The Experts below are selected from a list of 14370 Experts worldwide ranked by ideXlab platform
Martin Beer - One of the best experts on this subject based on the ideXlab platform.
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pathogenicity of highly pathogenic avian influenza virus h5n1 in adult mute swans
Emerging Infectious Diseases, 2008Co-Authors: Donata Kalthoff, Timm C Harder, Thomas C Mettenleiter, Jens Peter Teifke, Angele Breithaupt, Anja Globig, Martin BeerAbstract:Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus Cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus–specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.
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pathology of natural infections by h5n1 highly pathogenic avian influenza virus in mute Cygnus olor and whooper Cygnus Cygnus swans
Veterinary Pathology, 2007Co-Authors: Jens Peter Teifke, Thomas C Mettenleiter, Anja Globig, Martin Beer, Robert Klopfleisch, Elke Starick, Bernd Hoffmann, P U Wolf, Timm C HarderAbstract:Mortality in wild aquatic birds due to infection with highly pathogenic avian influenza viruses (HPAIV) is a rare event. During the recent outbreak of highly pathogenic avian influenza in Germany, mortality due to H5N1 HPAIV was observed among mute and whooper swans as part of a rapid spread of this virus. In contrast to earlier reports, swans appeared to be highly susceptible and represented the mainly affected species. We report gross and histopathology and distribution of influenza virus antigen in mute and whooper swans that died after natural infection with H5N1 HPAIV. At necropsy, the most reliable lesions were multifocal hemorrhagic necrosis in the pancreas, pulmonary congestion and edema, and subepicardial hemorrhages. Major histologic lesions were acute pancreatic necrosis, multifocal necrotizing hepatitis, and lymphoplasmacytic encephalitis with neuronal necrosis. Adrenals displayed consistently scattered cortical and medullary necrosis. In spleen and Peyer's patches, mild lymphocyte necrosis was present. Immunohistochemical demonstration of HPAIV nucleoprotein in pancreas, adrenals, liver, and brain was strongly consistent with histologic lesions. In the brain, a large number of neurons and glial cells, especially Purkinje cells, showed immunostaining. Occasionally, ependymal cells of the spinal cord were also positive. In the lungs, influenza virus antigen was identified in a few endothelial cells but not within pneumocytes. The infection of the central nervous system supports the view that the neurotropism of H5N1 HPAIV leads to nervous disturbances with loss of orientation. More investigations are necessary to clarify the mechanisms of the final circulatory failure, lung edema, and rapid death of the swans.
Donata Kalthoff - One of the best experts on this subject based on the ideXlab platform.
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pathogenicity of highly pathogenic avian influenza virus h5n1 in adult mute swans
Emerging Infectious Diseases, 2008Co-Authors: Donata Kalthoff, Timm C Harder, Thomas C Mettenleiter, Jens Peter Teifke, Angele Breithaupt, Anja Globig, Martin BeerAbstract:Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus Cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus–specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.
Timm C Harder - One of the best experts on this subject based on the ideXlab platform.
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pathogenicity of highly pathogenic avian influenza virus h5n1 in adult mute swans
Emerging Infectious Diseases, 2008Co-Authors: Donata Kalthoff, Timm C Harder, Thomas C Mettenleiter, Jens Peter Teifke, Angele Breithaupt, Anja Globig, Martin BeerAbstract:Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus Cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus–specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.
