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Kwok-yung Yuen - One of the best experts on this subject based on the ideXlab platform.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
BMC infectious diseases, 2020Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain.Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). Five patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption and handling of animal meat. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for Brucellosis in a highly Cosmopolitan City of southern China
2019Co-Authors: Hai-yan Ye, Fan-fan Xing, Kelvin H.y Chiu, Simon K. F. Lo, Jonathan H K Chen, Jin Yang, Kwok-yung YuenAbstract:Abstract Background:Brucellosis is one of the most widespread zoonosis worldwide, it is caused by Gram-negative coccobacilli, Brucella spp. In China, 90% of brucellosis occurred in six northern agricultural provinces. However, there is an increasing trend of human brucellosis in southern provinces but only limited cases were reported. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital of southern china. Methods:A retrospective study was conducted in the past 4 years. Clinical details of brucellosis including occupation, suspected transmission route and complications were retrieved. Serum for tube agglutination test to check Brucella antibody. Blood and aspirate were collected for culture, Vitek 2 and MALDL-TOF MS were used for identification.Results:Thirteen cases of laboratory confirmed brucellosis were encountered in a highly Cosmopolitan City Shenzhen of South China between January 2014 and October 2018. Seven of the thirteen patients were male, with age ranging from 29 to 73 years old. Five patients (38.5%) came from Guangdong province, and eight patients (61.5%) came from other provinces. The commonest route of transmission was handling and consumption of infected placenta from goats. Common presenting symptoms include fever, osteoarticular pain and urinary symptoms. Common physical signs were fever, splenomegaly and lymphadenopathy. The commonest complication was spondylodiscitis/ peripheral joint arthritis (n=4), while exotic complications including abdominal aortitis with pseudoaneurysm, hepatic and spleen abscess, soft tissue abscess, and epididymo-orchitis were also observed in 4 other patients. The most life-threating but rare complication of abdominal aortitis in the elderly could be easily missed due to the nonspecific presenting symptom. Conclusions:In summary, brucellosis is increasingly seen in highly Cosmopolitan part of southern China. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in the differential diagnosis of fever of unknown origin in this locality. Presence of extensive atherosclerosis in elderly patient may predispose them to endovascular infection by Brucella species.
Adekemi O Sekoni - One of the best experts on this subject based on the ideXlab platform.
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experiences of social oppression among men who have sex with men in a Cosmopolitan City in nigeria
HIV AIDS : Research and Palliative Care, 2014Co-Authors: Adekemi O Sekoni, Oluyemisi O Ayoola, Esther O SomefunAbstract:BACKGROUND In several African countries, men who have sex with men (MSM) are becoming visible, as a result of which they are now victims of human rights violations. This has a negative effect on their ability to access services targeted at human immunodeficiency virus (HIV) prevention and care. The main objective of this study was to document the experiences of social oppression among MSM in Lagos State, Nigeria. METHODS Simple random sampling was used to select three of the seven local government areas in Lagos State that had community centers. Snowball sampling was used to recruit 291 participants. The survey instrument was a pretested questionnaire. The results were presented as means and percentages. Univariate, bivariate, and multivariate analysis was carried out at P<0.05. RESULTS The mean age of the participants was 25.3±4.6 years, and the majority (66.0%) were currently single and not in a steady relationship. Half of the men self-identified as gay and about 48% as bisexual. Alcohol use occurred in 56.7% of the respondents, about a quarter (25.8%) smoked cigarettes, and 11.0% reported using hard drugs. The commonest acts of human rights violation and or violence reported were aggression 35.7%, alienation 29.9%, verbal abuse 19.2%, physical abuse 17.9%, rape by a man 16.8%, and psychological abuse 20.3%. The predictors of human rights violation were level of education (adjusted odds ratio 2.6, P=0.019), marital status (adjusted odds ratio 2.3, P=0.005), and sexual orientation (adjusted odds ratio 1.9, P=0.017). For physical and sexual abuse, MSM who consumed alcohol and were homosexual/transgender were at risk. CONCLUSION This study showed that a high proportion of MSM had experienced various forms of human rights violation and abuse as a result of their sexual orientation/identity. There is a need to document and quantify these happenings, which can serve as an advocacy tool for reform.
