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Ingyu Choi - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of (-)-α-pinene and geraniol to α-terpineol and p-menthane-3,8-diol by the white rot fungus, Polyporus brumalis
Journal of Microbiology, 2015Co-Authors: Su-yeon Lee, Seonhong Kim, Changyoung Hong, Seyeong Park, Ingyu ChoiAbstract:In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol Compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the aCyclic monoterpenoids geraniol was transformed into the Cyclic Compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol Compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
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biotransformation of α pinene and geraniol to α terpineol and p menthane 3 8 diol by the white rot fungus polyporus brumalis
Journal of Microbiology, 2015Co-Authors: S Lee, Seonhong Kim, Changyoung Hong, Seyeong Park, Ingyu ChoiAbstract:In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol Compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the aCyclic monoterpenoids geraniol was transformed into the Cyclic Compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol Compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
Nina P. Gritsan - One of the best experts on this subject based on the ideXlab platform.
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photochemistry of tetrasulfur tetranitride laser flash photolysis and quantum chemical study
Inorganic Chemistry, 2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem.2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S3N3 Cyclic Compound carrying an exoCyclic (S)–N═S group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S3N3 cycle carrying an exoCyclic (N)–S≡N group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (∼0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The...
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Photochemistry of Tetrasulfur Tetranitride: Laser Flash Photolysis and Quantum Chemical Study
Inorganic chemistry, 2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem. 2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S(3)N(3) Cyclic Compound carrying an exoCyclic (S)-N═S group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S(3)N(3) cycle carrying an exoCyclic (N)-S≡N group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (~0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The mechanism of the photochromic process was established, and the rate constants of the elementary reactions were measured.
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Photochemistry of Tetrasulfur Tetranitride: Laser Flash Photolysis and Quantum Chemical Study
2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem. 2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S3N3 Cyclic Compound carrying an exoCyclic (S)–NS group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S3N3 cycle carrying an exoCyclic (N)–SN group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (∼0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The mechanism of the photochromic process was established, and the rate constants of the elementary reactions were measured
Elena A. Pritchina - One of the best experts on this subject based on the ideXlab platform.
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photochemistry of tetrasulfur tetranitride laser flash photolysis and quantum chemical study
Inorganic Chemistry, 2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem.2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S3N3 Cyclic Compound carrying an exoCyclic (S)–N═S group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S3N3 cycle carrying an exoCyclic (N)–S≡N group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (∼0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The...
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Photochemistry of Tetrasulfur Tetranitride: Laser Flash Photolysis and Quantum Chemical Study
Inorganic chemistry, 2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem. 2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S(3)N(3) Cyclic Compound carrying an exoCyclic (S)-N═S group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S(3)N(3) cycle carrying an exoCyclic (N)-S≡N group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (~0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The mechanism of the photochromic process was established, and the rate constants of the elementary reactions were measured.
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Photochemistry of Tetrasulfur Tetranitride: Laser Flash Photolysis and Quantum Chemical Study
2012Co-Authors: Elena A. Pritchina, Daria S Terpilovskaya, Yuri P Tsentalovich, Matthew S Platz, Nina P. GritsanAbstract:The photochemistry of tetrasulfur tetranitride (1) was studied in hexane solution by the laser flash photolysis technique (LFP). The experimental findings were interpreted using the results of previous matrix isolation studies (Pritchina, E.A.; Gritsan, N.P.; Bally, T.; Zibarev, A.V. Inorg. Chem. 2009, 48, 4075) and high-level quantum chemical calculations. LFP produces two primary intermediates, one of which is the boat-shaped 8-membered Cyclic Compound (2) and the other is the 6-membered S3N3 Cyclic Compound carrying an exoCyclic (S)–NS group (3). The primary products 2 and 3 absorb a second photon and undergo transformation to the 6-membered S3N3 cycle carrying an exoCyclic (N)–SN group (4), which is very unstable and converts back to intermediate 3. The quantum yield of the primary product formation is close to unity even though the quantum yield of photodegradation of 1 is low (∼0.01). Thus, 1 is a photochromic Compound undergoing in solution the thermally reversible photochemical isomerization. The mechanism of the photochromic process was established, and the rate constants of the elementary reactions were measured
Stephen M. Taylor - One of the best experts on this subject based on the ideXlab platform.
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A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats.
