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Karina Citra Rani - One of the best experts on this subject based on the ideXlab platform.
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PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS Crospovidone-SODIUM STARCH GLYCOLATE
International Journal of Applied Pharmaceutics, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Nathanael Charles, Valencia GeovanyAbstract:Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-β-cyclodextrin which using co-process Crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Methods: Inclusion complex of atenolol-β-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed Crospovidone-sodium starch glycolate 1:1 (formula 1) and 1:2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-β-cyclodextrin using a physical mixture of Crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (F1-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Results: Orally disintegrating tablets of atenolol-β-cyclodextrin using co-processed Crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53±2.26 seconds) and in vitro dispersion time (47.44±2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-β-cyclodextrin orally disintegrating tablets. Conclusion: Orally disintegrating tablets of atenolol-β-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed Crospovidone-sodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.
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formulasi tablet orodispersibel atenolol dengan co process superdisintegran Crospovidone croscarmellose sodium 1 2
2018Co-Authors: Karina Citra Rani, Nani Parfati, Melisa MasrurohAbstract:Latar beiakang: Atenolol merupakan obat hipertensi yang terrnasuk dalam golongan /]-blocker. Atenolol termasuk kategori obat yang agak sukar larut dalam air. Pembentukan kompleks inklusi atenolol-P-siklodekstrir. merupakan salah satu strategi untuk meningkatkan disolusi atenolol. Formulasi tablet orodispersibel atenoloi-P-siklodekstrin merupakan salah satu solusi untuk mengatasi permasa1ahan efektifitas dan kepatuhan pasien. Tablet orodispersibel dapat hancur dirongga mulut dalam waktu kurang dari 1 menit, sehingga tidak memerlukan air untuk membantu menelan. Pembentukan co-process superdisintegran Crospovidone-croscarmellose sodium dalam formula tablet orodispersibel dapat mempercepat waktu hancur tablet, sehingga awal proses disolusi bisa berlangsung lebih cepat. Tujuan : Penelitian ini bertujuan untuk mengidentifikasi pengaruh pembentukan co-process crospovitlone-croscarmellose sodium ( 1:2) terhadap waktu pembasahan, rasio penyerapan air, waktu hancur, dan disolusi dibandingkan dengan campuran fisiknya dalam formulasi tablet orodispersibel atenolol. Metode: Tablet orodispersibel atenolol diformulasi dengan menggunakan materi awal kompleks inklusi atenoloi P-siklodekstrin. Tablet orodispersibel atenolol dalam penelitian ini dibuat dengan menggunakan co-process superdisintegran Crospovidone-croscarmellose sodium ( I :2)(formula 1) dan campuran fisiknya (formula 2). Co-process superdisintegran dibuat dengan metode solvent evaporation. Evaluasi dilakukan pada masa cetak (prekompresi) dan tablet orodispersibel yang dihasilkan (post kompresi). Hasil Penelitian: Tablet orodispersibel atenolol dengan co-process Crospovidone-croscarrnellose sodium (l :2) menunjukkan waktu pembasahan (36,33 ± 4,36 detik) yang lebih cepat, rasio penyerapan air yang lebih rendah (52,81±8,61 %), waktu hancur (24,47±5,97 detik) yang lebih cepat, dan efisiensi disolusi yang lebih tinggi dibandingkan tablet orodispersibel atenolol dengan campuran fisik crospovidonc-croscarmellose sodium. Kesimpulan : Tablet orodispersibel atenolol dengan co-process Crospovidone-croscarrnellose sodium (1 :2) mempercepat waktu pembasahan, waktu han cur, dan meningkatkan efisiensi disolusi
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formulasi tablet orally disintegrating atenolol dengan superdisintegran co process Crospovidone croscarmellose sodium 1 1
