The Experts below are selected from a list of 125826 Experts worldwide ranked by ideXlab platform
Hiroto Kita - One of the best experts on this subject based on the ideXlab platform.
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A helper T-cell antigen enhances generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro.
Journal of Medical Virology, 1995Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Hideaki Inamori, Shin Ohnishi, Tatsuhiko Kodama, Kazumasa HiroishiAbstract:A T-cell help for generation of hepatitis C virus-specific Cytotoxic T lymphocytes was studied in three patients with chronic hepatitis C. In all three, human leukocyte antigen B44-restricted Cytotoxic T lymphocytes recognizing an epitope in hepatitis C virus nucleocapsid protein residues 81–100 were generated from the peripheral blood lymphocytes by repeated stimulation with a synthetic hepatitis C virus nucleocapsid pep-tide. The proliferative response of peripheral blood lymphocytes to hepatitis C virus nucleocapsid protein residues 1–120 was observed in one patient, and was ascribed to CD4+ T cells. The helper T cells recognized a major epitope in residues 21–40 and a minor epitope(s) in residues 81–110. They produced interferon γ, but interleukin 4 was not detectable in the T-helper cell culture supernatants. The hepatitis C virus nucleocapsid protein residues 1–120 and the major helper T-cell epitope enhanced generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro, although the protein alone did not generate them. In the other two patients, the protein did not enhance generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro. The results suggest that a hepatitis C virus-specific helper T-cell epitope is helpful for inducing a strong specific Cytotoxic T-lymphocyte response. © 1995 Wiley-Liss, Inc.
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hla b44 restricted Cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
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HLA B44–restricted Cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
Michio Imawari - One of the best experts on this subject based on the ideXlab platform.
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hla b44 restricted Cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
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HLA B44–restricted Cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
Takashi Moriyama - One of the best experts on this subject based on the ideXlab platform.
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A helper T-cell antigen enhances generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro.
Journal of Medical Virology, 1995Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Hideaki Inamori, Shin Ohnishi, Tatsuhiko Kodama, Kazumasa HiroishiAbstract:A T-cell help for generation of hepatitis C virus-specific Cytotoxic T lymphocytes was studied in three patients with chronic hepatitis C. In all three, human leukocyte antigen B44-restricted Cytotoxic T lymphocytes recognizing an epitope in hepatitis C virus nucleocapsid protein residues 81–100 were generated from the peripheral blood lymphocytes by repeated stimulation with a synthetic hepatitis C virus nucleocapsid pep-tide. The proliferative response of peripheral blood lymphocytes to hepatitis C virus nucleocapsid protein residues 1–120 was observed in one patient, and was ascribed to CD4+ T cells. The helper T cells recognized a major epitope in residues 21–40 and a minor epitope(s) in residues 81–110. They produced interferon γ, but interleukin 4 was not detectable in the T-helper cell culture supernatants. The hepatitis C virus nucleocapsid protein residues 1–120 and the major helper T-cell epitope enhanced generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro, although the protein alone did not generate them. In the other two patients, the protein did not enhance generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro. The results suggest that a hepatitis C virus-specific helper T-cell epitope is helpful for inducing a strong specific Cytotoxic T-lymphocyte response. © 1995 Wiley-Liss, Inc.
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hla b44 restricted Cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
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HLA B44–restricted Cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
Yoshio Yazaki - One of the best experts on this subject based on the ideXlab platform.
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A helper T-cell antigen enhances generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro.
Journal of Medical Virology, 1995Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Hideaki Inamori, Shin Ohnishi, Tatsuhiko Kodama, Kazumasa HiroishiAbstract:A T-cell help for generation of hepatitis C virus-specific Cytotoxic T lymphocytes was studied in three patients with chronic hepatitis C. In all three, human leukocyte antigen B44-restricted Cytotoxic T lymphocytes recognizing an epitope in hepatitis C virus nucleocapsid protein residues 81–100 were generated from the peripheral blood lymphocytes by repeated stimulation with a synthetic hepatitis C virus nucleocapsid pep-tide. The proliferative response of peripheral blood lymphocytes to hepatitis C virus nucleocapsid protein residues 1–120 was observed in one patient, and was ascribed to CD4+ T cells. The helper T cells recognized a major epitope in residues 21–40 and a minor epitope(s) in residues 81–110. They produced interferon γ, but interleukin 4 was not detectable in the T-helper cell culture supernatants. The hepatitis C virus nucleocapsid protein residues 1–120 and the major helper T-cell epitope enhanced generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro, although the protein alone did not generate them. In the other two patients, the protein did not enhance generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro. The results suggest that a hepatitis C virus-specific helper T-cell epitope is helpful for inducing a strong specific Cytotoxic T-lymphocyte response. © 1995 Wiley-Liss, Inc.
