The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform

Gisele Soubrane - One of the best experts on this subject based on the ideXlab platform.

  • Surgical treatment of subfoveal neovascularization in Myopia: macular translocation vs surgical removal.
    American journal of ophthalmology, 2002
    Co-Authors: Nadine Hamelin, G Coscas, Agnès Glacet-bernard, Christophe Brindeau, G. Mimoun, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To compare the visual outcome of two different surgical approaches for subfoveal neovascularization in Degenerative Myopia: macular translocation and surgical removal of choroidal neovascularization (CNV). DESIGN: Interventional case series. METHODS: Retrospectively, 32 eyes with Degenerative Myopia (axial length over 26 mm or refraction over −6 diopters) and subfoveal CNV of 32 consecutive patients operated on by either surgical removal of CNV or limited macular translocation were reviewed. Surgical removal of CNV was performed in 18 eyes and limited macular translocation with a twofold suture in 14 eyes. The main outcome measurements were best-corrected visual acuity (BCVA) and findings from fluorescein angiography. Postoperatively, mean ± SD follow up was 14 ± 15 months (range, 6–48 months) in the removal group and 11 ± 4 months (range, 6–24 months, P = .37) in the translocation group. RESULTS: In both groups, there was no significant difference in preoperative age, sex, refractive error, or BCVA. The average of postoperative BCVA was statistically better after macular translocation (10 ETDRS lines or 20/100) than after surgical removal (6 lines 10/125, P = .019). Visual acuity improved by 3.8 lines after macular translocation and was unchanged after surgical removal (−0.7 line, P = .011). Macular translocation was successful in shifting the CNV to an extrafoveal location in 11 out of 14 eyes. Mean foveal displacement of all 18 translocated eyes was 695 ± 426 μm (range, 100–1520 μm). Recurrence of CNV occurred in seven eyes (39%) after surgical removal and in two eyes (14%) after translocation. Retinal detachment occurred in two eyes in each group. CONCLUSION: In this retrospective study, eyes with Degenerative Myopia and subfoveal neovascularization treated with limited macular translocation had better visual acuity recovery than eyes treated with surgical removal of the choroidal neovascularization. Further studies are required to confirm these results.

  • Imaging analysis with optical coherence tomography: relevance for submacular surgery in high Myopia and in multifocal choroiditis.
    Retina (Philadelphia Pa.), 2002
    Co-Authors: Ricky Zolf, G Coscas, Agnès Glacet-bernard, G. Mimoun, Nathanael Benhamou, Gisele Soubrane
    Abstract:

    To classify the preoperative and postoperative optical coherence tomography (OCT) findings for subfoveal choroidal neovascularization (CNV) related to high Myopia and multifocal choroiditis (MFC) and to correlate these findings with surgical outcome. Ten consecutive patients presenting with subfoveal CNV related to either MFC or Degenerative Myopia were evaluated. Each patient underwent a biomicroscopic examination, fluorescein and indocyanine green angiographies, as well as OCT before and after surgical removal of CNV. Four different parameters were considered in the analysis of all OCT scans: tissue reflectivity, location of the CNV band, presence or absence of a separation zone, and reflectivity underneath the retinal pigment epithelium (RPE) band. For all six eyes with MFC, OCT showed a hyperreflective band anterior to the RPE with a separation zone and an optically clear zone underneath the RPE. Visual acuity improved in all six eyes. For the Degenerative Myopia group (4 eyes), OCT revealed findings similar to those observed for MFC for 1 eye, which had a favorable postoperative outcome. The remaining three myopic eyes with different OCT patterns had poor postoperative outcomes. Optical coherence tomography can provide preoperative clues for submacular surgery. Eyes with CNV located anterior to and separated from the RPE that have an "optically clear zone" underneath are the best candidates for surgical removal. Such a feature was correlated with a good postoperative outcome.

