The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
R W Gunther - One of the best experts on this subject based on the ideXlab platform.
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molecular magnetic resonance imaging of Coronary Thrombosis and pulmonary emboli with a novel fibrin targeted contrast agent
Circulation, 2005Co-Authors: Elmar Spuentrup, Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, Robert M Weisskoff, Philip B Graham, Warren J Manning, R W GuntherAbstract:Background— The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include Coronary Thrombosis or pulmonary emboli. The aim of this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging of Coronary Thrombosis and pulmonary emboli. Methods and Results— Fresh clots were engineered ex vivo from human blood and delivered in the lungs and Coronary arteries of 7 swine. Subsequent molecular MR imaging was performed with a navigator-gated free-breathing and cardiac-triggered 3D inversion-recovery black-blood gradient-echo sequence before and after systemic administration of 7.5 μmol/kg EP-2104R. Two swine served as the control group. MR images were analyzed by 2 investigators, and contrast-to-noise ratio and gadolinium concentration in the clots were assessed. Before contrast media application, no thrombi were visible. After contrast administration, all 32 pulmonary emboli, 3 emboli in the right...
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in vivo magnetic resonance imaging of Coronary Thrombosis using a fibrin binding molecular magnetic resonance contrast agent
Circulation, 2004Co-Authors: Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, George Katsimaglis, Robert M Weisskoff, Randall B Lauffer, Philip B Graham, R W GuntherAbstract:Background— The advent of fibrin-binding molecular magnetic resonance (MR) contrast agents and advances in Coronary MRI techniques offers the potential for direct imaging of Coronary Thrombosis. We tested the feasibility of this approach using a gadolinium (Gd)-based fibrin-binding contrast agent, EP-2104R (EPIX Medical Inc), in a swine model of Coronary thrombus and in-stent Thrombosis. Methods and Results— Ex vivo and in vivo sensitivity of Coronary MR thrombus imaging was tested by use of intracoronarily delivered Gd-DTPA–labeled fibrinogen thrombi (n=6). After successful demonstration, in-stent Coronary Thrombosis was induced by x-ray–guided placement of thrombogenic-coated, MR-lucent stents (n=5). After stent placement, 60 μmol of EP-2104R was injected via the left main Coronary artery. Free-breathing, navigator-gated 3D Coronary MR angiography and thrombus imaging were performed (1) before and after stent placement and (2) before and after EP-2104R. Thrombi were confirmed by x-ray angiography and au...
Renu Virmani - One of the best experts on this subject based on the ideXlab platform.
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Plaque erosion is a major substrate for Coronary Thrombosis in acute myocardial infarction
Heart (British Cardiac Society), 1999Co-Authors: E. Arbustini, Allen P Burke, Patrizia Morbini, B Dal Bello, G. Specchia, M Bocciarelli, Renu VirmaniAbstract:Objective—To evaluate the prevalence of plaque erosion as a substrate for Coronary Thrombosis. Design—Pathological study in patients with acute myocardial infarction not treated with thrombolysis or Coronary interventional procedures. Patients—298 consecutive patients (189 men, mean (SD) age 66 (11) years; 109 women, 74 (8) years) dying in hospital between 1984 and 1996 from acute myocardial infarction, diagnosed by ECG changes and rise in cardiac enzymes. Main outcome measures—Histopathological determination of plaque erosion as substrate for acute Thrombosis; location and histological type of Coronary Thrombosis; acute and healed myocardial infarcts; ventricular rupture. Results—Acute Coronary thrombi were found in 291 hearts (98%); in 74 cases (25%; 40/107 women (37.4%) and 34/184 men (18.5%); p = 0.0004), the plaque substrate for Thrombosis was erosion. Healed infarcts were found in 37.5% of men v 22% of women (p = 0.01). Heart rupture was more common in women than in men (22% v 10.5%, p = 0.01). The distribution of infarcts, thrombus location, heart rupture, and healed infarcts was similar in cases of plaque rupture and plaque erosion. Conclusions—Plaque erosion is an important substrate for Coronary Thrombosis in patients dying of acute myocardial infarction. Its prevalence is significantly higher in women than in men. (Heart 1999;82:269‐272)
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Coronary plaque erosion without rupture into a lipid core a frequent cause of Coronary Thrombosis in sudden Coronary death
Circulation, 1996Co-Authors: Andrew Farb, Allen P Burke, Anita L Tang, Youhui Liang, Poonam Mannan, John E Smialek, Renu VirmaniAbstract:Background Coronary Thrombosis has been reported to occur most frequently in lipid-rich plaques with rupture of a thin fibrous cap and contact of the thrombus with a pool of extracellular lipid. However, the frequency of Coronary artery Thrombosis with or without fibrous cap rupture in sudden Coronary death is unknown. In this study, we compared the incidence and morphological characteristics of Coronary Thrombosis associated with plaque rupture versus Thrombosis in eroded plaques without rupture. Methods and results Fifty consecutive cases of sudden death due to Coronary artery Thrombosis were studied by histology and immunohistochemistry. Plaque rupture of a fibrous cap with communication of the thrombus with a lipid pool was identified in 28 cases. Thrombi without rupture were present in 22 cases, all of which had superficial erosion of a proteoglycan-rich plaque. The mean age at death was 53 +/- 10 years in plaque rupture cases versus 44 +/- 7 years in eroded plaques without rupture (P Conclusions Erosion of proteoglycan-rich and smooth muscle cell-rich plaques lacking a superficial lipid core or plaque rupture is a frequent finding in sudden death due to Coronary Thrombosis, comprising 44% of cases in the present study. These lesions are more often seen in younger individuals and women, have less luminal narrowing and less calcification, and less often have foci of macrophages and T cells compared with plaque ruptures.