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hla b44 restricted Cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
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HLA B44–restricted Cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
Ikuo Nakamura - One of the best experts on this subject based on the ideXlab platform.
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A helper T-cell antigen enhances generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro.
Journal of Medical Virology, 1995Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Hideaki Inamori, Shin Ohnishi, Tatsuhiko Kodama, Kazumasa HiroishiAbstract:A T-cell help for generation of hepatitis C virus-specific Cytotoxic T lymphocytes was studied in three patients with chronic hepatitis C. In all three, human leukocyte antigen B44-restricted Cytotoxic T lymphocytes recognizing an epitope in hepatitis C virus nucleocapsid protein residues 81–100 were generated from the peripheral blood lymphocytes by repeated stimulation with a synthetic hepatitis C virus nucleocapsid pep-tide. The proliferative response of peripheral blood lymphocytes to hepatitis C virus nucleocapsid protein residues 1–120 was observed in one patient, and was ascribed to CD4+ T cells. The helper T cells recognized a major epitope in residues 21–40 and a minor epitope(s) in residues 81–110. They produced interferon γ, but interleukin 4 was not detectable in the T-helper cell culture supernatants. The hepatitis C virus nucleocapsid protein residues 1–120 and the major helper T-cell epitope enhanced generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro, although the protein alone did not generate them. In the other two patients, the protein did not enhance generation of hepatitis C virus-specific Cytotoxic T lymphocytes in vitro. The results suggest that a hepatitis C virus-specific helper T-cell epitope is helpful for inducing a strong specific Cytotoxic T-lymphocyte response. © 1995 Wiley-Liss, Inc.
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hla b44 restricted Cytotoxic t lymphocytes recognizing an epitope on hepatitis c virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
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HLA B44–restricted Cytotoxic T lymphocytes recognizing an epitope on hepatitis C virus nucleocapsid protein
Hepatology, 1993Co-Authors: Hiroto Kita, Takashi Moriyama, Takashi Kaneko, Ichiro Harase, M. Nomura, Hideaki Miura, Ikuo Nakamura, Yoshio Yazaki, Michio ImawariAbstract:Cytotoxic T lymphocytes have been reported to be involved in the immune clearance of virus-infected cells and in the pathogenesis of viral infection. We studied the Cytotoxic T lymphocyte response to the putative nucleocapsid protein of hepatitis C virus in patients with chronic hepatitis C. Cytotoxic T lymphocytes specific for hepatitis C virus nucleocapsid protein were generated from peripheral blood lymphocytes by means of repeated stimulation with a synthetic hepatitis C virus nucleocapsid protein peptide. The Cytotoxic T lymphocytes were CD8 positive and recognized an epitope in hepatitis C virus nucleocapsid protein residues 81 to 100 in association with a human leukocyte antigen class I molecule, B44. The peptideinduced Cytotoxic T lymphocytes recognized target cells synthesizing hepatitis C virus nucleocapsid protein endogenously, though less efficiently than peptide-pulsed target cells. The human leukocyte antigen B44–restricted Cytotoxic T lymphocyte response was observed in three of five patients with chronic hepatitis C and a human leukocyte antigen B44 molecule but in neither of two hepatitis C virus–negative healthy individuals with human leukocyte antigen B44 molecules. The results demonstrate the presence of hepatitis C virus–specific Cytotoxic T lymphocytes in the peripheral blood of patients with chronic hepatitis C and provide a strategy to study the role of Cytotoxic T lymphocytes in the viral clearance and the pathogenesis of hepatitis C virus infection. (HEPATOLOGY 1993;18:1039-1044).
