The Experts below are selected from a list of 234 Experts worldwide ranked by ideXlab platform

Nagib Dahdah - One of the best experts on this subject based on the ideXlab platform.

  • Coronary Artery Dilatation in Viral Myocarditis Mimics Coronary Artery Findings in Kawasaki Disease
    Pediatric cardiology, 2016
    Co-Authors: Soha Rached-d’astous, Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Nagib Dahdah
    Abstract:

    Coronary Artery (CA) Dilatations are typical to Kawasaki disease (KD) in the pediatric population. CA involvement is a useful feature to help establish the diagnosis of KD. Since myocarditis is omnipresent in the acute phase of KD, we sought to investigate whether viral myocarditis may cause CA Dilatation. This retrospective study reviewed 14 consecutive patients diagnosed with acute myocarditis at CHU Sainte-Justine, Montreal. KD diagnosis was excluded for all patients. All echocardiography studies were reviewed by an independent experienced echocardiographer for CA size and myocardial function parameters. CA involvement was classified under three categories: definite Dilatation (Z-score ≥2.5 in one or more CA), occult Dilatation (Z-score variation ≥2 points for the same CA on two different echocardiograms, but maximum Z-score always

  • Coronary Artery Dilatation in viral myocarditis mimics Coronary Artery findings in kawasaki disease
    Pediatric Cardiology, 2016
    Co-Authors: Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Soha Racheddastous, Nagib Dahdah
    Abstract:

    Coronary Artery (CA) Dilatations are typical to Kawasaki disease (KD) in the pediatric population. CA involvement is a useful feature to help establish the diagnosis of KD. Since myocarditis is omnipresent in the acute phase of KD, we sought to investigate whether viral myocarditis may cause CA Dilatation. This retrospective study reviewed 14 consecutive patients diagnosed with acute myocarditis at CHU Sainte-Justine, Montreal. KD diagnosis was excluded for all patients. All echocardiography studies were reviewed by an independent experienced echocardiographer for CA size and myocardial function parameters. CA involvement was classified under three categories: definite Dilatation (Z-score ≥2.5 in one or more CA), occult Dilatation (Z-score variation ≥2 points for the same CA on two different echocardiograms, but maximum Z-score always <2.5), and no Dilatation otherwise. Demographics, laboratory values, microbial etiology testing, and diagnostic studies were collected from medical records. Mean age at presentation was 1.67 ± 3.22 years, where 11/14 (78 %) presented with acute and three with subacute myocarditis. Five (36 %) patients had normal CA measurements, six (43 %) had occult Dilatation, and three (21 %) had definite Dilatation. Maximal CA Z-score was within the first 8 days of presentation. Patients with viral myocarditis can present CA Dilatation during the acute phase of the illness. This finding should be taken into account when KD diagnosis is being based on the CA involvement as the two illnesses may present with similar features.

  • Abstract O.37: Coronary Artery Dilatation in Viral Myocarditis Mimics Coronary Artery Findings In Kawasaki Disease
    Circulation, 2015
    Co-Authors: Soha Rached-d’astous, Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Nagib Dahdah
    Abstract:

    Background: Coronary Artery Dilatations are almost always secondary to Kawasaki disease in the pediatric population. The presence of CA involvement is used as a criterion to diagnose incomplete KD ...

  • abstract 165 Coronary Artery Dilatation in kawasaki disease is associated with anatomical Coronary dominance an angiography based study
    Circulation, 2015
    Co-Authors: Baher Hanna, Anne Fournier, Chantale Lapierre, Frederick Trinh Tan, Larent Desjardins, Nagib Dahdah
    Abstract:

    Introduction: Coronary Artery (CA) Dilatation in Kawasaki disease (KD) is best determined by elevated Z-scores. Z-score equations, do not take into account anatomical CA dominance. We hypothesize that, except for CA aneurysms, CA dominance influences Dilatation status in KD (Z-score > 2.5). Material and Methods: We retrospectively analyzed CA status in KD patients followed at our institution for persistent CA Dilatation. All patients who had a diagnostic catheterization between 2002 and 2012 were considered. Serial echocardiographic dimensions of LCA, RCA, and LAD upon diagnosis, 1 week, 2 weeks, 4 weeks, 2 months, 3-6 months, and 9-12 months later were normalized to BSA using published CA Z-score equations. Data were contrasted with CA angiography description of CA dominance: right or left dominance was adopted when the respective CA supplies both diaphragmatic LV free wall and posterior inter ventricular septum (IVS); Co-dominance was when posterior IVS was supplied by RCA and diaphragmatic LV free wall by LCA. Results: Of 69 potential patients, 16 were excluded (9 never presented a CA Dilatation and 7 had CA aneurysms). The interval between acute onset and selective CA angiography of the remaining 53 patients was 69.5±52.8months at 9.2±5.2years old. Of the latter, 20(37.7%) had LCA-dominance, 31(58.5%) RCA-dominance, and 2(3.8%) Co-dominance. Upon KD onset, the LCA-dominant subset had 14/20(70%) ipsilateral Dilatation vs. 6/20(30%) contralateral Dilatation. Similarly, RCA-dominant Dilatation was ipsilateral in 21/31(68%) vs. 10/31(32%) contralateral Dilatation (p=0.89). On late follow-up, persistent CA Dilatation was similar between LCA-dominance 6/14(43%) and RCA-dominance 10/21(47%) (p=0.94). The interval between onset and normalizing CA Z-score was 1.16±1.65 vs. 2.45±3.6years in ispilateral vs. contralateral subsets (p=0.19). From the inflammatory perspective, serum albumin was significantly lower in patients with contralateral CA Dilatation (p=0.02). Nevertheless, other inflammatory markers did not show a significant difference. Conclusion: Transitory CA Dilatation following KD is closely related to anatomical dominance. This may be a reflection of vasodilation during immune carditis rather than Coronary vasculitis.

  • N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with Coronary Artery involvement.
    Cardiology in the young, 2014
    Co-Authors: Philippe Mahouna Adjagba, Laurent Desjardins, Anne Fournier, Linda Spigelblatt, Martine Montigny, Nagib Dahdah
    Abstract:

    We have lately documented the importance of N-terminal pro-brain natriuretic peptide in aiding the diagnosis of Kawasaki disease. We sought to investigate the potential value of N-terminal pro-brain natriuretic peptide pertaining to the prediction of Coronary Artery Dilatation (Z-score>2.5) and/or of resistance to intravenous immunoglobulin therapy. We hypothesised that increased serum N-terminal pro-brain natriuretic peptide level correlates with increased Coronary Artery Dilatation and/or resistance to intravenous immunoglobulin. We carried out a prospective study involving newly diagnosed patients treated with 2 g/kg intravenous immunoglobulin within 5-10 days of onset of fever. Echocardiography was performed in all patients at onset, then weekly for 3 weeks, then at month 2, and month 3. Coronary arteries were measured at each visit, and Coronary Artery Z-score was calculated. All the patients had N-terminal pro-brain natriuretic peptide serum level measured at onset, and the Z-score calculated. There were 109 patients enrolled at 6.58±2.82 days of fever, age 3.79±2.92 years. High N-terminal pro-brain natriuretic peptide level was associated with Coronary Artery Dilatation at onset in 22.2 versus 5.6% for normal N-terminal pro-brain natriuretic peptide levels (odds ratio 4.8 [95% confidence interval 1.05-22.4]; p=0.031). This was predictive of cumulative Coronary Artery Dilatation for the first 3 months (p=0.04-0.02), but not during convalescence at 2-3 months (odds ratio 1.28 [95% confidence interval 0.23-7.3]; p=non-significant). Elevated N-terminal pro-brain natriuretic peptide levels did not predict intravenous immunoglobulin resistance, 15.3 versus 13.5% (p=1). Elevated N-terminal pro-brain natriuretic peptide level correlates with acute Coronary Artery Dilatation in treated Kawasaki disease, but not with intravenous immunoglobulin resistance.

Anne Fournier - One of the best experts on this subject based on the ideXlab platform.

