The Experts below are selected from a list of 8808 Experts worldwide ranked by ideXlab platform
B J Miller - One of the best experts on this subject based on the ideXlab platform.
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A meta-analysis of blood Cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls ( P
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a meta analysis of blood Cytokine network alterations in psychiatric patients comparisons between schizophrenia bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls (P<0.01). Following treatment of the acute illness, IL-6 levels significantly decreased in both schizophrenia and MDD (P<0.01); sIL-2R levels increased in schizophrenia; and IL-1RA levels in bipolar mania decreased. In chronically ill patients, the levels of IL-6 were significantly increased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with controls (P<0.01). The levels of IL-1β and sIL-2R were significantly increased in both chronic schizophrenia and euthymic bipolar disorder. Overall, there were similarities in the pattern of Cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction. Effects of treatment on Cytokines were more robust for schizophrenia and MDD, but were more frequently studied than for acute mania. These findings have important implications for our understanding of the pathophysiology and treatment of major psychiatric disorders.
T. M. Fredeking - One of the best experts on this subject based on the ideXlab platform.
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Modulation of Cytokine and Cytokine Receptor/Antagonist by treatment with doxycycline and tetracycline in patients with dengue fever.
Clinical & developmental immunology, 2011Co-Authors: J. E. Z. Castro, I. Vado-solis, C. Perez-osorio, T. M. FredekingAbstract:Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various Cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and Cytokine Receptor/Receptor Antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum Cytokine and Cytokine Receptor/Antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and Cytokine Receptor/Antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in Cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating Cytokine and Cytokine Receptor/Antagonist levels than tetracycline.
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modulation of Cytokine and Cytokine Receptor Antagonist by treatment with doxycycline and tetracycline in patients with dengue fever
Clinical & Developmental Immunology, 2011Co-Authors: J. E. Z. Castro, I Vadosolis, C Perezosorio, T. M. FredekingAbstract:Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various Cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and Cytokine Receptor/Receptor Antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum Cytokine and Cytokine Receptor/Antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and Cytokine Receptor/Antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in Cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating Cytokine and Cytokine Receptor/Antagonist levels than tetracycline.
D R Goldsmith - One of the best experts on this subject based on the ideXlab platform.
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A meta-analysis of blood Cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls ( P
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a meta analysis of blood Cytokine network alterations in psychiatric patients comparisons between schizophrenia bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls (P<0.01). Following treatment of the acute illness, IL-6 levels significantly decreased in both schizophrenia and MDD (P<0.01); sIL-2R levels increased in schizophrenia; and IL-1RA levels in bipolar mania decreased. In chronically ill patients, the levels of IL-6 were significantly increased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with controls (P<0.01). The levels of IL-1β and sIL-2R were significantly increased in both chronic schizophrenia and euthymic bipolar disorder. Overall, there were similarities in the pattern of Cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction. Effects of treatment on Cytokines were more robust for schizophrenia and MDD, but were more frequently studied than for acute mania. These findings have important implications for our understanding of the pathophysiology and treatment of major psychiatric disorders.
J. E. Z. Castro - One of the best experts on this subject based on the ideXlab platform.
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Modulation of Cytokine and Cytokine Receptor/Antagonist by treatment with doxycycline and tetracycline in patients with dengue fever.
Clinical & developmental immunology, 2011Co-Authors: J. E. Z. Castro, I. Vado-solis, C. Perez-osorio, T. M. FredekingAbstract:Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various Cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and Cytokine Receptor/Receptor Antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum Cytokine and Cytokine Receptor/Antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and Cytokine Receptor/Antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in Cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating Cytokine and Cytokine Receptor/Antagonist levels than tetracycline.
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modulation of Cytokine and Cytokine Receptor Antagonist by treatment with doxycycline and tetracycline in patients with dengue fever
Clinical & Developmental Immunology, 2011Co-Authors: J. E. Z. Castro, I Vadosolis, C Perezosorio, T. M. FredekingAbstract:Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF). Disease severity has been linked to an increase in various Cytokine levels. In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and Cytokine Receptor/Receptor Antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy. Serum Cytokine and Cytokine Receptor/Antagonist levels were determined at the onset of therapy and after 3 and 7 days. Cytokine and Cytokine Receptor/Antagonist levels were substantially elevated at day 0. IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients. Treatment with tetracycline or doxycycline resulted in a significant decline in Cytokine levels. Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients. Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients. In contrast, treatment did not affect a similar result for TNF-R1. When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis. Further analysis demonstrated that doxycycline was significantly more effective at modulating Cytokine and Cytokine Receptor/Antagonist levels than tetracycline.
M H Rapaport - One of the best experts on this subject based on the ideXlab platform.
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A meta-analysis of blood Cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls ( P
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a meta analysis of blood Cytokine network alterations in psychiatric patients comparisons between schizophrenia bipolar disorder and depression
Molecular Psychiatry, 2016Co-Authors: D R Goldsmith, M H Rapaport, B J MillerAbstract:Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood Cytokine levels; however, neither the pattern of Cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood Cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two Cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble Cytokine Receptor (sIL-2R), and one Cytokine Receptor Antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls (P<0.01). Following treatment of the acute illness, IL-6 levels significantly decreased in both schizophrenia and MDD (P<0.01); sIL-2R levels increased in schizophrenia; and IL-1RA levels in bipolar mania decreased. In chronically ill patients, the levels of IL-6 were significantly increased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with controls (P<0.01). The levels of IL-1β and sIL-2R were significantly increased in both chronic schizophrenia and euthymic bipolar disorder. Overall, there were similarities in the pattern of Cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction. Effects of treatment on Cytokines were more robust for schizophrenia and MDD, but were more frequently studied than for acute mania. These findings have important implications for our understanding of the pathophysiology and treatment of major psychiatric disorders.
