Coronary Vascular Resistance

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Paul Knaapen - One of the best experts on this subject based on the ideXlab platform.

Ibrahim Danad - One of the best experts on this subject based on the ideXlab platform.

  • carotid artery intima media thickness but not Coronary artery calcium predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Journal of Echocardiography, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, Mark Lubberink, Pieter G Raijmakers, Adriaan A. Lammertsma, Stefan De Haan, Cornelis Van Kuijk, Otto S Hoekstra, Yvo M. Smulders
    Abstract:

    Aims There is growing evidence that Coronary artery disease (CAD) affects not only the conduit epicardial Coronary arteries, but also the microVascular Coronary bed. Moreover, Coronary microVascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal Coronary Vascular Resistance (CVR). Methods and results We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress 15O-water positron emission tomography (PET)/CT, during which the Coronary flow reserve (CFR) and minimal CVR were analysed. Minimal CVR increased significantly with increasing tertiles of C-IMT (22 ± 6, 27 ± 11, and 28 ± 9 mmHg mL−1min−1 g−1, P < 0.01), whereas the CFR was comparable across all C-IMT groups ( P = 0.50). Minimal CVR increased significantly with an increase in CAC score (23 ± 9, 27 ± 8, 32 ± 10, and 32 ± 7 mmHg mL−1 min−1 g−1, P < 0.01), whereas the CFR did not show a significant decrease with higher CAC scores ( P = 0.18). Multivariable regression analysis revealed that C-IMT ( P = 0.03), but not CAC, was independently associated with minimal CVR. Conclusion C-IMT, but not CAC score, independently predicts minimal CVR in patients with multiple cardioVascular risk factors and suspected of CAD.

  • Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Heart Journal, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, I. I. Tulevski, Mark Lubberink, Pieter G Raijmakers, Albert C. Van Rossum, Adriaan A. Lammertsma, Yvo M. Smulders, Paul Knaapen
    Abstract:

    Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease

Yvo M. Smulders - One of the best experts on this subject based on the ideXlab platform.

  • carotid artery intima media thickness but not Coronary artery calcium predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Journal of Echocardiography, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, Mark Lubberink, Pieter G Raijmakers, Adriaan A. Lammertsma, Stefan De Haan, Cornelis Van Kuijk, Otto S Hoekstra, Yvo M. Smulders
    Abstract:

    Aims There is growing evidence that Coronary artery disease (CAD) affects not only the conduit epicardial Coronary arteries, but also the microVascular Coronary bed. Moreover, Coronary microVascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal Coronary Vascular Resistance (CVR). Methods and results We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress 15O-water positron emission tomography (PET)/CT, during which the Coronary flow reserve (CFR) and minimal CVR were analysed. Minimal CVR increased significantly with increasing tertiles of C-IMT (22 ± 6, 27 ± 11, and 28 ± 9 mmHg mL−1min−1 g−1, P < 0.01), whereas the CFR was comparable across all C-IMT groups ( P = 0.50). Minimal CVR increased significantly with an increase in CAC score (23 ± 9, 27 ± 8, 32 ± 10, and 32 ± 7 mmHg mL−1 min−1 g−1, P < 0.01), whereas the CFR did not show a significant decrease with higher CAC scores ( P = 0.18). Multivariable regression analysis revealed that C-IMT ( P = 0.03), but not CAC, was independently associated with minimal CVR. Conclusion C-IMT, but not CAC score, independently predicts minimal CVR in patients with multiple cardioVascular risk factors and suspected of CAD.

  • Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Heart Journal, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, I. I. Tulevski, Mark Lubberink, Pieter G Raijmakers, Albert C. Van Rossum, Adriaan A. Lammertsma, Yvo M. Smulders, Paul Knaapen
    Abstract:

    Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease

Parisa Kamali - One of the best experts on this subject based on the ideXlab platform.

  • carotid artery intima media thickness but not Coronary artery calcium predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Journal of Echocardiography, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, Mark Lubberink, Pieter G Raijmakers, Adriaan A. Lammertsma, Stefan De Haan, Cornelis Van Kuijk, Otto S Hoekstra, Yvo M. Smulders
    Abstract:

    Aims There is growing evidence that Coronary artery disease (CAD) affects not only the conduit epicardial Coronary arteries, but also the microVascular Coronary bed. Moreover, Coronary microVascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal Coronary Vascular Resistance (CVR). Methods and results We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress 15O-water positron emission tomography (PET)/CT, during which the Coronary flow reserve (CFR) and minimal CVR were analysed. Minimal CVR increased significantly with increasing tertiles of C-IMT (22 ± 6, 27 ± 11, and 28 ± 9 mmHg mL−1min−1 g−1, P < 0.01), whereas the CFR was comparable across all C-IMT groups ( P = 0.50). Minimal CVR increased significantly with an increase in CAC score (23 ± 9, 27 ± 8, 32 ± 10, and 32 ± 7 mmHg mL−1 min−1 g−1, P < 0.01), whereas the CFR did not show a significant decrease with higher CAC scores ( P = 0.18). Multivariable regression analysis revealed that C-IMT ( P = 0.03), but not CAC, was independently associated with minimal CVR. Conclusion C-IMT, but not CAC score, independently predicts minimal CVR in patients with multiple cardioVascular risk factors and suspected of CAD.

  • Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Heart Journal, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, I. I. Tulevski, Mark Lubberink, Pieter G Raijmakers, Albert C. Van Rossum, Adriaan A. Lammertsma, Yvo M. Smulders, Paul Knaapen
    Abstract:

    Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease

Mark Lubberink - One of the best experts on this subject based on the ideXlab platform.

  • carotid artery intima media thickness but not Coronary artery calcium predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Journal of Echocardiography, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, Mark Lubberink, Pieter G Raijmakers, Adriaan A. Lammertsma, Stefan De Haan, Cornelis Van Kuijk, Otto S Hoekstra, Yvo M. Smulders
    Abstract:

    Aims There is growing evidence that Coronary artery disease (CAD) affects not only the conduit epicardial Coronary arteries, but also the microVascular Coronary bed. Moreover, Coronary microVascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal Coronary Vascular Resistance (CVR). Methods and results We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress 15O-water positron emission tomography (PET)/CT, during which the Coronary flow reserve (CFR) and minimal CVR were analysed. Minimal CVR increased significantly with increasing tertiles of C-IMT (22 ± 6, 27 ± 11, and 28 ± 9 mmHg mL−1min−1 g−1, P < 0.01), whereas the CFR was comparable across all C-IMT groups ( P = 0.50). Minimal CVR increased significantly with an increase in CAC score (23 ± 9, 27 ± 8, 32 ± 10, and 32 ± 7 mmHg mL−1 min−1 g−1, P < 0.01), whereas the CFR did not show a significant decrease with higher CAC scores ( P = 0.18). Multivariable regression analysis revealed that C-IMT ( P = 0.03), but not CAC, was independently associated with minimal CVR. Conclusion C-IMT, but not CAC score, independently predicts minimal CVR in patients with multiple cardioVascular risk factors and suspected of CAD.

  • Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease
    European Heart Journal, 2012
    Co-Authors: Ibrahim Danad, Parisa Kamali, Hendrik J. Harms, I. I. Tulevski, Mark Lubberink, Pieter G Raijmakers, Albert C. Van Rossum, Adriaan A. Lammertsma, Yvo M. Smulders, Paul Knaapen
    Abstract:

    Carotid artery intima media thickness, but not Coronary artery calcium, predicts Coronary Vascular Resistance in patients evaluated for Coronary artery disease

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