2018Co-Authors: Nani Parfati, Karina Citra RaniAbstract:LATAR BELAKANG :Tablet orally disintegrating atenolol adalah merupakan tablet yang dirancang untuk hancur dalam rongga mulut, sehingga lebih memudahkan untuk dengan sangat cepat ditelan dan diharapkan disolusi bahan aktif lebih cepat serta mula kerja obat lebih cepat. Atenolol merupakan obat antihipertensi mempunyai karakteristiJ:c agak sukar larut dalam air, kategori BCS kelas 2, sehingga diperlukan untuk meningkatkan disolusi dengan cara pembuatan kompleks inklusi dengan atenolol-P-siklodekstrin dan penggunaan superdisintegran co-process Crospovidone-croscarmellose sodium ( I: 1). Dalam penelitian ini dibuat dua formula superdisintegran, yaitu campuran fisik (formula I) dan superdisintegran co-process Crospovidone-croscarmellose sodium 1: I (formula 2). Parameter yang diamati adalah waktu hancur, waktu dispersi, waktu pembasahan dan disolusi. TUJUAN : Membuat sediaan tablet Atenolol orally disintegran dengan menggunakan superdisintegran copresses crospovidon-croscarmellose yang memenuhi mutu ODT. METODE : Pembutan ODT Atenonolol dibuat dua tahap , tahap pertama atenolol dibuat sistem inklusi dengan =siklodekstrin ; tahap kedua dibuat coproses superdisintegran crospovidune- croscarmellose keduanya dengan metode solven evaporation; sedangkan pembuatan tablet ODT dengan metode cetak langsung. KESIMPULAN: Hasil parameter fisikia tablet orally disintegrating formula 2 dapat mempercepat waktu hancur, waktu dispersi in vitro, dan waktu pembasahan dan disolusi dan memenuhi sarat ODT.
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THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (Crospovidone-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS
Asian Journal of Pharmaceutical and Clinical Research, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Meilany MeilanyAbstract:Â Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed Crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p
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the effect of coprocessed superdisintegrants ratio Crospovidone sodium starch glycolate to the physicochemical characteristics of atenolol orally disintegrating tablets
Asian Journal of Pharmaceutical and Clinical Research, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Meilany MeilanyAbstract: Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed Crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91±0.11)% and area under the curve value (11149.13±13.15) compared to formula 2 and formula 3.Conclusion: The results from this study showed that coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.
Nani Parfati - One of the best experts on this subject based on the ideXlab platform.
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PREPARATION AND EVALUATION OF ATENOLOL-β-CYCLODEXTRIN ORALLY DISINTEGRATING TABLETS USING CO-PROCESS Crospovidone-SODIUM STARCH GLYCOLATE
International Journal of Applied Pharmaceutics, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Nathanael Charles, Valencia GeovanyAbstract:Objective: The aim of this current research was to formulate and analyze the characteristics of atenolol-β-cyclodextrin which using co-process Crospovidone-sodium starch glycolate as the disintegrants. Evaluation which has been conducted on orally disintegrating tablets consist of wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Methods: Inclusion complex of atenolol-β-cyclodextrin which were prepared using solvent evaporation method, then formulated using co-processed Crospovidone-sodium starch glycolate 1:1 (formula 1) and 1:2 (formula 2) into orally disintegrating tablets by direct compression technique. Orally disintegrating tablets of atenolol-β-cyclodextrin using a physical mixture of Crospovidone-sodium starch glycolate 1:1 (formula 3), 1:2 (formula 4) was also prepared as a control. The prepared formulations (F1-F4) were evaluated by several parameters such as wetting time, water absorption ratio, in vitro dispersion time, and dissolution. Results: Orally disintegrating tablets of atenolol-β-cyclodextrin using co-processed Crospovidone-sodium starch glycolate 1:1 (formula 1) showed shorter wetting time (53.53±2.26 seconds) and in vitro dispersion time (47.44±2.49 seconds) compare to the other formulas. Formula 1 also exhibited the highest dissolution efficiency compare to the formula which was used in the physical mixture. The results of this study also revealed that there was a high correlation between in vitro dispersion time and dissolution efficiency of atenolol-β-cyclodextrin orally disintegrating tablets. Conclusion: Orally disintegrating tablets of atenolol-β-cyclodextrin showed enhanced dissolution efficiency due to the presence of inclusion complex and co-processed Crospovidone-sodium starch glycolate. Formula 1 was found to be the best formula in this study. This formula effectively reduces in vitro dispersion time, hence the dissolution efficiency became higher.
