The Experts below are selected from a list of 8100 Experts worldwide ranked by ideXlab platform
Juyoung Yoon - One of the best experts on this subject based on the ideXlab platform.
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a highly selective ratiometric near infrared fluorescent Cyanine sensor for cysteine with remarkable shift and its application in bioimaging
Chemical Science, 2012Co-Authors: Sungsu Park, Juyoung YoonAbstract:We developed a highly selective ratiometric near-infrared Cyanine-based probe CyAC for cysteine (Cys) over homocysteine (Hcy) and glutathione (GSH). Upon the addition of Cys to the solution of CyAC, remarkable shifts in the spectra of CyAC can be monitored (from 770 nm to 515 nm in absorption spectra and from 780 nm to 570 nm in emission spectra). For the first time, the novel strategy that reversibly modulates the polymethine π-electron system by conjugation and removal of the specific trigger moiety was implemented for the generation of a ratiometric Cyanine-based sensor. Hydroxy Cyanine CyAE was chosen as the flurophore scaffold because the tautomerism (CyAE and CyAK or CyAD) can cause the reversible change in the π-conjugation system of the dyes with large shifts in the spectra. An acrylate group containing a α, β-unsaturated ketone as a functional trigger moiety was incorporated with CyAK to form the sensor CyAC. This specific response for Cys was based on the differences of the kinetics of intramolecular adduct/cyclizations. Moreover, CyAC was successfully applied for bioimaging Cys in living cancer cells. This paradigm by modulation of the polymethine π-electron system in the Cyanine dye provides a promising methodology for the design of ratiometric Cyanine-based sensors.
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a near infrared fluorescent sensor for detection of cyanide in aqueous solution and its application for bioimaging
Chemical Communications, 2010Co-Authors: Nari Song, Yongsuk Jeong, Sungsu Park, Injae Shin, Xiaoqiang Chen, Juyoung YoonAbstract:A new NIR fluorescent sensor based on an amine-substituted heptamethine Cyanine dye displayed a highly selective fluorescence enhancement with cyanide in aqueous solutions, and was applied for the imaging of anthropogenic and biogenic cyanide.
Angelica Maria Baenamoncada - One of the best experts on this subject based on the ideXlab platform.
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development of a new electrochemical sensor based on silver sulfide nanoparticles and hierarchical porous carbon modified carbon paste electrode for determination of cyanide in river water samples
Sensors and Actuators B-chemical, 2019Co-Authors: Andy Cardenas Riojas, Ademar Wong, Gabriel A Planes, Maria Del Pilar Taboada Sotomayor, Adolfo La Rosatoro, Angelica Maria BaenamoncadaAbstract:Abstract In this study, a new electrochemical sensor for determination of cyanide is proposed. The sensor is formed by a carbon paste electrode modified with hierarchical porous carbon and silver sulfide nanoparticles. The morphology characterization was performed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM), while the chemical and electrochemistry characterization were performed by energy dispersive X-ray spectroscopy and cyclic voltammetry, respectively. Under the optimized conditions, the Ag2SNPs-HPC300 sensor presented a large concentration linear range of 5.9 × 10−7 to 1.1 × 10-3 mol L-1, and limit of detection of 7.0 × 10-8 mol L-1 using square-wave adsorptive anodic stripping voltammetry (SWAdASV) technique. The analytical response of the Ag2SNPs-HPC300 sensor was evaluated in presence of different compounds, and the results showed a RSD of 4.3% in triplicate experiments. The applicability of the Ag2SNPs-HPC300 sensor in river water samples contaminated with Cyanine showed recoveries values near 100%. The developed method exhibited high sensitivity and selectivity, good reproducibility, repeatability and low-cost, demonstrating to be a very promising analytical alternative for determination of cyanide in this matrix.
Xiaoqiang Chen - One of the best experts on this subject based on the ideXlab platform.
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a near infrared fluorescent sensor for detection of cyanide in aqueous solution and its application for bioimaging
Chemical Communications, 2010Co-Authors: Nari Song, Yongsuk Jeong, Sungsu Park, Injae Shin, Xiaoqiang Chen, Juyoung YoonAbstract:A new NIR fluorescent sensor based on an amine-substituted heptamethine Cyanine dye displayed a highly selective fluorescence enhancement with cyanide in aqueous solutions, and was applied for the imaging of anthropogenic and biogenic cyanide.
S M Yarmoluk - One of the best experts on this subject based on the ideXlab platform.