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sexually transmitted infections prevalence knowledge and treatment practices among female sex workers in a Cosmopolitan City in nigeria
African Journal of Reproductive Health, 2013Co-Authors: Adekemi O Sekoni, Oluwakemi Ololade Odukoya, A T Onajole, K A OdeyemiAbstract:Sexually transmitted infections constitute economic burden for developing countries, exposure to causative agents is an occupational hazard for female sex workers. Targeted interventions for this population can reduce the incidence and prevalence of sexually transmitted infections including human immunodeficiency virus, but barriers exists which can hinder effective implementation of such programs. This descriptive cross sectional study sought to assess the prevalence, knowledge and treatment practices of sexually transmitted infections among brothel based female sex workers Three hundred and twenty three consenting female sex workers were surveyed using pre tested, interviewer administered questionnaires. More than half of the respondents (54.2%) had poor knowledge of symptoms of sexually transmitted infections. Only 13.9% were aware that sexually transmitted infections could be asymptomatic. The self reported prevalence of symptomatic sexually transmitted infections was 36.5%. About half of those with sexually transmitted infectionss sought treatment in a hospital or health centre while 32.5% from a patent medicine vendor. Most respondents (53.8%) mentioned the perceived quality of care as the main reason for seeking treatment in their chosen place. More of the respondents with good knowledge of sexually transmitted infections reported symptoms compared to those with fair and poor knowledge. The knowledge of sexually transmitted infections among these female sex workers is poor and the prevalence is relatively high. Efforts to improve knowledge promote and encourage preventive as well as effective treatment practices must be made for this population. Resume Les infections sexuellement transmissibles constituent un fardeau economique pour les pays en developpement et l'exposition aux agents pathogenes est un risque professionnel pour les prostituees. Les interventions qui visent cette population peuvent reduire l'incidence et la prevalence des infections sexuellement transmissibles, y compris le virus de l'immunodeficience humaine, mais il existe des obstacles qui peuvent entraver la mise en oeuvre effective de ces programmes. Cette etude descriptive transversale a cherche a evaluer les pratiques de la prevalence, la connaissance et le traitement des infections sexuellement transmissibles chez les prostituees qui pratiquent leur metier dans des bordels. Trois cent vingt-trois prostituees consentants ont ete interrogees a l'aide des questionnaires deja testes et administres par l’intervieweur. Plus de la moitie des interviewees (54,2%) avaient une mauvaise connaissance des symptomes des infections sexuellement transmissibles. Seulement 13,9% etaient au courant que les infections sexuellement transmissibles peuvent etre asymptomatiques. La prevalence des symptomes d'infections sexuellement transmissibles auto signales etait de 36,5%. Environ la moitie de ceux qui sont atteints des infections sexuellement transmissibles ont recherche un traitement dans un centre hospitalier ou dans un centre de sante tandis que 32,5% le recherchaient aupres d'un vendeur des medicaments brevetes. La plupart des interviewees (53,8%) ont mentionne la qualite percue des soins comme la principale raison pour se faire soigner dans les lieux choisis. Beaucoup d’interviewees qui ont une bonne connaissance des infections sexuellement transmissibles ont signale des symptomes par rapport a ceux qui les connaissent passablement ou mal. La connaissance des infections sexuellement transmissibles chez les prostituees est mauvaise et la prevalence est relativement elevee. Il faut faire des efforts pour ameliorer les connaissances, pour promouvoir et pour encourager la prevention ainsi que les pratiques de traitement efficaces a l’interet de cette population. Keywords: Symptomatic STIs, Patent medicine vendor, Brothels
K A Odeyemi - One of the best experts on this subject based on the ideXlab platform.
