The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Richard J Wakefield - One of the best experts on this subject based on the ideXlab platform.
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thu0605 shear wave elastography muscle stiffness may diminish after Corticosteroid treatment
Annals of the Rheumatic Diseases, 2019Co-Authors: Abdulrahman M Alfuraih, Ai Lyn Tan, Philip Oconnor, Paul Emery, Richard J WakefieldAbstract:Background: The use of Corticosteroids is associated with several adverse effects including Corticosteroid-Induced Myopathy (CIM). CIM may cause structural alterations to the myofibres, which support the hypothesis of altered muscle stiffness as seen in histological and preclinical studies [1,2]. Shear wave elastography is an ultrasound technology that can quantify tissue stiffness non-invasively. Objectives: To investigate the changes in muscle stiffness as measured by SWE and muscle strength tests in giant cell arteritis (GCA) patients exposed to high doses (40–60 mg/day) of Corticosteroid treatment. Methods: Fourteen GCA patients (4 males, mean age 68.2±4.3 years) were recruited and evaluated at baseline, after 3 months and 6 months on prednisolone. Shear wave velocity (SWV), as a surrogate for tissue stiffness, and muscle strength were evaluated at each visit. Baseline data were compared to frequency-matched healthy controls. Linear mixed models were used to analyse the longitudinal data. Results: The patients did not have a significantly different muscle SWV to healthy controls (all p >0.05) at baseline. However, after 3 months, the quadriceps and hamstrings SWV decreased on average by 14% (range 8.3%–17.3%; p=0.001) and after 6 months decreased by 18% (range 10.2%–25.3% p Conclusion: The GCA patients showed a significant loss of muscle stiffness after 3 and 6 months of Corticosteroid treatment. With further validation in larger samples, shear wave elastography may be useful for detecting subclinical CIM. References: [1] -Alev, K., et al., Glucocorticoid-Induced Changes in Rat Skeletal Muscle Biomechanical and Viscoelastic Properties: Aspects of Aging. J Manipulative Physiol Ther, 2018. 41(1): p.19-24. [2] - Schakman, O., et al., Glucocorticoid-Induced skeletal muscle atrophy. The International Journal of Biochemistry & Cell Biology, 2013. 45(10): p.2163-2172. Disclosure of Interests: Abdulrahman M. Alfuraih: None declared, Ai Lyn Tan: None declared, Philip O’Connor: None declared, Paul Emery Grant/research support from: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, Roche, Consultant for: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, UCB, Roche, Novartis, Gilead,Samsung, Sandoz and Lilly, Richard Wakefield: None declared
Abdulrahman M Alfuraih - One of the best experts on this subject based on the ideXlab platform.
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thu0605 shear wave elastography muscle stiffness may diminish after Corticosteroid treatment
Annals of the Rheumatic Diseases, 2019Co-Authors: Abdulrahman M Alfuraih, Ai Lyn Tan, Philip Oconnor, Paul Emery, Richard J WakefieldAbstract:Background: The use of Corticosteroids is associated with several adverse effects including Corticosteroid-Induced Myopathy (CIM). CIM may cause structural alterations to the myofibres, which support the hypothesis of altered muscle stiffness as seen in histological and preclinical studies [1,2]. Shear wave elastography is an ultrasound technology that can quantify tissue stiffness non-invasively. Objectives: To investigate the changes in muscle stiffness as measured by SWE and muscle strength tests in giant cell arteritis (GCA) patients exposed to high doses (40–60 mg/day) of Corticosteroid treatment. Methods: Fourteen GCA patients (4 males, mean age 68.2±4.3 years) were recruited and evaluated at baseline, after 3 months and 6 months on prednisolone. Shear wave velocity (SWV), as a surrogate for tissue stiffness, and muscle strength were evaluated at each visit. Baseline data were compared to frequency-matched healthy controls. Linear mixed models were used to analyse the longitudinal data. Results: The patients did not have a significantly different muscle SWV to healthy controls (all p >0.05) at baseline. However, after 3 months, the quadriceps and hamstrings SWV decreased on average by 14% (range 8.3%–17.3%; p=0.001) and after 6 months decreased by 18% (range 10.2%–25.3% p Conclusion: The GCA patients showed a significant loss of muscle stiffness after 3 and 6 months of Corticosteroid treatment. With further validation in larger samples, shear wave elastography may be useful for detecting subclinical CIM. References: [1] -Alev, K., et al., Glucocorticoid-Induced Changes in Rat Skeletal Muscle Biomechanical and Viscoelastic Properties: Aspects of Aging. J Manipulative Physiol Ther, 2018. 41(1): p.19-24. [2] - Schakman, O., et al., Glucocorticoid-Induced skeletal muscle atrophy. The International Journal of Biochemistry & Cell Biology, 2013. 45(10): p.2163-2172. Disclosure of Interests: Abdulrahman M. Alfuraih: None declared, Ai Lyn Tan: None declared, Philip O’Connor: None declared, Paul Emery Grant/research support from: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, Roche, Consultant for: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, UCB, Roche, Novartis, Gilead,Samsung, Sandoz and Lilly, Richard Wakefield: None declared
Ai Lyn Tan - One of the best experts on this subject based on the ideXlab platform.