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formulasi tablet orodispersibel atenolol dengan co process superdisintegran Crospovidone croscarmellose sodium 1 2
2018Co-Authors: Karina Citra Rani, Nani Parfati, Melisa MasrurohAbstract:Latar beiakang: Atenolol merupakan obat hipertensi yang terrnasuk dalam golongan /]-blocker. Atenolol termasuk kategori obat yang agak sukar larut dalam air. Pembentukan kompleks inklusi atenolol-P-siklodekstrir. merupakan salah satu strategi untuk meningkatkan disolusi atenolol. Formulasi tablet orodispersibel atenoloi-P-siklodekstrin merupakan salah satu solusi untuk mengatasi permasa1ahan efektifitas dan kepatuhan pasien. Tablet orodispersibel dapat hancur dirongga mulut dalam waktu kurang dari 1 menit, sehingga tidak memerlukan air untuk membantu menelan. Pembentukan co-process superdisintegran Crospovidone-croscarmellose sodium dalam formula tablet orodispersibel dapat mempercepat waktu hancur tablet, sehingga awal proses disolusi bisa berlangsung lebih cepat. Tujuan : Penelitian ini bertujuan untuk mengidentifikasi pengaruh pembentukan co-process crospovitlone-croscarmellose sodium ( 1:2) terhadap waktu pembasahan, rasio penyerapan air, waktu hancur, dan disolusi dibandingkan dengan campuran fisiknya dalam formulasi tablet orodispersibel atenolol. Metode: Tablet orodispersibel atenolol diformulasi dengan menggunakan materi awal kompleks inklusi atenoloi P-siklodekstrin. Tablet orodispersibel atenolol dalam penelitian ini dibuat dengan menggunakan co-process superdisintegran Crospovidone-croscarmellose sodium ( I :2)(formula 1) dan campuran fisiknya (formula 2). Co-process superdisintegran dibuat dengan metode solvent evaporation. Evaluasi dilakukan pada masa cetak (prekompresi) dan tablet orodispersibel yang dihasilkan (post kompresi). Hasil Penelitian: Tablet orodispersibel atenolol dengan co-process Crospovidone-croscarrnellose sodium (l :2) menunjukkan waktu pembasahan (36,33 ± 4,36 detik) yang lebih cepat, rasio penyerapan air yang lebih rendah (52,81±8,61 %), waktu hancur (24,47±5,97 detik) yang lebih cepat, dan efisiensi disolusi yang lebih tinggi dibandingkan tablet orodispersibel atenolol dengan campuran fisik crospovidonc-croscarmellose sodium. Kesimpulan : Tablet orodispersibel atenolol dengan co-process Crospovidone-croscarrnellose sodium (1 :2) mempercepat waktu pembasahan, waktu han cur, dan meningkatkan efisiensi disolusi
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formulasi tablet orally disintegrating atenolol dengan superdisintegran co process Crospovidone croscarmellose sodium 1 1
2018Co-Authors: Nani Parfati, Karina Citra RaniAbstract:LATAR BELAKANG :Tablet orally disintegrating atenolol adalah merupakan tablet yang dirancang untuk hancur dalam rongga mulut, sehingga lebih memudahkan untuk dengan sangat cepat ditelan dan diharapkan disolusi bahan aktif lebih cepat serta mula kerja obat lebih cepat. Atenolol merupakan obat antihipertensi mempunyai karakteristiJ:c agak sukar larut dalam air, kategori BCS kelas 2, sehingga diperlukan untuk meningkatkan disolusi dengan cara pembuatan kompleks inklusi dengan atenolol-P-siklodekstrin dan penggunaan superdisintegran co-process Crospovidone-croscarmellose sodium ( I: 1). Dalam penelitian ini dibuat dua formula superdisintegran, yaitu campuran fisik (formula I) dan superdisintegran co-process Crospovidone-croscarmellose sodium 1: I (formula 2). Parameter yang diamati adalah waktu hancur, waktu dispersi, waktu pembasahan dan disolusi. TUJUAN : Membuat sediaan tablet Atenolol orally disintegran dengan menggunakan superdisintegran copresses crospovidon-croscarmellose yang memenuhi mutu ODT. METODE : Pembutan ODT Atenonolol dibuat dua tahap , tahap pertama atenolol dibuat sistem inklusi dengan =siklodekstrin ; tahap kedua dibuat coproses superdisintegran crospovidune- croscarmellose keduanya dengan metode solven evaporation; sedangkan pembuatan tablet ODT dengan metode cetak langsung. KESIMPULAN: Hasil parameter fisikia tablet orally disintegrating formula 2 dapat mempercepat waktu hancur, waktu dispersi in vitro, dan waktu pembasahan dan disolusi dan memenuhi sarat ODT.