Rene M Botnar - One of the best experts on this subject based on the ideXlab platform.
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molecular magnetic resonance imaging of Coronary Thrombosis and pulmonary emboli with a novel fibrin targeted contrast agent
Circulation, 2005Co-Authors: Elmar Spuentrup, Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, Robert M Weisskoff, Philip B Graham, Warren J Manning, R W GuntherAbstract:Background— The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include Coronary Thrombosis or pulmonary emboli. The aim of this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging of Coronary Thrombosis and pulmonary emboli. Methods and Results— Fresh clots were engineered ex vivo from human blood and delivered in the lungs and Coronary arteries of 7 swine. Subsequent molecular MR imaging was performed with a navigator-gated free-breathing and cardiac-triggered 3D inversion-recovery black-blood gradient-echo sequence before and after systemic administration of 7.5 μmol/kg EP-2104R. Two swine served as the control group. MR images were analyzed by 2 investigators, and contrast-to-noise ratio and gadolinium concentration in the clots were assessed. Before contrast media application, no thrombi were visible. After contrast administration, all 32 pulmonary emboli, 3 emboli in the right...
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in vivo magnetic resonance imaging of Coronary Thrombosis using a fibrin binding molecular magnetic resonance contrast agent
Circulation, 2004Co-Authors: Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, George Katsimaglis, Robert M Weisskoff, Randall B Lauffer, Philip B Graham, R W GuntherAbstract:Background— The advent of fibrin-binding molecular magnetic resonance (MR) contrast agents and advances in Coronary MRI techniques offers the potential for direct imaging of Coronary Thrombosis. We tested the feasibility of this approach using a gadolinium (Gd)-based fibrin-binding contrast agent, EP-2104R (EPIX Medical Inc), in a swine model of Coronary thrombus and in-stent Thrombosis. Methods and Results— Ex vivo and in vivo sensitivity of Coronary MR thrombus imaging was tested by use of intracoronarily delivered Gd-DTPA–labeled fibrinogen thrombi (n=6). After successful demonstration, in-stent Coronary Thrombosis was induced by x-ray–guided placement of thrombogenic-coated, MR-lucent stents (n=5). After stent placement, 60 μmol of EP-2104R was injected via the left main Coronary artery. Free-breathing, navigator-gated 3D Coronary MR angiography and thrombus imaging were performed (1) before and after stent placement and (2) before and after EP-2104R. Thrombi were confirmed by x-ray angiography and au...
Philip B Graham - One of the best experts on this subject based on the ideXlab platform.
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molecular magnetic resonance imaging of Coronary Thrombosis and pulmonary emboli with a novel fibrin targeted contrast agent
Circulation, 2005Co-Authors: Elmar Spuentrup, Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, Robert M Weisskoff, Philip B Graham, Warren J Manning, R W GuntherAbstract:Background— The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include Coronary Thrombosis or pulmonary emboli. The aim of this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging of Coronary Thrombosis and pulmonary emboli. Methods and Results— Fresh clots were engineered ex vivo from human blood and delivered in the lungs and Coronary arteries of 7 swine. Subsequent molecular MR imaging was performed with a navigator-gated free-breathing and cardiac-triggered 3D inversion-recovery black-blood gradient-echo sequence before and after systemic administration of 7.5 μmol/kg EP-2104R. Two swine served as the control group. MR images were analyzed by 2 investigators, and contrast-to-noise ratio and gadolinium concentration in the clots were assessed. Before contrast media application, no thrombi were visible. After contrast administration, all 32 pulmonary emboli, 3 emboli in the right...
