The Experts below are selected from a list of 129 Experts worldwide ranked by ideXlab platform
Mayank R. Mehta - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions. Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo , implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
Thomas T.g. Hahn - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions. Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo , implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
Bert Sakmann - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions. Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo , implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
Sven Berberich - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions. Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo , implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
James M. Mcfarland - One of the best experts on this subject based on the ideXlab platform.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions. Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo , implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity can mediate working memory during behavior. Here, the authors report persistent activity during sleep, occurring spontaneously in medial entorhinal Cortex Layer III (MECIII) neurons' membrane potential. This persistent activity excited hippocampal CA1 neurons. Thus, persistent activity in MECIII contributes to cortico-hippocampal interaction, which could serve several important mnemonic functions.
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Spontaneous persistent activity in entorhinal Cortex modulates cortico-hippocampal interaction in vivo
Nature Neuroscience, 2012Co-Authors: Thomas T.g. Hahn, James M. Mcfarland, Sven Berberich, Bert Sakmann, Mayank R. MehtaAbstract:Persistent activity is thought to mediate working memory during behavior. Can it also occur during sleep? We found that the membrane potential of medial entorhinal Cortex Layer III (MECIII) neurons, a gateway between neoCortex and hippocampus, showed spontaneous, stochastic persistent activity in vivo in mice during Up-Down state oscillations (UDS). This persistent activity was locked to the neocortical Up states with a short delay, but persisted over several cortical UDS cycles. Lateral entorhinal neurons did not show substantial persistence, and current injections similar to those used in vitro failed to elicit persistence in vivo, implicating network mechanisms. Hippocampal CA1 neurons' spiking activity was reduced during neocortical Up states, but was increased during MECIII persistent states. These results provide, to the best of our knowledge, the first direct evidence for persistent activity in MECIII neurons in vivo and reveal its contribution to cortico-hippocampal interaction that could be involved in working memory and learning of long behavioral sequences during behavior, and memory consolidation during sleep.
