The Experts below are selected from a list of 165 Experts worldwide ranked by ideXlab platform
Moeko Kanaya - One of the best experts on this subject based on the ideXlab platform.
-
neonatal septal lesions prevent behavioral Defeminization caused by neonatal treatment with estradiol in female rats
Neuroscience Letters, 2019Co-Authors: Moeko Kanaya, Shinji Tsukahara, Korehito YamanouchiAbstract:Abstract Male rats rarely show lordosis, a female sexual behavior, because of strong inhibition of the behavior in the lateral septum. Because neonatal treatment with estradiol (E2) in female rats decreases lordosis, it is believed that the lateral septum is a target of E2 action to defeminize or masculinize the lordosis-inhibiting system. Here, we tested the hypothesis that disruption of the lateral septum before E2 treatment prevents the effect of neonatal E2 on lordosis. Female rats that underwent radiofrequency-induced septal lesions or sham operation on postnatal day 4 (PD4, day of birth = PD1) were subcutaneously injected with E2 or sesame oil vehicle alone on PD5. Vaginal opening and smears were checked. After sexual maturation, lordosis tests were performed. The effects of neonatal septal lesions on lordosis in male rats were also observed. Sham-operated and E2-treated female rats showed a reduction in lordosis and irregular estrous cycles. Conversely, septal lesioned and E2-treated females exhibited higher levels of lordosis, although their estrous cycles were irregular. These results suggest that neonatal septal lesions prevent females from being behaviorally defeminized by neonatal E2. Additionally, neonatally septal lesioned males displayed higher levels of lordosis than sham-operated males. These results suggest that E2, which is produced by the aromatization of testicular testosterone in the neonatal period, acts on the lateral septum to organize the lordosis-inhibiting system.
-
Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats
Neuroendocrinology, 2012Co-Authors: Moeko Kanaya, Korehito YamanouchiAbstract:Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly,
Korehito Yamanouchi - One of the best experts on this subject based on the ideXlab platform.
-
neonatal septal lesions prevent behavioral Defeminization caused by neonatal treatment with estradiol in female rats
Neuroscience Letters, 2019Co-Authors: Moeko Kanaya, Shinji Tsukahara, Korehito YamanouchiAbstract:Abstract Male rats rarely show lordosis, a female sexual behavior, because of strong inhibition of the behavior in the lateral septum. Because neonatal treatment with estradiol (E2) in female rats decreases lordosis, it is believed that the lateral septum is a target of E2 action to defeminize or masculinize the lordosis-inhibiting system. Here, we tested the hypothesis that disruption of the lateral septum before E2 treatment prevents the effect of neonatal E2 on lordosis. Female rats that underwent radiofrequency-induced septal lesions or sham operation on postnatal day 4 (PD4, day of birth = PD1) were subcutaneously injected with E2 or sesame oil vehicle alone on PD5. Vaginal opening and smears were checked. After sexual maturation, lordosis tests were performed. The effects of neonatal septal lesions on lordosis in male rats were also observed. Sham-operated and E2-treated female rats showed a reduction in lordosis and irregular estrous cycles. Conversely, septal lesioned and E2-treated females exhibited higher levels of lordosis, although their estrous cycles were irregular. These results suggest that neonatal septal lesions prevent females from being behaviorally defeminized by neonatal E2. Additionally, neonatally septal lesioned males displayed higher levels of lordosis than sham-operated males. These results suggest that E2, which is produced by the aromatization of testicular testosterone in the neonatal period, acts on the lateral septum to organize the lordosis-inhibiting system.
-
Defeminization of brain functions by a single injection of estrogen receptor α or β agonist in neonatal female rats
Neuroendocrinology, 2012Co-Authors: Moeko Kanaya, Korehito YamanouchiAbstract:Sexual differentiation of brain function is regulated by estrogen in the perinatal period of rodents. However, the role of the estrogen receptor subtypes ERα and ERβ is still in question. Accordingly,
R Mills - One of the best experts on this subject based on the ideXlab platform.
-
prepubertal testosterone treatment of female rats Defeminization of behavioral and endocrine function in adulthood
Neuroscience & Biobehavioral Reviews, 1995Co-Authors: G J Bloch, R Mills, Shawn D GaleAbstract:Abstract This study assesed the capacity of testosterone (T) administered well after the neonatal “critical” period to permanently sexually differentiate reproductive function. Females received T filled or empty Silastic capsules during days 15–30 of age and vaginal cyclicity, ovarian weight and. appearance, lordosis and proceptive behaviors, mounting behavior, and the gonadotropin response to estrogen and progesterone were measured in adulthood. T-treated females (plasma levels of 0.66 ng T/ml) showed constant vaginal estrus from the day of vaginal opening and small, polyfollicular ovaries. Proceptive behaviors were dramatically reduced whether or not the ovaries were present after day 15 of age, but lordosis behavior was not affected. Exposure to T for 5–6 h was ineffective. Compared to controls, T-treated females had dramatically reduced plasma FSH and LH surges. No effects were observed on mounting behavior, phallus size, or body weights. These results suggest that androgen at approximately male levels can act on neural substrates well beyond the neonatal period to permanently defeminize endocrine and behavioral function in the female rat.
