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Daniele Botticelli - One of the best experts on this subject based on the ideXlab platform.

  • influence of the buccal bone Crest Width on peri implant hard and soft tissues dimensions a histomorphometric study in humans
    Implant Dentistry, 2018
    Co-Authors: Yuki Omori, Giovanna Iezzi, Vittoria Perrotti, Adriano Piattelli, Mauro Ferri, Yasushi Nakajima, Daniele Botticelli
    Abstract:

    OBJECTIVE: To histologically evaluate hard and soft tissues adaptation at screw-shaped devices installed at recipient sites in the distal segments of the alveolar edentulous ridge prepared with a buccal bone Width of 1 or 2 mm. MATERIAL AND METHODS: Sixteen volunteers received 2 nonsubmerged titanium implants each; after 3 months, biopsies were obtained and processed for histology. The distances between implant shoulder (IS), top of the bony Crest (C), coronal level of osseointegration (B), peri-implant mucosa (PM), and apical extension of the junctional epithelium (aJE) were measured. RESULTS: There were no significant statistically differences between test and control sites regarding IS-C, IS-B, PM-IS, PM-B, PM-aJE, aJE-B measurements. The horizontal bone resorption 1 mm below IS was 0.3 ± 0.3 and 1.0 ± 0.7 mm at the test and control sites, respectively. This difference was statistically significant. CONCLUSIONS: Similar hard and soft tissues dimensions were observed in both groups. However, a higher horizontal bone resorption was seen at the control sites. Nonsubmerged implant installation should be performed when a 1 mm buccal bony Crest Width is present so as to limit the horizontal bone resorption.

  • influence of buccal bony Crest Width on marginal dimensions of peri implant hard and soft tissues after implant installation an experimental study in dogs
    Clinical Oral Implants Research, 2013
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

  • Influence of buccal bony Crest Width on marginal dimensions of peri‐implant hard and soft tissues after implant installation. An experimental study in dogs
    Clinical Oral Implants Research, 2012
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

Niklaus P Lang - One of the best experts on this subject based on the ideXlab platform.

  • influence of buccal bony Crest Width on marginal dimensions of peri implant hard and soft tissues after implant installation an experimental study in dogs
    Clinical Oral Implants Research, 2013
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

  • Influence of buccal bony Crest Width on marginal dimensions of peri‐implant hard and soft tissues after implant installation. An experimental study in dogs
    Clinical Oral Implants Research, 2012
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

Mariano Sanz - One of the best experts on this subject based on the ideXlab platform.

  • Safety and performance of a novel collagenated xenogeneic bone block for lateral alveolar Crest augmentation for staged implant placement
    Clinical Oral Implants Research, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martínez‐villa, Ignacio Sanz‐martín, Juan Bollain, Mariano Sanz
    Abstract:

    Objectives To evaluate the performance and safety of placing a collagenated xenogeneic bone block (CXBB) graft for the lateral bone augmentation of the alveolar Crest prior to implant placement. Material & Methods In patients with single or multiple tooth gaps and a severe horizontal collapse of the alveolar ridge, a ridge augmentation procedure was performed using CXBB fixated with osteosynthesis screws to the atrophic bone Crest and complemented with deproteinized bovine bone mineral particles (DBBM) and a native bilayer collagen membrane (NBCM). Patients were examined with CBCT prior to and 24 weeks after the augmentation. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width and availability for adequate implant placement. Results Fifteen patients received 28 CXBB, and in 13 patients, a re-entry procedure was performed. Eleven patients (84.6%) gained enough bone volume for implant insertion without additional contouring or secondary bone augmentation. The mean Crest Width at baseline was 2.83 mm (SD 0.57), and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Soft tissue dehiscence occurred during the follow-up in 5 of 14 patients (35.7%) at various time points. In addition, there was a high incidence of early implant loss (30.8% [patient-based]). Conclusions CXBB achieved significant horizontal Crestal Width gains allowing a secondary implant placement in the majority of the patients. However, the occurrence of soft tissue dehiscence may notably affect the outcome of the subsequent implant therapy.

  • Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
    International Journal of Implant Dentistry, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martinez-villa, Fabio Vignoletti, Mariano Sanz
    Abstract:

    Background The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. Methods In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed. Results Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean Crest Width at baseline was 2.78 mm (SD 0.57) and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2). Conclusions CCXBB achieved significant horizontal Crestal Width allowing for staged implant placement in most of the patients. In light of the histological outcomes and implant failures, special attention must be placed to prevent soft tissue dehiscence when CCXBB is used in severe atrophic alveolar Crests.

  • Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
    International Journal of Implant Dentistry, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martínez‐villa, Fabio Vignoletti, Mariano Sanz
    Abstract:

    The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed. Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean Crest Width at baseline was 2.78 mm (SD 0.57) and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2). CCXBB achieved significant horizontal Crestal Width allowing for staged implant placement in most of the patients. In light of the histological outcomes and implant failures, special attention must be placed to prevent soft tissue dehiscence when CCXBB is used in severe atrophic alveolar Crests.

Gabriele M Baffone - One of the best experts on this subject based on the ideXlab platform.