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thu0605 shear wave elastography muscle stiffness may diminish after Corticosteroid treatment
Annals of the Rheumatic Diseases, 2019Co-Authors: Abdulrahman M Alfuraih, Ai Lyn Tan, Philip Oconnor, Paul Emery, Richard J WakefieldAbstract:Background: The use of Corticosteroids is associated with several adverse effects including Corticosteroid-Induced Myopathy (CIM). CIM may cause structural alterations to the myofibres, which support the hypothesis of altered muscle stiffness as seen in histological and preclinical studies [1,2]. Shear wave elastography is an ultrasound technology that can quantify tissue stiffness non-invasively. Objectives: To investigate the changes in muscle stiffness as measured by SWE and muscle strength tests in giant cell arteritis (GCA) patients exposed to high doses (40–60 mg/day) of Corticosteroid treatment. Methods: Fourteen GCA patients (4 males, mean age 68.2±4.3 years) were recruited and evaluated at baseline, after 3 months and 6 months on prednisolone. Shear wave velocity (SWV), as a surrogate for tissue stiffness, and muscle strength were evaluated at each visit. Baseline data were compared to frequency-matched healthy controls. Linear mixed models were used to analyse the longitudinal data. Results: The patients did not have a significantly different muscle SWV to healthy controls (all p >0.05) at baseline. However, after 3 months, the quadriceps and hamstrings SWV decreased on average by 14% (range 8.3%–17.3%; p=0.001) and after 6 months decreased by 18% (range 10.2%–25.3% p Conclusion: The GCA patients showed a significant loss of muscle stiffness after 3 and 6 months of Corticosteroid treatment. With further validation in larger samples, shear wave elastography may be useful for detecting subclinical CIM. References: [1] -Alev, K., et al., Glucocorticoid-Induced Changes in Rat Skeletal Muscle Biomechanical and Viscoelastic Properties: Aspects of Aging. J Manipulative Physiol Ther, 2018. 41(1): p.19-24. [2] - Schakman, O., et al., Glucocorticoid-Induced skeletal muscle atrophy. The International Journal of Biochemistry & Cell Biology, 2013. 45(10): p.2163-2172. Disclosure of Interests: Abdulrahman M. Alfuraih: None declared, Ai Lyn Tan: None declared, Philip O’Connor: None declared, Paul Emery Grant/research support from: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, Roche, Consultant for: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, UCB, Roche, Novartis, Gilead,Samsung, Sandoz and Lilly, Richard Wakefield: None declared
Paul Emery - One of the best experts on this subject based on the ideXlab platform.
