear corneas with Cord Serum compared with autologous Serum and artificial tears (P = 0.048). No significant difference was seen between the groups with regard to symblepharon formation (P = 0.07). CONCLUSIONS Umbilical Cord Serum therapy is more effective than autologous Serum eye drops or artificial tears in ocular surface restoration after acute chemical injuries. (www.controlled-trials.com number, ISRCTN08131903.).

  • evaluation of umbilical Cord Serum therapy for persistent corneal epithelial defects
    British Journal of Ophthalmology, 2003
    Co-Authors: Rasik B Vajpayee, Namrata Sharma, Radhika Tandon, Ravindra Mohan Pandey, Nitin Mukerji, N R Biswas, N Malhotra, Samir A Melki
    Abstract:

    Aims: To evaluate umbilical Cord Serum therapy as a means of promoting the healing of persistent corneal epithelial defects. Methods: Umbilical Cord Serum or autologous Serum drops were used to promote the healing of persistent epithelial defects. The study design was a prospective randomised controlled clinical trial. 60 eyes of 59 patients were divided into two groups, 31 in the Cord Serum group and 29 in the autologous Serum control group. Epithelial defects measuring at least 2 mm in linear dimension resistant to conventional medical management were included. Serial measurements of the size of the epithelial defects—namely, two maximum linear dimensions perpendicular to each other, and the area and perimeter was done at start of therapy and follow up days 3, 7, 14, 21. Rate of healing of the epithelial defects were measured as percentage decrease from the baseline parameter at each subsequent follow up. The data were analysed by the non-parametric Wilcoxon rank sum test using STATA 7.0. Results: The median percentage decrease in the size of the epithelial defect was significantly greater in the Cord Serum group at days 7, 14 and 21 (p Conclusions: Umbilical Cord Serum leads to faster healing of the persistent corneal epithelial defects refractory to all medical management compared to autologous Serum.

Kyungchul Yoon - One of the best experts on this subject based on the ideXlab platform.

  • application of umbilical Cord Serum eyedrops after laser epithelial keratomileusis
    Acta Ophthalmologica, 2013
    Co-Authors: Kyungchul Yoon, Hanjin Oh, Jung Won Park, Jin Choi
    Abstract:

    . Purpose:  To investigate the efficacy of umbilical Cord Serum eyedrops after laser epithelial keratomileusis (LASEK). Methods:  Sixty patients (120 eyes) with myopia who underwent LASEK were studied. Thirty-two patients (64 eyes) were treated with 20% umbilical Cord Serum eyedrops in combination with conventional treatment (group A), and 28 patients (56 eyes) received conventional treatment only (group B). Epithelial healing time was analysed. Visual acuity, refraction, haze score (0–4) and tear film and ocular surface parameters were evaluated at 1, 2, 4 and 12 weeks after LASEK. The concentration of transforming growth factor (TGF)-β1 in tears was measured with ELISA at 1 week after LASEK. Results:  No significant differences in visual acuity and refraction were found between groups. The mean time to epithelial healing was 3.53 ± 1.19 days in group A and 3.91 ± 1.41 days in group B (p = 0.18). The mean haze scores at 2 and 4 weeks were 0.59 ± 0.80 and 0.31 ± 0.54 in group A and 1.06 ± 0.91 (p = 0.02) and 0.69 ± 0.78 (p = 0.03) in group B. Four and 12 weeks after LASEK, tear film break-up time was longer and keratoepitheliopathy score was lower in group A compared with group B. The mean concentration of TGF-β1 was lower in group A compared with group B (p = 0.01). Conclusion:  Application of 20% umbilical Cord Serum eyedrops in addition to conventional treatment after LASEK can reduce early postoperative corneal haze and improve tear film and ocular surface parameters.