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THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (Crospovidone-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS
Asian Journal of Pharmaceutical and Clinical Research, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Meilany MeilanyAbstract:Â Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed Crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p
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the effect of coprocessed superdisintegrants ratio Crospovidone sodium starch glycolate to the physicochemical characteristics of atenolol orally disintegrating tablets
Asian Journal of Pharmaceutical and Clinical Research, 2018Co-Authors: Nani Parfati, Karina Citra Rani, Meilany MeilanyAbstract: Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (Crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed Crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91±0.11)% and area under the curve value (11149.13±13.15) compared to formula 2 and formula 3.Conclusion: The results from this study showed that coprocessed superdisintegrants (Crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.
Sanat Kumar Basu - One of the best experts on this subject based on the ideXlab platform.
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Development of topical gel containing aceclofenac-Crospovidone solid dispersion by “Quality by Design (QbD)” approach
Chemical Engineering Research & Design, 2014Co-Authors: Sougata Jana, Syed Ansar Ali, Amit Kumar Nayak, Kalyan Kumar Sen, Sanat Kumar BasuAbstract:Abstract This article describes the development, optimization, and evaluation of Carbopol 940 topical gel containing aceclofenac-Crospovidone (1:4) solid dispersion using “Quality by Design (QbD)” approach based on 2 3 factorial design. The effect of Crospovidone, tri-ethanolamine, and ethyl alcohol amount on the drug permeation profile of the topical gel containing aceclofenac-Crospovidone solid dispersion was optimized by 2 3 factorial design. The optimized gel showed improved permeation profile with cumulative drug permeation of 26.262 ± 2.157%, and permeation flux of 0.059 ± 0.011 μg/cm 2 /h. These gels were characterized by pH, viscosity, gel strength and FTIR study. The in vivo anti-inflammatory activity of the optimized gel was evaluated in rats using carrageenan-induced rat-paw oedema model and found excellent anti-inflammatory comparable with a marketed gel without producing any skin irritation.
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development of topical gel containing aceclofenac Crospovidone solid dispersion by quality by design qbd approach
Chemical Engineering Research & Design, 2014Co-Authors: Sougata Jana, Syed Ansar Ali, Amit Kumar Nayak, Kalyan Kumar Sen, Sanat Kumar BasuAbstract:Abstract This article describes the development, optimization, and evaluation of Carbopol 940 topical gel containing aceclofenac-Crospovidone (1:4) solid dispersion using “Quality by Design (QbD)” approach based on 2 3 factorial design. The effect of Crospovidone, tri-ethanolamine, and ethyl alcohol amount on the drug permeation profile of the topical gel containing aceclofenac-Crospovidone solid dispersion was optimized by 2 3 factorial design. The optimized gel showed improved permeation profile with cumulative drug permeation of 26.262 ± 2.157%, and permeation flux of 0.059 ± 0.011 μg/cm 2 /h. These gels were characterized by pH, viscosity, gel strength and FTIR study. The in vivo anti-inflammatory activity of the optimized gel was evaluated in rats using carrageenan-induced rat-paw oedema model and found excellent anti-inflammatory comparable with a marketed gel without producing any skin irritation.
