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Americo A. Migliaccio - One of the best experts on this subject based on the ideXlab platform.

  • Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex.
    Journal of the Association for Research in Otolaryngology : JARO, 2017
    Co-Authors: Patrick P. Hübner, David M. Lasker, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P 

  • Core Body Temperature effects on the mouse vestibulo ocular reflex
    Jaro-journal of The Association for Research in Otolaryngology, 2017
    Co-Authors: David M. Lasker, Patrick P. Hübner, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P < 0.001). Temperature had no other effects on the behavioural VOR. Our data suggest that Temperature effects on regularly firing afferents best correspond to the changes that we observed in the VOR gain.

Jacob Rosenberg - One of the best experts on this subject based on the ideXlab platform.

  • Disturbances in Melatonin, Cortisol and Core Body Temperature Rhythms after Major Surgery
    World Journal of Surgery, 2007
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    Background It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery. Methods Blood samples (melatonin and cortisol) and Core Body Temperature readings were collected every hour in the 24-h period prior to surgery and the 48 h after surgery from 11 patients undergoing major abdominal surgery. All patients had private rooms. Light exposure was controlled and monitored. Phase markers [50% dim light melatonin onset (DLMO 50%) and offset (DLMOff 50%), cortisol and Core Body Temperature acrophase] for the three circadian rhythm profiles were calculated before and after surgery. The correlation between the melatonin rhythm and time of surgery, duration of surgery and opioid use was examined. Results A median delay in the onset of melatonin was seen on the first postoperative day [median DLMO 50% 22:46 hours (range: 21:15–01:08 hours) on the preoperative day compared with 23:54 hours (range: 19:09–02:46 hours) on the first postoperative day; P  ≤ 0.05] . A significant positive correlation existed between the duration of surgery and the time of melatonin onset ( r = 0.67, P  ≤ 0.05) . There was a significantly reduced basal secretion of melatonin immediately after surgery, with a subsequent significant increase in maximum melatonin values on the second postoperative night. A median delay of up to 4 h was seen in the timing of the peak of the Temperature rhythm on the second postoperative day. Both cortisol secretion and Core Body Temperature were increased after surgery and did not return to preoperative values in the 48 h of the postoperative study period. No significant correlation between opioid dose and the basal or maximum melatonin levels or the time of melatonin onset was found. Conclusion We found disturbances in three circadian markers after major surgery. The clinical consequences of postoperative circadian disturbances should be investigated further in the future.

  • Disturbances in melatonin and Core Body Temperature circadian rhythms after minimal invasive surgery
    Acta anaesthesiologica Scandinavica, 2007
    Co-Authors: Ismail Gögenur, Benita Middleton, Debra J. Skene, Viggo B. Kristiansen, Jacob Rosenberg
    Abstract:

    Sleep disturbances, fatigue and reduced general well-being frequently occur after minimal invasive surgery. The circadian rhythms of melatonin and Core Body Temperature are central to the regulation of normal sleep. The aim of this study was to assess changes in these circadian rhythms after laparoscopic cholecystectomy. Twelve women were studied before and after laparoscopic cholecystectomy. The major urinary melatonin metabolite, 6-sulphatoxymelatonin (aMT6s), and the Core Body Temperature were measured for 1 day before and 1 day after surgery. The basal and maximum secretion of aMT6s were determined, as well as the timing and amplitude of aMT6s and the Temperature rhythm. The patients' rest-activity and calculated sleep parameters were assessed by actigraphy. A significant delay in the timing of aMT6s rhythm was observed after surgery [median (range) peak time of aMT6s: after surgery, 05:49 h (02:57-08:23 h); before surgery, 04:32 h (02:18-06:49 h); P< or = 0.05]. The amplitude of the aMT6s rhythm was also significantly decreased after surgery [after surgery, 7.1 ng aMT6s/mg creatinine (1-15.9 ng); before surgery, 13.2 ng aMT6s/mg creatinine (2.9-22.7 ng); P< or = 0.005]. There was almost a 12-h phase delay of the Core Body Temperature rhythm after surgery [peak time: before surgery, 17:39 h (15:17-22:06 h); after surgery, 05:14 h (03:24-21:43 h); P< or = 0.01]. Following laparoscopic cholecystectomy, there was a delay in the timing of the aMT6s rhythm and a decreased evening decline in the Temperature rhythm.

  • Disturbances in melatonin, cortisol and Core Body Temperature rhythms after major surgery.
    World journal of surgery, 2006
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    Background It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery.

