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Cesar L Ramireztortosa - One of the best experts on this subject based on the ideXlab platform.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Clínica e Investigación en Arteriosclerosis, 2003Co-Authors: Jose L Quiles, Cesar L Ramireztortosa, M C Ramireztortosa, Concepción M. Aguilera, Maria D. Mesa, Maurizio Battino, M AlegretAbstract:Objetivo En este estudio se evalua el efecto de un extracto de Curcuma longa sobre el desarrollo de aterosclerosis experimental (estrias grasas) en conejos, y su interaccion con otros antioxidantes plasmaticos. Metodos y resultados Dos grupos de conejos macho New Zealand White, un grupo control y un grupo que recibio extracto de Curcuma (CU), fueron alimentados con dieta aterogenica. El grupo CU fue tratado adicionalmente con un extracto hidroalcoholico de Curcuma por via oral. Seis animales de cada grupo se sacrificaron a los 10, 20 y 30 dias. En comparacion con el grupo CU, el grupo control presento concentraciones plasmaticas de peroxidos lipidicos significativamente superiores en todos los tiempos ensayados (10, 20 y 30 dias) y valores de d-tocoferol y coenzima Q significativamente menores a los 20 y 30 dias. El analisis histologico de las estrias grasas revelo que la lesion en la aorta toracica abdominal fue significativamente menor en el grupo CU que en el grupo control a los 30 dias. Conclusiones Los suplementos de Curcuma longa reducen el estres oxidativo y atenuan el desarrollo de estrias grasas en conejos alimentados con una dieta rica en colesterol.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Arteriosclerosis Thrombosis and Vascular Biology, 2002Co-Authors: Jose L Quiles, Dolores M Mesa, Cesar L Ramireztortosa, Concepción M. Aguilera, Maurizio BattinoAbstract:Objective— This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. Methods and Results— Two experimental groups of male New Zealand White rabbits, a control group and a Curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral Curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower α-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. Conclusions— Supplementation with Curcuma longa reduces oxidative stress and attenuates the dev...
Jose L Quiles - One of the best experts on this subject based on the ideXlab platform.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Clínica e Investigación en Arteriosclerosis, 2003Co-Authors: Jose L Quiles, Cesar L Ramireztortosa, M C Ramireztortosa, Concepción M. Aguilera, Maria D. Mesa, Maurizio Battino, M AlegretAbstract:Objetivo En este estudio se evalua el efecto de un extracto de Curcuma longa sobre el desarrollo de aterosclerosis experimental (estrias grasas) en conejos, y su interaccion con otros antioxidantes plasmaticos. Metodos y resultados Dos grupos de conejos macho New Zealand White, un grupo control y un grupo que recibio extracto de Curcuma (CU), fueron alimentados con dieta aterogenica. El grupo CU fue tratado adicionalmente con un extracto hidroalcoholico de Curcuma por via oral. Seis animales de cada grupo se sacrificaron a los 10, 20 y 30 dias. En comparacion con el grupo CU, el grupo control presento concentraciones plasmaticas de peroxidos lipidicos significativamente superiores en todos los tiempos ensayados (10, 20 y 30 dias) y valores de d-tocoferol y coenzima Q significativamente menores a los 20 y 30 dias. El analisis histologico de las estrias grasas revelo que la lesion en la aorta toracica abdominal fue significativamente menor en el grupo CU que en el grupo control a los 30 dias. Conclusiones Los suplementos de Curcuma longa reducen el estres oxidativo y atenuan el desarrollo de estrias grasas en conejos alimentados con una dieta rica en colesterol.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Arteriosclerosis Thrombosis and Vascular Biology, 2002Co-Authors: Jose L Quiles, Dolores M Mesa, Cesar L Ramireztortosa, Concepción M. Aguilera, Maurizio BattinoAbstract:Objective— This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. Methods and Results— Two experimental groups of male New Zealand White rabbits, a control group and a Curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral Curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower α-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. Conclusions— Supplementation with Curcuma longa reduces oxidative stress and attenuates the dev...