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in vivo magnetic resonance imaging of Coronary Thrombosis using a fibrin binding molecular magnetic resonance contrast agent
Circulation, 2004Co-Authors: Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, George Katsimaglis, Robert M Weisskoff, Randall B Lauffer, Philip B Graham, R W GuntherAbstract:Background— The advent of fibrin-binding molecular magnetic resonance (MR) contrast agents and advances in Coronary MRI techniques offers the potential for direct imaging of Coronary Thrombosis. We tested the feasibility of this approach using a gadolinium (Gd)-based fibrin-binding contrast agent, EP-2104R (EPIX Medical Inc), in a swine model of Coronary thrombus and in-stent Thrombosis. Methods and Results— Ex vivo and in vivo sensitivity of Coronary MR thrombus imaging was tested by use of intracoronarily delivered Gd-DTPA–labeled fibrinogen thrombi (n=6). After successful demonstration, in-stent Coronary Thrombosis was induced by x-ray–guided placement of thrombogenic-coated, MR-lucent stents (n=5). After stent placement, 60 μmol of EP-2104R was injected via the left main Coronary artery. Free-breathing, navigator-gated 3D Coronary MR angiography and thrombus imaging were performed (1) before and after stent placement and (2) before and after EP-2104R. Thrombi were confirmed by x-ray angiography and au...
Robert M Weisskoff - One of the best experts on this subject based on the ideXlab platform.
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molecular magnetic resonance imaging of Coronary Thrombosis and pulmonary emboli with a novel fibrin targeted contrast agent
Circulation, 2005Co-Authors: Elmar Spuentrup, Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, Robert M Weisskoff, Philip B Graham, Warren J Manning, R W GuntherAbstract:Background— The differential diagnosis of acute chest pain is challenging, especially in patients with normal ECG findings, and may include Coronary Thrombosis or pulmonary emboli. The aim of this study was to investigate the novel fibrin-specific contrast agent EP-2104R for molecular targeted MR imaging of Coronary Thrombosis and pulmonary emboli. Methods and Results— Fresh clots were engineered ex vivo from human blood and delivered in the lungs and Coronary arteries of 7 swine. Subsequent molecular MR imaging was performed with a navigator-gated free-breathing and cardiac-triggered 3D inversion-recovery black-blood gradient-echo sequence before and after systemic administration of 7.5 μmol/kg EP-2104R. Two swine served as the control group. MR images were analyzed by 2 investigators, and contrast-to-noise ratio and gadolinium concentration in the clots were assessed. Before contrast media application, no thrombi were visible. After contrast administration, all 32 pulmonary emboli, 3 emboli in the right...
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in vivo magnetic resonance imaging of Coronary Thrombosis using a fibrin binding molecular magnetic resonance contrast agent
Circulation, 2004Co-Authors: Rene M Botnar, Arno Buecker, Andrea J Wiethoff, Edward C Parsons, Marcus Katoh, George Katsimaglis, Robert M Weisskoff, Randall B Lauffer, Philip B Graham, R W GuntherAbstract:Background— The advent of fibrin-binding molecular magnetic resonance (MR) contrast agents and advances in Coronary MRI techniques offers the potential for direct imaging of Coronary Thrombosis. We tested the feasibility of this approach using a gadolinium (Gd)-based fibrin-binding contrast agent, EP-2104R (EPIX Medical Inc), in a swine model of Coronary thrombus and in-stent Thrombosis. Methods and Results— Ex vivo and in vivo sensitivity of Coronary MR thrombus imaging was tested by use of intracoronarily delivered Gd-DTPA–labeled fibrinogen thrombi (n=6). After successful demonstration, in-stent Coronary Thrombosis was induced by x-ray–guided placement of thrombogenic-coated, MR-lucent stents (n=5). After stent placement, 60 μmol of EP-2104R was injected via the left main Coronary artery. Free-breathing, navigator-gated 3D Coronary MR angiography and thrombus imaging were performed (1) before and after stent placement and (2) before and after EP-2104R. Thrombi were confirmed by x-ray angiography and au...