Laura E. Depero - One of the best experts on this subject based on the ideXlab platform.
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Microstructure and morphology of nimesulide/Crospovidone nanocomposites by Raman and electron microscopies
Composites Part A-applied Science and Manufacturing, 2005Co-Authors: Paolo Bergese, Italo Colombo, Ivano Alessandri, N. Coceani, Laura E. DeperoAbstract:In the present work the arrangement of nanostructured nimesulide embedded inside Crospovidone microparticles is experimentally studied. The analysis was carried out by observing cross-sections of the microparticles with electron and Raman microscopes. Scanning electron microscopy (SEM) gave a morphological picture of the cross-sections, energy dispersive X-ray spectroscopy (EDS) allowed to investigate the nimesulide distribution at molecular level in- and outside the Crospovidone matrix, and microRaman spectroscopy (μRaman) shed some light on the nimesulide phase composition. The drug resulted to be constrained by Crospovidone into three main arrangements: an amorphous phase dispersed into the molecular cross-linked network of the polymer, nanocrystals wrapped up by the polymer, and drug layers, made of micro- and nanocrystals, segregated onto the popcorn-like surface of the polymer. According to X-ray diffraction data, the micro- and nanocrystals are highly disordered and made of crystallites with an average diameter of 17 nm.
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microstructure and morphology of nimesulide Crospovidone nanocomposites by raman and electron microscopies
Composites Part A-applied Science and Manufacturing, 2005Co-Authors: Paolo Bergese, Italo Colombo, Ivano Alessandri, N. Coceani, Laura E. DeperoAbstract:In the present work the arrangement of nanostructured nimesulide embedded inside Crospovidone microparticles is experimentally studied. The analysis was carried out by observing cross-sections of the microparticles with electron and Raman microscopes. Scanning electron microscopy (SEM) gave a morphological picture of the cross-sections, energy dispersive X-ray spectroscopy (EDS) allowed to investigate the nimesulide distribution at molecular level in- and outside the Crospovidone matrix, and microRaman spectroscopy (μRaman) shed some light on the nimesulide phase composition. The drug resulted to be constrained by Crospovidone into three main arrangements: an amorphous phase dispersed into the molecular cross-linked network of the polymer, nanocrystals wrapped up by the polymer, and drug layers, made of micro- and nanocrystals, segregated onto the popcorn-like surface of the polymer. According to X-ray diffraction data, the micro- and nanocrystals are highly disordered and made of crystallites with an average diameter of 17 nm.
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Microstructural investigation of nimesulide–Crospovidone composites by X-ray diffraction and thermal analysis
Composites Science and Technology, 2003Co-Authors: Paolo Bergese, Elza Bontempi, Italo Colombo, D. Gervasoni, Laura E. DeperoAbstract:Abstract Dispersion into Crospovidone is a widely employed method for enhancing the solubility of poorly water-soluble drugs, since the 3D polymeric network stabilizes the active substance in molecular clusters and nano-crystalline phases. Nimesulide loaded into Crospovidone shows two polymorphic modifications: the native material (form I) and the phase reported on ICDD and CSD databases (form II). Microstructure and polymorphism of the composites have been investigated as they affect the drug dissolution rate and in vivo absorption kinetics (i.e. the bio-availability of the drug from its dosage form). Differential scanning calorimetry (DSC) showed that the lower melting form (form II) is metastable. X-ray diffraction (XRD) evidenced that the embedded crystalline phases are made up of nano-crystallites and that no significant difference on their size exists. Quantitative analysis of the composites turned out to be a challenge with both XRD (preferred orientation effects and form I crystalline structure unknown) and DSC (high nimesulide-Crospovidone reactivity). Nevertheless, the results suggest a direct correlation between Crospovidone and form II weight fractions.