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thu0605 shear wave elastography muscle stiffness may diminish after Corticosteroid treatment
Annals of the Rheumatic Diseases, 2019Co-Authors: Abdulrahman M Alfuraih, Ai Lyn Tan, Philip Oconnor, Paul Emery, Richard J WakefieldAbstract:Background: The use of Corticosteroids is associated with several adverse effects including Corticosteroid-Induced Myopathy (CIM). CIM may cause structural alterations to the myofibres, which support the hypothesis of altered muscle stiffness as seen in histological and preclinical studies [1,2]. Shear wave elastography is an ultrasound technology that can quantify tissue stiffness non-invasively. Objectives: To investigate the changes in muscle stiffness as measured by SWE and muscle strength tests in giant cell arteritis (GCA) patients exposed to high doses (40–60 mg/day) of Corticosteroid treatment. Methods: Fourteen GCA patients (4 males, mean age 68.2±4.3 years) were recruited and evaluated at baseline, after 3 months and 6 months on prednisolone. Shear wave velocity (SWV), as a surrogate for tissue stiffness, and muscle strength were evaluated at each visit. Baseline data were compared to frequency-matched healthy controls. Linear mixed models were used to analyse the longitudinal data. Results: The patients did not have a significantly different muscle SWV to healthy controls (all p >0.05) at baseline. However, after 3 months, the quadriceps and hamstrings SWV decreased on average by 14% (range 8.3%–17.3%; p=0.001) and after 6 months decreased by 18% (range 10.2%–25.3% p Conclusion: The GCA patients showed a significant loss of muscle stiffness after 3 and 6 months of Corticosteroid treatment. With further validation in larger samples, shear wave elastography may be useful for detecting subclinical CIM. References: [1] -Alev, K., et al., Glucocorticoid-Induced Changes in Rat Skeletal Muscle Biomechanical and Viscoelastic Properties: Aspects of Aging. J Manipulative Physiol Ther, 2018. 41(1): p.19-24. [2] - Schakman, O., et al., Glucocorticoid-Induced skeletal muscle atrophy. The International Journal of Biochemistry & Cell Biology, 2013. 45(10): p.2163-2172. Disclosure of Interests: Abdulrahman M. Alfuraih: None declared, Ai Lyn Tan: None declared, Philip O’Connor: None declared, Paul Emery Grant/research support from: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, Roche, Consultant for: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, UCB, Roche, Novartis, Gilead,Samsung, Sandoz and Lilly, Richard Wakefield: None declared
Philip Oconnor - One of the best experts on this subject based on the ideXlab platform.
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thu0605 shear wave elastography muscle stiffness may diminish after Corticosteroid treatment
Annals of the Rheumatic Diseases, 2019Co-Authors: Abdulrahman M Alfuraih, Ai Lyn Tan, Philip Oconnor, Paul Emery, Richard J WakefieldAbstract:Background: The use of Corticosteroids is associated with several adverse effects including Corticosteroid-Induced Myopathy (CIM). CIM may cause structural alterations to the myofibres, which support the hypothesis of altered muscle stiffness as seen in histological and preclinical studies [1,2]. Shear wave elastography is an ultrasound technology that can quantify tissue stiffness non-invasively. Objectives: To investigate the changes in muscle stiffness as measured by SWE and muscle strength tests in giant cell arteritis (GCA) patients exposed to high doses (40–60 mg/day) of Corticosteroid treatment. Methods: Fourteen GCA patients (4 males, mean age 68.2±4.3 years) were recruited and evaluated at baseline, after 3 months and 6 months on prednisolone. Shear wave velocity (SWV), as a surrogate for tissue stiffness, and muscle strength were evaluated at each visit. Baseline data were compared to frequency-matched healthy controls. Linear mixed models were used to analyse the longitudinal data. Results: The patients did not have a significantly different muscle SWV to healthy controls (all p >0.05) at baseline. However, after 3 months, the quadriceps and hamstrings SWV decreased on average by 14% (range 8.3%–17.3%; p=0.001) and after 6 months decreased by 18% (range 10.2%–25.3% p Conclusion: The GCA patients showed a significant loss of muscle stiffness after 3 and 6 months of Corticosteroid treatment. With further validation in larger samples, shear wave elastography may be useful for detecting subclinical CIM. References: [1] -Alev, K., et al., Glucocorticoid-Induced Changes in Rat Skeletal Muscle Biomechanical and Viscoelastic Properties: Aspects of Aging. J Manipulative Physiol Ther, 2018. 41(1): p.19-24. [2] - Schakman, O., et al., Glucocorticoid-Induced skeletal muscle atrophy. The International Journal of Biochemistry & Cell Biology, 2013. 45(10): p.2163-2172. Disclosure of Interests: Abdulrahman M. Alfuraih: None declared, Ai Lyn Tan: None declared, Philip O’Connor: None declared, Paul Emery Grant/research support from: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, Roche, Consultant for: Pfizer, MSD, AbbVie, Bristol-Myers Squibb, UCB, Roche, Novartis, Gilead,Samsung, Sandoz and Lilly, Richard Wakefield: None declared