  • translocation of the macula for management of subfoveal choroidal neovascularization comparison of results in age related macular degeneration and Degenerative Myopia
    American Journal of Ophthalmology, 2001
    Co-Authors: A Glacetbernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. METHODS: The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). RESULTS: The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group ( P P CONCLUSIONS: Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

  • Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and Degenerative Myopia.
    American journal of ophthalmology, 2001
    Co-Authors: Agnès Glacet-bernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group (P <.05). At the end of follow-up, visual acuity improved by 2 lines or more in seven age-related macular degeneration eyes (30%), including four eyes (13%) with an improvement of 6 lines or more, and in six myopic eyes (67%), including two eyes (22%) with an improvement of 6 lines or more. Final visual acuity was unchanged in four age-related macular degeneration eyes (17%) and three myopic eyes (33%), and decreased in 12 age-related macular degeneration eyes (52%). Conversely, the mean foveal displacement was greater in age-related macular degeneration than in Myopia (1,105 microm and 685 microm, respectively; P <.05). Main complications were retinal detachment (six eyes), neovascularization at the injection site (two eyes), and recurrence of neovascularization (43% of the age-related macular degeneration group and 11% of the myopic group). Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

  • The macula lutea in Myopia
    La Revue du praticien, 1993
    Co-Authors: Gisele Soubrane, Coscas G
    Abstract:

    High or Degenerative Myopia is associated to abnormalities of the posterior pole of the eye. Their expansion with time progresses to the occurrence of complications, especially neovascular ingrowth in the central macular area. The natural evolution of these new vessels results in loss of central vision at long term. Photocoagulation of the new vessels, sparing initially the center, has delayed the loss of central vision at 2 years in our randomized clinical trial. Only treated eyes retained useful acuity at 5 years. New therapeutic modalities will be possible when the mechanisms of occurrence of Degenerative Myopia are elucidated.

G Coscas - One of the best experts on this subject based on the ideXlab platform.

  • Surgical treatment of subfoveal neovascularization in Myopia: macular translocation vs surgical removal.
    American journal of ophthalmology, 2002
    Co-Authors: Nadine Hamelin, G Coscas, Agnès Glacet-bernard, Christophe Brindeau, G. Mimoun, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To compare the visual outcome of two different surgical approaches for subfoveal neovascularization in Degenerative Myopia: macular translocation and surgical removal of choroidal neovascularization (CNV). DESIGN: Interventional case series. METHODS: Retrospectively, 32 eyes with Degenerative Myopia (axial length over 26 mm or refraction over −6 diopters) and subfoveal CNV of 32 consecutive patients operated on by either surgical removal of CNV or limited macular translocation were reviewed. Surgical removal of CNV was performed in 18 eyes and limited macular translocation with a twofold suture in 14 eyes. The main outcome measurements were best-corrected visual acuity (BCVA) and findings from fluorescein angiography. Postoperatively, mean ± SD follow up was 14 ± 15 months (range, 6–48 months) in the removal group and 11 ± 4 months (range, 6–24 months, P = .37) in the translocation group. RESULTS: In both groups, there was no significant difference in preoperative age, sex, refractive error, or BCVA. The average of postoperative BCVA was statistically better after macular translocation (10 ETDRS lines or 20/100) than after surgical removal (6 lines 10/125, P = .019). Visual acuity improved by 3.8 lines after macular translocation and was unchanged after surgical removal (−0.7 line, P = .011). Macular translocation was successful in shifting the CNV to an extrafoveal location in 11 out of 14 eyes. Mean foveal displacement of all 18 translocated eyes was 695 ± 426 μm (range, 100–1520 μm). Recurrence of CNV occurred in seven eyes (39%) after surgical removal and in two eyes (14%) after translocation. Retinal detachment occurred in two eyes in each group. CONCLUSION: In this retrospective study, eyes with Degenerative Myopia and subfoveal neovascularization treated with limited macular translocation had better visual acuity recovery than eyes treated with surgical removal of the choroidal neovascularization. Further studies are required to confirm these results.

