The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Michaela Kress - One of the best experts on this subject based on the ideXlab platform.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Abstract Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as Cytokine effects involving further mediators. The final outcome of Cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1β, interleukin-6 and tumor necrosis factor-α, with regards to pain and hyperalgesia.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as Cytokine effects involving further mediators. The final outcome of Cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, with regards to pain and hyperalgesia.
Douglas L Mann - One of the best experts on this subject based on the ideXlab platform.
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natural variability of circulating levels of Cytokines and Cytokine receptors in patients with heart failure implications for clinical trials
Journal of the American College of Cardiology, 1999Co-Authors: Bill G White, Ziad Dibbs, Douglas L MannAbstract:OBJECTIVES: The purpose of this study was to examine the variability in Cytokines and Cytokine receptors in patients with heart failure in comparison with a group of healthy control subjects who were free of cardiovascular disease. BACKGROUND: Despite increasing interest in Cytokines as mediators of disease progression in heart failure and the recent interest in suppressing Cytokines in clinical studies, the extent of variability in Cytokines and Cytokine receptors is largely unknown. This information is important for interpreting the results of studies in which changes in Cytokine levels are measured in response to a specific form of therapy. METHODS: Circulating levels of tumor necrosis factor-alpha (TNF-alpha), and soluble TNF receptors (types 1 and 2), as well as interleukin (IL)-6 and IL-6 receptor were measured on a daily, weekly and monthly basis in heart failure patients (New York Heart Association class IIIa and IIIb; n = 10) and healthy volunteer subjects (n = 10). Measurements of Cytokines and Cytokine receptors were performed on plasma samples by enzyme-linked immunoassay. The daily, weekly and monthly degree of variability in Cytokine and Cytokine receptor levels was assessed by determining the coefficient of variation each point in time. RESULTS: The coefficient of variation for TNF-alpha and IL-6 levels increased over time in patients with heart failure; moreover, the coefficient of variation in heart failure subjects was significantly greater for IL-6 than for TNF-alpha. The coefficient of variation in Cytokine receptor levels was minimal, and did not differ significantly between heart failure and control subjects. CONCLUSIONS: In patients with heart failure the degree of natural variability in circulating Cytokine levels increases with time, and is greater for IL-6 than for TNF-alpha. Accordingly, the results of the present study suggest that the sample size needed to show a statistically significant change in the circulating level of a given Cytokine will vary depending on the specific Cytokine that is being measured, as well as the time period over which that Cytokine is being assayed.
Claudia Sommer - One of the best experts on this subject based on the ideXlab platform.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Abstract Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as Cytokine effects involving further mediators. The final outcome of Cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1β, interleukin-6 and tumor necrosis factor-α, with regards to pain and hyperalgesia.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as Cytokine effects involving further mediators. The final outcome of Cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha, with regards to pain and hyperalgesia.
Artika P Nath - One of the best experts on this subject based on the ideXlab platform.
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multivariate genome wide association analysis of a Cytokine network reveals variants with widespread immune haematological and cardiometabolic pleiotropy
American Journal of Human Genetics, 2019Co-Authors: Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard H F Tang, Qin Qin Huang, Shu Mei TeoAbstract:Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that Cytokines operate in concert, many of the physiological interactions between Cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pleiotropic effects on Cytokines. Using three population-based cohorts (n = 9,263), we performed multivariate genome-wide association studies (GWAS) for a correlation network of 11 circulating Cytokines, then combined our results in meta-analysis. We identified a total of eight loci significantly associated with the Cytokine network, of which two (PDGFRB and ABO) had not been detected previously. In addition, conditional analyses revealed a further four secondary signals at three known Cytokine loci. Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summary statistics with the Cytokine network associations revealed shared causal variants between the eight Cytokine loci and other traits; in particular, Cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins, on metabolic traits such as lipoprotein and lipid levels, on blood-cell-related traits such as platelet count, and on disease traits such as coronary artery disease and type 2 diabetes.
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multivariate genome wide association analysis of a Cytokine network reveals variants with widespread immune haematological and cardiometabolic pleiotropy
bioRxiv, 2019Co-Authors: Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard H F Tang, Qin Qin Huang, Shu Mei Teo, Ari V Aholaolli, Peter WurtzAbstract:Abstract Cytokines are essential regulatory components of the immune system and their aberrant levels have been linked to many disease states. Despite increasing evidence that Cytokines operate in concert, many of the physiological interactions between Cytokines, and the shared genetic architecture that underlie them, remain unknown. Here we aimed to identify and characterise genetic variants with pleiotropic effects on Cytokines – to do this we performed a multivariate genome-wide association study on a correlation network of 11 circulating Cytokines measured in 9,263 individuals. Meta-analysis identified a total of 8 loci significantly associated with the Cytokine network, of which two (PDGFRB and ABO) had not been detected previously. Bayesian colocalisation analysis revealed shared causal variants between the eight Cytokine loci and other traits; in particular, Cytokine network variants at the ABO, SERPINE2, and ZFPM2 loci showed pleiotropic effects on the production of immune-related proteins; on metabolic traits such as lipoprotein and lipid levels; on blood-cell related traits such as platelet count; and on disease traits such as coronary artery disease and type 2 diabetes.
Ziad Dibbs - One of the best experts on this subject based on the ideXlab platform.
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natural variability of circulating levels of Cytokines and Cytokine receptors in patients with heart failure implications for clinical trials
Journal of the American College of Cardiology, 1999Co-Authors: Bill G White, Ziad Dibbs, Douglas L MannAbstract:OBJECTIVES: The purpose of this study was to examine the variability in Cytokines and Cytokine receptors in patients with heart failure in comparison with a group of healthy control subjects who were free of cardiovascular disease. BACKGROUND: Despite increasing interest in Cytokines as mediators of disease progression in heart failure and the recent interest in suppressing Cytokines in clinical studies, the extent of variability in Cytokines and Cytokine receptors is largely unknown. This information is important for interpreting the results of studies in which changes in Cytokine levels are measured in response to a specific form of therapy. METHODS: Circulating levels of tumor necrosis factor-alpha (TNF-alpha), and soluble TNF receptors (types 1 and 2), as well as interleukin (IL)-6 and IL-6 receptor were measured on a daily, weekly and monthly basis in heart failure patients (New York Heart Association class IIIa and IIIb; n = 10) and healthy volunteer subjects (n = 10). Measurements of Cytokines and Cytokine receptors were performed on plasma samples by enzyme-linked immunoassay. The daily, weekly and monthly degree of variability in Cytokine and Cytokine receptor levels was assessed by determining the coefficient of variation each point in time. RESULTS: The coefficient of variation for TNF-alpha and IL-6 levels increased over time in patients with heart failure; moreover, the coefficient of variation in heart failure subjects was significantly greater for IL-6 than for TNF-alpha. The coefficient of variation in Cytokine receptor levels was minimal, and did not differ significantly between heart failure and control subjects. CONCLUSIONS: In patients with heart failure the degree of natural variability in circulating Cytokine levels increases with time, and is greater for IL-6 than for TNF-alpha. Accordingly, the results of the present study suggest that the sample size needed to show a statistically significant change in the circulating level of a given Cytokine will vary depending on the specific Cytokine that is being measured, as well as the time period over which that Cytokine is being assayed.
