The Experts below are selected from a list of 1346346 Experts worldwide ranked by ideXlab platform
Shigaku Ikeda - One of the best experts on this subject based on the ideXlab platform.
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Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections.
Journal of medical microbiology, 2020Co-Authors: Yumi Shiraki, Masataro Hiruma, Akemi Nishikawa, Yoshio Ishibashi, Shigaku IkedaAbstract:Dermatophytes cause intractable superficial infections in humans. Arthroderma benhamiae, a zoophilic dermatophyte, triggers severe inflammatory responses in humans, while Trichophyton tonsurans, an anthropophilic dermatophyte, triggers minimal ones. Cytokines and other factors derived from keratinocytes play important roles in inflammatory and immune responses in the skin. The authors performed an in vitro investigation to determine the human keratinocyte cytokine profiles during dermatophyte infection. The human keratinocyte cell line PHK16-0b was infected with A. benhamiae or T. tonsurans for 24 h, and the Cytokines secreted were analysed using a human cytokine antibody array. Marked differences were observed in the cytokine profiles of the cells infected with the two dermatophytes. A. benhamiae infection resulted in the secretion of a broad spectrum of Cytokines, including proinflammatory Cytokines, chemokines, and immunomodulatory Cytokines. In contrast, T. tonsurans-infected keratinocytes secreted only limited Cytokines, including eotaxin-2, interleukin (IL)-8 and IL-16. cDNA microarray analysis confirmed that A. benhamiae infection upregulated genes encoding IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-13, IL-15, IL-16, IL-17 and interferon (IFN)-gamma, while T. tonsurans infection upregulated only a few genes, such as those encoding IL-1beta and IL-16. RT-PCR demonstrated that infection by both dermatophytes enhanced IL-8 mRNA expression in keratinocytes. These results suggest that A. benhamiae-induced secretion of several Cytokines from keratinocytes may be involved in a severe inflammatory response, and that the limited cytokine secretion from keratinocytes in response to T. tonsurans infection may result in a minimal inflammatory response in the skin. These cytokine profiles may aid in proving the clinical features of dermatophytosis.
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cytokine secretion profiles of human keratinocytes during trichophyton tonsurans and arthroderma benhamiae infections
Journal of Medical Microbiology, 2006Co-Authors: Yumi Shiraki, Masataro Hiruma, Akemi Nishikawa, Yoshio Ishibashi, Shigaku IkedaAbstract:Dermatophytes cause intractable superficial infections in humans. Arthroderma benhamiae ,a zoophilic dermatophyte, triggers severe inflammatory responses in humans, while Trichophyton tonsurans, an anthropophilic dermatophyte, triggers minimal ones. Cytokines and other factors derived from keratinocytes play important roles in inflammatory and immune responses in the skin. The authors performed an in vitro investigation to determine the human keratinocyte cytokine profiles during dermatophyte infection. The human keratinocyte cell line PHK16-0b was infected with A. benhamiae or T. tonsurans for 24 h, and the Cytokines secreted were analysed using a human cytokine antibody array. Marked differences were observed in the cytokine profiles of the cells infected with the two dermatophytes. A. benhamiae infection resulted in the secretion of a broad spectrum of Cytokines, including proinflammatory Cytokines, chemokines, and immunomodulatory Cytokines. In contrast, T. tonsurans-infected keratinocytes secreted only limited Cytokines, including eotaxin-2, interleukin (IL)-8 and IL-16. cDNA microarray analysis confirmed that A. benhamiae infection upregulated genes encoding IL-1b, IL-2, IL-4, IL-6, IL-10, IL-13, IL-15, IL-16, IL-17 and interferon (IFN)-c, while T. tonsurans infection upregulated only a few genes, such as those encoding IL-1b and IL-16. RT-PCR demonstrated that infection by both dermatophytes enhanced IL-8 mRNA expression in keratinocytes. These results suggest that A. benhamiaeinduced secretion of several Cytokines from keratinocytes may be involved in a severe inflammatory response, and that the limited cytokine secretion from keratinocytes in response to T. tonsurans infectionmayresultinaminimalinflammatoryresponseintheskin.Thesecytokineprofilesmayaidin proving the clinical features of dermatophytosis.
Michaela Kress - One of the best experts on this subject based on the ideXlab platform.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Abstract Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as cytokine effects involving further mediators. The final outcome of cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1β, interleukin-6 and tumor necrosis factor-α, with regards to pain and hyperalgesia.
Yumi Shiraki - One of the best experts on this subject based on the ideXlab platform.
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Cytokine secretion profiles of human keratinocytes during Trichophyton tonsurans and Arthroderma benhamiae infections.