  • Imaging analysis with optical coherence tomography: relevance for submacular surgery in high Myopia and in multifocal choroiditis.
    Retina (Philadelphia Pa.), 2002
    Co-Authors: Ricky Zolf, G Coscas, Agnès Glacet-bernard, G. Mimoun, Nathanael Benhamou, Gisele Soubrane
    Abstract:

    To classify the preoperative and postoperative optical coherence tomography (OCT) findings for subfoveal choroidal neovascularization (CNV) related to high Myopia and multifocal choroiditis (MFC) and to correlate these findings with surgical outcome. Ten consecutive patients presenting with subfoveal CNV related to either MFC or Degenerative Myopia were evaluated. Each patient underwent a biomicroscopic examination, fluorescein and indocyanine green angiographies, as well as OCT before and after surgical removal of CNV. Four different parameters were considered in the analysis of all OCT scans: tissue reflectivity, location of the CNV band, presence or absence of a separation zone, and reflectivity underneath the retinal pigment epithelium (RPE) band. For all six eyes with MFC, OCT showed a hyperreflective band anterior to the RPE with a separation zone and an optically clear zone underneath the RPE. Visual acuity improved in all six eyes. For the Degenerative Myopia group (4 eyes), OCT revealed findings similar to those observed for MFC for 1 eye, which had a favorable postoperative outcome. The remaining three myopic eyes with different OCT patterns had poor postoperative outcomes. Optical coherence tomography can provide preoperative clues for submacular surgery. Eyes with CNV located anterior to and separated from the RPE that have an "optically clear zone" underneath are the best candidates for surgical removal. Such a feature was correlated with a good postoperative outcome.

  • Évolution de la néovascularisation choroïdienne après translocation maculaire dans la DMLA et dans la myopie forte
    Journal francais d'ophtalmologie, 2002
    Co-Authors: P Simon, G Coscas, Agnès Glacet-bernard, G. Soubrane
    Abstract:

    To study the progression of choroidal neovascularization (CNV) after macular translocation in age-related macular degeneration (AMD) and Degenerative Myopia. The data from 42 consecutive eyes (28 AMD, and 14 Degenerative Myopia) operated on by limited macular translocation (DeJuan technique), with a follow-up of 6 months or more, were prospectively analyzed. In the AMD group, neovascularization was classic in 54% of eyes and classic and occult in 46% of eyes. Previous laser treatment was applied on extra- or juxtafoveal CNV in 3 eyes. The major outcome measures were visual acuity, fluorescein and indocyanine green angiographies. After translocation, foveal displacement was greater in AMD than in myopic eyes (mean: 1 260 and 812 micro m, respectively). Laser photocoagulation was applied postoperatively onto extra-or juxtafoveal CNV in 26 (93%) AMD eyes and 12 myopic eyes (86%). Mean follow-up was 10 months (range, 6-18 months). Recurrence of CNV occurred in 14 AMD eyes (50%) and 2 myopic eyes (14%) an average of 5.6 months after surgery (range, 1-18 months). Recurrence was more frequent in AMD eyes with preoperative occult CNV (66%) than without (36%). Recurrence reached the new fovea in 69% of cases. Supplementary laser treatment was possible and successful on extra- or juxtafoveal recurrence in 3 eyes. Recurrence was significantly correlated with a poor visual prognosis: eyes without recurrence or with extra- or juxtafoveal recurrence had a final gain in visual acuity of 2.4 lines, eyes with subfoveal recurrence had a loss of 1.3 lines, and eyes with diffuse recurrence had a loss of 4.2 lines. CNV appeared in a new area at a BSS injection site in one eye. Occult CNV seemed to fade relatively within the first postoperative weeks, but were unchanged at the end of follow-up. In one eye, a small polypoidal lesion near the disc noted preoperatively disappeared after surgery. Our results suggest that the surgical procedure does not affect the course of classic or occult CNV. The rate of recurrence of CNV after macular translocation seemed similar to that observed after conventional laser treatment for extrafoveal CNV in AMD. Neovascular recurrence is the most frequent postoperative complication and was frequently directed at the new fovea. Despite these complications, macular translocation moves CNV outside of the subfoveolar zone so the eyes can be treated with conventional laser, leading to a favorable outcome at the last follow-up in 57% of cases. Further studies are required to confirm these findings and to define the best criteria for treatment.