-
prepubertal testosterone treatment of neonatally gonadectomized male rats Defeminization and masculinization of behavioral and endocrine function in adulthood
Neuroscience & Biobehavioral Reviews, 1995Co-Authors: G J Bloch, R MillsAbstract:Abstract Testosterone (T) administered well after the neonatal “critical” period to females at a dose approximating male levels permanently defeminizes reproductive function (see companion publication.) To obtain comparable data for the male, neonatally gonadectomized (NeoGx) males received T filled or empty Silastic capsules during days 15–30 of age and were studied in adulthood. Compared to controls, the T treatment resulted in reduced lordosis and proceptive behaviors, increased mounting and intronussion behaviors without differences in penile reflexes or size, and reduced plasma FSH and LH surges. Twenty of twenty-three sham-NeoGx males, but only one NeoGx male, showed ejaculatory behavior despite equivalence in penile reflexes and size after detaching a frenulum when present on the penis. These results show that T can still act on neural substrates well beyond the neonatal period to defeminize and masculinize endocrine and behavioral function in the male rat. A comparison with effects in females indicates a sex difference, the male appearing to be more sensitive to these actions of T.
Sharon M Irving - One of the best experts on this subject based on the ideXlab platform.
-
effects of prenatal antiandrogen treatment on masculinization and Defeminization of guinea pigs
Physiology & Behavior, 1991Co-Authors: Janice E Thornton, Sharon M IrvingAbstract:Abstract Gonadectomized (gdx) guinea pigs which had received the antiandrogen flutamide prenatally were tested for female-typical and male-typical sexual behavior in adulthood. In tests for lordosis behavior, gdx males and females were injected with estradiol benzoate and progesterone. Prenatally flutamide-treated females showed a longer mean lordosis response than control females. This was true whether they were given either a high or a low dose of EB. No male ever showed a lordosis response. In tests for male-typical sexual behavior, gdx adult males were treated with testosterone propionate and tested with stimulus females. The prenatally flutamide-treated males showed significantly decreased levels of ejaculation, a lower intromission rate and a decreased percentage of mounts which included pelvic thrusts, when compared to control males. Mount rate and rate of pericopulatory behavior did not differ between the flutamide and control males. The fact that prenatal administration of flutamide increased female-typical behavior in adult females suggests that the female guinea pig is normally partially defeminized by androgens in utero. The male guinea pig appears to be resilient to attempts to block Defeminization with prenatal antiandrogens. However, some aspects of masculinization can be blocked.
G J Bloch - One of the best experts on this subject based on the ideXlab platform.
-
prepubertal testosterone treatment of female rats Defeminization of behavioral and endocrine function in adulthood
Neuroscience & Biobehavioral Reviews, 1995Co-Authors: G J Bloch, R Mills, Shawn D GaleAbstract:Abstract This study assesed the capacity of testosterone (T) administered well after the neonatal “critical” period to permanently sexually differentiate reproductive function. Females received T filled or empty Silastic capsules during days 15–30 of age and vaginal cyclicity, ovarian weight and. appearance, lordosis and proceptive behaviors, mounting behavior, and the gonadotropin response to estrogen and progesterone were measured in adulthood. T-treated females (plasma levels of 0.66 ng T/ml) showed constant vaginal estrus from the day of vaginal opening and small, polyfollicular ovaries. Proceptive behaviors were dramatically reduced whether or not the ovaries were present after day 15 of age, but lordosis behavior was not affected. Exposure to T for 5–6 h was ineffective. Compared to controls, T-treated females had dramatically reduced plasma FSH and LH surges. No effects were observed on mounting behavior, phallus size, or body weights. These results suggest that androgen at approximately male levels can act on neural substrates well beyond the neonatal period to permanently defeminize endocrine and behavioral function in the female rat.
-
prepubertal testosterone treatment of neonatally gonadectomized male rats Defeminization and masculinization of behavioral and endocrine function in adulthood
Neuroscience & Biobehavioral Reviews, 1995Co-Authors: G J Bloch, R MillsAbstract:Abstract Testosterone (T) administered well after the neonatal “critical” period to females at a dose approximating male levels permanently defeminizes reproductive function (see companion publication.) To obtain comparable data for the male, neonatally gonadectomized (NeoGx) males received T filled or empty Silastic capsules during days 15–30 of age and were studied in adulthood. Compared to controls, the T treatment resulted in reduced lordosis and proceptive behaviors, increased mounting and intronussion behaviors without differences in penile reflexes or size, and reduced plasma FSH and LH surges. Twenty of twenty-three sham-NeoGx males, but only one NeoGx male, showed ejaculatory behavior despite equivalence in penile reflexes and size after detaching a frenulum when present on the penis. These results show that T can still act on neural substrates well beyond the neonatal period to defeminize and masculinize endocrine and behavioral function in the male rat. A comparison with effects in females indicates a sex difference, the male appearing to be more sensitive to these actions of T.