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microstructural investigation of nimesulide Crospovidone composites by x ray diffraction and thermal analysis
Composites Science and Technology, 2003Co-Authors: Paolo Bergese, Elza Bontempi, Italo Colombo, D. Gervasoni, Laura E. DeperoAbstract:Abstract Dispersion into Crospovidone is a widely employed method for enhancing the solubility of poorly water-soluble drugs, since the 3D polymeric network stabilizes the active substance in molecular clusters and nano-crystalline phases. Nimesulide loaded into Crospovidone shows two polymorphic modifications: the native material (form I) and the phase reported on ICDD and CSD databases (form II). Microstructure and polymorphism of the composites have been investigated as they affect the drug dissolution rate and in vivo absorption kinetics (i.e. the bio-availability of the drug from its dosage form). Differential scanning calorimetry (DSC) showed that the lower melting form (form II) is metastable. X-ray diffraction (XRD) evidenced that the embedded crystalline phases are made up of nano-crystallites and that no significant difference on their size exists. Quantitative analysis of the composites turned out to be a challenge with both XRD (preferred orientation effects and form I crystalline structure unknown) and DSC (high nimesulide-Crospovidone reactivity). Nevertheless, the results suggest a direct correlation between Crospovidone and form II weight fractions.
Sougata Jana - One of the best experts on this subject based on the ideXlab platform.
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Development of topical gel containing aceclofenac-Crospovidone solid dispersion by “Quality by Design (QbD)” approach
Chemical Engineering Research & Design, 2014Co-Authors: Sougata Jana, Syed Ansar Ali, Amit Kumar Nayak, Kalyan Kumar Sen, Sanat Kumar BasuAbstract:Abstract This article describes the development, optimization, and evaluation of Carbopol 940 topical gel containing aceclofenac-Crospovidone (1:4) solid dispersion using “Quality by Design (QbD)” approach based on 2 3 factorial design. The effect of Crospovidone, tri-ethanolamine, and ethyl alcohol amount on the drug permeation profile of the topical gel containing aceclofenac-Crospovidone solid dispersion was optimized by 2 3 factorial design. The optimized gel showed improved permeation profile with cumulative drug permeation of 26.262 ± 2.157%, and permeation flux of 0.059 ± 0.011 μg/cm 2 /h. These gels were characterized by pH, viscosity, gel strength and FTIR study. The in vivo anti-inflammatory activity of the optimized gel was evaluated in rats using carrageenan-induced rat-paw oedema model and found excellent anti-inflammatory comparable with a marketed gel without producing any skin irritation.
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development of topical gel containing aceclofenac Crospovidone solid dispersion by quality by design qbd approach
Chemical Engineering Research & Design, 2014Co-Authors: Sougata Jana, Syed Ansar Ali, Amit Kumar Nayak, Kalyan Kumar Sen, Sanat Kumar BasuAbstract:Abstract This article describes the development, optimization, and evaluation of Carbopol 940 topical gel containing aceclofenac-Crospovidone (1:4) solid dispersion using “Quality by Design (QbD)” approach based on 2 3 factorial design. The effect of Crospovidone, tri-ethanolamine, and ethyl alcohol amount on the drug permeation profile of the topical gel containing aceclofenac-Crospovidone solid dispersion was optimized by 2 3 factorial design. The optimized gel showed improved permeation profile with cumulative drug permeation of 26.262 ± 2.157%, and permeation flux of 0.059 ± 0.011 μg/cm 2 /h. These gels were characterized by pH, viscosity, gel strength and FTIR study. The in vivo anti-inflammatory activity of the optimized gel was evaluated in rats using carrageenan-induced rat-paw oedema model and found excellent anti-inflammatory comparable with a marketed gel without producing any skin irritation.