  • translocation of the macula for management of subfoveal choroidal neovascularization comparison of results in age related macular degeneration and Degenerative Myopia
    American Journal of Ophthalmology, 2001
    Co-Authors: A Glacetbernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. METHODS: The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). RESULTS: The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group ( P P CONCLUSIONS: Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

  • Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and Degenerative Myopia.
    American journal of ophthalmology, 2001
    Co-Authors: Agnès Glacet-bernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group (P <.05). At the end of follow-up, visual acuity improved by 2 lines or more in seven age-related macular degeneration eyes (30%), including four eyes (13%) with an improvement of 6 lines or more, and in six myopic eyes (67%), including two eyes (22%) with an improvement of 6 lines or more. Final visual acuity was unchanged in four age-related macular degeneration eyes (17%) and three myopic eyes (33%), and decreased in 12 age-related macular degeneration eyes (52%). Conversely, the mean foveal displacement was greater in age-related macular degeneration than in Myopia (1,105 microm and 685 microm, respectively; P <.05). Main complications were retinal detachment (six eyes), neovascularization at the injection site (two eyes), and recurrence of neovascularization (43% of the age-related macular degeneration group and 11% of the myopic group). Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

Nadine Hamelin - One of the best experts on this subject based on the ideXlab platform.

  • Surgical treatment of subfoveal neovascularization in Myopia: macular translocation vs surgical removal.
    American journal of ophthalmology, 2002
    Co-Authors: Nadine Hamelin, G Coscas, Agnès Glacet-bernard, Christophe Brindeau, G. Mimoun, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To compare the visual outcome of two different surgical approaches for subfoveal neovascularization in Degenerative Myopia: macular translocation and surgical removal of choroidal neovascularization (CNV). DESIGN: Interventional case series. METHODS: Retrospectively, 32 eyes with Degenerative Myopia (axial length over 26 mm or refraction over −6 diopters) and subfoveal CNV of 32 consecutive patients operated on by either surgical removal of CNV or limited macular translocation were reviewed. Surgical removal of CNV was performed in 18 eyes and limited macular translocation with a twofold suture in 14 eyes. The main outcome measurements were best-corrected visual acuity (BCVA) and findings from fluorescein angiography. Postoperatively, mean ± SD follow up was 14 ± 15 months (range, 6–48 months) in the removal group and 11 ± 4 months (range, 6–24 months, P = .37) in the translocation group. RESULTS: In both groups, there was no significant difference in preoperative age, sex, refractive error, or BCVA. The average of postoperative BCVA was statistically better after macular translocation (10 ETDRS lines or 20/100) than after surgical removal (6 lines 10/125, P = .019). Visual acuity improved by 3.8 lines after macular translocation and was unchanged after surgical removal (−0.7 line, P = .011). Macular translocation was successful in shifting the CNV to an extrafoveal location in 11 out of 14 eyes. Mean foveal displacement of all 18 translocated eyes was 695 ± 426 μm (range, 100–1520 μm). Recurrence of CNV occurred in seven eyes (39%) after surgical removal and in two eyes (14%) after translocation. Retinal detachment occurred in two eyes in each group. CONCLUSION: In this retrospective study, eyes with Degenerative Myopia and subfoveal neovascularization treated with limited macular translocation had better visual acuity recovery than eyes treated with surgical removal of the choroidal neovascularization. Further studies are required to confirm these results.