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pathology of natural infections by h5n1 highly pathogenic avian influenza virus in mute Cygnus olor and whooper Cygnus Cygnus swans
Veterinary Pathology, 2007Co-Authors: Jens Peter Teifke, Thomas C Mettenleiter, Anja Globig, Martin Beer, Robert Klopfleisch, Elke Starick, Bernd Hoffmann, P U Wolf, Timm C HarderAbstract:Mortality in wild aquatic birds due to infection with highly pathogenic avian influenza viruses (HPAIV) is a rare event. During the recent outbreak of highly pathogenic avian influenza in Germany, mortality due to H5N1 HPAIV was observed among mute and whooper swans as part of a rapid spread of this virus. In contrast to earlier reports, swans appeared to be highly susceptible and represented the mainly affected species. We report gross and histopathology and distribution of influenza virus antigen in mute and whooper swans that died after natural infection with H5N1 HPAIV. At necropsy, the most reliable lesions were multifocal hemorrhagic necrosis in the pancreas, pulmonary congestion and edema, and subepicardial hemorrhages. Major histologic lesions were acute pancreatic necrosis, multifocal necrotizing hepatitis, and lymphoplasmacytic encephalitis with neuronal necrosis. Adrenals displayed consistently scattered cortical and medullary necrosis. In spleen and Peyer's patches, mild lymphocyte necrosis was present. Immunohistochemical demonstration of HPAIV nucleoprotein in pancreas, adrenals, liver, and brain was strongly consistent with histologic lesions. In the brain, a large number of neurons and glial cells, especially Purkinje cells, showed immunostaining. Occasionally, ependymal cells of the spinal cord were also positive. In the lungs, influenza virus antigen was identified in a few endothelial cells but not within pneumocytes. The infection of the central nervous system supports the view that the neurotropism of H5N1 HPAIV leads to nervous disturbances with loss of orientation. More investigations are necessary to clarify the mechanisms of the final circulatory failure, lung edema, and rapid death of the swans.
Barres U De Almeida - One of the best experts on this subject based on the ideXlab platform.
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search for very high energy gamma ray emission from the microquasar Cygnus x 1 with the magic telescopes
Monthly Notices of the Royal Astronomical Society, 2017Co-Authors: M L Ahnen, S Ansoldi, L A Antonelli, C Arcaro, A Babic, B Banerjee, P Bangale, Barres U De AlmeidaAbstract:The microquasar Cygnus X-1 displays the two typical soft and hard X-ray states of a black hole transient. During the latter, Cygnus X-1 shows a one-sided relativistic radio-jet. Recent detection of the system in the high energy (HE; E greater than or similar to 60 MeV) gamma-ray range with FermiLAT associates this emission with the outflow. Former MAGIC observations revealed a hint of flaring activity in the very high-energy (VHE; E greater than or similar to 100 GeV) regime during this X-ray state. We analyse ~ to 97 h of Cygnus X-1 data taken with the MAGIC telescopes between July 2007 and October 2014. To shed light on the correlation between hard X-ray and VHE gamma rays as previously suggested, we study each main X-ray state separately. We perform an orbital phase-folded analysis to look for variability in the VHE band. Additionally, to place this variability behaviour in a multiwavelength context, we compare our results with Fermi-LAT, AGILE, Swift-BAT, MAXI, RXTE-ASM, AMI and RATAN-600 data. We do not detect Cygnus X-1 in the VHE regime. We establish upper limits for each X-ray state, assuming a power-law distribution with photon index Γ = 3.2. For steady emission in the hard and soft X-ray states, we set integral upper limits at 95 %per cent confidence level for energies above 200 GeV at 2.6 x 10⁻¹² photons cm⁻² s⁻¹ and 1.0 x 10⁻¹¹ photons cm⁻² s ⁻¹, respectively. We rule out steady VHE gamma-ray emission above this energy range, at the level of theMAGIC sensitivity, originating in the interaction between the relativistic jet and the surrounding medium, while the emission above this flux level produced inside the binary still remains a valid possibility.
Jeonghwa Shin - One of the best experts on this subject based on the ideXlab platform.
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identification of two novel reassortant avian influenza a h5n6 viruses in whooper swans in korea 2016
Virology Journal, 2017Co-Authors: Jipseol Jeong, Chanjin Woo, Youngsik Kim, Kwang Hee Lee, Kidong Son, Saemi Lee, Jaeku Oem, Seungjun Wang, Yongkwan Kim, Jeonghwa ShinAbstract:Background On November 20, 2016 two novel strains of H5N6 highly pathogenic avian influenza virus (HPAIVs) were isolated from three whooper swans (Cygnus Cygnus) at Gangjin Bay in South Jeolla province, South Korea. Identification of HPAIVs in wild birds is significant as there is a potential risk of transmission of these viruses to poultry and humans.
