The Experts below are selected from a list of 27522 Experts worldwide ranked by ideXlab platform
Stefanie A. Kane - One of the best experts on this subject based on the ideXlab platform.
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1, slope 0.94), with the greatest contraction obtained between 1-10 muM in most tissues. In contrast, telcagepant at concentrations up to 30 muM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone. (Less)
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 microM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1; slope 0.94), with the greatest contraction obtained between 1 and 10 microM in most tissues. In contrast, telcagepant at concentrations up to 30 microM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone.
Joseph J Lynch - One of the best experts on this subject based on the ideXlab platform.
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1, slope 0.94), with the greatest contraction obtained between 1-10 muM in most tissues. In contrast, telcagepant at concentrations up to 30 muM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone. (Less)
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 microM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1; slope 0.94), with the greatest contraction obtained between 1 and 10 microM in most tissues. In contrast, telcagepant at concentrations up to 30 microM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone.
Lars Edvinsson - One of the best experts on this subject based on the ideXlab platform.
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1, slope 0.94), with the greatest contraction obtained between 1-10 muM in most tissues. In contrast, telcagepant at concentrations up to 30 muM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone. (Less)
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 microM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1; slope 0.94), with the greatest contraction obtained between 1 and 10 microM in most tissues. In contrast, telcagepant at concentrations up to 30 microM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone.
Richard Hargreaves - One of the best experts on this subject based on the ideXlab platform.
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1, slope 0.94), with the greatest contraction obtained between 1-10 muM in most tissues. In contrast, telcagepant at concentrations up to 30 muM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone. (Less)
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 microM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1; slope 0.94), with the greatest contraction obtained between 1 and 10 microM in most tissues. In contrast, telcagepant at concentrations up to 30 microM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone.
Christopher P Regan - One of the best experts on this subject based on the ideXlab platform.
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant, and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl-precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 muM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1, slope 0.94), with the greatest contraction obtained between 1-10 muM in most tissues. In contrast, telcagepant at concentrations up to 30 muM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone. (Less)
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comparison of the vasoconstrictor effects of the calcitonin gene related peptide cgrp receptor antagonist telcagepant mk 0974 and zolmitriptan in human isolated Coronary arteries
Journal of Cardiovascular Pharmacology, 2010Co-Authors: Joseph J Lynch, Lars Edvinsson, Richard Hargreaves, Christopher P Regan, Stefanie A. KaneAbstract:Studies were conducted in human isolated Coronary arteries to explore the vascular effects of the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant and to compare its Coronary vasoconstrictive potential to that of zolmitriptan. KCl precontracted Coronary Vessels were shown to relax to human alphaCGRP, with the CGRP-mediated vasorelaxation completely blocked with 30 microM telcagepant. In Coronary Vessels at basal tone, zolmitriptan caused a concentration-dependent contraction (pEC50 = 6.9 +/- 0.1; slope 0.94), with the greatest contraction obtained between 1 and 10 microM in most tissues. In contrast, telcagepant at concentrations up to 30 microM evoked no change in contractile tone. These findings suggest the potential for CGRP receptor antagonists to exert antimigraine efficacy in the absence of adverse effects on Coronary tone.
