The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Heung Bae Jeon - One of the best experts on this subject based on the ideXlab platform.
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selective oxidation of sulfides to sulfoxides with Cyanuric Chloride and urea hydrogen peroxide adduct
ChemInform, 2014Co-Authors: Heung Bae JeonAbstract:Urea-hydrogen peroxide adduct is a more reactive oxidant for the selective oxidation of sulfides to sulfoxides than H2O2 when utilized with Cyanuric Chloride as an activator.
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Selective Oxidation of Sulfides to Sulfoxides with Cyanuric Chloride and Urea—Hydrogen Peroxide Adduct.
ChemInform, 2014Co-Authors: Heung Bae Jeon, Kyoung Tae Kim, Sang Hyun KimAbstract:Urea-hydrogen peroxide adduct is a more reactive oxidant for the selective oxidation of sulfides to sulfoxides than H2O2 when utilized with Cyanuric Chloride as an activator.
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selective oxidation of sulfides to sulfoxides with Cyanuric Chloride and urea hydrogen peroxide adduct
Tetrahedron Letters, 2014Co-Authors: Heung Bae JeonAbstract:Abstract Although a number of methods have been developed for the selective oxidation of sulfides to sulfoxides, the need remains for alternative efficient, reliable strategies that can be generally applied to various sulfides and that use readily available reagents under mild reaction conditions. Herein, we report the use of urea–hydrogen peroxide adduct (UHP) and Cyanuric Chloride in CH3CN at room temperature to convert sulfides to sulfoxides in excellent yields. In particular, this protocol produced sulfoxides with aromatic rings bearing electron-withdrawing groups in excellent yields.
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Selective oxidation of sulfides to sulfoxides with Cyanuric Chloride and urea–hydrogen peroxide adduct
Tetrahedron Letters, 2014Co-Authors: Heung Bae Jeon, Kyoung Tae Kim, Sang Hyun KimAbstract:Abstract Although a number of methods have been developed for the selective oxidation of sulfides to sulfoxides, the need remains for alternative efficient, reliable strategies that can be generally applied to various sulfides and that use readily available reagents under mild reaction conditions. Herein, we report the use of urea–hydrogen peroxide adduct (UHP) and Cyanuric Chloride in CH3CN at room temperature to convert sulfides to sulfoxides in excellent yields. In particular, this protocol produced sulfoxides with aromatic rings bearing electron-withdrawing groups in excellent yields.
C. M. Brennan - One of the best experts on this subject based on the ideXlab platform.
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mechanism of a solid liquid interfacial reaction the reaction of an aqueous solution of an aromatic amine with Cyanuric Chloride
The Journal of Physical Chemistry, 1993Co-Authors: Richard G. Compton, M. S. Harding, J. H. Atherton, C. M. BrennanAbstract:The reaction between solid Cyanuric Chloride and an aromatic amine, N,N-dimethyl-p-phenylendiamine (DMPA) in aqueous solution is studied using the channel flow cell method in which a constant geometric area of solid is exposed to solution. It is shown that reaction occurs via the dissolution of the solid (with a constant flux of material being released into solution) followed by homogeneous coupling to the amine in parallel with hydrolysis of Cyanuric Chloride. Kinetic parameters for the process are reported and the value of the approach used for the determination of mechanisms for interfacial processes at insulator solid/liquid interfaces noted
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Mechanism of a solid/liquid interfacial reaction: the reaction of an aqueous solution of an aromatic amine with Cyanuric Chloride
The Journal of Physical Chemistry, 1993Co-Authors: Richard G. Compton, M. S. Harding, J. H. Atherton, C. M. BrennanAbstract:The reaction between solid Cyanuric Chloride and an aromatic amine, N,N-dimethyl-p-phenylendiamine (DMPA) in aqueous solution is studied using the channel flow cell method in which a constant geometric area of solid is exposed to solution. It is shown that reaction occurs via the dissolution of the solid (with a constant flux of material being released into solution) followed by homogeneous coupling to the amine in parallel with hydrolysis of Cyanuric Chloride. Kinetic parameters for the process are reported and the value of the approach used for the determination of mechanisms for interfacial processes at insulator solid/liquid interfaces noted
Sang Hyun Kim - One of the best experts on this subject based on the ideXlab platform.
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Selective Oxidation of Sulfides to Sulfoxides with Cyanuric Chloride and Urea—Hydrogen Peroxide Adduct.
ChemInform, 2014Co-Authors: Heung Bae Jeon, Kyoung Tae Kim, Sang Hyun KimAbstract:Urea-hydrogen peroxide adduct is a more reactive oxidant for the selective oxidation of sulfides to sulfoxides than H2O2 when utilized with Cyanuric Chloride as an activator.
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Selective oxidation of sulfides to sulfoxides with Cyanuric Chloride and urea–hydrogen peroxide adduct
Tetrahedron Letters, 2014Co-Authors: Heung Bae Jeon, Kyoung Tae Kim, Sang Hyun KimAbstract:Abstract Although a number of methods have been developed for the selective oxidation of sulfides to sulfoxides, the need remains for alternative efficient, reliable strategies that can be generally applied to various sulfides and that use readily available reagents under mild reaction conditions. Herein, we report the use of urea–hydrogen peroxide adduct (UHP) and Cyanuric Chloride in CH3CN at room temperature to convert sulfides to sulfoxides in excellent yields. In particular, this protocol produced sulfoxides with aromatic rings bearing electron-withdrawing groups in excellent yields.
