The Experts below are selected from a list of 1152 Experts worldwide ranked by ideXlab platform

Alvin L Young - One of the best experts on this subject based on the ideXlab platform.

  • infectious keratitis and orthokeratology lens use a systematic review
    Infection, 2017
    Co-Authors: Ka Wai Kam, Wing Yung, Li Jia Chen, Alvin L Young
    Abstract:

    Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. We searched in the PubMed and EMBASE for articles adopting the search strategy “(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR Cornea Ulcer OR microbial keratitis OR bacterial keratitis)”, from the start date of the databases to August 23, 2016. Articles reporting infectious keratitis in orthokeratology lens users with data of individual cases were considered eligible for this systematic review. We recorded the outcome measures including method of diagnosis, etiological agents, duration and mode of treatment and treatment outcomes. Our literature search yielded 172 papers. After removing duplicated and irrelevant reports, we included 29 articles for data analysis, involving 173 eyes. Among all reported cases, the mean age at presentation was 15.4 ± 6.2 years, with a female preponderance (male-to-female ratio 1:1.7). Positive microbiological cultures were reported in 69.4% of cases, with Pseudomonas aeruginosa and Acanthamoeba being the most common etiological agents. The mean duration of hospitalization was 7.7 ± 6.7 days. Mean LogMAR visual acuity at presentation was 1.17 ± 0.78, increased to 0.33 ± 0.41 at final visit (p < 0.001). Despite early intervention and treatment, the majority of infections resulted in the formation of Corneal scars and almost 10% of eyes needed surgical treatment. Timely awareness and treatment of keratitis should be emphasized to the users.

Ka Wai Kam - One of the best experts on this subject based on the ideXlab platform.

  • infectious keratitis and orthokeratology lens use a systematic review
    Infection, 2017
    Co-Authors: Ka Wai Kam, Wing Yung, Li Jia Chen, Alvin L Young
    Abstract:

    Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. We searched in the PubMed and EMBASE for articles adopting the search strategy “(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR Cornea Ulcer OR microbial keratitis OR bacterial keratitis)”, from the start date of the databases to August 23, 2016. Articles reporting infectious keratitis in orthokeratology lens users with data of individual cases were considered eligible for this systematic review. We recorded the outcome measures including method of diagnosis, etiological agents, duration and mode of treatment and treatment outcomes. Our literature search yielded 172 papers. After removing duplicated and irrelevant reports, we included 29 articles for data analysis, involving 173 eyes. Among all reported cases, the mean age at presentation was 15.4 ± 6.2 years, with a female preponderance (male-to-female ratio 1:1.7). Positive microbiological cultures were reported in 69.4% of cases, with Pseudomonas aeruginosa and Acanthamoeba being the most common etiological agents. The mean duration of hospitalization was 7.7 ± 6.7 days. Mean LogMAR visual acuity at presentation was 1.17 ± 0.78, increased to 0.33 ± 0.41 at final visit (p < 0.001). Despite early intervention and treatment, the majority of infections resulted in the formation of Corneal scars and almost 10% of eyes needed surgical treatment. Timely awareness and treatment of keratitis should be emphasized to the users.

Wing Yung - One of the best experts on this subject based on the ideXlab platform.

  • infectious keratitis and orthokeratology lens use a systematic review
    Infection, 2017
    Co-Authors: Ka Wai Kam, Wing Yung, Li Jia Chen, Alvin L Young
    Abstract:

    Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. We searched in the PubMed and EMBASE for articles adopting the search strategy “(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR Cornea Ulcer OR microbial keratitis OR bacterial keratitis)”, from the start date of the databases to August 23, 2016. Articles reporting infectious keratitis in orthokeratology lens users with data of individual cases were considered eligible for this systematic review. We recorded the outcome measures including method of diagnosis, etiological agents, duration and mode of treatment and treatment outcomes. Our literature search yielded 172 papers. After removing duplicated and irrelevant reports, we included 29 articles for data analysis, involving 173 eyes. Among all reported cases, the mean age at presentation was 15.4 ± 6.2 years, with a female preponderance (male-to-female ratio 1:1.7). Positive microbiological cultures were reported in 69.4% of cases, with Pseudomonas aeruginosa and Acanthamoeba being the most common etiological agents. The mean duration of hospitalization was 7.7 ± 6.7 days. Mean LogMAR visual acuity at presentation was 1.17 ± 0.78, increased to 0.33 ± 0.41 at final visit (p < 0.001). Despite early intervention and treatment, the majority of infections resulted in the formation of Corneal scars and almost 10% of eyes needed surgical treatment. Timely awareness and treatment of keratitis should be emphasized to the users.

Li Jia Chen - One of the best experts on this subject based on the ideXlab platform.

  • infectious keratitis and orthokeratology lens use a systematic review
    Infection, 2017
    Co-Authors: Ka Wai Kam, Wing Yung, Li Jia Chen, Alvin L Young
    Abstract:

    Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. We searched in the PubMed and EMBASE for articles adopting the search strategy “(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR Cornea Ulcer OR microbial keratitis OR bacterial keratitis)”, from the start date of the databases to August 23, 2016. Articles reporting infectious keratitis in orthokeratology lens users with data of individual cases were considered eligible for this systematic review. We recorded the outcome measures including method of diagnosis, etiological agents, duration and mode of treatment and treatment outcomes. Our literature search yielded 172 papers. After removing duplicated and irrelevant reports, we included 29 articles for data analysis, involving 173 eyes. Among all reported cases, the mean age at presentation was 15.4 ± 6.2 years, with a female preponderance (male-to-female ratio 1:1.7). Positive microbiological cultures were reported in 69.4% of cases, with Pseudomonas aeruginosa and Acanthamoeba being the most common etiological agents. The mean duration of hospitalization was 7.7 ± 6.7 days. Mean LogMAR visual acuity at presentation was 1.17 ± 0.78, increased to 0.33 ± 0.41 at final visit (p < 0.001). Despite early intervention and treatment, the majority of infections resulted in the formation of Corneal scars and almost 10% of eyes needed surgical treatment. Timely awareness and treatment of keratitis should be emphasized to the users.

Alessandro Lambiase - One of the best experts on this subject based on the ideXlab platform.

  • the topical application of nerve growth factor as a pharmacological tool for human Corneal and skin Ulcers
    Pharmacological Research, 2008
    Co-Authors: Luigi Aloe, Paola Tirassa, Alessandro Lambiase
    Abstract:

    Abstract Aim The nerve growth factor is a soluble protein produced by and acting upon a number of different cells located in the nervous, endocrine and immune systems. Recent studies have shown that nerve growth factor (NGF) exerts a critical role on epithelial cells and fibroblasts under normal and pathological conditions. In this review, we present data prospecting the clinical potentiality of NGF in cutaneous and ocular “non-healing” chronic Ulcers. Data synthesis A consistent number of in vitro and in vivo studies carried out on animal models and in humans indicated that fibroblasts and epithelial cells are receptive to the action of NGF and that NGF promotes skin and Cornea Ulcer healing. These observations lead to the hypothesis that NGF can be a potential useful pharmacological agent for clinical investigations. Conclusion The available clinical evidences suggest that the topical application of NGF promotes healing action without side effects on Corneal and cutaneous tissues damaged by chemical, physical and surgical insults and autoimmune disorders.