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sexually transmitted infections prevalence knowledge and treatment practices among female sex workers in a Cosmopolitan City in nigeria
African Journal of Reproductive Health, 2013Co-Authors: Adekemi O Sekoni, Oluwakemi Ololade Odukoya, A T Onajole, K A OdeyemiAbstract:Sexually transmitted infections constitute economic burden for developing countries, exposure to causative agents is an occupational hazard for female sex workers. Targeted interventions for this population can reduce the incidence and prevalence of sexually transmitted infections including human immunodeficiency virus, but barriers exists which can hinder effective implementation of such programs. This descriptive cross sectional study sought to assess the prevalence, knowledge and treatment practices of sexually transmitted infections among brothel based female sex workers Three hundred and twenty three consenting female sex workers were surveyed using pre tested, interviewer administered questionnaires. More than half of the respondents (54.2%) had poor knowledge of symptoms of sexually transmitted infections. Only 13.9% were aware that sexually transmitted infections could be asymptomatic. The self reported prevalence of symptomatic sexually transmitted infections was 36.5%. About half of those with sexually transmitted infectionss sought treatment in a hospital or health centre while 32.5% from a patent medicine vendor. Most respondents (53.8%) mentioned the perceived quality of care as the main reason for seeking treatment in their chosen place. More of the respondents with good knowledge of sexually transmitted infections reported symptoms compared to those with fair and poor knowledge. The knowledge of sexually transmitted infections among these female sex workers is poor and the prevalence is relatively high. Efforts to improve knowledge promote and encourage preventive as well as effective treatment practices must be made for this population. Resume Les infections sexuellement transmissibles constituent un fardeau economique pour les pays en developpement et l'exposition aux agents pathogenes est un risque professionnel pour les prostituees. Les interventions qui visent cette population peuvent reduire l'incidence et la prevalence des infections sexuellement transmissibles, y compris le virus de l'immunodeficience humaine, mais il existe des obstacles qui peuvent entraver la mise en oeuvre effective de ces programmes. Cette etude descriptive transversale a cherche a evaluer les pratiques de la prevalence, la connaissance et le traitement des infections sexuellement transmissibles chez les prostituees qui pratiquent leur metier dans des bordels. Trois cent vingt-trois prostituees consentants ont ete interrogees a l'aide des questionnaires deja testes et administres par l’intervieweur. Plus de la moitie des interviewees (54,2%) avaient une mauvaise connaissance des symptomes des infections sexuellement transmissibles. Seulement 13,9% etaient au courant que les infections sexuellement transmissibles peuvent etre asymptomatiques. La prevalence des symptomes d'infections sexuellement transmissibles auto signales etait de 36,5%. Environ la moitie de ceux qui sont atteints des infections sexuellement transmissibles ont recherche un traitement dans un centre hospitalier ou dans un centre de sante tandis que 32,5% le recherchaient aupres d'un vendeur des medicaments brevetes. La plupart des interviewees (53,8%) ont mentionne la qualite percue des soins comme la principale raison pour se faire soigner dans les lieux choisis. Beaucoup d’interviewees qui ont une bonne connaissance des infections sexuellement transmissibles ont signale des symptomes par rapport a ceux qui les connaissent passablement ou mal. La connaissance des infections sexuellement transmissibles chez les prostituees est mauvaise et la prevalence est relativement elevee. Il faut faire des efforts pour ameliorer les connaissances, pour promouvoir et pour encourager la prevention ainsi que les pratiques de traitement efficaces a l’interet de cette population. Keywords: Symptomatic STIs, Patent medicine vendor, Brothels
Fan-fan Xing - One of the best experts on this subject based on the ideXlab platform.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
BMC infectious diseases, 2020Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain.Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). Five patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption and handling of animal meat. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for Brucellosis in a highly Cosmopolitan City of southern China