  • Coronary Artery Dilatation in Viral Myocarditis Mimics Coronary Artery Findings in Kawasaki Disease
    Pediatric cardiology, 2016
    Co-Authors: Soha Rached-d’astous, Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Nagib Dahdah
    Abstract:

    Coronary Artery (CA) Dilatations are typical to Kawasaki disease (KD) in the pediatric population. CA involvement is a useful feature to help establish the diagnosis of KD. Since myocarditis is omnipresent in the acute phase of KD, we sought to investigate whether viral myocarditis may cause CA Dilatation. This retrospective study reviewed 14 consecutive patients diagnosed with acute myocarditis at CHU Sainte-Justine, Montreal. KD diagnosis was excluded for all patients. All echocardiography studies were reviewed by an independent experienced echocardiographer for CA size and myocardial function parameters. CA involvement was classified under three categories: definite Dilatation (Z-score ≥2.5 in one or more CA), occult Dilatation (Z-score variation ≥2 points for the same CA on two different echocardiograms, but maximum Z-score always

  • Coronary Artery Dilatation in viral myocarditis mimics Coronary Artery findings in kawasaki disease
    Pediatric Cardiology, 2016
    Co-Authors: Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Soha Racheddastous, Nagib Dahdah
    Abstract:

    Coronary Artery (CA) Dilatations are typical to Kawasaki disease (KD) in the pediatric population. CA involvement is a useful feature to help establish the diagnosis of KD. Since myocarditis is omnipresent in the acute phase of KD, we sought to investigate whether viral myocarditis may cause CA Dilatation. This retrospective study reviewed 14 consecutive patients diagnosed with acute myocarditis at CHU Sainte-Justine, Montreal. KD diagnosis was excluded for all patients. All echocardiography studies were reviewed by an independent experienced echocardiographer for CA size and myocardial function parameters. CA involvement was classified under three categories: definite Dilatation (Z-score ≥2.5 in one or more CA), occult Dilatation (Z-score variation ≥2 points for the same CA on two different echocardiograms, but maximum Z-score always <2.5), and no Dilatation otherwise. Demographics, laboratory values, microbial etiology testing, and diagnostic studies were collected from medical records. Mean age at presentation was 1.67 ± 3.22 years, where 11/14 (78 %) presented with acute and three with subacute myocarditis. Five (36 %) patients had normal CA measurements, six (43 %) had occult Dilatation, and three (21 %) had definite Dilatation. Maximal CA Z-score was within the first 8 days of presentation. Patients with viral myocarditis can present CA Dilatation during the acute phase of the illness. This finding should be taken into account when KD diagnosis is being based on the CA involvement as the two illnesses may present with similar features.

  • Abstract O.37: Coronary Artery Dilatation in Viral Myocarditis Mimics Coronary Artery Findings In Kawasaki Disease
    Circulation, 2015
    Co-Authors: Soha Rached-d’astous, Anne Fournier, Ibtissama Boukas, Marie-josée Raboisson, Nagib Dahdah
    Abstract:

    Background: Coronary Artery Dilatations are almost always secondary to Kawasaki disease in the pediatric population. The presence of CA involvement is used as a criterion to diagnose incomplete KD ...

  • abstract 165 Coronary Artery Dilatation in kawasaki disease is associated with anatomical Coronary dominance an angiography based study
    Circulation, 2015
    Co-Authors: Baher Hanna, Anne Fournier, Chantale Lapierre, Frederick Trinh Tan, Larent Desjardins, Nagib Dahdah
    Abstract:

    Introduction: Coronary Artery (CA) Dilatation in Kawasaki disease (KD) is best determined by elevated Z-scores. Z-score equations, do not take into account anatomical CA dominance. We hypothesize that, except for CA aneurysms, CA dominance influences Dilatation status in KD (Z-score > 2.5). Material and Methods: We retrospectively analyzed CA status in KD patients followed at our institution for persistent CA Dilatation. All patients who had a diagnostic catheterization between 2002 and 2012 were considered. Serial echocardiographic dimensions of LCA, RCA, and LAD upon diagnosis, 1 week, 2 weeks, 4 weeks, 2 months, 3-6 months, and 9-12 months later were normalized to BSA using published CA Z-score equations. Data were contrasted with CA angiography description of CA dominance: right or left dominance was adopted when the respective CA supplies both diaphragmatic LV free wall and posterior inter ventricular septum (IVS); Co-dominance was when posterior IVS was supplied by RCA and diaphragmatic LV free wall by LCA. Results: Of 69 potential patients, 16 were excluded (9 never presented a CA Dilatation and 7 had CA aneurysms). The interval between acute onset and selective CA angiography of the remaining 53 patients was 69.5±52.8months at 9.2±5.2years old. Of the latter, 20(37.7%) had LCA-dominance, 31(58.5%) RCA-dominance, and 2(3.8%) Co-dominance. Upon KD onset, the LCA-dominant subset had 14/20(70%) ipsilateral Dilatation vs. 6/20(30%) contralateral Dilatation. Similarly, RCA-dominant Dilatation was ipsilateral in 21/31(68%) vs. 10/31(32%) contralateral Dilatation (p=0.89). On late follow-up, persistent CA Dilatation was similar between LCA-dominance 6/14(43%) and RCA-dominance 10/21(47%) (p=0.94). The interval between onset and normalizing CA Z-score was 1.16±1.65 vs. 2.45±3.6years in ispilateral vs. contralateral subsets (p=0.19). From the inflammatory perspective, serum albumin was significantly lower in patients with contralateral CA Dilatation (p=0.02). Nevertheless, other inflammatory markers did not show a significant difference. Conclusion: Transitory CA Dilatation following KD is closely related to anatomical dominance. This may be a reflection of vasodilation during immune carditis rather than Coronary vasculitis.

  • N-terminal pro-brain natriuretic peptide in acute Kawasaki disease correlates with Coronary Artery involvement.
    Cardiology in the young, 2014
    Co-Authors: Philippe Mahouna Adjagba, Laurent Desjardins, Anne Fournier, Linda Spigelblatt, Martine Montigny, Nagib Dahdah
    Abstract:

    We have lately documented the importance of N-terminal pro-brain natriuretic peptide in aiding the diagnosis of Kawasaki disease. We sought to investigate the potential value of N-terminal pro-brain natriuretic peptide pertaining to the prediction of Coronary Artery Dilatation (Z-score>2.5) and/or of resistance to intravenous immunoglobulin therapy. We hypothesised that increased serum N-terminal pro-brain natriuretic peptide level correlates with increased Coronary Artery Dilatation and/or resistance to intravenous immunoglobulin. We carried out a prospective study involving newly diagnosed patients treated with 2 g/kg intravenous immunoglobulin within 5-10 days of onset of fever. Echocardiography was performed in all patients at onset, then weekly for 3 weeks, then at month 2, and month 3. Coronary arteries were measured at each visit, and Coronary Artery Z-score was calculated. All the patients had N-terminal pro-brain natriuretic peptide serum level measured at onset, and the Z-score calculated. There were 109 patients enrolled at 6.58±2.82 days of fever, age 3.79±2.92 years. High N-terminal pro-brain natriuretic peptide level was associated with Coronary Artery Dilatation at onset in 22.2 versus 5.6% for normal N-terminal pro-brain natriuretic peptide levels (odds ratio 4.8 [95% confidence interval 1.05-22.4]; p=0.031). This was predictive of cumulative Coronary Artery Dilatation for the first 3 months (p=0.04-0.02), but not during convalescence at 2-3 months (odds ratio 1.28 [95% confidence interval 0.23-7.3]; p=non-significant). Elevated N-terminal pro-brain natriuretic peptide levels did not predict intravenous immunoglobulin resistance, 15.3 versus 13.5% (p=1). Elevated N-terminal pro-brain natriuretic peptide level correlates with acute Coronary Artery Dilatation in treated Kawasaki disease, but not with intravenous immunoglobulin resistance.

Isabelle Koné-paut - One of the best experts on this subject based on the ideXlab platform.

