The Experts below are selected from a list of 47877 Experts worldwide ranked by ideXlab platform
Messoud Ashina - One of the best experts on this subject based on the ideXlab platform.
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo ( P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3–11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4–11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation. * Abbreviations : AUC : area under the curve CGRP : calcitonin gene-related peptide PACAP : pituitary adenylate cyclase-activating peptide PDE : phosphodiesterase
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo (P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3-11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4-11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation.
Song Guo - One of the best experts on this subject based on the ideXlab platform.
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo ( P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3–11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4–11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation. * Abbreviations : AUC : area under the curve CGRP : calcitonin gene-related peptide PACAP : pituitary adenylate cyclase-activating peptide PDE : phosphodiesterase
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo (P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3-11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4-11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation.
Jes Olesen - One of the best experts on this subject based on the ideXlab platform.
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo ( P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3–11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4–11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation. * Abbreviations : AUC : area under the curve CGRP : calcitonin gene-related peptide PACAP : pituitary adenylate cyclase-activating peptide PDE : phosphodiesterase
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phosphodiesterase 3 inhibitor cilostazol induces migraine like attacks via Cyclic AMP increase
Brain, 2014Co-Authors: Song Guo, Jes Olesen, Messoud AshinaAbstract:The initiating mechanisms of migraine attacks are very complex but may involve the Cyclic AMP signalling pathway. It is unknown whether intracellular Cyclic AMP accumulation induces migraine attacks. We investigated whether administration of cilostazol, which causes Cyclic AMP accumulation, may induce migraine attacks. We included 14 migraine patients without aura in a double-blind, placebo-controlled crossover study. All participants received oral cilostazol or placebo on two separate days. We recorded migraine headache characteristics, associated symptoms and time of rescue medication intake using a questionnaire. Cilostazol induced delayed migraine-like attacks in 12 patients (86%) compared with two (14%) patients after placebo (P = 0.002). The median time to onset for migraine-like attacks was 6 h (range 3-11 h). Patients reported that the attacks mimicked their usual migraine attacks and that cilostazol-induced attacks responded to their usual migraine treatment. Median time of medication intake was 6 h (range 4-11 h). The present study suggests that intracellular Cyclic AMP accumulation plays a crucial role in migraine induction. This knowledge is a further step in our understanding of the intracellular pathway of migraine initiation.
L T Young - One of the best experts on this subject based on the ideXlab platform.
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Cyclic AMP responsive element binding protein phosphorylation and dna binding is decreased by chronic lithium but not valproate treatment of sh sy5y neuroblastoma cells
Neuroscience, 1999Co-Authors: J F Wang, V Asghari, C Rockel, L T YoungAbstract:Mood stabilizing drugs decrease central nervous system Cyclic AMP signaling. We report here that chronic, but not acute treatment with lithium chloride in human neuroblastoma SH-SY5Y cells, inhibits phosphorylation of Cyclic AMP responsive element binding protein and Cyclic AMP responsive element DNA binding induced by the adenylyl cyclase activator forskolin, but has no effect on constitutive expression of Cyclic AMP responsive element binding protein. These results are consistent with an effect of lithium to blunt the Cyclic AMP signal transduction pathway. Such an effect is not shared by the other commonly prescribed mood stabilizer, sodium valproate. Our results suggest that Cyclic AMP responsive element binding protein regulated gene expression may be relevant to the long-term prophylactic effect of lithium. Furthermore, sodium valproate, which is also effective in bipolar disorder, would appear to act on other pathways to bring about its therapeutic effects.
Masao Endoh - One of the best experts on this subject based on the ideXlab platform.
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Cyclic AMP metabolism in intact rat ventricular cardiac myocytes interaction of carbachol with isoproterenol and 3 isobutyl 1 methylxanthine
Molecular and Cellular Biochemistry, 1993Co-Authors: Yumi Katano, Masao EndohAbstract:Experiments were carried out to elucidate the characteristics of regulation of Cyclic AMP levels in intact myocardial cells. For this purpose, the influence of isoproterenol, a nonselective Cyclic nucleotide phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (IBMX) and carbachol on Cyclic AMP levels was investigated in isolated rat cardiac myocytes. The extent of Cyclic AMP accumulation induced by isoproterenol was much less than that produced by IBMX: submaximal concentrations of isoproterenol and IBMX elevated the Cyclic AMP level 2.4- and 4.8-fold of the control level, respectively. Both agents in combination increased the Cyclic AMP level markedly 48-fold. Carbachol inhibited the Cyclic AMP accumulation induced by isoproterenol, IBMX and their combination by 30%, 60% and 80% of the respective response. The extent of inhibition produced by carbachol of the Cyclic AMP accumulation induced by IBMX + isoproterenol was smaller than that caused by propranolol, and carbachol produced only a marginal additional inhibitory action to that of propranolol, implying that carbachol does not affect the process of Cyclic AMP degradation. The present findings indicate that in intact cardiac myocytes the rate of Cyclic AMP degradation catalyzed by PDE may be a crucial process of Cyclic AMP turnover. This view is supported by the observations that the inhibitory action of carbachol on the effect of isoproterenol was less than that on the effect of IBMX, and that the inhibitory action of carbachol was markedly enhanced by the simultaneous presence of IBMX.
