The Experts below are selected from a list of 214068 Experts worldwide ranked by ideXlab platform
Albert B Reynolds - One of the best experts on this subject based on the ideXlab platform.
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JCB Article A Core Function for p120-catenin in cadherin turnover
2013Co-Authors: Michael A. Davis, Renee C Ireton, Albert B ReynoldsAbstract:p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and �-catenin were Functionally redundant, suggesting that proper cadherindependent adhesion requires the presence of at least one p120 family member. The data reveal a Core Function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120. The Journal of Cell Biolog
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a Core Function for p120 catenin in cadherin turnover
Journal of Cell Biology, 2003Co-Authors: Michael Davis, Renee C Ireton, Albert B ReynoldsAbstract:p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were Functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a Core Function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
Charan Ranganath - One of the best experts on this subject based on the ideXlab platform.
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space time and episodic memory the hippocampus is all over the cognitive map
Hippocampus, 2018Co-Authors: Arne D Ekstrom, Charan RanganathAbstract:In recent years, the field has reached an impasse between models suggesting that the hippocampus is fundamentally involved in spatial processing and models suggesting that the hippocampus automatically encodes all dimensions of experience in the service of memory. Here, we consider key conceptual issues that have impeded progress in our understanding of hippocampal Function, and we review findings that establish the scope and limits of hippocampal involvement in navigation and memory. We argue that space and time serve as a primary scaffold to break up experiences into specific contexts, and to organize multimodal input that is to be associated within a context. However, the hippocampus is clearly capable of incorporating additional dimensions into the scaffold if they are determined to be relevant in the event-defined context. Conceiving of the hippocampal representation as constrained by immediate task demands-yet preferring axes that involve space and time-helps to reconcile an otherwise disparate set of findings on the Core Function of the hippocampus.
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space time and episodic memory the hippocampus is all over the cognitive map
Hippocampus, 2018Co-Authors: Arne D Ekstrom, Charan RanganathAbstract:In recent years, the field has reached an impasse between models suggesting that the hippocampus is fundamentally involved in spatial processing and models suggesting that the hippocampus automatically encodes all dimensions of experience in the service of memory. Here, we consider key conceptual issues that have impeded progress in our understanding of hippocampal Function, and we review findings that establish the scope and limits of hippocampal involvement in navigation and memory. We argue that space and time serve as a primary scaffold to break up experiences into specific contexts, and to organize multimodal input that is to be associated within a context. However, the hippocampus is clearly capable of incorporating additional dimensions into the scaffold if they are determined to be relevant in the event-defined context. Conceiving of the hippocampal representation as constrained by immediate task demands—yet preferring axes that involve space and time—helps to reconcile an otherwise disparate set of findings on the Core Function of the hippocampus. This article is protected by copyright. All rights reserved.
Arne D Ekstrom - One of the best experts on this subject based on the ideXlab platform.
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space time and episodic memory the hippocampus is all over the cognitive map
Hippocampus, 2018Co-Authors: Arne D Ekstrom, Charan RanganathAbstract:In recent years, the field has reached an impasse between models suggesting that the hippocampus is fundamentally involved in spatial processing and models suggesting that the hippocampus automatically encodes all dimensions of experience in the service of memory. Here, we consider key conceptual issues that have impeded progress in our understanding of hippocampal Function, and we review findings that establish the scope and limits of hippocampal involvement in navigation and memory. We argue that space and time serve as a primary scaffold to break up experiences into specific contexts, and to organize multimodal input that is to be associated within a context. However, the hippocampus is clearly capable of incorporating additional dimensions into the scaffold if they are determined to be relevant in the event-defined context. Conceiving of the hippocampal representation as constrained by immediate task demands-yet preferring axes that involve space and time-helps to reconcile an otherwise disparate set of findings on the Core Function of the hippocampus.
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space time and episodic memory the hippocampus is all over the cognitive map
Hippocampus, 2018Co-Authors: Arne D Ekstrom, Charan RanganathAbstract:In recent years, the field has reached an impasse between models suggesting that the hippocampus is fundamentally involved in spatial processing and models suggesting that the hippocampus automatically encodes all dimensions of experience in the service of memory. Here, we consider key conceptual issues that have impeded progress in our understanding of hippocampal Function, and we review findings that establish the scope and limits of hippocampal involvement in navigation and memory. We argue that space and time serve as a primary scaffold to break up experiences into specific contexts, and to organize multimodal input that is to be associated within a context. However, the hippocampus is clearly capable of incorporating additional dimensions into the scaffold if they are determined to be relevant in the event-defined context. Conceiving of the hippocampal representation as constrained by immediate task demands—yet preferring axes that involve space and time—helps to reconcile an otherwise disparate set of findings on the Core Function of the hippocampus. This article is protected by copyright. All rights reserved.
Michael Davis - One of the best experts on this subject based on the ideXlab platform.
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a Core Function for p120 catenin in cadherin turnover
Journal of Cell Biology, 2003Co-Authors: Michael Davis, Renee C Ireton, Albert B ReynoldsAbstract:p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were Functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a Core Function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
Renee C Ireton - One of the best experts on this subject based on the ideXlab platform.
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JCB Article A Core Function for p120-catenin in cadherin turnover
2013Co-Authors: Michael A. Davis, Renee C Ireton, Albert B ReynoldsAbstract:p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and �-catenin were Functionally redundant, suggesting that proper cadherindependent adhesion requires the presence of at least one p120 family member. The data reveal a Core Function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120. The Journal of Cell Biolog
-
a Core Function for p120 catenin in cadherin turnover
Journal of Cell Biology, 2003Co-Authors: Michael Davis, Renee C Ireton, Albert B ReynoldsAbstract:p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels. p120 knockdown by siRNA expression resulted in dose-dependent elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell–cell adhesion. ARVCF and δ-catenin were Functionally redundant, suggesting that proper cadherin-dependent adhesion requires the presence of at least one p120 family member. The data reveal a Core Function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.