  • translocation of the macula for management of subfoveal choroidal neovascularization comparison of results in age related macular degeneration and Degenerative Myopia
    American Journal of Ophthalmology, 2001
    Co-Authors: A Glacetbernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. METHODS: The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). RESULTS: The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group ( P P CONCLUSIONS: Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

  • Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and Degenerative Myopia.
    American journal of ophthalmology, 2001
    Co-Authors: Agnès Glacet-bernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group (P <.05). At the end of follow-up, visual acuity improved by 2 lines or more in seven age-related macular degeneration eyes (30%), including four eyes (13%) with an improvement of 6 lines or more, and in six myopic eyes (67%), including two eyes (22%) with an improvement of 6 lines or more. Final visual acuity was unchanged in four age-related macular degeneration eyes (17%) and three myopic eyes (33%), and decreased in 12 age-related macular degeneration eyes (52%). Conversely, the mean foveal displacement was greater in age-related macular degeneration than in Myopia (1,105 microm and 685 microm, respectively; P <.05). Main complications were retinal detachment (six eyes), neovascularization at the injection site (two eyes), and recurrence of neovascularization (43% of the age-related macular degeneration group and 11% of the myopic group). Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

Agnès Glacet-bernard - One of the best experts on this subject based on the ideXlab platform.

  • Surgical treatment of subfoveal neovascularization in Myopia: macular translocation vs surgical removal.
    American journal of ophthalmology, 2002
    Co-Authors: Nadine Hamelin, G Coscas, Agnès Glacet-bernard, Christophe Brindeau, G. Mimoun, Gisele Soubrane
    Abstract:

    Abstract PURPOSE: To compare the visual outcome of two different surgical approaches for subfoveal neovascularization in Degenerative Myopia: macular translocation and surgical removal of choroidal neovascularization (CNV). DESIGN: Interventional case series. METHODS: Retrospectively, 32 eyes with Degenerative Myopia (axial length over 26 mm or refraction over −6 diopters) and subfoveal CNV of 32 consecutive patients operated on by either surgical removal of CNV or limited macular translocation were reviewed. Surgical removal of CNV was performed in 18 eyes and limited macular translocation with a twofold suture in 14 eyes. The main outcome measurements were best-corrected visual acuity (BCVA) and findings from fluorescein angiography. Postoperatively, mean ± SD follow up was 14 ± 15 months (range, 6–48 months) in the removal group and 11 ± 4 months (range, 6–24 months, P = .37) in the translocation group. RESULTS: In both groups, there was no significant difference in preoperative age, sex, refractive error, or BCVA. The average of postoperative BCVA was statistically better after macular translocation (10 ETDRS lines or 20/100) than after surgical removal (6 lines 10/125, P = .019). Visual acuity improved by 3.8 lines after macular translocation and was unchanged after surgical removal (−0.7 line, P = .011). Macular translocation was successful in shifting the CNV to an extrafoveal location in 11 out of 14 eyes. Mean foveal displacement of all 18 translocated eyes was 695 ± 426 μm (range, 100–1520 μm). Recurrence of CNV occurred in seven eyes (39%) after surgical removal and in two eyes (14%) after translocation. Retinal detachment occurred in two eyes in each group. CONCLUSION: In this retrospective study, eyes with Degenerative Myopia and subfoveal neovascularization treated with limited macular translocation had better visual acuity recovery than eyes treated with surgical removal of the choroidal neovascularization. Further studies are required to confirm these results.

  • Imaging analysis with optical coherence tomography: relevance for submacular surgery in high Myopia and in multifocal choroiditis.
    Retina (Philadelphia Pa.), 2002
    Co-Authors: Ricky Zolf, G Coscas, Agnès Glacet-bernard, G. Mimoun, Nathanael Benhamou, Gisele Soubrane
    Abstract:

    To classify the preoperative and postoperative optical coherence tomography (OCT) findings for subfoveal choroidal neovascularization (CNV) related to high Myopia and multifocal choroiditis (MFC) and to correlate these findings with surgical outcome. Ten consecutive patients presenting with subfoveal CNV related to either MFC or Degenerative Myopia were evaluated. Each patient underwent a biomicroscopic examination, fluorescein and indocyanine green angiographies, as well as OCT before and after surgical removal of CNV. Four different parameters were considered in the analysis of all OCT scans: tissue reflectivity, location of the CNV band, presence or absence of a separation zone, and reflectivity underneath the retinal pigment epithelium (RPE) band. For all six eyes with MFC, OCT showed a hyperreflective band anterior to the RPE with a separation zone and an optically clear zone underneath the RPE. Visual acuity improved in all six eyes. For the Degenerative Myopia group (4 eyes), OCT revealed findings similar to those observed for MFC for 1 eye, which had a favorable postoperative outcome. The remaining three myopic eyes with different OCT patterns had poor postoperative outcomes. Optical coherence tomography can provide preoperative clues for submacular surgery. Eyes with CNV located anterior to and separated from the RPE that have an "optically clear zone" underneath are the best candidates for surgical removal. Such a feature was correlated with a good postoperative outcome.

  • Évolution de la néovascularisation choroïdienne après translocation maculaire dans la DMLA et dans la myopie forte
    Journal francais d'ophtalmologie, 2002
    Co-Authors: P Simon, G Coscas, Agnès Glacet-bernard, G. Soubrane
    Abstract:

    To study the progression of choroidal neovascularization (CNV) after macular translocation in age-related macular degeneration (AMD) and Degenerative Myopia. The data from 42 consecutive eyes (28 AMD, and 14 Degenerative Myopia) operated on by limited macular translocation (DeJuan technique), with a follow-up of 6 months or more, were prospectively analyzed. In the AMD group, neovascularization was classic in 54% of eyes and classic and occult in 46% of eyes. Previous laser treatment was applied on extra- or juxtafoveal CNV in 3 eyes. The major outcome measures were visual acuity, fluorescein and indocyanine green angiographies. After translocation, foveal displacement was greater in AMD than in myopic eyes (mean: 1 260 and 812 micro m, respectively). Laser photocoagulation was applied postoperatively onto extra-or juxtafoveal CNV in 26 (93%) AMD eyes and 12 myopic eyes (86%). Mean follow-up was 10 months (range, 6-18 months). Recurrence of CNV occurred in 14 AMD eyes (50%) and 2 myopic eyes (14%) an average of 5.6 months after surgery (range, 1-18 months). Recurrence was more frequent in AMD eyes with preoperative occult CNV (66%) than without (36%). Recurrence reached the new fovea in 69% of cases. Supplementary laser treatment was possible and successful on extra- or juxtafoveal recurrence in 3 eyes. Recurrence was significantly correlated with a poor visual prognosis: eyes without recurrence or with extra- or juxtafoveal recurrence had a final gain in visual acuity of 2.4 lines, eyes with subfoveal recurrence had a loss of 1.3 lines, and eyes with diffuse recurrence had a loss of 4.2 lines. CNV appeared in a new area at a BSS injection site in one eye. Occult CNV seemed to fade relatively within the first postoperative weeks, but were unchanged at the end of follow-up. In one eye, a small polypoidal lesion near the disc noted preoperatively disappeared after surgery. Our results suggest that the surgical procedure does not affect the course of classic or occult CNV. The rate of recurrence of CNV after macular translocation seemed similar to that observed after conventional laser treatment for extrafoveal CNV in AMD. Neovascular recurrence is the most frequent postoperative complication and was frequently directed at the new fovea. Despite these complications, macular translocation moves CNV outside of the subfoveolar zone so the eyes can be treated with conventional laser, leading to a favorable outcome at the last follow-up in 57% of cases. Further studies are required to confirm these findings and to define the best criteria for treatment.