  • Disturbances in melatonin, cortisol and Core Body Temperature rhythms after major surgery.
    World journal of surgery, 2006
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery. Blood samples (melatonin and cortisol) and Core Body Temperature readings were collected every hour in the 24-h period prior to surgery and the 48 h after surgery from 11 patients undergoing major abdominal surgery. All patients had private rooms. Light exposure was controlled and monitored. Phase markers [50% dim light melatonin onset (DLMO 50%) and offset (DLMOff 50%), cortisol and Core Body Temperature acrophase] for the three circadian rhythm profiles were calculated before and after surgery. The correlation between the melatonin rhythm and time of surgery, duration of surgery and opioid use was examined. A median delay in the onset of melatonin was seen on the first postoperative day [median DLMO 50% 22:46 hours (range: 21:15-01:08 hours) on the preoperative day compared with 23:54 hours (range: 19:09-02:46 hours) on the first postoperative day; P </= 0.05] . A significant positive correlation existed between the duration of surgery and the time of melatonin onset (r = 0.67, P </= 0.05) . There was a significantly reduced basal secretion of melatonin immediately after surgery, with a subsequent significant increase in maximum melatonin values on the second postoperative night. A median delay of up to 4 h was seen in the timing of the peak of the Temperature rhythm on the second postoperative day. Both cortisol secretion and Core Body Temperature were increased after surgery and did not return to preoperative values in the 48 h of the postoperative study period. No significant correlation between opioid dose and the basal or maximum melatonin levels or the time of melatonin onset was found. We found disturbances in three circadian markers after major surgery. The clinical consequences of postoperative circadian disturbances should be investigated further in the future.

Patrick P. Hübner - One of the best experts on this subject based on the ideXlab platform.

  • Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex.
    Journal of the Association for Research in Otolaryngology : JARO, 2017
    Co-Authors: Patrick P. Hübner, David M. Lasker, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P 

  • Core Body Temperature effects on the mouse vestibulo ocular reflex
    Jaro-journal of The Association for Research in Otolaryngology, 2017
    Co-Authors: David M. Lasker, Patrick P. Hübner, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P < 0.001). Temperature had no other effects on the behavioural VOR. Our data suggest that Temperature effects on regularly firing afferents best correspond to the changes that we observed in the VOR gain.

Ismail Gögenur - One of the best experts on this subject based on the ideXlab platform.

  • Disturbances in Melatonin, Cortisol and Core Body Temperature Rhythms after Major Surgery
    World Journal of Surgery, 2007
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    Background It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery. Methods Blood samples (melatonin and cortisol) and Core Body Temperature readings were collected every hour in the 24-h period prior to surgery and the 48 h after surgery from 11 patients undergoing major abdominal surgery. All patients had private rooms. Light exposure was controlled and monitored. Phase markers [50% dim light melatonin onset (DLMO 50%) and offset (DLMOff 50%), cortisol and Core Body Temperature acrophase] for the three circadian rhythm profiles were calculated before and after surgery. The correlation between the melatonin rhythm and time of surgery, duration of surgery and opioid use was examined. Results A median delay in the onset of melatonin was seen on the first postoperative day [median DLMO 50% 22:46 hours (range: 21:15–01:08 hours) on the preoperative day compared with 23:54 hours (range: 19:09–02:46 hours) on the first postoperative day; P  ≤ 0.05] . A significant positive correlation existed between the duration of surgery and the time of melatonin onset ( r = 0.67, P  ≤ 0.05) . There was a significantly reduced basal secretion of melatonin immediately after surgery, with a subsequent significant increase in maximum melatonin values on the second postoperative night. A median delay of up to 4 h was seen in the timing of the peak of the Temperature rhythm on the second postoperative day. Both cortisol secretion and Core Body Temperature were increased after surgery and did not return to preoperative values in the 48 h of the postoperative study period. No significant correlation between opioid dose and the basal or maximum melatonin levels or the time of melatonin onset was found. Conclusion We found disturbances in three circadian markers after major surgery. The clinical consequences of postoperative circadian disturbances should be investigated further in the future.