Prem M S Chauhan - One of the best experts on this subject based on the ideXlab platform.
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Cyanuric Chloride Catalyzed Mild Protocol for Synthesis of Biologically Active Dihydro/Spiro Quinazolinones and Quinazolinone-glycoconjugates
2016Co-Authors: Moni Sharma, Kuldeep Chauhan, Deepty Sharma, Brijesh Kumar, Shashi Pandey, Prem M S ChauhanAbstract:We have developed an efficient Cyanuric Chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a–3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8–20 min) with 10 mol % Cyanuric Chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones
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synthesis of biologically active pyridoimidazole imidazobenzothiazole annulated polyheterocycles using Cyanuric Chloride in water
RSC Advances, 2014Co-Authors: Anand Kumar Pandey, Brijesh Kumar, Rashmi Sharma, Awantika Singh, Sanjeev K. Shukla, Kumkum Srivastava, Sunil Kumar Puri, Prem M S ChauhanAbstract:An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet–Spengler type 6-endo cyclization using Cyanuric Chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a–o), ketones (10a–e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a–c) using Cyanuric Chloride (15–20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80–90 °C to give a good to excellent yield (66–92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum.
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Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using Cyanuric Chloride in water
RSC Adv., 2014Co-Authors: Anand Kumar Pandey, Brijesh Kumar, Rashmi Sharma, Awantika Singh, Sanjeev K. Shukla, Kumkum Srivastava, Sunil Kumar Puri, Prem M S ChauhanAbstract:An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet–Spengler type 6-endo cyclization using Cyanuric Chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a–o), ketones (10a–e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a–c) using Cyanuric Chloride (15–20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80–90 °C to give a good to excellent yield (66–92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum.
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Cyanuric Chloride catalyzed mild protocol for synthesis of biologically active dihydro spiro quinazolinones and quinazolinone glycoconjugates
Journal of Organic Chemistry, 2012Co-Authors: Moni Sharma, S B Pandey, Kuldeep Chauhan, Deepty Sharma, Brijesh Kumar, Prem M S ChauhanAbstract:We have developed an efficient Cyanuric Chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a–3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8–20 min) with 10 mol % Cyanuric Chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.
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Cyanuric Chloride Catalyzed Mild Protocol for Synthesis of Biologically Active Dihydro/Spiro Quinazolinones and Quinazolinone-glycoconjugates
The Journal of organic chemistry, 2012Co-Authors: Moni Sharma, S B Pandey, Kuldeep Chauhan, Deepty Sharma, Brijesh Kumar, Prem M S ChauhanAbstract:We have developed an efficient Cyanuric Chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a–3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8–20 min) with 10 mol % Cyanuric Chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.
Richard G. Compton - One of the best experts on this subject based on the ideXlab platform.
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mechanism of a solid liquid interfacial reaction the reaction of an aqueous solution of an aromatic amine with Cyanuric Chloride
The Journal of Physical Chemistry, 1993Co-Authors: Richard G. Compton, M. S. Harding, J. H. Atherton, C. M. BrennanAbstract:The reaction between solid Cyanuric Chloride and an aromatic amine, N,N-dimethyl-p-phenylendiamine (DMPA) in aqueous solution is studied using the channel flow cell method in which a constant geometric area of solid is exposed to solution. It is shown that reaction occurs via the dissolution of the solid (with a constant flux of material being released into solution) followed by homogeneous coupling to the amine in parallel with hydrolysis of Cyanuric Chloride. Kinetic parameters for the process are reported and the value of the approach used for the determination of mechanisms for interfacial processes at insulator solid/liquid interfaces noted
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Evidence for anisotropy in chlorine/nitrogen interactions in the Cyanuric Chloride crystal structure
Tetrahedron Letters, 1993Co-Authors: S. J. Maginn, Richard G. Compton, Mark S. Harding, Colin Brennan, Robert DochertyAbstract:Abstract The non-linearity of some of the chlorine/nitrogen intermolecular interactions upon which the known crystal structure of Cyanuric Chloride depends is evidence for the inadequacy of current isotropic models of interatomic potentials used for crystal packing predictions.
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Mechanism of a solid/liquid interfacial reaction: the reaction of an aqueous solution of an aromatic amine with Cyanuric Chloride
The Journal of Physical Chemistry, 1993Co-Authors: Richard G. Compton, M. S. Harding, J. H. Atherton, C. M. BrennanAbstract:The reaction between solid Cyanuric Chloride and an aromatic amine, N,N-dimethyl-p-phenylendiamine (DMPA) in aqueous solution is studied using the channel flow cell method in which a constant geometric area of solid is exposed to solution. It is shown that reaction occurs via the dissolution of the solid (with a constant flux of material being released into solution) followed by homogeneous coupling to the amine in parallel with hydrolysis of Cyanuric Chloride. Kinetic parameters for the process are reported and the value of the approach used for the determination of mechanisms for interfacial processes at insulator solid/liquid interfaces noted