  • influence of buccal bony Crest Width on marginal dimensions of peri implant hard and soft tissues after implant installation an experimental study in dogs
    Clinical Oral Implants Research, 2013
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

  • Influence of buccal bony Crest Width on marginal dimensions of peri‐implant hard and soft tissues after implant installation. An experimental study in dogs
    Clinical Oral Implants Research, 2012
    Co-Authors: Gabriele M Baffone, Daniele Botticelli, Flavia Priscila Pereira, Giacomo Favero, Michael T Schweikert, Niklaus P Lang
    Abstract:

    Aim To evaluate the influence of the Width of the buccal bony wall on hard and soft tissue dimensions following implant installation. Material and methods Mandibular premolars and first molars of six Labrador dogs were extracted bilaterally. After 3 months of healing, two recipient sites, one on each side of the mandible, were prepared in such a way as to obtain a buccal bony ridge Width of about 2 mm in the right (control) and 1 mm in the left sides (test), respectively. Implants were installed with the coronal margin flush with the buccal alveolar bony Crest. Abutments were placed and the flaps were sutured to allow a non-submerged healing. After 3 months, the animals were euthanized and ground sections obtained. Results All implants were completely osseointegrated. In respect to the coronal rough margin of the implant, the most coronal bone-to-implant contact was apically located 1.04 ± 0.91 and 0.94 ± 0.87 mm at the test and control sites, respectively, whereas the top of the bony Crest was located 0.30 ± 0.40 mm at the test and 0.57 ± 0.49 mm at the control sites. No statistically significant differences were found. A larger horizontal bone resorption, however, evaluated 1 mm apically to the rough margin, was found at the control (1.1 ± 0.7 mm) compared to the test (0.3 ± 0.3 mm) sites, the difference being statistically significant. A thin peri-implant mucosa (2.4–2.6 mm) was found at implant installation while, after 3 months of healing, a biological Width of 3.90–4.40 mm was observed with no statistically significant differences between control and test sites. Conclusions A Width of the buccal bony wall of 1or 2 mm at implant sites yielded similar results after 3 months of healing in relation of hard tissue and soft tissues dimensions after implant installation.

Alberto Ortiz-vigón - One of the best experts on this subject based on the ideXlab platform.

  • Safety and performance of a novel collagenated xenogeneic bone block for lateral alveolar Crest augmentation for staged implant placement
    Clinical Oral Implants Research, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martínez‐villa, Ignacio Sanz‐martín, Juan Bollain, Mariano Sanz
    Abstract:

    Objectives To evaluate the performance and safety of placing a collagenated xenogeneic bone block (CXBB) graft for the lateral bone augmentation of the alveolar Crest prior to implant placement. Material & Methods In patients with single or multiple tooth gaps and a severe horizontal collapse of the alveolar ridge, a ridge augmentation procedure was performed using CXBB fixated with osteosynthesis screws to the atrophic bone Crest and complemented with deproteinized bovine bone mineral particles (DBBM) and a native bilayer collagen membrane (NBCM). Patients were examined with CBCT prior to and 24 weeks after the augmentation. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width and availability for adequate implant placement. Results Fifteen patients received 28 CXBB, and in 13 patients, a re-entry procedure was performed. Eleven patients (84.6%) gained enough bone volume for implant insertion without additional contouring or secondary bone augmentation. The mean Crest Width at baseline was 2.83 mm (SD 0.57), and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Soft tissue dehiscence occurred during the follow-up in 5 of 14 patients (35.7%) at various time points. In addition, there was a high incidence of early implant loss (30.8% [patient-based]). Conclusions CXBB achieved significant horizontal Crestal Width gains allowing a secondary implant placement in the majority of the patients. However, the occurrence of soft tissue dehiscence may notably affect the outcome of the subsequent implant therapy.

  • Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
    International Journal of Implant Dentistry, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martinez-villa, Fabio Vignoletti, Mariano Sanz
    Abstract:

    Background The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. Methods In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed. Results Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean Crest Width at baseline was 2.78 mm (SD 0.57) and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2). Conclusions CCXBB achieved significant horizontal Crestal Width allowing for staged implant placement in most of the patients. In light of the histological outcomes and implant failures, special attention must be placed to prevent soft tissue dehiscence when CCXBB is used in severe atrophic alveolar Crests.

  • Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement
    International Journal of Implant Dentistry, 2017
    Co-Authors: Alberto Ortiz-vigón, Iñaki Suarez, Sergio Martínez‐villa, Fabio Vignoletti, Mariano Sanz
    Abstract:

    The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed using CCXBB as bone replacement grafts. Twenty-six weeks postoperatively, a re-entry procedure was performed to evaluate the bone Width for adequate implant placement and two histological specimens were retrieved from each patient, one being processed for ground sectioning and the other for decalcified paraffin-included sections. In non-decalcified sections, the relative proportions occupied by bone, biomaterials, and connective tissue present in the biopsies were identified. In de-calcified sections, structures and cells positive for osteopontin (OPN), tartrate-resistant acid phosphatase activity (TRAP), osteocalcin (OSC), and alkaline phosphatase (ALP) were assessed. Soft tissue dehiscence occurred during the follow-up in 5 out of 15 patients (33.3%). The mean Crest Width at baseline was 2.78 mm (SD 0.57) and the mean Crest Width at re-entry was 6.90 mm (SD 1.22), with a mean ridge Width increase of 4.12 mm (SD 1.32). Twenty-six bone biopsies were obtained from 13 patients. Histomorphometric analysis showed a mean of 26.90% (SD 12.21) of mineralized vital bone (MVB), 21.37% (SD 7.36) of residual CCXBB, 47.13% (SD 19.15) of non-mineralized tissue, and 0.92% of DBBM. The immunohistochemical analysis revealed a large number of OPN-positive cells 8.12% (SD 4.73), a lower proportion of TRAP positive multinuclear cells 5.09% (SD 4.91), OSC-positive cells 4.09% (SD 4.34), and a limited amount of ALP positive cells 1.63% (SD 2). CCXBB achieved significant horizontal Crestal Width allowing for staged implant placement in most of the patients. In light of the histological outcomes and implant failures, special attention must be placed to prevent soft tissue dehiscence when CCXBB is used in severe atrophic alveolar Crests.