  • effects of umbilical Cord Serum eye drops in a mouse model of ocular chemical burn
    Current Eye Research, 2012
    Co-Authors: Hanjin Oh, Jaeyong Jang, Zhengri Li, Soo Hyun Park, Kyungchul Yoon
    Abstract:

    Purpose: To evaluate the effect of umbilical Cord Serum (UCS) eye drops on corneal wound healing and haze in a mouse model of ocular chemical burn and compare with that of peripheral blood Serum (PBS) eye drops or artificial tears (AT).Methods: Chemical burn of the ocular surface was induced by 1N NaOH in C57BL/6 mice. Injured mice were topically treated with 20% UCS, 20% PBS, or AT four times daily. The changes of corneal epithelial defects and degree of haze were analyzed at 6 h, 1, 2, 3, 5, and 7 days, and histological examination was performed at 3 and 7 days. The concentration of IL-1β in the cornea was measured by enzyme-linked immunosorbent assay at 7 days after treatment.Results: The UCS group showed lower epithelial defect parameters compared with the PBS group at 1 and 2 days (p < 0.05), and with the AT group from 1–5 days (p < 0.05). The haze scores were significantly lower in the UCS group than in the PBS group at 2 and 3 days (p < 0.05), and in the AT group from 2–7 days (p < 0.05). Histologi...

  • application of umbilical Cord Serum eyedrops for the treatment of neurotrophic keratitis
    Ophthalmology, 2007
    Co-Authors: Kyungchul Yoon, Incheon You, T S Jeong, Yeounggeol Park, Jin Choi
    Abstract:

    Purpose To investigate the efficacy of umbilical Cord Serum eyedrops for the treatment of neurotrophic keratitis. Design Prospective noncomparative case series. Participants Twenty-eight eyes of 28 patients with neurotrophic keratitis who were refractory to conventional treatment. Methods The patients with neurotrophic keraitis were treated with 20% umbilical Cord Serum eyedrops 6 to 10 times a day. Ophthalmic examinations including best-corrected visual acuity (VA) measurement, corneal sensitivity test, corneal fluorescein staining, and anterior segment photography were performed before and after the treatment. Concentrations of substance P, insulinlike growth factor 1 (IGF-1), and nerve growth factor (NGF) in umbilical Cord Serum, normal peripheral blood Serum, and tears were measured. Main Outcome Measures Epithelial healing time; changes of VA and corneal sensitivity after treatment; and levels of substance P, IGF-1, and NGF in umbilical Cord Serum, normal peripheral blood Serum, and tears. Results The epithelial defect healed completely in all eyes, with a mean healing time of 4.4±4.0 weeks. The epithelial defect healed within 2 weeks in 8 eyes (28.6%), between 2 and 4 weeks in 14 eyes (50.0%), and after 4 weeks in 6 eyes (21.4%). After treatment, VA improved by >2 lines in 17 eyes (60.7%). Mean pretreatment corneal sensitivity was 21.1±10.5 mm, and mean posttreatment corneal sensitivity was 24.3±11.7 mm ( P Conclusions Umbilical Cord Serum contains many neurotrophic factors, and umbilical Cord Serum eyedrops appeared to be effective for the treatment of neurotrophic keratitis.

  • comparison of autologous Serum and umbilical Cord Serum eye drops for dry eye syndrome
    American Journal of Ophthalmology, 2007
    Co-Authors: Kyungchul Yoon, Seongkyu Im, Yeounggeol Park
    Abstract:

    PURPOSE: To compare the therapeutic effect between autologous Serum and umbilical Cord Serum eye drops in the treatment of severe dry eye syndrome. DESIGN: Prospective case-control study. METHODS: Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjogren syndrome and 58 eyes of 31 patients with non-Sjogren syndrome) were treated with either 20% autologous Serum (41 eyes of 21 patients) or umbilical Cord Serum eye drops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytologic analysis were performed before and one month and two months after treatment. RESULTS: Both autologous Serum and umbilical Serum treatments led to improvement in the symptom score, tear film BUT, keratoepitheliopathy score, and impression cytologic findings. Symptom and keratoepitheliopathy scores were lower at one month (P = .03 and P = .12) and two months (P = .04 and .02) for those treated with umbilical Cord Serum compared with those treated with autologous Serum. In Sjogren syndrome patients, goblet cell density was higher at two months of umbilical Cord Serum treatment compared with autologous Serum treatment (P = .04). CONCLUSIONS: Umbilical Cord Serum eye drops were more effective in decreasing symptoms and keratoepitheliopathy in severe dry eye syndrome and increasing goblet cell density in Sjogren syndrome compared with autologous Serum eye drops.