Journal of medical microbiology, 2020Co-Authors: Yumi Shiraki, Masataro Hiruma, Akemi Nishikawa, Yoshio Ishibashi, Shigaku IkedaAbstract:Dermatophytes cause intractable superficial infections in humans. Arthroderma benhamiae, a zoophilic dermatophyte, triggers severe inflammatory responses in humans, while Trichophyton tonsurans, an anthropophilic dermatophyte, triggers minimal ones. Cytokines and other factors derived from keratinocytes play important roles in inflammatory and immune responses in the skin. The authors performed an in vitro investigation to determine the human keratinocyte cytokine profiles during dermatophyte infection. The human keratinocyte cell line PHK16-0b was infected with A. benhamiae or T. tonsurans for 24 h, and the Cytokines secreted were analysed using a human cytokine antibody array. Marked differences were observed in the cytokine profiles of the cells infected with the two dermatophytes. A. benhamiae infection resulted in the secretion of a broad spectrum of Cytokines, including proinflammatory Cytokines, chemokines, and immunomodulatory Cytokines. In contrast, T. tonsurans-infected keratinocytes secreted only limited Cytokines, including eotaxin-2, interleukin (IL)-8 and IL-16. cDNA microarray analysis confirmed that A. benhamiae infection upregulated genes encoding IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-13, IL-15, IL-16, IL-17 and interferon (IFN)-gamma, while T. tonsurans infection upregulated only a few genes, such as those encoding IL-1beta and IL-16. RT-PCR demonstrated that infection by both dermatophytes enhanced IL-8 mRNA expression in keratinocytes. These results suggest that A. benhamiae-induced secretion of several Cytokines from keratinocytes may be involved in a severe inflammatory response, and that the limited cytokine secretion from keratinocytes in response to T. tonsurans infection may result in a minimal inflammatory response in the skin. These cytokine profiles may aid in proving the clinical features of dermatophytosis.
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cytokine secretion profiles of human keratinocytes during trichophyton tonsurans and arthroderma benhamiae infections
Journal of Medical Microbiology, 2006Co-Authors: Yumi Shiraki, Masataro Hiruma, Akemi Nishikawa, Yoshio Ishibashi, Shigaku IkedaAbstract:Dermatophytes cause intractable superficial infections in humans. Arthroderma benhamiae ,a zoophilic dermatophyte, triggers severe inflammatory responses in humans, while Trichophyton tonsurans, an anthropophilic dermatophyte, triggers minimal ones. Cytokines and other factors derived from keratinocytes play important roles in inflammatory and immune responses in the skin. The authors performed an in vitro investigation to determine the human keratinocyte cytokine profiles during dermatophyte infection. The human keratinocyte cell line PHK16-0b was infected with A. benhamiae or T. tonsurans for 24 h, and the Cytokines secreted were analysed using a human cytokine antibody array. Marked differences were observed in the cytokine profiles of the cells infected with the two dermatophytes. A. benhamiae infection resulted in the secretion of a broad spectrum of Cytokines, including proinflammatory Cytokines, chemokines, and immunomodulatory Cytokines. In contrast, T. tonsurans-infected keratinocytes secreted only limited Cytokines, including eotaxin-2, interleukin (IL)-8 and IL-16. cDNA microarray analysis confirmed that A. benhamiae infection upregulated genes encoding IL-1b, IL-2, IL-4, IL-6, IL-10, IL-13, IL-15, IL-16, IL-17 and interferon (IFN)-c, while T. tonsurans infection upregulated only a few genes, such as those encoding IL-1b and IL-16. RT-PCR demonstrated that infection by both dermatophytes enhanced IL-8 mRNA expression in keratinocytes. These results suggest that A. benhamiaeinduced secretion of several Cytokines from keratinocytes may be involved in a severe inflammatory response, and that the limited cytokine secretion from keratinocytes in response to T. tonsurans infectionmayresultinaminimalinflammatoryresponseintheskin.Thesecytokineprofilesmayaidin proving the clinical features of dermatophytosis.
Claudia Sommer - One of the best experts on this subject based on the ideXlab platform.
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recent findings on how proinflammatory Cytokines cause pain peripheral mechanisms in inflammatory and neuropathic hyperalgesia
Neuroscience Letters, 2004Co-Authors: Claudia Sommer, Michaela KressAbstract:Abstract Numerous experimental studies provide evidence that proinflammatory Cytokines induce or facilitate inflammatory as well as neuropathic pain and hyperalgesia. Direct receptor-mediated actions of Cytokines on afferent nerve fibers have been reported as well as cytokine effects involving further mediators. The final outcome of cytokine action greatly depends on whether they act in the central of in the peripheral nervous system. Here we summarize recent findings on the peripheral mechanisms of action of three prototypic proinflammatory Cytokines, interleukin-1β, interleukin-6 and tumor necrosis factor-α, with regards to pain and hyperalgesia.
Rachel M Tribe - One of the best experts on this subject based on the ideXlab platform.
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cytokine networks and the regulation of uterine function in pregnancy and parturition
Journal of Neuroendocrinology, 2008Co-Authors: Nicolas M Orsi, Rachel M TribeAbstract:Complex cytokine networks play an important role in a wide range of reproductive and pregnancy related processes. Here, we review the current knowledge concerning the impact of Cytokines on uterine physiology and pathophysiology. Cytokines influence a range of uterine functions during the menstrual cycle, implantation, pregnancy and labour. The synergistic interactions between individual Cytokines are intricate and dynamic, and modulated by pregnancy hormones. It is not surprising therefore, that perturbations to cytokine signalling are associated with adverse pregnancy outcomes, such as miscarriage, pre-eclampsia, preterm labour and foetal brain injury. Further insight into the complexity of cytokine networks will be required to develop novel therapeutic strategies for the treatment of cytokine imbalances in pregnancy.
