The Experts below are selected from a list of 6549 Experts worldwide ranked by ideXlab platform
Yonggui Zhou - One of the best experts on this subject based on the ideXlab platform.
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c h oxidation michael addition cyclization cascade for enantioselective synthesis of functionalized 2 amino 4h chromenes
ChemInform, 2016Co-Authors: Xiang Gao, Zhong Yan, Muwang Chen, Yonggui ZhouAbstract:A streamlined method for the enantioselective synthesis of 2-amino-4H-chromenes from readily available 2-alkyl-substituted phenols and active methylene compounds bearing a Cyano Group with up to 97% ee is presented. This reaction is a cascade procedure including manganese dioxide mediated C-H oxidation for the generation of o-quinone methides and bifunctional squaramide-catalyzed Michael addition/cyclization.
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enantioselective synthesis of functionalized 2 amino 4h chromenes via the o quinone methides generated from 2 1 tosylalkyl phenols
Tetrahedron Letters, 2015Co-Authors: Xiang Gao, Zhong Yan, Wenxue Huang, Yonggui ZhouAbstract:An efficient bifunctional squaramide-catalyzed Michael addition/cyclization reaction of o-quinone methides generated in situ from 2-(1-tosylalkyl)phenols with active methylene compounds bearing a Cyano Group has been realized to synthesize chiral 2-amino-4H-chromenes with excellent enantioselectivities and broad substrate scope. (c) 2015 Elsevier Ltd. All rights reserved.
Tahsien Chuang - One of the best experts on this subject based on the ideXlab platform.
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one pot oxidative coupling decyanation of 6 7 diphenylindolizine 5 carbonitriles and 2 3 diphenylquinolizine 4 carbonitriles
Journal of Organic Chemistry, 2019Co-Authors: Yihsuan Chen, Rongshiow Tang, Liyuan Chen, Tahsien ChuangAbstract:The one-pot oxidative coupling/decyanation reactions of 6,7-diphenylindolizine-5-carbonitriles and 2,3-diphenylquinolizine-4-carbonitriles were investigated using aryl-aryl oxidative coupling reagents. The phenanthroindolizidinones and phenanthroquinolizidinones were produced in 52-89% yields under VOF3/trifluoroacetic acid or [bis(trifluoroacetoxy)iodo]benzene/BF3-mediated conditions. This represents a mild and efficient approach to construct these types of pentacyclic skeletons from the corresponding Cyano Group-activated aza-Diels-Alder cycloadducts. A plausible mechanism of the one-pot oxidative coupling/decyanation reaction was proposed.
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One-Pot Oxidative Coupling/Decyanation of 6,7-Diphenylindolizine-5-carbonitriles and 2,3-Diphenylquinolizine-4-carbonitriles
2019Co-Authors: Yihsuan Chen, Rongshiow Tang, Liyuan Chen, Tahsien ChuangAbstract:The one-pot oxidative coupling/decyanation reactions of 6,7-diphenylindolizine-5-carbonitriles and 2,3-diphenylquinolizine-4-carbonitriles were investigated using aryl–aryl oxidative coupling reagents. The phenanthroindolizidinones and phenanthroquinolizidinones were produced in 52–89% yields under VOF3/trifluoroacetic acid or [bis(trifluoroacetoxy)iodo]benzene/BF3-mediated conditions. This represents a mild and efficient approach to construct these types of pentacyclic skeletons from the corresponding Cyano Group-activated aza-Diels–Alder cycloadducts. A plausible mechanism of the one-pot oxidative coupling/decyanation reaction was proposed
Pilar Garcia Mendoza - One of the best experts on this subject based on the ideXlab platform.
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Application of the Hofmann rearrangement in the synthesis of 3-amino sugar derivatives: preparation of some 3-tert-butoxycarbonylamino-3-Cyano-3-deoxy and 3-acetamido-methyl-3-tert-butoxycarbonylamino-3-deoxy sugars
Carbohydrate Research, 1991Co-Authors: Francisco Santoyo González, Antonio Vargas Berenguel, Fernando Hernández Mateo, Pilar Garcia MendozaAbstract:Abstract The cyclisation of dialdehydes, obtained from sugars, with Cyanoacetamide and subsequent Hofmann rearrangement is a convenient and short approach to the synthesis of 3-amino sugar derivatives branched at C-3. Thus, derivatives of 3-carbamoyl-3-Cyano-3-deoxy sugars 1–4 were transformed into N-protected 3-amino-3-Cyano-3-deoxy sugars 5–8 by Hofmann rearrangement (lead tetra-acetate-N,N-dimethylformamide-tert-butyl alcohol). Reduction of the Cyano Group in these compounds (NaBH4-CoCl2) gave, after acetylation, the corresponding 1,2-diamino derivatives 13–16.
Yuanhong Liu - One of the best experts on this subject based on the ideXlab platform.
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copper catalyzed borylative cyclization of in situ generated o allenylaryl nitriles with bis pinacolato diboron
Organic Letters, 2017Co-Authors: Meijun Xiong, Xin Xie, Yuanhong LiuAbstract:A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with B2pin2 has been developed, which provides highly substituted 3-boryl-1-naphthylamines with excellent regioselectivity and wide functional Group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a Cyano Group from a normal nitrile to furnish a carbocycle.
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Copper-Catalyzed Borylative Cyclization of in Situ Generated o‑Allenylaryl Nitriles with Bis(pinacolato)diboron
2017Co-Authors: Meijun Xiong, Xin Xie, Yuanhong LiuAbstract:A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with B2pin2 has been developed, which provides highly substituted 3-boryl-1-naphthylamines with excellent regioselectivity and wide functional Group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a Cyano Group from a normal nitrile to furnish a carbocycle
Kazunori Kataoka - One of the best experts on this subject based on the ideXlab platform.
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primary amino terminal heterobifunctional poly ethylene oxide facile synthesis of poly ethylene oxide with a primary amino Group at one end and a hydroxyl Group at the other end
Bioconjugate Chemistry, 1995Co-Authors: Yukio Nagasaki, Michihiro Iijima, Masao Kato, Kazunori KataokaAbstract:Well-defined poly(ethylene oxide) (PEO) with a Cyano Group at one end and a hydroxyl Group at the other terminus was synthesized by the anionic ring opening polymerization of ethylene oxide (EO) initiated with (Cyanomethyl)potassium (CMP) which was prepared by the metalation reaction of acetonitrile with potassium naphthalene in THF. Primary amino-terminal heterotelechelic PEO was obtained by the reduction of the Cyano Group at the end of the polymer chain by lithium aluminum hydride.