  • therapeutic effect of umbilical Cord Serum eyedrops for the treatment of dry eye associated with graft versus host disease
    Bone Marrow Transplantation, 2007
    Co-Authors: Kyungchul Yoon, Yeounggeol Park, Inyoung Jeong, H Kim, J Choi
    Abstract:

    Therapeutic effect of umbilical Cord Serum eyedrops for the treatment of dry eye associated with graft-versus-host disease

Francois Andre - One of the best experts on this subject based on the ideXlab platform.

Jeanphilippe Antignac - One of the best experts on this subject based on the ideXlab platform.

  • Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and Cord Serum of French women and their newborns
    Environment International, 2015
    Co-Authors: Ronan Cariou, Daniel Zalko, Alain Berrebi, Philippe Marchand, Bruno Veyrand, Ami Yamada, Sophie Durand, Charles Pollono, Jean-charles Leblanc, Jeanphilippe Antignac
    Abstract:

    One major concern regarding perfluoroalkyl acids (PFAAs) is their potential role in onset of health troubles consecutive to early exposure during the perinatal period. In the present work, the internal exposure levels of 18 targeted PFAAs were determined in ca. 100 mother–newborn pairs recruited in France between 2010 and 2013. In Serum, the cumulated concentrations of the 7 most frequently detected compounds were 5.70 ng/mL and 2.83 ng/mL (median values) in maternal and Cord Serum, respectively. Perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexylesulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) contributed to around 90% of the total PFAAs contamination, with concentration levels and contamination profiles in acCordance with other published work in Europe. Levels measured in breast milk were far lower (20 to 150 fold) than those determined in Serum. Associations between the different monitored substances as well as between levels determined in the different investigated biological matrices mostly do not appear statistically significant. The estimated materno-foetal transfer would be thus substance-dependant, mainly driven by the physico-chemical properties of the different PFAAs (nature of polar group and length of alkylated side chain). We conclude that trans-placental passage and breastfeeding are both significant routes of human exposure to PFAAs.

  • exposure assessment of french women and their newborn to brominated flame retardants determination of tri to deca polybromodiphenylethers pbde in maternal adipose tissue Serum breast milk and Cord Serum
    Environmental Pollution, 2009
    Co-Authors: Jeanphilippe Antignac, Ronan Cariou, Daniel Zalko, Alain Berrebi, Jeanpierre Cravedi, Daniel Maume, Philippe Marchand, Fabrice Monteau, Anne Riu, Francois Andre
    Abstract:

    In the frame of a French monitoring program, tri- to deca- polybromodiphenylethers (PBDE) have been measured in maternal and Cord Serum, adipose tissue, and breast milk samples, collected from 93 volunteer women during caesarean deliveries. The seven major tri- to heptaBDE (BDE-28, 47, 99, 100, 153, 154, and 183) were detected in adipose tissue and breast milk with cumulated median values of 2.59 and 2.51 ng g(-1) l w. Nine highly brominated octa- to decaBDE (BDE-196, 197, 201, 202, 203, 206, 207, 208 and 209) was performed in the same samples, with cumulated median values of 2.73 and 3.39 ng g(-1) l w in adipose tissue and breast milk, respectively. At this opposite, median levels of octa- to decaBDE in maternal and Cord Serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) l w, respectively.

  • exposure assessment of french women and their newborns to tetrabromobisphenol a occurrence measurements in maternal adipose tissue Serum breast milk and Cord Serum
    Chemosphere, 2008
    Co-Authors: Ronan Cariou, Jeanphilippe Antignac, Daniel Zalko, Alain Berrebi, Jeanpierre Cravedi, Daniel Maume, Philippe Marchand, Fabrice Monteau, Anne Riu, Francois Andre
    Abstract:

    A French monitoring study was initiated to evaluate the exposure of fetus and newborn to brominated flame retardants (BFR). A previously developed multi-residue analytical method was used for measuring the main classes of BFR (tetrabromobisphenol-A, and tri- to decabomodiphenyl ethers) in various human biological matrices. Analyzed samples (maternal and Cord Serum, adipose tissue and breast milk) were collected from 93 volunteer women during caesarean deliveries. TBBPA was detected in 44% of the analyzed breast milk samples, at levels varying from 0.06 to 37.34 ng g(-1) lipid weight, but was not detected in adipose tissue. This compound was also detected in 30% of the analyzed Serum samples, with similar average values in maternal and Cord Serum (154 pg g(-1) fresh weight versus 199 pg g(-1) fresh weight, respectively). The interpretation of the collected data permitted the demonstration of (1) a significant exposure to TBBPA both for mothers and fetuses and (2) a possible risk of overexposure of newborns through breastfeeding.