  • Disturbances in melatonin and Core Body Temperature circadian rhythms after minimal invasive surgery
    Acta anaesthesiologica Scandinavica, 2007
    Co-Authors: Ismail Gögenur, Benita Middleton, Debra J. Skene, Viggo B. Kristiansen, Jacob Rosenberg
    Abstract:

    Sleep disturbances, fatigue and reduced general well-being frequently occur after minimal invasive surgery. The circadian rhythms of melatonin and Core Body Temperature are central to the regulation of normal sleep. The aim of this study was to assess changes in these circadian rhythms after laparoscopic cholecystectomy. Twelve women were studied before and after laparoscopic cholecystectomy. The major urinary melatonin metabolite, 6-sulphatoxymelatonin (aMT6s), and the Core Body Temperature were measured for 1 day before and 1 day after surgery. The basal and maximum secretion of aMT6s were determined, as well as the timing and amplitude of aMT6s and the Temperature rhythm. The patients' rest-activity and calculated sleep parameters were assessed by actigraphy. A significant delay in the timing of aMT6s rhythm was observed after surgery [median (range) peak time of aMT6s: after surgery, 05:49 h (02:57-08:23 h); before surgery, 04:32 h (02:18-06:49 h); P< or = 0.05]. The amplitude of the aMT6s rhythm was also significantly decreased after surgery [after surgery, 7.1 ng aMT6s/mg creatinine (1-15.9 ng); before surgery, 13.2 ng aMT6s/mg creatinine (2.9-22.7 ng); P< or = 0.005]. There was almost a 12-h phase delay of the Core Body Temperature rhythm after surgery [peak time: before surgery, 17:39 h (15:17-22:06 h); after surgery, 05:14 h (03:24-21:43 h); P< or = 0.01]. Following laparoscopic cholecystectomy, there was a delay in the timing of the aMT6s rhythm and a decreased evening decline in the Temperature rhythm.

  • Disturbances in melatonin, cortisol and Core Body Temperature rhythms after major surgery.
    World journal of surgery, 2006
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    Background It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery.

  • Disturbances in melatonin, cortisol and Core Body Temperature rhythms after major surgery.
    World journal of surgery, 2006
    Co-Authors: Ismail Gögenur, Ubbat Ocak, Ömer Altunpinar, Benita Middleton, Debra J. Skene, Jacob Rosenberg
    Abstract:

    It has been suggested that circadian rhythm disturbances are present after major surgery and that this may play a role in the development of postoperative sleep disturbances, fatigue, cognitive dysfunction and cardiovascular morbidity. The objective of this study was to examine the profile of melatonin, cortisol and Core Body Temperature rhythms before and after major surgery. Blood samples (melatonin and cortisol) and Core Body Temperature readings were collected every hour in the 24-h period prior to surgery and the 48 h after surgery from 11 patients undergoing major abdominal surgery. All patients had private rooms. Light exposure was controlled and monitored. Phase markers [50% dim light melatonin onset (DLMO 50%) and offset (DLMOff 50%), cortisol and Core Body Temperature acrophase] for the three circadian rhythm profiles were calculated before and after surgery. The correlation between the melatonin rhythm and time of surgery, duration of surgery and opioid use was examined. A median delay in the onset of melatonin was seen on the first postoperative day [median DLMO 50% 22:46 hours (range: 21:15-01:08 hours) on the preoperative day compared with 23:54 hours (range: 19:09-02:46 hours) on the first postoperative day; P </= 0.05] . A significant positive correlation existed between the duration of surgery and the time of melatonin onset (r = 0.67, P </= 0.05) . There was a significantly reduced basal secretion of melatonin immediately after surgery, with a subsequent significant increase in maximum melatonin values on the second postoperative night. A median delay of up to 4 h was seen in the timing of the peak of the Temperature rhythm on the second postoperative day. Both cortisol secretion and Core Body Temperature were increased after surgery and did not return to preoperative values in the 48 h of the postoperative study period. No significant correlation between opioid dose and the basal or maximum melatonin levels or the time of melatonin onset was found. We found disturbances in three circadian markers after major surgery. The clinical consequences of postoperative circadian disturbances should be investigated further in the future.

Serajul I. Khan - One of the best experts on this subject based on the ideXlab platform.

  • Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex.
    Journal of the Association for Research in Otolaryngology : JARO, 2017
    Co-Authors: Patrick P. Hübner, David M. Lasker, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P 

  • Core Body Temperature effects on the mouse vestibulo ocular reflex
    Jaro-journal of The Association for Research in Otolaryngology, 2017
    Co-Authors: David M. Lasker, Patrick P. Hübner, Serajul I. Khan, Americo A. Migliaccio
    Abstract:

    Core Body Temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with Temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-Body sinusoidal rotations ranging 0.5–12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-Body transient rotations with acceleration 3000 or 6000 °/s2 reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse’s Core Body Temperature was held at either 32 or 37 °C for at least 35 min before recording. The Temperature presentation order and timing were pseudo-randomized. We found that a Temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P < 0.001). Temperature had no other effects on the behavioural VOR. Our data suggest that Temperature effects on regularly firing afferents best correspond to the changes that we observed in the VOR gain.