Concepción M. Aguilera - One of the best experts on this subject based on the ideXlab platform.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Clínica e Investigación en Arteriosclerosis, 2003Co-Authors: Jose L Quiles, Cesar L Ramireztortosa, M C Ramireztortosa, Concepción M. Aguilera, Maria D. Mesa, Maurizio Battino, M AlegretAbstract:Objetivo En este estudio se evalua el efecto de un extracto de Curcuma longa sobre el desarrollo de aterosclerosis experimental (estrias grasas) en conejos, y su interaccion con otros antioxidantes plasmaticos. Metodos y resultados Dos grupos de conejos macho New Zealand White, un grupo control y un grupo que recibio extracto de Curcuma (CU), fueron alimentados con dieta aterogenica. El grupo CU fue tratado adicionalmente con un extracto hidroalcoholico de Curcuma por via oral. Seis animales de cada grupo se sacrificaron a los 10, 20 y 30 dias. En comparacion con el grupo CU, el grupo control presento concentraciones plasmaticas de peroxidos lipidicos significativamente superiores en todos los tiempos ensayados (10, 20 y 30 dias) y valores de d-tocoferol y coenzima Q significativamente menores a los 20 y 30 dias. El analisis histologico de las estrias grasas revelo que la lesion en la aorta toracica abdominal fue significativamente menor en el grupo CU que en el grupo control a los 30 dias. Conclusiones Los suplementos de Curcuma longa reducen el estres oxidativo y atenuan el desarrollo de estrias grasas en conejos alimentados con una dieta rica en colesterol.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Arteriosclerosis Thrombosis and Vascular Biology, 2002Co-Authors: Jose L Quiles, Dolores M Mesa, Cesar L Ramireztortosa, Concepción M. Aguilera, Maurizio BattinoAbstract:Objective— This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. Methods and Results— Two experimental groups of male New Zealand White rabbits, a control group and a Curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral Curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower α-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. Conclusions— Supplementation with Curcuma longa reduces oxidative stress and attenuates the dev...
Maurizio Battino - One of the best experts on this subject based on the ideXlab platform.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Clínica e Investigación en Arteriosclerosis, 2003Co-Authors: Jose L Quiles, Cesar L Ramireztortosa, M C Ramireztortosa, Concepción M. Aguilera, Maria D. Mesa, Maurizio Battino, M AlegretAbstract:Objetivo En este estudio se evalua el efecto de un extracto de Curcuma longa sobre el desarrollo de aterosclerosis experimental (estrias grasas) en conejos, y su interaccion con otros antioxidantes plasmaticos. Metodos y resultados Dos grupos de conejos macho New Zealand White, un grupo control y un grupo que recibio extracto de Curcuma (CU), fueron alimentados con dieta aterogenica. El grupo CU fue tratado adicionalmente con un extracto hidroalcoholico de Curcuma por via oral. Seis animales de cada grupo se sacrificaron a los 10, 20 y 30 dias. En comparacion con el grupo CU, el grupo control presento concentraciones plasmaticas de peroxidos lipidicos significativamente superiores en todos los tiempos ensayados (10, 20 y 30 dias) y valores de d-tocoferol y coenzima Q significativamente menores a los 20 y 30 dias. El analisis histologico de las estrias grasas revelo que la lesion en la aorta toracica abdominal fue significativamente menor en el grupo CU que en el grupo control a los 30 dias. Conclusiones Los suplementos de Curcuma longa reducen el estres oxidativo y atenuan el desarrollo de estrias grasas en conejos alimentados con una dieta rica en colesterol.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Arteriosclerosis Thrombosis and Vascular Biology, 2002Co-Authors: Jose L Quiles, Dolores M Mesa, Cesar L Ramireztortosa, Concepción M. Aguilera, Maurizio BattinoAbstract:Objective— This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. Methods and Results— Two experimental groups of male New Zealand White rabbits, a control group and a Curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral Curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower α-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. Conclusions— Supplementation with Curcuma longa reduces oxidative stress and attenuates the dev...
Dolores M Mesa - One of the best experts on this subject based on the ideXlab platform.
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Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits
Arteriosclerosis Thrombosis and Vascular Biology, 2002Co-Authors: Jose L Quiles, Dolores M Mesa, Cesar L Ramireztortosa, Concepción M. Aguilera, Maurizio BattinoAbstract:Objective— This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants. Methods and Results— Two experimental groups of male New Zealand White rabbits, a control group and a Curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral Curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower α-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days. Conclusions— Supplementation with Curcuma longa reduces oxidative stress and attenuates the dev...