Namrata Sharma - One of the best experts on this subject based on the ideXlab platform.

  • comparison of amniotic membrane transplantation and umbilical Cord Serum in acute ocular chemical burns a randomized controlled trial
    American Journal of Ophthalmology, 2016
    Co-Authors: Namrata Sharma, Thirumurthy Velpandian, Divya Singh, Prafulla K Maharana, Alka Kriplani, Ravindra Mohan Pandey, Rasik B Vajpayee
    Abstract:

    Purpose To compare the efficacy of topical umbilical Cord Serum drops (UCS) and amniotic membrane transplantation (AMT) in acute ocular chemical burns. Design Randomized controlled trial. Methods setting: Tertiary care hospital. study population: Forty-five eyes with acute chemical burns of grade III, IV, and V (Dua's classification) presenting within the first week of injury were randomized into 3 groups (15 each). Patients with perforation/impending corneal perforation were excluded from the study. intervention: Groups 1, 2, and 3 received UCS with medical therapy (MT), AMT with MT, and MT alone, respectively. main outcome measure: Time to complete epithelialization. Results The mean time to complete epithelialization was 56.7 ± 14.9, 22.0 ± 10.2, and 22.9 ± 10.1 days in MT, AMT, and UCS groups, respectively, with a significant difference between MT and AMT ( P  = .001) and between MT and UCS ( P  = .001), but not between UCS and AMT ( P  = .9). Improvement in pain score was better with UCS than AMT ( P value: .012, .002, and .012 on days 7, 14, and 21, respectively). Corneal clarity was better in the UCS group at 21 ( P  = .008) and 30 days ( P  = .002), but not at 3 months ( P  = .9). By month 3, visual outcome, symblepharon, tear film status, and lid abnormalities were comparable between the 3 groups. Conclusions UCS and AMT, as an adjuvant to standard medical therapy in acute chemical injury, are equally efficacious. UCS has the advantage of faster improvement in corneal clarity, better pain control, and avoidance of surgery in an inflamed eye.

  • comparison of umbilical Cord Serum and amniotic membrane transplantation in acute ocular chemical burns
    British Journal of Ophthalmology, 2015
    Co-Authors: Namrata Sharma, Shiv Shankar Lathi, Sri Vatsa Sehra, Tushar Agarwal, Rajesh Sinha, Jeewan S Titiyal, Thirumurthy Velpandian, Radhika Tandon, Rasik B Vajpayee
    Abstract:

    Purpose To compare the efficacy of umbilical Cord Serum (UCS) with amniotic membrane transplantation (AMT) in cases of acute ocular chemical burns. Methods In a retrospective, interventional, comparative case series, 55 eyes with grades III, IV and V chemical burns (Dua9s classification) who presented within 3 weeks of injury were evaluated. Patients were treated with conventional medical (CM group, 20 eyes) management alone or combined with either UCS (UCS group, 17 eyes) or AMT (AMT group, 18 eyes). The parameters evaluated were time to epithelialisation, epithelial defect diameter, epithelial defect area, corneal clarity, tear break-up time (TBUT), Schirmer test and best-corrected vision. Results UCS and AMT groups showed early epithelialisation as compared with the CM group (Kaplan–Meier analysis=0.01). Mean time for healing of epithelial defect was 57.7±29.3, 27.4±19.0, 41.1±28.9 days in the CM, UCS and AMT groups, respectively (p=0.02). Mean TBUT at the last follow-up was 8.6±0.7, 10.3±1.1, 9.4±1.2 s in the CM, UCS and AMT groups, respectively (p=0.02). The mean Schirmer value at the last follow-up was 13.7±1.0, 16.9±3.0 and 13.2±1.5 mm in the CM, UCS and AMT groups, respectively (p=0.01). The visual outcomes and the occurrence of corneal vascularisation, symblepheron, ectropion and entropion were comparable in between the groups. Conclusions Our study suggests that the UCS therapy may be a better alternative to AMT in acute moderate to severe (grades III, IV and V) ocular chemical burns, as it avoids surgical manoeuvre in already inflamed eyes.

