The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Junichi Yoshikawa - One of the best experts on this subject based on the ideXlab platform.
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Deletion Polymorphisms in the Angiotensin Converting Enzyme Gene Are Associated with Pulmonary Hypertension Evoked by Exercise Challenge in Patients with Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. Howev...
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Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. However, the Ppa after exercise challenge in patients with the DD genotype (55.7 +/- 4.9 mm Hg [mean +/- SD]) was significantly higher than in patients with the II genotype (42.6 +/- 7.1 mm Hg, p = 0.008). The Rpv after exercise in patients with the DD genotype was also significantly higher than in patients with the ID and II genotypes. During breathing of oxygen to diminish acute hypoxic pulmonary vasoconstriction, the Ppa in patients with the DD genotype (52.3 +/- 3.1 mm Hg) was higher than in patients with the ID genotype (40.5 +/- 5.9 mm Hg, p = 0.0049) or the II genotype (37.7 +/- 5.9 mm Hg, p = 0.0027). In addition, the Rpv in patients with the DD genotype was higher than in patients with the ID and II genotypes. These results suggest that D-I polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with COPD. However, the number of patients in this study was very small for a genetic association study, and our results should be examined in larger studies.
Avishai Wool - One of the best experts on this subject based on the ideXlab platform.
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CRUST: cryptographic remote untrusted storage without public keys
International Journal of Information Security, 2009Co-Authors: Erel Geron, Avishai WoolAbstract:This paper presents CRUST, a stackable file system layer designed to provide secure file sharing over remote untrusted storage systems. CRUST is intended to be layered over insecure network file systems without changing the existing systems. In our approach, Data at Rest is kept encrypted, and Data integrity and access control are provided by cryptographic means. Our design completely avoids public-key cryptography operations and uses more efficient symmetric-key alternatives to achieve improved performance. As a generic and self-contained system, CRUST includes its own in-band key distribution mechanism and does not rely on any special capabilities of the server or the clients. We have implemented CRUST as a Linux file system and shown that it performs comparably with typical underlying file systems, while providing significantly stronger security.
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IEEE Security in Storage Workshop - CRUST: Cryptographic Remote Untrusted Storage without Public Keys
Fourth International IEEE Security in Storage Workshop, 2007Co-Authors: Erel Geron, Avishai WoolAbstract:This paper presents CRUST, a stackablefile system layer designed to provide secure file sharing over remote untrusted storage systems. CRUST is intended to be layered over insecure network file systems without changing the existing systems. In our approach, Data at Rest is kept encrypted, and Data integrity and access control are provided by cryptographic means. Our design completely avoids public-key cryptography operations and uses more efficient symmetric-key alternatives to achieve improved performance. As a generic and self-contained system, CRUST includes its own in-band key distribution mechanism and does not rely on any special capabilities of the server or the clients. We have implemented CRUST as a Linux file system and shown that it performs comparably with typical underlying file systems, while providing significantly stronger security.
Hiroshi Kanazawa - One of the best experts on this subject based on the ideXlab platform.
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Deletion Polymorphisms in the Angiotensin Converting Enzyme Gene Are Associated with Pulmonary Hypertension Evoked by Exercise Challenge in Patients with Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. Howev...
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Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. However, the Ppa after exercise challenge in patients with the DD genotype (55.7 +/- 4.9 mm Hg [mean +/- SD]) was significantly higher than in patients with the II genotype (42.6 +/- 7.1 mm Hg, p = 0.008). The Rpv after exercise in patients with the DD genotype was also significantly higher than in patients with the ID and II genotypes. During breathing of oxygen to diminish acute hypoxic pulmonary vasoconstriction, the Ppa in patients with the DD genotype (52.3 +/- 3.1 mm Hg) was higher than in patients with the ID genotype (40.5 +/- 5.9 mm Hg, p = 0.0049) or the II genotype (37.7 +/- 5.9 mm Hg, p = 0.0027). In addition, the Rpv in patients with the DD genotype was higher than in patients with the ID and II genotypes. These results suggest that D-I polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with COPD. However, the number of patients in this study was very small for a genetic association study, and our results should be examined in larger studies.
Kazuto Hirata - One of the best experts on this subject based on the ideXlab platform.
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Deletion Polymorphisms in the Angiotensin Converting Enzyme Gene Are Associated with Pulmonary Hypertension Evoked by Exercise Challenge in Patients with Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. Howev...
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Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. However, the Ppa after exercise challenge in patients with the DD genotype (55.7 +/- 4.9 mm Hg [mean +/- SD]) was significantly higher than in patients with the II genotype (42.6 +/- 7.1 mm Hg, p = 0.008). The Rpv after exercise in patients with the DD genotype was also significantly higher than in patients with the ID and II genotypes. During breathing of oxygen to diminish acute hypoxic pulmonary vasoconstriction, the Ppa in patients with the DD genotype (52.3 +/- 3.1 mm Hg) was higher than in patients with the ID genotype (40.5 +/- 5.9 mm Hg, p = 0.0049) or the II genotype (37.7 +/- 5.9 mm Hg, p = 0.0027). In addition, the Rpv in patients with the DD genotype was higher than in patients with the ID and II genotypes. These results suggest that D-I polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with COPD. However, the number of patients in this study was very small for a genetic association study, and our results should be examined in larger studies.
Takashi Okamoto - One of the best experts on this subject based on the ideXlab platform.
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Deletion Polymorphisms in the Angiotensin Converting Enzyme Gene Are Associated with Pulmonary Hypertension Evoked by Exercise Challenge in Patients with Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. Howev...
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Deletion polymorphisms in the angiotensin converting enzyme gene are associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine, 2000Co-Authors: Hiroshi Kanazawa, Takashi Okamoto, Kazuto Hirata, Junichi YoshikawaAbstract:Angiotensin converting enzyme (ACE) plays an important role in the pathogenesis of pulmonary hypertension. In this study we determined whether the deletion (D)/insertion (I) polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with chronic obstructive pulmonary disease (COPD). ACE genotypes were determined in 19 patients with COPD. All patients underwent right heart catheterization followed by a constant-load exercise test while breathing room air or oxygen. Subgroups were created of seven patients with the II genotype, six with the ID genotype, and six with the DD genotype who were well-matched with respect to age, blood gas Data at Rest or after exercise, baseline lung function, results of incremental exercise testing, and hemodynamic Data at Rest. The mean pulmonary arterial pressure (Ppa) and pulmonary vascular resistance (Rpv) at Rest in the three subgrpoups did not differ significantly during breathing of either room air or oxygen. However, the Ppa after exercise challenge in patients with the DD genotype (55.7 +/- 4.9 mm Hg [mean +/- SD]) was significantly higher than in patients with the II genotype (42.6 +/- 7.1 mm Hg, p = 0.008). The Rpv after exercise in patients with the DD genotype was also significantly higher than in patients with the ID and II genotypes. During breathing of oxygen to diminish acute hypoxic pulmonary vasoconstriction, the Ppa in patients with the DD genotype (52.3 +/- 3.1 mm Hg) was higher than in patients with the ID genotype (40.5 +/- 5.9 mm Hg, p = 0.0049) or the II genotype (37.7 +/- 5.9 mm Hg, p = 0.0027). In addition, the Rpv in patients with the DD genotype was higher than in patients with the ID and II genotypes. These results suggest that D-I polymorphism in the ACE gene may be associated with pulmonary hypertension evoked by exercise challenge in patients with COPD. However, the number of patients in this study was very small for a genetic association study, and our results should be examined in larger studies.
