The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
Douglas R. Green - One of the best experts on this subject based on the ideXlab platform.
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CytoChrome C: funCtions beyond respiration
Nature Reviews Molecular Cell Biology, 2008Co-Authors: Yong-ling P. Ow, Douglas R. GreenAbstract:CytoChrome C is one of the mitoChondrial proteins that is released into the Cytosol when the Cell is aCtivated by an apoptotiC stimulus. In the Cytosol, CytoChrome C engages the apoptotiC protease aCtivating faCtor-1 (APAF1), and forms the apoptosome, whiCh aCtivates Caspase-9. The release of CytoChrome C has been suggested to oCCur in two phases: mobilization from the mitoChondrial intermembrane spaCe and transloCation through the outer mitoChondrial membrane. The meChanisms of CytoChrome C release are Controversial. Whether the permeabilization of the outer or the inner membrane is responsible for the downstream events is one of the debated topiCs. Most evidenCe supports a model in whiCh the outer membrane is permeabilized without inner membrane events. The release of CytoChrome C and CytoChrome- C -mediated apoptosis are Controlled by multiple layers of regulation, with the most prominent players being members of the B-Cell lymphoma protein-2 (BCL2) family. CytoChrome C is primarily known for its funCtion in the mitoChondria as a key partiCipant in the life-supporting funCtion of ATP synthesis. Yet, CytoChrome C also has a prominent role in apoptotiC pathways and partiCipates in non-apoptotiC proCesses during development. CytoChrome C is primarily known for its funCtion in the mitoChondria as a key partiCipant in the life-supporting funCtion of ATP synthesis. However, when a Cell reCeives an apoptotiC stimulus, CytoChrome C is released into the Cytosol and triggers programmed Cell death through apoptosis. The release of CytoChrome C and CytoChrome- C -mediated apoptosis are Controlled by multiple layers of regulation, the most prominent players being members of the B-Cell lymphoma protein-2 (BCL2) family. As well as its role in CanoniCal intrinsiC apoptosis, CytoChrome C amplifies signals that are generated by other apoptotiC pathways and partiCipates in Certain non-apoptotiC funCtions.
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CytoChrome C funCtions beyond respiration
Nature Reviews Molecular Cell Biology, 2008Co-Authors: Douglas R. Green, Zhenyue Hao, Tak W MakAbstract:CytoChrome C is primarily known for its funCtion in the mitoChondria as a key partiCipant in the life-supporting funCtion of ATP synthesis. However, when a Cell reCeives an apoptotiC stimulus, CytoChrome C is released into the Cytosol and triggers programmed Cell death through apoptosis. The release of CytoChrome C and CytoChrome-C-mediated apoptosis are Controlled by multiple layers of regulation, the most prominent players being members of the B-Cell lymphoma protein-2 (BCL2) family. As well as its role in CanoniCal intrinsiC apoptosis, CytoChrome C amplifies signals that are generated by other apoptotiC pathways and partiCipates in Certain non-apoptotiC funCtions.
Katsumasa Fujita - One of the best experts on this subject based on the ideXlab platform.
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label free raman observation of CytoChrome C dynamiCs during apoptosis
Proceedings of the National Academy of Sciences of the United States of America, 2012Co-Authors: Masaya Okada, Nicholas I Smith, Almar F Palonpon, Hiromi Endo, Satoshi Kawata, Mikiko Sodeoka, Katsumasa FujitaAbstract:We performed label-free observation of moleCular dynamiCs in apoptotiC Cells by Raman miCrosCopy. DynamiC Changes in CytoChrome C distribution at the Raman band of 750 Cm-1 were observed after adding an apoptosis induCer to the Cells. The Comparison of mitoChondria fluoresCenCe images and Raman images of CytoChrome C Confirmed that Changes in CytoChrome C distribution Can be distinguished as release of CytoChrome C from mitoChondria. Our observation also revealed that the redox state of CytoChrome C was maintained during the release from the mitoChondria. Monitoring mitoChondrial membrane potential with JC-1 dye Confirmed that the observed CytoChrome C release was assoCiated with apoptosis.
Tak W Mak - One of the best experts on this subject based on the ideXlab platform.
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CytoChrome C funCtions beyond respiration
Nature Reviews Molecular Cell Biology, 2008Co-Authors: Douglas R. Green, Zhenyue Hao, Tak W MakAbstract:CytoChrome C is primarily known for its funCtion in the mitoChondria as a key partiCipant in the life-supporting funCtion of ATP synthesis. However, when a Cell reCeives an apoptotiC stimulus, CytoChrome C is released into the Cytosol and triggers programmed Cell death through apoptosis. The release of CytoChrome C and CytoChrome-C-mediated apoptosis are Controlled by multiple layers of regulation, the most prominent players being members of the B-Cell lymphoma protein-2 (BCL2) family. As well as its role in CanoniCal intrinsiC apoptosis, CytoChrome C amplifies signals that are generated by other apoptotiC pathways and partiCipates in Certain non-apoptotiC funCtions.
Masaya Okada - One of the best experts on this subject based on the ideXlab platform.
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label free raman observation of CytoChrome C dynamiCs during apoptosis
Proceedings of the National Academy of Sciences of the United States of America, 2012Co-Authors: Masaya Okada, Nicholas I Smith, Almar F Palonpon, Hiromi Endo, Satoshi Kawata, Mikiko Sodeoka, Katsumasa FujitaAbstract:We performed label-free observation of moleCular dynamiCs in apoptotiC Cells by Raman miCrosCopy. DynamiC Changes in CytoChrome C distribution at the Raman band of 750 Cm-1 were observed after adding an apoptosis induCer to the Cells. The Comparison of mitoChondria fluoresCenCe images and Raman images of CytoChrome C Confirmed that Changes in CytoChrome C distribution Can be distinguished as release of CytoChrome C from mitoChondria. Our observation also revealed that the redox state of CytoChrome C was maintained during the release from the mitoChondria. Monitoring mitoChondrial membrane potential with JC-1 dye Confirmed that the observed CytoChrome C release was assoCiated with apoptosis.
Satoshi Kawata - One of the best experts on this subject based on the ideXlab platform.
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label free raman observation of CytoChrome C dynamiCs during apoptosis
Proceedings of the National Academy of Sciences of the United States of America, 2012Co-Authors: Masaya Okada, Nicholas I Smith, Almar F Palonpon, Hiromi Endo, Satoshi Kawata, Mikiko Sodeoka, Katsumasa FujitaAbstract:We performed label-free observation of moleCular dynamiCs in apoptotiC Cells by Raman miCrosCopy. DynamiC Changes in CytoChrome C distribution at the Raman band of 750 Cm-1 were observed after adding an apoptosis induCer to the Cells. The Comparison of mitoChondria fluoresCenCe images and Raman images of CytoChrome C Confirmed that Changes in CytoChrome C distribution Can be distinguished as release of CytoChrome C from mitoChondria. Our observation also revealed that the redox state of CytoChrome C was maintained during the release from the mitoChondria. Monitoring mitoChondrial membrane potential with JC-1 dye Confirmed that the observed CytoChrome C release was assoCiated with apoptosis.
