The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Kuender D Yang - One of the best experts on this subject based on the ideXlab platform.
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Cyclosporin A therApy in A cAse with hyperimmunoglobulin e And nephrotic syndrome
Journal of Microbiology Immunology and Infection, 2005Co-Authors: Chinnam Bong, Shunchen Huang, Chihlu Wang, Pomai Liu, Hsinhsu Chen, Kuender D YangAbstract:We describe the beneficiAl effects of treAtment with Cyclosporin A in A 10-yeAr-old boy with hyperimmunoglobulin E And refrActory nephrotic syndrome. The pAtient wAs initiAlly resistAnt to steroid therApy with prednisolone Alone. AdditionAl therApy with Cyclosporin A wAs then prescribed, effectively reducing levels of serum immunoglobulin E And preventing flAre up of nephrotic syndrome.
Erol Dulger - One of the best experts on this subject based on the ideXlab platform.
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mAnAgement of severe Allergic conjunctivitis with topicAl Cyclosporin A 0 05 eyedrops
Cornea, 2007Co-Authors: Altan A Ozcan, Reha T Ersoz, Erol DulgerAbstract:PURPOSE To evAluAte the efficAcy of topicAl Cyclosporin A 0.05% in the mAnAgement of severe Allergic conjunctivitis. METHODS Seven pAtients with severe Allergic conjunctivitis who were not responding to topicAl steroids, AntihistAmines, And mAst cell stAbilizers were given topicAl Cyclosporin A 0.05%. All pAtients hAd An Active diseAse when they were included in the study. Signs And symptoms were recorded before And After treAtment. RESULTS Seven pAtients, 6 boys And 1 girl, 6-14 yeArs old, 6 with vernAl kerAtoconjunctivitis And 1 with Atopic kerAtoconjunctivitis, were enrolled in the study. TreAtment with topicAl Cyclosporin A 0.05% decreAsed the severity of symptoms And clinicAl signs significAntly After 6 months (P < 0.05, Wilcoxon signed rAnk test). In Addition, the need for steroids wAs reduced or even stopped. The pAtients experienced no side effects during the follow-up periods (meAn, 14.0 +/- 2.1 months; rAnge, 8-18 months). CONCLUSIONS TopicAl Cyclosporin A is An effective treAtment in the mAnAgement of severe Allergic conjunctivitis with A benefit As A steroid-spAring Agent.
Takao Saito - One of the best experts on this subject based on the ideXlab platform.
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nephrotic syndrome AssociAted with hypocomplementAemic urticAriAl vAsculitis syndrome successful treAtment with Cyclosporin A
Nephrology Dialysis Transplantation, 1999Co-Authors: Jun Soma, Hiroshi Sato, Sadayoshi Ito, Takao SaitoAbstract:Cyclosporin A; hypocomplementAemic FAmily history And pAst medicAl history were unre-urticAriAl vAsculitis syndrome; nephrotic syndrome; mArkAble, except for recurrent urticAriA. He did notsystemic lupus erythemAtosus; tubulointerstitiAl injury complAin of joint pAin, dry eyes, dry mouth or Abdom-inAl pAin.PhysicAl exAminAtion showed slight fAciAl oedemA.UrinAlysis showed 3+ protein And 1 red blood cell/
Martin Crompton - One of the best experts on this subject based on the ideXlab platform.
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on the involvement of A Cyclosporin A sensitive mitochondriAl pore in myocArdiAl reperfusion injury
Cardiovascular Research, 1993Co-Authors: Michael R Duchen, Orla Mcguinness, Leslie A Brown, Martin CromptonAbstract:MAmmAliAn cArdiomyocytes mAy withstAnd prolonged periods of ischAemiA, only to die on reperfusion. We review dAtA thAt implicAte mitochondriAl dysfunction As A bAsis for reperfusion induced cell injury, And present some new evidence thAt suggests thAt such A mechAnism operAtes in intAct cArdiomyocytes. The mitochondriAl dysfunction is the consequence of the opening of high conductAnce pores in the inner mitochondriAl membrAne, which uncouple mitochondriAl oxidAtive phosphorylAtion, promoting ATP hydrolysis. The conditions required to open the pores correlAte closely to conditions thAt prevAil upon reperfusion of the ischAemic heArt: A high [CA2+]i And Pi, low [ATP], And oxidAtive stress. Pore opening is suppressed by physiologicAl concentrAtions of ATP. Pore opening mAy be prevented by Cyclosporin A. Studies in isolAted myocytes show thAt mitochondriA become uncoupled After reoxygenAtion, And thAt this is AssociAted with the hypercontrActure thAt signAls cell deAth. Cyclosporin A reduces the proportion of hypercontrActed myocytes in populAtions of cells rendered Anoxic.
Chinnam Bong - One of the best experts on this subject based on the ideXlab platform.
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Cyclosporin A therApy in A cAse with hyperimmunoglobulin e And nephrotic syndrome
Journal of Microbiology Immunology and Infection, 2005Co-Authors: Chinnam Bong, Shunchen Huang, Chihlu Wang, Pomai Liu, Hsinhsu Chen, Kuender D YangAbstract:We describe the beneficiAl effects of treAtment with Cyclosporin A in A 10-yeAr-old boy with hyperimmunoglobulin E And refrActory nephrotic syndrome. The pAtient wAs initiAlly resistAnt to steroid therApy with prednisolone Alone. AdditionAl therApy with Cyclosporin A wAs then prescribed, effectively reducing levels of serum immunoglobulin E And preventing flAre up of nephrotic syndrome.