2019Co-Authors: Hai-yan Ye, Fan-fan Xing, Kelvin H.y Chiu, Simon K. F. Lo, Jonathan H K Chen, Jin Yang, Kwok-yung YuenAbstract:Abstract Background:Brucellosis is one of the most widespread zoonosis worldwide, it is caused by Gram-negative coccobacilli, Brucella spp. In China, 90% of brucellosis occurred in six northern agricultural provinces. However, there is an increasing trend of human brucellosis in southern provinces but only limited cases were reported. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital of southern china. Methods:A retrospective study was conducted in the past 4 years. Clinical details of brucellosis including occupation, suspected transmission route and complications were retrieved. Serum for tube agglutination test to check Brucella antibody. Blood and aspirate were collected for culture, Vitek 2 and MALDL-TOF MS were used for identification.Results:Thirteen cases of laboratory confirmed brucellosis were encountered in a highly Cosmopolitan City Shenzhen of South China between January 2014 and October 2018. Seven of the thirteen patients were male, with age ranging from 29 to 73 years old. Five patients (38.5%) came from Guangdong province, and eight patients (61.5%) came from other provinces. The commonest route of transmission was handling and consumption of infected placenta from goats. Common presenting symptoms include fever, osteoarticular pain and urinary symptoms. Common physical signs were fever, splenomegaly and lymphadenopathy. The commonest complication was spondylodiscitis/ peripheral joint arthritis (n=4), while exotic complications including abdominal aortitis with pseudoaneurysm, hepatic and spleen abscess, soft tissue abscess, and epididymo-orchitis were also observed in 4 other patients. The most life-threating but rare complication of abdominal aortitis in the elderly could be easily missed due to the nonspecific presenting symptom. Conclusions:In summary, brucellosis is increasingly seen in highly Cosmopolitan part of southern China. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in the differential diagnosis of fever of unknown origin in this locality. Presence of extensive atherosclerosis in elderly patient may predispose them to endovascular infection by Brucella species.
Kelvin H.y Chiu - One of the best experts on this subject based on the ideXlab platform.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
BMC infectious diseases, 2020Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain.Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for brucellosis in a highly Cosmopolitan City in southern China
2019Co-Authors: Fan-fan Xing, Kelvin H.y Chiu, Jonathan H K Chen, Jin Yang, Ricky Wing-tong Lau, Kwok-yung YuenAbstract:Abstract Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients’ occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). Five patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption and handling of animal meat. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly Cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.
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High index of suspicion for Brucellosis in a highly Cosmopolitan City of southern China
2019Co-Authors: Hai-yan Ye, Fan-fan Xing, Kelvin H.y Chiu, Simon K. F. Lo, Jonathan H K Chen, Jin Yang, Kwok-yung YuenAbstract:Abstract Background:Brucellosis is one of the most widespread zoonosis worldwide, it is caused by Gram-negative coccobacilli, Brucella spp. In China, 90% of brucellosis occurred in six northern agricultural provinces. However, there is an increasing trend of human brucellosis in southern provinces but only limited cases were reported. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital of southern china. Methods:A retrospective study was conducted in the past 4 years. Clinical details of brucellosis including occupation, suspected transmission route and complications were retrieved. Serum for tube agglutination test to check Brucella antibody. Blood and aspirate were collected for culture, Vitek 2 and MALDL-TOF MS were used for identification.Results:Thirteen cases of laboratory confirmed brucellosis were encountered in a highly Cosmopolitan City Shenzhen of South China between January 2014 and October 2018. Seven of the thirteen patients were male, with age ranging from 29 to 73 years old. Five patients (38.5%) came from Guangdong province, and eight patients (61.5%) came from other provinces. The commonest route of transmission was handling and consumption of infected placenta from goats. Common presenting symptoms include fever, osteoarticular pain and urinary symptoms. Common physical signs were fever, splenomegaly and lymphadenopathy. The commonest complication was spondylodiscitis/ peripheral joint arthritis (n=4), while exotic complications including abdominal aortitis with pseudoaneurysm, hepatic and spleen abscess, soft tissue abscess, and epididymo-orchitis were also observed in 4 other patients. The most life-threating but rare complication of abdominal aortitis in the elderly could be easily missed due to the nonspecific presenting symptom. Conclusions:In summary, brucellosis is increasingly seen in highly Cosmopolitan part of southern China. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in the differential diagnosis of fever of unknown origin in this locality. Presence of extensive atherosclerosis in elderly patient may predispose them to endovascular infection by Brucella species.