  • Coronary Artery abnormalities in children with systemic-onset juvenile idiopathic arthritis
    Joint bone spine, 2014
    Co-Authors: Alain Lefèvre-utile, Caroline Galeotti, Isabelle Koné-paut
    Abstract:

    Still's disease (Systemic-onset Juvenile Idiopathic Arthritis: SoJIA) is characterised by high-spiking daily fevers, arthritis and evanescent rashes. Diagnosis of Still's disease is often challenging. Infectious diseases and other inflammatory conditions, especially in young children, Kawasaki disease may look similar. Clinicians often rely on echocardiographic evidence of Coronary Artery abnormalities to differentiate between Kawasaki disease and Still's disease. Coronary Artery dilation would typically favour the diagnosis of Kawasaki disease. We present four children with Still's disease and Coronary Artery abnormalities who were initially misdiagnosed as Kawasaki disease. The first patient had pericarditis and an irregular wall of the left Coronary Artery, without dilation on echocardiography. The second patient had a left Coronary Artery Dilatation and a pericarditis. The third patient had thickened left Coronary Artery walls, and the fourth patient had a hyperechogenicity of the left and right Coronary arteries. They received IVIG without success. The diagnosis of Still's disease was made secondary with evidence of persistent arthritis. All but one patient finally needed biologic treatments. Coronary abnormalities may be observed during various febrile conditions and do not exclude the diagnosis of Still's disease.

Alain Lefèvre-utile - One of the best experts on this subject based on the ideXlab platform.

  • Coronary Artery abnormalities in children with systemic-onset juvenile idiopathic arthritis
    Joint bone spine, 2014
    Co-Authors: Alain Lefèvre-utile, Caroline Galeotti, Isabelle Koné-paut
    Abstract:

    Still's disease (Systemic-onset Juvenile Idiopathic Arthritis: SoJIA) is characterised by high-spiking daily fevers, arthritis and evanescent rashes. Diagnosis of Still's disease is often challenging. Infectious diseases and other inflammatory conditions, especially in young children, Kawasaki disease may look similar. Clinicians often rely on echocardiographic evidence of Coronary Artery abnormalities to differentiate between Kawasaki disease and Still's disease. Coronary Artery dilation would typically favour the diagnosis of Kawasaki disease. We present four children with Still's disease and Coronary Artery abnormalities who were initially misdiagnosed as Kawasaki disease. The first patient had pericarditis and an irregular wall of the left Coronary Artery, without dilation on echocardiography. The second patient had a left Coronary Artery Dilatation and a pericarditis. The third patient had thickened left Coronary Artery walls, and the fourth patient had a hyperechogenicity of the left and right Coronary arteries. They received IVIG without success. The diagnosis of Still's disease was made secondary with evidence of persistent arthritis. All but one patient finally needed biologic treatments. Coronary abnormalities may be observed during various febrile conditions and do not exclude the diagnosis of Still's disease.

Caroline Galeotti - One of the best experts on this subject based on the ideXlab platform.

  • Coronary Artery abnormalities in children with systemic-onset juvenile idiopathic arthritis
    Joint bone spine, 2014
    Co-Authors: Alain Lefèvre-utile, Caroline Galeotti, Isabelle Koné-paut
    Abstract:

    Still's disease (Systemic-onset Juvenile Idiopathic Arthritis: SoJIA) is characterised by high-spiking daily fevers, arthritis and evanescent rashes. Diagnosis of Still's disease is often challenging. Infectious diseases and other inflammatory conditions, especially in young children, Kawasaki disease may look similar. Clinicians often rely on echocardiographic evidence of Coronary Artery abnormalities to differentiate between Kawasaki disease and Still's disease. Coronary Artery dilation would typically favour the diagnosis of Kawasaki disease. We present four children with Still's disease and Coronary Artery abnormalities who were initially misdiagnosed as Kawasaki disease. The first patient had pericarditis and an irregular wall of the left Coronary Artery, without dilation on echocardiography. The second patient had a left Coronary Artery Dilatation and a pericarditis. The third patient had thickened left Coronary Artery walls, and the fourth patient had a hyperechogenicity of the left and right Coronary arteries. They received IVIG without success. The diagnosis of Still's disease was made secondary with evidence of persistent arthritis. All but one patient finally needed biologic treatments. Coronary abnormalities may be observed during various febrile conditions and do not exclude the diagnosis of Still's disease.