Kidney international, 2003Co-Authors: Thiruma V. Arumugam, Ian A. Shiels, Anna J. Strachan, Giovani Abbenante, David P. Fairlie, Stephen M. TaylorAbstract:A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Background C5a has been implicated in numerous pathophysiological conditions, including ischemia/reperfusion (I/R) injury of the kidney. We examined whether a novel and specific C5a receptor antagonist, the Cyclic Compound AcF-[OPdChaWR] could moderate I/R-induced renal injury in rats. Methods Female Wistar rats were subjected to renal ischemia (60 min) and reperfusion (5 h). Rats were treated with either 1 mg/kg IV in 5% ethanol/saline or 10 mg/kg PO in 25% ethanol/saline prior to ischemia. I/R injury was characterized by significant tissue hemorrhage with increased microvascular permeability, elevated renal tissue levels of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO), increased serum levels of creatinine and aspartate aminotransferase (AST) and hematuria. Results Pre-ischemic treatment with the C5a receptor (C5aR) antagonist (1 mg/kg IV or 10 mg/kg PO) substantially inhibited or prevented I/R-induced hematuria, vascular leakage, tissue levels of TNF-α and MPO, and serum levels of AST and creatinine. Histological examination of kidneys from antagonist pretreated I/R animals showed a marked reduction in tissue damage compared to drug-free I/R rats. This antagonist, however, did not inhibit complement-mediated lysis of red blood cells, suggesting unimpaired formation of the membrane attack complex (MAC). Conclusions The results demonstrate for the first time that a selective antagonist of both human and rat C5a receptors, given either intravenously or orally, significantly protects the kidney from I/R injury in the rat. We conclude that C5a is an important pathogenic agent in renal I/R injury, and that C5a receptor antagonists may be useful therapeutic agents for the pretreatment of anticipated renal reperfusion injury in humans.
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a small molecule c5a receptor antagonist protects kidneys from ischemia reperfusion injury in rats
Kidney International, 2003Co-Authors: Thiruma V. Arumugam, Ian A. Shiels, Anna J. Strachan, Giovani Abbenante, David P. Fairlie, Stephen M. TaylorAbstract:A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Background C5a has been implicated in numerous pathophysiological conditions, including ischemia/reperfusion (I/R) injury of the kidney. We examined whether a novel and specific C5a receptor antagonist, the Cyclic Compound AcF-[OPdChaWR] could moderate I/R-induced renal injury in rats. Methods Female Wistar rats were subjected to renal ischemia (60 min) and reperfusion (5 h). Rats were treated with either 1 mg/kg IV in 5% ethanol/saline or 10 mg/kg PO in 25% ethanol/saline prior to ischemia. I/R injury was characterized by significant tissue hemorrhage with increased microvascular permeability, elevated renal tissue levels of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO), increased serum levels of creatinine and aspartate aminotransferase (AST) and hematuria. Results Pre-ischemic treatment with the C5a receptor (C5aR) antagonist (1 mg/kg IV or 10 mg/kg PO) substantially inhibited or prevented I/R-induced hematuria, vascular leakage, tissue levels of TNF-α and MPO, and serum levels of AST and creatinine. Histological examination of kidneys from antagonist pretreated I/R animals showed a marked reduction in tissue damage compared to drug-free I/R rats. This antagonist, however, did not inhibit complement-mediated lysis of red blood cells, suggesting unimpaired formation of the membrane attack complex (MAC). Conclusions The results demonstrate for the first time that a selective antagonist of both human and rat C5a receptors, given either intravenously or orally, significantly protects the kidney from I/R injury in the rat. We conclude that C5a is an important pathogenic agent in renal I/R injury, and that C5a receptor antagonists may be useful therapeutic agents for the pretreatment of anticipated renal reperfusion injury in humans.
Seyeong Park - One of the best experts on this subject based on the ideXlab platform.
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Biotransformation of (-)-α-pinene and geraniol to α-terpineol and p-menthane-3,8-diol by the white rot fungus, Polyporus brumalis
Journal of Microbiology, 2015Co-Authors: Su-yeon Lee, Seonhong Kim, Changyoung Hong, Seyeong Park, Ingyu ChoiAbstract:In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol Compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the aCyclic monoterpenoids geraniol was transformed into the Cyclic Compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol Compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
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biotransformation of α pinene and geraniol to α terpineol and p menthane 3 8 diol by the white rot fungus polyporus brumalis
Journal of Microbiology, 2015Co-Authors: S Lee, Seonhong Kim, Changyoung Hong, Seyeong Park, Ingyu ChoiAbstract:In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol Compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the aCyclic monoterpenoids geraniol was transformed into the Cyclic Compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol Compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
