The Experts below are selected from a list of 267 Experts worldwide ranked by ideXlab platform
Shimon Sakaguchi - One of the best experts on this subject based on the ideXlab platform.
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immunologic self tolerance maintained by cd25 cd4 naturally anergic and suppressive t cells induction of autoimmune disease by breaking their anergic suppressive state
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
Takeshi Takahashi - One of the best experts on this subject based on the ideXlab platform.
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immunologic self tolerance maintained by cd25 cd4 naturally anergic and suppressive t cells induction of autoimmune disease by breaking their anergic suppressive state
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
Liu Jizhen - One of the best experts on this subject based on the ideXlab platform.
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Application of Data Mining Method in Real-time Optimal Load Dispatching of Power Plant
2010Co-Authors: Liu JizhenAbstract:A solution to real-time optimal load dispatching problem of power plant was introduced in this paper.Based on analysis of operating data,it was proved that the characteristics curve of unit coal consumption rate(CCR) against load are constructed by discrete points and it can't be fit by linear regression.In the Default Condition of accurate thermodynamic calculation,factors impacting unit CCR for power supply are studied.Multi-factors weight distribution method based on information entropy was employed to predict CCR for power supply at different operating points based on history and real-time data.Thus,discrete mathematical model between load and CCR was build up for each unit.Based on the proposed speediness and economy constraints,global optimal solution for optimal load dispatching was approached by dynamic programming method.The method proposed in this paper was applied in Panshan power plant of China Datang Corporation and it was proved to be practical and effective.
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Real-time Optimal Load Dispatching of Power Plant Based on Data Mining Method
IFAC Proceedings Volumes, 2009Co-Authors: Zeng Deliang, Yang Tingting, Niu Yuguang, Cheng Xiao, Liu JizhenAbstract:Abstract A solution to real-time optimal load dispatching problem of power plant is introduced in this paper. Based on analysis of amounts of operating data, it is proved that the characteristics curve of unit coal consumption rate (CCR) against load are constructed by discrete points and it can't be deduced by linear regression. At the Default Condition of accurate thermodynamic calculation, the factors impacting unit CCR for power supply are studied at different operating Conditions. Data mining method is employed to predict CCR for power supply at different operating points and environmental Condition based on history and real-time data. Thus, discrete mathematical model between load and CCR is build up for optimal load dispatching (OLD) among the units. Global optimal solution can be approached by dynamic programming method for the reason of the low dimension (number of units in one plant) of this issue now. The method proposed in this paper is applied in a power plant of Datang group and it is proved to be practical and effective.
M. Lima-marques - One of the best experts on this subject based on the ideXlab platform.
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Quality of Service Control in IP Networks Using Fuzzy Logic for Policy Condition Evaluation
The 14th IEEE International Conference on Fuzzy Systems 2005. FUZZ '05., 2005Co-Authors: R.a. Resende, N.a. Nassif, M.a. De Siqueira, A.e. Da Silva, M. Lima-marquesAbstract:This paper presents the architecture of a policy-based network management system designed specifically for quality of service management, where high level business policies are modeled as ECA (event-Condition-action) rules. Specifically, the system is mainly based on the policy architecture being proposed by the IETF (Internet engineering task force), DMTF (distributed management task force), and TMF (telemanagement forum) standardization bodies. This work proposes a novel approach for policy Condition evaluation using fuzzy logic. The fuzzy controller has the ability to examine policy Conditions differently from Default Condition analyzers that employ simple Conditions formed by a set of (IFs, ANDs and ORs), allowing the consideration and correlation of several input variables before taking decisions for the execution of policy actions. The system have been implemented and evaluated over a test bed network formed by Ciscoreg routers
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FUZZ-IEEE - Quality of Service Control in IP Networks Using Fuzzy Logic for Policy Condition Evaluation
The 14th IEEE International Conference on Fuzzy Systems 2005. FUZZ '05., 2005Co-Authors: R.a. Resende, N.a. Nassif, M.a. De Siqueira, A.e. Da Silva, M. Lima-marquesAbstract:This paper presents the architecture of a policy-based network management system designed specifically for quality of service management, where high level business policies are modeled as ECA (event-Condition-action) rules. Specifically, the system is mainly based on the policy architecture being proposed by the IETF (Internet engineering task force), DMTF (distributed management task force), and TMF (telemanagement forum) standardization bodies. This work proposes a novel approach for policy Condition evaluation using fuzzy logic. The fuzzy controller has the ability to examine policy Conditions differently from Default Condition analyzers that employ simple Conditions formed by a set of (IFs, ANDs and ORs), allowing the consideration and correlation of several input variables before taking decisions for the execution of policy actions. The system have been implemented and evaluated over a test bed network formed by Ciscoreg routers
Makoto Iwata - One of the best experts on this subject based on the ideXlab platform.
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immunologic self tolerance maintained by cd25 cd4 naturally anergic and suppressive t cells induction of autoimmune disease by breaking their anergic suppressive state
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
International Immunology, 1998Co-Authors: Takeshi Takahashi, Yuhshi Kuniyasu, Masaaki Toda, Noriko Sakaguchi, Misako Itoh, Makoto Iwata, Jun Shimizu, Shimon SakaguchiAbstract:Elimination of CD25 F T cells, which constitute 5‐10% of peripheral CD4 F T cells in normal naive mice, leads to spontaneous development of various autoimmune diseases. These immunoregulatory CD25 F CD4 F T cells are naturally unresponsive (anergic) in vitro to TCR stimulation, and, upon stimulation, suppress proliferation of CD25 ‐ CD4 F T cells and CD8 F T cells. The antigen concentration required for stimulating CD25 F CD4 F T cells to exert suppression is much lower than that required for stimulating CD25 ‐ CD4 F T cells to proliferate. The suppression, which results in reduced IL-2 production by CD25 ‐ CD4 F T cells, is dependent on cellular interactions on antigen-presenting cells (and not mediated by far-reaching or long-lasting humoral factors or apoptosis-inducing signals) and antigen non-specific in its effector phase. Addition of high doses of IL-2 or anti-CD28 antibody to the in vitro T cell stimulation culture not only breaks the anergic state of CD25 F CD4 F T cells, but also abrogates their suppressive activity simultaneously. Importantly, the anergic/suppressive state of CD25 F CD4 F T cells appeared to be their basal Default Condition, since removal of IL-2 or anti-CD28 antibody from the culture milieu allows them to revert to the original anergic/suppressive state. Furthermore, transfer of such anergy/suppression-broken T cells from normal mice produces various autoimmune diseases in syngeneic athymic nude mice. These results taken together indicate that one aspect of immunologic self-tolerance is maintained by this unique CD25 F CD4 F naturally anergic/