  • Translocation of the macula for management of subfoveal choroidal neovascularization: comparison of results in age-related macular degeneration and Degenerative Myopia.
    American journal of ophthalmology, 2001
    Co-Authors: Agnès Glacet-bernard, P Simon, Nadine Hamelin, G Coscas, Gisele Soubrane
    Abstract:

    To report the results of limited macular translocation in subfoveal choroidal neovascularization resulting from age-related macular degeneration or Degenerative Myopia. The first consecutive 32 patients (23 age-related macular degeneration eyes and nine myopic eyes) were operated on with the limited macular translocation technique described by de Juan. Before and after surgery, a complete examination included fluorescein and indocyanine-green angiographies and optical coherence tomography. Mean follow-up was 9 months in the age-related macular degeneration group (range, 6 to 14 months) and 10 months in the myopic group (range, 6 to 15 months). The improvement in visual acuity was better in the myopic group than in the age-related macular degeneration group and was correlated with younger age in the myopic group (P <.05). At the end of follow-up, visual acuity improved by 2 lines or more in seven age-related macular degeneration eyes (30%), including four eyes (13%) with an improvement of 6 lines or more, and in six myopic eyes (67%), including two eyes (22%) with an improvement of 6 lines or more. Final visual acuity was unchanged in four age-related macular degeneration eyes (17%) and three myopic eyes (33%), and decreased in 12 age-related macular degeneration eyes (52%). Conversely, the mean foveal displacement was greater in age-related macular degeneration than in Myopia (1,105 microm and 685 microm, respectively; P <.05). Main complications were retinal detachment (six eyes), neovascularization at the injection site (two eyes), and recurrence of neovascularization (43% of the age-related macular degeneration group and 11% of the myopic group). Limited macular translocation allowed a significant improvement in visual acuity in some eyes with subfoveal neovascularization and resulted in a moderate rate of complications. Longer follow-up and additional studies are required to confirm these findings.

  • Surgical removal of subfoveal choroidal neovascularization: visual outcome and prognostic value of fluorescein angiography and optical coherence tomography
    European journal of ophthalmology, 2001
    Co-Authors: C Brindeau, G Coscas, Agnès Glacet-bernard, G. Mimoun, Florence Coscas, L Boukhli, G. Soubrane
    Abstract:

    PURPOSE. To study the functional results of macular surgery and determine pre-operative features associated with better final visual outcome. METHODS. Forty-two consecutive patients underwent surgical removal of subfoveal choroidal neovascularization (CNV), related to age-related macular degeneration (AMD) in 8 eyes, Degenerative Myopia in 14 eyes, multifocal choroiditis (MFC) in 10 eyes, idiopathic CNV in 6 eyes and other etiologies in 4 eyes. Mean age was 49 years. Pre-operative visual acuity (VA) was 20/200 or less in 30 eyes (71.4%) and never better than 20/40. Fluorescein angiography was analyzed before and after surgery. Pre-operative optical coherence tomographs (OCT) were studied in a masked fashion. Mean follow-up was 12 months (range 4-48 months). RESULTS. Final VA was 20/200 or less in 25 eyes (60%). According to the CNV etiology, the percentage were 87.5%, 80%, 57.1% and 20% respectively in eyes with AMD, MFC, high Myopia, and idiopathic or other diseases. Post-operative VA improved in 21 eyes (50%) but subsequently declined in 7% by the final examination. Patients younger than 50 years had better functional results (p=0.006). Lack of retinal pigment epithelium (RPE) changes on pre-operative angiography was correlated with good visual outcome (p

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  • original paper protective effect on visual functions of long term use of trimetazidine in treatment of primary open angle glaucoma and Degenerative Myopia
    Archives of Medical Science, 2007
    Co-Authors: Michal S Nowak, Katarzyna Wybor, Roman Goś, Alicja Zemanmiecznik, Arleta Waszczykowska, Miroslaw Pastuszka, Anna Klysik, Agnieszka Gajdowska
    Abstract:

    Introduction: The purpose of the study was to evaluate selected visual parameters in the group of patients undergoing long-term treatment with trimetazidine as an adjuvant therapy for primary open angle glaucoma and Degenerative Myopia. Material and methods: Thirty patients, including 20 patients with advanced primary open angle glaucoma (40 eyes) and 10 patients with severe Degenerative Myopia (20 eyes), were treated with trimetazidine 20 mg twice a day. We excluded from the study patients with: systemic hypertension and/or diabetes, cataract, history of chronic and recurrent severe inflammatory eye disease and smokers. Patients with primary open angle glaucoma were taking various ocular hypotensive drops topically. Ophthalmic examination has been performed before administration of trimetazidine and then every month. Visual acuity, contrast sensitivity test (Pelli-Robson test), glare test, color vision (Farnsworth-Munsell test) and visual field were recorded. Follow-up period was 6 months. For statistical analysis paired Student’s t- test (p<0.05) was used. Results: The contrast sensitivity and visual acuity improved in all patients and the results were statistically significant. Glare tests, colour vision and visual fields did not reveal any statistically significant changes. Conclusions: The results of the study demonstrate that long term use of trimetazidine improved contrast sensitivity and visual acuity. The drug was well tolerated and might be considered as the adjunctive therapy in patients with primary open angle glaucoma and Degenerative Myopia.

  • Original paper Protective effect on visual functions of long-term use of trimetazidine in treatment of primary open angle glaucoma and Degenerative Myopia
    Archives of Medical Science, 2007
    Co-Authors: Michal S Nowak, Katarzyna Wybor, Roman Goś, Arleta Waszczykowska, Miroslaw Pastuszka, Anna Klysik, Alicja Zeman-miecznik, Agnieszka Gajdowska
    Abstract:

    Introduction: The purpose of the study was to evaluate selected visual parameters in the group of patients undergoing long-term treatment with trimetazidine as an adjuvant therapy for primary open angle glaucoma and Degenerative Myopia. Material and methods: Thirty patients, including 20 patients with advanced primary open angle glaucoma (40 eyes) and 10 patients with severe Degenerative Myopia (20 eyes), were treated with trimetazidine 20 mg twice a day. We excluded from the study patients with: systemic hypertension and/or diabetes, cataract, history of chronic and recurrent severe inflammatory eye disease and smokers. Patients with primary open angle glaucoma were taking various ocular hypotensive drops topically. Ophthalmic examination has been performed before administration of trimetazidine and then every month. Visual acuity, contrast sensitivity test (Pelli-Robson test), glare test, color vision (Farnsworth-Munsell test) and visual field were recorded. Follow-up period was 6 months. For statistical analysis paired Student’s t- test (p

  • Original paperProtective effect on visual functions of long-term use of trimetazidine in treatment of primary open angle glaucoma and Degenerative Myopia
    Termedia Publishing House, 2007
    Co-Authors: Michal S Nowak, Katarzyna Wybor, Roman Goś, Arleta Waszczykowska, Miroslaw Pastuszka, Alicja Zeman-miecznik, Anna Kłysik, Agnieszka Gajdowska
    Abstract:

    Introduction: The purpose of the study was to evaluate selected visual parameters in the group of patients undergoing long-term treatment with trimetazidine as an adjuvant therapy for primary open angle glaucoma and Degenerative Myopia.Material and methods: Thirty patients, including 20 patients with advanced primary open angle glaucoma (40 eyes) and 10 patients with severe Degenerative Myopia (20 eyes), were treated with trimetazidine 20 mg twice a day. We excluded from the study patients with: systemic hypertension and/or diabetes, cataract, history of chronic and recurrent severe inflammatory eye disease and smokers. Patients with primary open angle glaucoma were taking various ocular hypotensive drops topically. Ophthalmic examination has been performed before administration of trimetazidine and then every month. Visual acuity, contrast sensitivity test (Pelli-Robson test), glare test, color vision (Farnsworth-Munsell test) and visual field were recorded. Follow-up period was 6 months. For statistical analysis paired Student’s t- test (p