The Experts below are selected from a list of 207 Experts worldwide ranked by ideXlab platform
Alison Bentley - One of the best experts on this subject based on the ideXlab platform.
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women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
The Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Abstract Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation.
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Women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective: Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation. © 2013 by the American Pain Society.
Fiona C. Baker - One of the best experts on this subject based on the ideXlab platform.
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women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
The Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Abstract Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation.
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Women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective: Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation. © 2013 by the American Pain Society.
Stella Iacovides - One of the best experts on this subject based on the ideXlab platform.
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women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
The Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Abstract Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation.
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Women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective: Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation. © 2013 by the American Pain Society.
Ingrid Avidon - One of the best experts on this subject based on the ideXlab platform.
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women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
The Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Abstract Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation.
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Women with dysmenorrhea are hypersensitive to experimental Deep Muscle pain across the menstrual cycle
Journal of Pain, 2013Co-Authors: Stella Iacovides, Ingrid Avidon, Fiona C. Baker, Alison BentleyAbstract:Primary dysmenorrhea is a common painful condition in women that recurs every month across the reproductive years. The recurrent nociceptive input into the central nervous system that occurs during menstruation each month in women with dysmenorrhea is hypothesized to lead to increased sensitivity to painful stimuli. We investigated whether women with primary dysmenorrhea are hyperalgesic to Deep Muscle pain induced by a cleanly nociceptive method of hypertonic saline injection. Pain stimulation was applied both within an area of referred menstrual pain (lower back) and at a remote site outside of referred menstrual pain (forearm) in 12 healthy women with severe dysmenorrhea and 9 healthy women without dysmenorrhea, at 3 phases of the menstrual cycle: menstruation and follicular and luteal phases. Women rated their pain severity on a 100-mm visual analog scale every 30 seconds after injection until the pain subsided. In both groups of women, menstrual cycle phase had no effect on the reported intensity and duration of Muscle pain. However, women with dysmenorrhea had increased sensitivity to experimental Muscle pain both at the site of referred pain and at a remote nonpainful site, as assessed by peak pain severity visual analog scale rating, area under the visual analog scale curve, and pain duration, compared to women without dysmenorrhea. These data show that women with severe primary dysmenorrhea, who experience monthly menstrual pain, are hyperalgesic to Deep Muscle pain compared to women without dysmenorrhea. Perspective: Our findings that dysmenorrheic women are hyperalgesic to a clinically relevant, Deep Muscle pain in areas within and outside of referred menstrual pain indicates lasting changes in pain sensitivity outside of the painful period during menstruation. © 2013 by the American Pain Society.
Alba Veggetti - One of the best experts on this subject based on the ideXlab platform.
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Differentiation and growth of Muscle in the fish Sparus aurata (L): I. Myosin expression and organization of fibre types in lateral Muscle from hatching to adult
Journal of Muscle Research & Cell Motility, 1995Co-Authors: Francesco Mascarello, Anthea Rowlerson, Giuseppe Radaelli, Pier-augusto Scapolo, Alba VeggettiAbstract:Post-hatching development of lateral Muscle in a teleost fish, Sparus aurata (L) was examined. At hatching only two fibre types were present; several layers of mitochondria-poor, myofibril-rich Deep Muscle fibres surrounded the notochord and were covered by a superficial monolayer of mitochondria-rich, myofibril-poor fibres. A third ultrastructurally distinct fibre type first appeared as one or two fibres located just under the lateral line at 6 days post-hatching. This type, which gradually increased in number during larval life, contained a slow isoform of myosin, identified by mATPase staining and immunostaining with myosin isoform-specific antibodies. Deep Muscle fibres — the presumptive fast-white type — contained a fast myosin, and superficial monolayer fibres an isoform similar but not identical to that in adult pink Muscle fibres. The only fibres present during larval life which showed a clear change in myosin expression were the superficial monolayer fibres, which gradually transformed into the slow type post-larvally. Pink Muscle fibres first appeared near the end of larval life. Both slow and pink Muscle fibres remained concentrated around the horizontal septum under the lateral line during larval life, expanding outwards towards the apices of the myotomes only after metamorphosis. Between 60 and 90 days very small diameter fibres with a distinct mATPase profile appeared scattered throughout the Deep, fast-white Muscle layer, giving it a ‘mosaic’ appearance, which persisted into adult life. A marked expansion in the slow Muscle layer began at the same time, partly by transformation of superficial monolayer fibres, but mainly by addition of new fibres both on the Deep surface of the superficial monolayer and close to the lateral line. The order of appearance of these fibre types, their myosin composition, and the significance of the superificial monolayer layer are discussed and compared to Muscle fibre type development in higher vertebrates.