  • evaluation of umbilical Cord Serum therapy in acute ocular chemical burns
    Investigative Ophthalmology & Visual Science, 2011
    Co-Authors: Namrata Sharma, Jeewan S Titiyal, Thirumurthy Velpandian, Radhika Tandon, Rasik B Vajpayee, Manik Goel
    Abstract:

    PURPOSE To evaluate the role of umbilical Cord Serum therapy in cases of acute ocular chemical burns. METHODS In a double-blind prospective randomized controlled clinical study, 33 eyes of 32 patients with acute ocular chemical burns of grade III, IV, and V severity were randomized into three groups: umbilical Cord Serum (n = 12), autologous Serum (n = 11), and artificial tears (0.5% HPMC+0.3% glycerin; n = 10). In addition, all eyes received standard medical therapy. The parameters evaluated were pain score, size, and area of epithelial defect, extent of limbal ischemia, corneal clarity, and symblepharon formation. The patients were followed up at day 1, 3, 7, 14, and 21 and at the end of months 1, 2, and 3. RESULTS Mean time to complete epithelialization was 21.16 ± 26.81, 56.6 ± 35.5, and 40.13 ± 35.79 days in Cord Serum, autologous Serum, and artificial tears groups respectively (P = 0.02). By day 21, the mean percentage decrease in epithelial defect diameter was 94.63 ± 11.99 with Cord Serum compared with 53.17 ± 34.81 and 64.22 ± 42.43 with autologous Serum and artificial tears, respectively (P = 0.01). By month 3, the extent of limbal ischemia with Cord Serum showed a mean percentage decrease of 73.43 ± 25.51 compared with 35.64 ± 25.60 and 43.71 ± 28.71 with autologous Serum and artificial tears, respectively (P = 0.008). More patients had clear corneas with Cord Serum compared with autologous Serum and artificial tears (P = 0.048). No significant difference was seen between the groups with regard to symblepharon formation (P = 0.07). CONCLUSIONS Umbilical Cord Serum therapy is more effective than autologous Serum eye drops or artificial tears in ocular surface restoration after acute chemical injuries. (www.controlled-trials.com number, ISRCTN08131903.).

  • evaluation of umbilical Cord Serum therapy for persistent corneal epithelial defects
    British Journal of Ophthalmology, 2003
    Co-Authors: Rasik B Vajpayee, Namrata Sharma, Radhika Tandon, Ravindra Mohan Pandey, Nitin Mukerji, N R Biswas, N Malhotra, Samir A Melki
    Abstract:

    Aims: To evaluate umbilical Cord Serum therapy as a means of promoting the healing of persistent corneal epithelial defects. Methods: Umbilical Cord Serum or autologous Serum drops were used to promote the healing of persistent epithelial defects. The study design was a prospective randomised controlled clinical trial. 60 eyes of 59 patients were divided into two groups, 31 in the Cord Serum group and 29 in the autologous Serum control group. Epithelial defects measuring at least 2 mm in linear dimension resistant to conventional medical management were included. Serial measurements of the size of the epithelial defects—namely, two maximum linear dimensions perpendicular to each other, and the area and perimeter was done at start of therapy and follow up days 3, 7, 14, 21. Rate of healing of the epithelial defects were measured as percentage decrease from the baseline parameter at each subsequent follow up. The data were analysed by the non-parametric Wilcoxon rank sum test using STATA 7.0. Results: The median percentage decrease in the size of the epithelial defect was significantly greater in the Cord Serum group at days 7, 14 and 21 (p Conclusions: Umbilical Cord Serum leads to faster healing of the persistent corneal epithelial defects refractory to all medical management compared to autologous Serum.