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specific fluorescent detection of fibrillar α synuclein using mono and trimethine Cyanine dyes
Bioorganic & Medicinal Chemistry, 2008Co-Authors: Kateryna D Volkova, V B Kovalska, A O Balanda, Yu M Losytskyy, Andriy G Golub, R J Vermeij, Vinod Subramaniam, O I Tolmachev, S M YarmolukAbstract:With the aim of searching of novel amyloid-specific fluorescent probes the ability of series of mono- and trimethine Cyanines based on benzothiazole, pyridine and quinoline heterocycle end groups to recognize fibrillar formations of α-synuclein (ASN) was studied. For the first time it was revealed that monomethine Cyanines can specifically increase their fluorescence in aggregated ASN presence. Dialkylamino-substituted monomethine Cyanine T-284 and meso-ethyl-substituted trimethine Cyanine SH-516 demonstrated the higher emission intensity and selectivity to aggregated ASN than classic amyloid stain Thioflavin T, and could be proposed as novel efficient fluorescent probes for fibrillar ASN detection. Studies of structure–function dependences have shown that incorporation of amino- or diethylamino- substituents into the 6-position of the benzothiazole heterocycle yields in a appearance of a selective fluorescent response to fibrillar α-synuclein presence. Performed calculations of molecular dimensions of studied Cyanine dyes gave us the possibility to presume, that dyes bind with their long axes parallel to the fibril axis via insertion into the neat rows (so called ‘channels’) running along fibril.
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interaction of Cyanine dyes with nucleic acids part 19 new method for the covalent labeling of oligonucleotides with pyrylium Cyanine dyes
Bioorganic & Medicinal Chemistry Letters, 2000Co-Authors: S M Yarmoluk, Alexander M Kostenko, Igor DubeyAbstract:New chemistry for the fluorescent labeling of oligonucleotides with Cyanine dyes is proposed. It is based on the use of pyrylium salts as amine-specific reagents. Monomethyne pyrylium Cyanine dye 1 was covalently linked to 5'-aminoalkyl modified oligonucleotide, with simultaneous conversion of the non-fluorescent dye 1 into fluorescent pyridinium Cyanine structure 2.
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interaction of Cyanine dyes with nucleic acids 4 efficient 5 fluorescent labelling of oligonucleotides with monomethyne pyrylium Cyanine dye cyan 39
Biopolymers & Cell, 1998Co-Authors: S M Yarmoluk, Alexander M Kostenko, Olga S Kornushyna, Igor DubeyAbstract:A new system for fluorescent 5'-end labelling of oligonucleoti des with Cyanine dyes is proposed. Reaction of primary amine with pyrylium salt was used for the efficient conjugation of monomethyne pyrylium Cyanine dye with 5'-aminoalkyl oligonucleotide with simultaneous conversion of the «brightless» pyrylium dye Cyan 39 into «bright» pyridinium one Cyan 40.
Andy Cardenas Riojas - One of the best experts on this subject based on the ideXlab platform.
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development of a new electrochemical sensor based on silver sulfide nanoparticles and hierarchical porous carbon modified carbon paste electrode for determination of cyanide in river water samples
Sensors and Actuators B-chemical, 2019Co-Authors: Andy Cardenas Riojas, Ademar Wong, Gabriel A Planes, Maria Del Pilar Taboada Sotomayor, Adolfo La Rosatoro, Angelica Maria BaenamoncadaAbstract:Abstract In this study, a new electrochemical sensor for determination of cyanide is proposed. The sensor is formed by a carbon paste electrode modified with hierarchical porous carbon and silver sulfide nanoparticles. The morphology characterization was performed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM), while the chemical and electrochemistry characterization were performed by energy dispersive X-ray spectroscopy and cyclic voltammetry, respectively. Under the optimized conditions, the Ag2SNPs-HPC300 sensor presented a large concentration linear range of 5.9 × 10−7 to 1.1 × 10-3 mol L-1, and limit of detection of 7.0 × 10-8 mol L-1 using square-wave adsorptive anodic stripping voltammetry (SWAdASV) technique. The analytical response of the Ag2SNPs-HPC300 sensor was evaluated in presence of different compounds, and the results showed a RSD of 4.3% in triplicate experiments. The applicability of the Ag2SNPs-HPC300 sensor in river water samples contaminated with Cyanine showed recoveries values near 100%. The developed method exhibited high sensitivity and selectivity, good reproducibility, repeatability and low-cost, demonstrating to be a very promising analytical alternative for determination of cyanide in this matrix.
