The Experts below are selected from a list of 1200 Experts worldwide ranked by ideXlab platform
Sousa Martins - One of the best experts on this subject based on the ideXlab platform.
-
Anemias causadas pela deficiencia de acido folico vitamina b12 e ferro em gestantes Anemias caused by folic acid Deficiency vitamin b12 and iron in pregnant women
2015Co-Authors: Fabiana Cunha Borges, Debora Susany, Sousa Martins, Jessica S Oliveira, Andressa L Nobrega, Frankly Eudes, Mara SinthyaAbstract:Anemia is characterized by the amount of hemoglobin in cells that often can be a clinical and laboratorial condition, resulting in a pathological condition. It's not seen as a disease sign of disease. During the gestational cycle occur several metabolic adjustments to provide normal fetus growth, a framework of inadequate nutrition can lead to growth retardation, reduced resistance to infectious diseases interfered with the development of the child. The objective of this research was to identify the incidence of folate Deficiency anemia, iron and vitamin B12 in pregnant women seen in a USF town Sao Bento-PB. Venipuncture was performed to collect 10 mL of blood for subsequent realization of the dosage of serum iron, folate and vitamin B12. Of 20 pregnant women recruited to participate in the survey, all performed within the standards of normality to the dosages of iron, Folate and Vitamin B12. During the research it was observed an average of 72.44 188.66 the pg/ml 262.87, the mcg/dl and 125.33 9.56 to 15.97 ng/ml for dosages of Vitamin B12, Folic Acid and iron respectively. This research distinguishes a high regularity of pregnant women with suitable nutritional framework, met in a USF. While conducting the research one can also conclude that the relationship of a proper diet during pregnancy and of extreme importance in order to avoid the occurrence of the Deficiency Anemias.
Franco Dammacco - One of the best experts on this subject based on the ideXlab platform.
-
a paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma
Haematologica, 2003Co-Authors: Angelo Vacca, Roberto Ria, Domenico Ribatti, Fabrizio Semeraro, Valentin Djonov, Francesco Di Raimondo, Franco DammaccoAbstract:BACKGROUND AND OBJECTIVES: In tumors, vascular endothelial growth factor-A (VEGF-A) stimulates angiogenesis and vascular permeability by activating the tyrosine kinase receptor-2 (VEGFR-2 or KDR/Flk-1) and-1 (VEGFR-1 or Flt-1). DESIGN AND METHODS: The distribution and function of VEGF homologs and their receptors on bone marrow plasma cells, endothelial cells, and other stromal cells (residual stromal cells) were examined in patients with multiple myeloma (MM). RESULTS. Plasma cells secrete VEGF-A (and VEGF-B, VEGF-C and VEGF-D, albeit marginally) into their conditioned medium (CM). CM VEGF-A stimulates proliferation and chemotaxis in endothelial cells (both being mandatory for angiogenesis) via VEGF receptor-2 (VEGFR-2), and in residual stromal cells via the VEGFR-1. Residual stromal cells secrete VEGF-C and VEGF-D, but little of the other homologs. Their CM VEGF-C and VEGF-D increase in response to plasma cell CM and trigger plasma cell proliferation via VEGFR-3. Proliferation in all cell types parallels VEGFR and extracellular signal-regulated protein kinase-2 (ERK-2) phosphorylation. The homologs and receptors are weakly or inconstantly expressed in patients with monoclonal gammopathies of undetermined significance or vitamin B12/iron Deficiency Anemias. INTERPRETATION AND CONCLUSIONS: This study shows that the VEGF pathway is directly involved in tumor angiogenesis and growth in MM. A paracrine VEGF loop for MM progression is suggested. This, in turn, provides a further indication that the VEGF pathway and its signaling proteins may be appropriate targets in the management of MM.
Hünkerler Zeynep - One of the best experts on this subject based on the ideXlab platform.
