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Ernest C. Borden - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of Angiogenesis by Interferons: Effects on Tumor- and
2013Co-Authors: Younan A. Sidky, Ernest C. Borden, Contact The Aacr Publications, Lymphocyte-induced Vascular ResponsesAbstract:Interferons (IFNs) have established antiTumor action; the mechanism underlying this effect is, however, not yet clear. To probe the possible contribution of inhibition of angiogenesis, we have assessed angiogenesis in the mouse initiated by either human or murine Tumor cell lines. Whether test cells were inoculated in the dermis or Tumor fragments were grafted onto the Cornea, Tumor-induced angiogenesis (TIA) was inhibited by IFNs. TIA was also inhibited by the potent IFN inducer polyriboinosinic-polyribocytidylic acid. The effect of IFN was species specific; human IFNs inhibited human Tumors and mouse IFNs inhibited murine Tumors. This effect suggested that in contrast to other angiogen esis inhibitors, IFNs modulated the signal for angiogenesis produced by the Tumor cells. Tumor cells treated in vitro with homologous IFN were significantly (P < 0.005) less competent to initiate angiogenesis than were untreated cells. Inhibition of angiogenesis was achieved whethe
Younan A. Sidky - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of Angiogenesis by Interferons: Effects on Tumor- and
2013Co-Authors: Younan A. Sidky, Ernest C. Borden, Contact The Aacr Publications, Lymphocyte-induced Vascular ResponsesAbstract:Interferons (IFNs) have established antiTumor action; the mechanism underlying this effect is, however, not yet clear. To probe the possible contribution of inhibition of angiogenesis, we have assessed angiogenesis in the mouse initiated by either human or murine Tumor cell lines. Whether test cells were inoculated in the dermis or Tumor fragments were grafted onto the Cornea, Tumor-induced angiogenesis (TIA) was inhibited by IFNs. TIA was also inhibited by the potent IFN inducer polyriboinosinic-polyribocytidylic acid. The effect of IFN was species specific; human IFNs inhibited human Tumors and mouse IFNs inhibited murine Tumors. This effect suggested that in contrast to other angiogen esis inhibitors, IFNs modulated the signal for angiogenesis produced by the Tumor cells. Tumor cells treated in vitro with homologous IFN were significantly (P < 0.005) less competent to initiate angiogenesis than were untreated cells. Inhibition of angiogenesis was achieved whethe
Contact The Aacr Publications - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of Angiogenesis by Interferons: Effects on Tumor- and
2013Co-Authors: Younan A. Sidky, Ernest C. Borden, Contact The Aacr Publications, Lymphocyte-induced Vascular ResponsesAbstract:Interferons (IFNs) have established antiTumor action; the mechanism underlying this effect is, however, not yet clear. To probe the possible contribution of inhibition of angiogenesis, we have assessed angiogenesis in the mouse initiated by either human or murine Tumor cell lines. Whether test cells were inoculated in the dermis or Tumor fragments were grafted onto the Cornea, Tumor-induced angiogenesis (TIA) was inhibited by IFNs. TIA was also inhibited by the potent IFN inducer polyriboinosinic-polyribocytidylic acid. The effect of IFN was species specific; human IFNs inhibited human Tumors and mouse IFNs inhibited murine Tumors. This effect suggested that in contrast to other angiogen esis inhibitors, IFNs modulated the signal for angiogenesis produced by the Tumor cells. Tumor cells treated in vitro with homologous IFN were significantly (P < 0.005) less competent to initiate angiogenesis than were untreated cells. Inhibition of angiogenesis was achieved whethe
Lymphocyte-induced Vascular Responses - One of the best experts on this subject based on the ideXlab platform.
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Inhibition of Angiogenesis by Interferons: Effects on Tumor- and
2013Co-Authors: Younan A. Sidky, Ernest C. Borden, Contact The Aacr Publications, Lymphocyte-induced Vascular ResponsesAbstract:Interferons (IFNs) have established antiTumor action; the mechanism underlying this effect is, however, not yet clear. To probe the possible contribution of inhibition of angiogenesis, we have assessed angiogenesis in the mouse initiated by either human or murine Tumor cell lines. Whether test cells were inoculated in the dermis or Tumor fragments were grafted onto the Cornea, Tumor-induced angiogenesis (TIA) was inhibited by IFNs. TIA was also inhibited by the potent IFN inducer polyriboinosinic-polyribocytidylic acid. The effect of IFN was species specific; human IFNs inhibited human Tumors and mouse IFNs inhibited murine Tumors. This effect suggested that in contrast to other angiogen esis inhibitors, IFNs modulated the signal for angiogenesis produced by the Tumor cells. Tumor cells treated in vitro with homologous IFN were significantly (P < 0.005) less competent to initiate angiogenesis than were untreated cells. Inhibition of angiogenesis was achieved whethe
Karampatakis Vasileios - One of the best experts on this subject based on the ideXlab platform.
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The Antiangiogenic Properties of Adipose-Derived Mesenchymal Stem/Stromal Cells in Corneal Neovascularization in a Rabbit Model
IVORC, 2020Co-Authors: Pirounides Demetrios, Komnenou Anastasia, Papaioannou Nikolaos, Gounari Eleni, Stylianaki Ioanna, Alexandridis Alexandros, Chranioti Angeliki, Kofidou Evangelia, Koliakos Georgios, Karampatakis VasileiosAbstract:The purpose was to study the anti-angiogenic effect of adipose-derived mesenchymal stem/stromal cells (ADMSCs) on experimentally induced Corneal injuries. Corneal neovascularization (NV) was induced by incising and subsequently suturing the Corneal surface in 32 New Zealand rabbits. Following suturing, the rabbits were randomly allocated into 2 groups, and received either phosphate-buffered saline (PBS) (control) or ADMSCs, both administered via three different routes. Digital images of the Cornea were obtained two weeks post-incision to measure the area of neovascularized Cornea. Tumor necrosis factor (TNF) was immunohistochemically assessed in the both groups. The Corneal tissue was evaluated for vascular endothelial growth factor (VEGF). The extent of Corneal NV in all eyes was assessed photographically by an independent observer. Fourteen days after the incisions, the degree of Corneal NV was substantially decreased in the ADMSC-treated group (1.87 ± 0.9 mm2, 1.4 % ± 0.67 % of Corneal surface) compared to the control and PBS-treated group (4.66 ± 1.74 mm2, 3.51 % ± 1.31 %, p < 0.001). ADMSCs significantly decreased injury-induced Corneal NV in New Zealand rabbits two weeks post-treatment. This strategy has potential for use in the control of Corneal NV in vivo.