The Experts below are selected from a list of 23448 Experts worldwide ranked by ideXlab platform
Dong-ku Kim - One of the best experts on this subject based on the ideXlab platform.
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Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC Chemokine receptor, CXCR2.
Cellular immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
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mesenchymal stem cells regulate the proliferation of t cells via the growth related oncogene cxc Chemokine receptor cxcr2
Cellular Immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
Yong Soo Lee - One of the best experts on this subject based on the ideXlab platform.
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Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC Chemokine receptor, CXCR2.
Cellular immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
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mesenchymal stem cells regulate the proliferation of t cells via the growth related oncogene cxc Chemokine receptor cxcr2
Cellular Immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
Kyung-jong Won - One of the best experts on this subject based on the ideXlab platform.
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Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC Chemokine receptor, CXCR2.
Cellular immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
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mesenchymal stem cells regulate the proliferation of t cells via the growth related oncogene cxc Chemokine receptor cxcr2
Cellular Immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
Sung-won Park - One of the best experts on this subject based on the ideXlab platform.
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Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC Chemokine receptor, CXCR2.
Cellular immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
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mesenchymal stem cells regulate the proliferation of t cells via the growth related oncogene cxc Chemokine receptor cxcr2
Cellular Immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
Hyeon-woo Lee - One of the best experts on this subject based on the ideXlab platform.
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Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC Chemokine receptor, CXCR2.
Cellular immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
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mesenchymal stem cells regulate the proliferation of t cells via the growth related oncogene cxc Chemokine receptor cxcr2
Cellular Immunology, 2012Co-Authors: Yong Soo Lee, Kyung-jong Won, Sung-won Park, Hyeon-woo Lee, Bokyung Kim, Jin-hoi Kim, Dong-ku KimAbstract:Mesenchymal stem cells (MSCs) have known to induce immunosuppressive properties by preventing T cell proliferation. However, it is remains unclear how MSCs inhibit T cell proliferation. To identify the factor that inhibits T cell proliferation, we conducted a cytokine array analysis of culture medium from a co-culture of MSCs and T cells and found that the Chemokines, CXCL1, 2 and 3, were induced in T cells. MSCs also induced the expression of the CXCR2 receptor on T cell surface. Particularly, CXCL3 inhibited proliferation and increased apoptosis in T cells, which were reversed by CXCR2 inhibitor treatment. Moreover, CXCL3 decreased JAK2, STAT3, and AKT phosphorylation and these responses were also abolished by CXCR2 inhibitor treatment. MSCs suppressed the proliferation of T cells into tumor tissue. Collectively, these data demonstrate that MSCs directly regulate T cell proliferation by induction of CXCL3 Chemokine and its receptor, CXCR2 on the surface in T cells.