-
Oxidative stress, hepcidin and nesfatin-I status in childhood iron and vitamin B12 Deficiency Anemias
'Wroclaw Medical University', 2017Co-Authors: Aşkar, Tünay Kontaş, Büyükleblebici Olga, Hismioğulları, Adnan Adil, Hünkerler ZeynepAbstract:Büyükleblebici, Olga (Aksaray, Yazar)Background. Anemia is a disease that is long and often repetitive and can result in a great burden to the national economy. The most frequent nutritional Deficiency Anemias in children are related with iron and vitamin B12 deficiencies. Objectives. The aim of this study was to determine the oxidative stress, hepcidin, and nesfatin-I levels in childhood iron and vitamin B12 Deficiency Anemias. Material and Methods. The study had 3 groups of 15 children, iron anemia Deficiency group, vitamin B12 Deficiency group and a control group. Results. The TBARS and nesfatin-I levels were significantly higher in the iron and vitamin B12 Deficiency groups and the total antioxidant levels were significantly lower when compared to the control group. In contrast, the plasma hepcidin levels were significantly lower in the iron Deficiency group (p < 0.01) when compared to the control group; however, no significant differences were observed in the vitamin B12 Deficiency group. Plasma homocysteine levels were significantly higher in the vitamin B12 Deficiency group when compared to the control group (p < 0.001), but no differences were determined between the iron Deficiency and control groups. Conclusion. Our results showed that there are high levels of oxidative stress in childhood iron and vitamin B12 Deficiency Anemias, and we propose that plasma hepcidin and homocycteine levels may be useful in the differential diagnosis of childhood nutritional Deficiency Anemias. Nesfatin-1 hormone levels were identified for the first time in childhood iron Deficiency and vitamin B12 Deficiency Anemias within this study and this hormone may also be useful in the differential diagnosis of Anemias
Zeynep Hunkerler - One of the best experts on this subject based on the ideXlab platform.
-
oxidative stress hepcidin and nesfatin i status in childhood iron and vitamin b12 Deficiency Anemias
Advances in Clinical and Experimental Medicine, 2017Co-Authors: Tunay Kontas Askar, Olga Buyukleblebici, Adnan Adil Hismiogullari, Zeynep HunkerlerAbstract:BACKGROUND Anemia is a disease that is long and often repetitive and can result in a great burden to the national economy. The most frequent nutritional Deficiency Anemias in children are related with iron and vitamin B12 deficiencies. OBJECTIVES The aim of this study was to determine the oxidative stress, hepcidin, and nesfatin-I levels in childhood iron and vitamin B12 Deficiency Anemias. MATERIAL AND METHODS The study had 3 groups of 15 children, iron anemia Deficiency group, vitamin B12 Deficiency group and a control group. RESULTS The TBARS and nesfatin-I levels were significantly higher in the iron and vitamin B12 Deficiency groups and the total antioxidant levels were significantly lower when compared to the control group. In contrast, the plasma hepcidin levels were significantly lower in the iron Deficiency group (p < 0.01) when compared to the control group; however, no significant differences were observed in the vitamin B12 Deficiency group. Plasma homocysteine levels were significantly higher in the vitamin B12 Deficiency group when compared to the control group (p < 0.001), but no differences were determined between the iron Deficiency and control groups. CONCLUSIONS Our results showed that there are high levels of oxidative stress in childhood iron and vitamin B12 Deficiency Anemias, and we propose that plasma hepcidin and homocycteine levels may be useful in the differential diagnosis of childhood nutritional Deficiency Anemias. Nesfatin-1 hormone levels were identified for the first time in childhood iron Deficiency and vitamin B12 Deficiency Anemias within this study and this hormone may also be useful in the differential diagnosis of Anemias.
Angelo Vacca - One of the best experts on this subject based on the ideXlab platform.
-
a paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma
Haematologica, 2003Co-Authors: Angelo Vacca, Roberto Ria, Domenico Ribatti, Fabrizio Semeraro, Valentin Djonov, Francesco Di Raimondo, Franco DammaccoAbstract:BACKGROUND AND OBJECTIVES: In tumors, vascular endothelial growth factor-A (VEGF-A) stimulates angiogenesis and vascular permeability by activating the tyrosine kinase receptor-2 (VEGFR-2 or KDR/Flk-1) and-1 (VEGFR-1 or Flt-1). DESIGN AND METHODS: The distribution and function of VEGF homologs and their receptors on bone marrow plasma cells, endothelial cells, and other stromal cells (residual stromal cells) were examined in patients with multiple myeloma (MM). RESULTS. Plasma cells secrete VEGF-A (and VEGF-B, VEGF-C and VEGF-D, albeit marginally) into their conditioned medium (CM). CM VEGF-A stimulates proliferation and chemotaxis in endothelial cells (both being mandatory for angiogenesis) via VEGF receptor-2 (VEGFR-2), and in residual stromal cells via the VEGFR-1. Residual stromal cells secrete VEGF-C and VEGF-D, but little of the other homologs. Their CM VEGF-C and VEGF-D increase in response to plasma cell CM and trigger plasma cell proliferation via VEGFR-3. Proliferation in all cell types parallels VEGFR and extracellular signal-regulated protein kinase-2 (ERK-2) phosphorylation. The homologs and receptors are weakly or inconstantly expressed in patients with monoclonal gammopathies of undetermined significance or vitamin B12/iron Deficiency Anemias. INTERPRETATION AND CONCLUSIONS: This study shows that the VEGF pathway is directly involved in tumor angiogenesis and growth in MM. A paracrine VEGF loop for MM progression is suggested. This, in turn, provides a further indication that the VEGF pathway and its signaling proteins may be appropriate targets in the management of MM.
