The Experts below are selected from a list of 151347 Experts worldwide ranked by ideXlab platform
Adam Chlipala - One of the best experts on this subject based on the ideXlab platform.
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a program optimization for automatic Database Result caching
Symposium on Principles of Programming Languages, 2017Co-Authors: Ziv Scully, Adam ChlipalaAbstract:Most popular Web applications rely on persistent Databases based on languages like SQL for declarative specification of data models and the operations that read and modify them. As applications scale up in user base, they often face challenges responding quickly enough to the high volume of requests. A common aid is caching of Database Results in the application's memory space, taking advantage of program-specific knowledge of which caching schemes are sound and useful, embodied in handwritten modifications that make the program less maintainable. These modifications also require nontrivial reasoning about the read-write dependencies across operations. In this paper, we present a compiler optimization that automatically adds sound SQL caching to Web applications coded in the Ur/Web domain-specific functional language, with no modifications required to source code. We use a custom cache implementation that supports concurrent operations without compromising the transactional semantics of the Database abstraction. Through experiments with microbenchmarks and production Ur/Web applications, we show that our optimization in many cases enables an easy doubling or more of an application's throughput, requiring nothing more than passing an extra command-line flag to the compiler.
Ziv Scully - One of the best experts on this subject based on the ideXlab platform.
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a program optimization for automatic Database Result caching
Symposium on Principles of Programming Languages, 2017Co-Authors: Ziv Scully, Adam ChlipalaAbstract:Most popular Web applications rely on persistent Databases based on languages like SQL for declarative specification of data models and the operations that read and modify them. As applications scale up in user base, they often face challenges responding quickly enough to the high volume of requests. A common aid is caching of Database Results in the application's memory space, taking advantage of program-specific knowledge of which caching schemes are sound and useful, embodied in handwritten modifications that make the program less maintainable. These modifications also require nontrivial reasoning about the read-write dependencies across operations. In this paper, we present a compiler optimization that automatically adds sound SQL caching to Web applications coded in the Ur/Web domain-specific functional language, with no modifications required to source code. We use a custom cache implementation that supports concurrent operations without compromising the transactional semantics of the Database abstraction. Through experiments with microbenchmarks and production Ur/Web applications, we show that our optimization in many cases enables an easy doubling or more of an application's throughput, requiring nothing more than passing an extra command-line flag to the compiler.
Darius A Paduch - One of the best experts on this subject based on the ideXlab platform.
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klinefelter syndrome an argument for early aggressive hormonal and fertility management
Fertility and Sterility, 2012Co-Authors: Akanksha Mehta, Darius A PaduchAbstract:Objective To investigate the impact of early hormone replacement therapy (HT) on sperm retrieval rates in patients with Klinefelter syndrome (KS). Design A systematic review of the relevant literature using the PubMed NLM Database. Result(s) There are no randomized controlled trials evaluating the impact of HT on sperm retrieval or reproductive outcomes in men with KS. On average, surgical sperm retrieval rates in men with KS are around 51%, with a range of 28%–69%. Young patient age is the most consistent positive predictor of sperm retrieval. Lower retrieval rates have been reported in a small subset of KS adults who previously received exogenous T, although the nature, duration, and reason for such therapy in these patient subsets are unknown. Conclusion(s) Early HT is recommended in patients with KS, but its effect on fertility potential has not been definitively studied. Larger studies are needed to better answer this question. Cryopreservation of sperm-containing semen or testicular tissue from a significant proportion of affected adolescents is possible, even when containing very low numbers of spermatozoa, and should be considered to maximize future fertility potential.
Xuezhi Hao - One of the best experts on this subject based on the ideXlab platform.
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prognostic significance of cd276 in non small cell lung cancer
Open Medicine, 2019Co-Authors: Changgong Zhang, Xuezhi HaoAbstract:Background The expression and significance of CD276 in non-small cell lung cancer (NSCLC) was explored. Method The BioGPS Database was used to analyze the expression level of CD276 in normal tissues. Studies on the expression of CD276 in NSCLC patients using the Oncomine Database. The prognostic roles of CD276 in NSCLC was studied using the Kaplan-Meier plotter Database. Result The BioGPS Database showed CD276 expression in all the human normal tissues. Compared with normal lung tissue, CD276 gene highly expressed in NSCLC tissue at mRNA level (P<0.05). The expression level of CD276 gene was negatively correlated with overall survival (OS) of NSCLC patients. Subgroup analysis showed that CD276 expression level had a significant effect on OS of patients with lung adenocarcinoma, while in squamous cell carcinoma its expression level had no significant effect on OS. Conclusion According to the information mined from the tumor gene Database, CD276 mRNA was found highly expressed in NSCLC tissue and the expression of CD276 has a significant impact on survival of NSCLC patients, which provides an important theoretical basis for further study of the role of CD276 in the occurrence and development of NSCLC.
Yutaka Shimazu - One of the best experts on this subject based on the ideXlab platform.
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outcomes of ixazomib lenalidomide dexamethasone for multiple myeloma a multicenter retrospective analysis
European Journal of Haematology, 2021Co-Authors: Teruhito Takakuwa, Ryosuke Yamamura, Kensuke Ohta, Hitomi Kaneko, Kazunori Imada, Aya Nakaya, Shinichi Fuchida, Hirohiko Shibayama, Mitsuhiro Matsuda, Yutaka ShimazuAbstract:Objectives This study aimed to investigate real-world data of ixazomib plus lenalidomide and dexamethasone (IRd) therapy for patients with relapsed and refractory multiple myeloma (RRMM). Methods We retrospectively analyzed 122 patients treated with IRd at 16 centers from May 2017 to January 2019 by using the Kansai Myeloma Forum Database. Result At the start of IRd, the median age was 72 years, 66.7% of patients had IgG type, and the median number of prior therapies was 4, comprising bortezomib (85.4%) and lenalidomide (89.3%)-based regimens. Disease progression and adverse events accounted for treatment discontinuation in 46 and 32 patients, respectively. The median overall survival (OS) was not reached, and the median progression-free survival (PFS) was 11.9 months. Sensitivity to bortezomib did not affect the PFS, whereas lenalidomide-refractory patients had significantly lower PFS than lenalidomide-sensitive patients, who were comparable to TOURMALINE-MM1 study. The patients with IgG type had significantly better PFS and OS than those with non-IgG type. Conclusion This study presents the largest real-world data of patients treated with IRd in Asia. However, in real clinical practice, the patient background is different from the TOURMALINE-MM1 study, and IRd showed poor efficacy, especially in the non-IgG type and lenalidomide-refractory patients with RRMM.
