The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Steven M Haffner - One of the best experts on this subject based on the ideXlab platform.

  • Relation of sex hormones and Dehydroepiandrosterone Sulfate (DHEA-so4) to cardiovascular risk factors in postmenopausal women
    American Journal of Epidemiology, 1995
    Co-Authors: Steven M Haffner, Barbara E. K. Klein, P. M. Marcus, Polly A. Newcomb, Ronald Klein
    Abstract:

    Sex hormones play a major role in determining the risk of cardiovascular disease. While several studies have shown that reduced sex hormone-binding globulin is associated with an atherogenic pattern of lipoproteins and increased glucose concentrations in premenopausal women, little data are available examining the association of sex hormone-binding globulin and sex hormones with cardiovascular risk factors in postmenopausal women, a group with high rates of cardiovascular disease. The investigators hypothesized that in postmenopausal women decreased sex hormone-binding globulin and increased testosterone would be associated with an atherogenic pattern of cardiovascular risk factors. The sex hormone-binding globulin, total and free testosterone, estrone, and Dehydroepiandrosterone Sulfate (DHEA-SO-4) in 253 postmenopausal women who were not taking hormones were measured in a population-based study, the Beaver Dam Eye Study (Beaver Dam, Wisconsin, 1988-1990). Sex hormone-binding globulin was significantly inversely correlated with body mass index (r = -0.53, p lt 0.001), glycosylated hemoglobin (r = -0.34, p lt 0.001), and diastolic blood pressure (r = -0.25, p lt 0.01), and positively correlated with high density lipoprotein cholesterol (HDL cholesterol) (r = 0.31, p lt 0.001), and HDL cholesterol/total cholesterol (r = 0.31, p lt -.001). Total (r = -0.20, p lt 0.01) and free (r = -0.14, p lt 0.05) testosterone were significantly inversely correlated with HDL cholesterol/total cholesterol ratio. Total testosterone concentrations were also significantly positively correlated with total cholesterol (r = 0.15), body mass index (r = 0.16), and systolic (r = 0.17) and diastolic (r = 0.1 8) blood pressures (all p lt 0.01). DHEA-SO-4 was not associated with any of the metabolic variables, while estrone was inversely associated only with the HDL cholesterol/total cholesterol ratio (r = 0.13, p lt 0.05). The authors conclude that increased androgenization in postmenopausal women is associated with atherogenic changes in cardiovascular risk factors

  • decreased testosterone and Dehydroepiandrosterone Sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men
    Metabolism-clinical and Experimental, 1994
    Co-Authors: Steven M Haffner, Rodolfo Valdez, Leena Mykkanen, Michael P Stern, Michael S Katz
    Abstract:

    Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, Dehydroepiandrosterone Sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.

Michael S Katz - One of the best experts on this subject based on the ideXlab platform.

  • decreased testosterone and Dehydroepiandrosterone Sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men
    Metabolism-clinical and Experimental, 1994
    Co-Authors: Steven M Haffner, Rodolfo Valdez, Leena Mykkanen, Michael P Stern, Michael S Katz
    Abstract:

    Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, Dehydroepiandrosterone Sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.

Hubert Vaudry - One of the best experts on this subject based on the ideXlab platform.

  • Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the hypothalamus
    Endocrinology, 2013
    Co-Authors: Delphine Burel, Jae Young Seong, Hyuk Bang Kwon, Jean-luc Do-rego, Ai Fen Wang, Van Luu-the, Georges Pelletier, Yves Tillet, Catherine Taragnat, Hubert Vaudry
    Abstract:

    The Sulfated neurosteroids pregnenolone Sulfate (Δ(5)PS) and Dehydroepiandrosterone Sulfate (DHEAS) are known to play a role in the control of reproductive behavior. In the frog Pelophylax ridibundus, the enzyme hydroxysteroid sulfotransferase (HST), responsible for the biosynthesis of Δ(5)PS and DHEAS, is expressed in the magnocellular nucleus (Mgd) and the anterior preoptic area (Poa), two hypothalamic regions that are richly innervated by GnRH1-containing fibers. This observation suggests that GnRH1 may regulate the formation of Sulfated neurosteroids to control sexual activity. Double-labeling of frog brain slices with HST and GnRH1 antibodies revealed that GnRH1-immunoreactive fibers are located in close vicinity of HST-positive neurons. The cDNAs encoding three GnRH receptors (designated riGnRHR-1, -2, and -3) were cloned from the frog brain. Reverse transcription-polymerase chain reaction analyses revealed that riGnRHR-1 is strongly expressed in the hypothalamus and the pituitary while riGnRHR-2 and -3 are primarily expressed in the brain. In situ hybridization histochemistry indicated that GnRHR-1 and GnRHR-3 mRNAs are particularly abundant in Poa and Mgd whereas the concentration of GnRHR-2 mRNA in these two nuclei is much lower. Pulse-chase experiments using tritiated Δ(5)P and DHEA as steroid precursors, and 3'-phosphoadenosine 5'-phosphoSulfate (PAPS) as a sulfonate moiety donor, showed that GnRH1 stimulates in a dose-dependent manner the biosynthesis of Δ(5)PS and DHEAS in frog diencephalic explants. Since Δ(5)PS and DHEAS, like GnRH, stimulate sexual activity, our data strongly suggest that some of the behavioral effects of GnRH could be mediated via the modulation of Sulfated neurosteroid production.

Ronald Klein - One of the best experts on this subject based on the ideXlab platform.

  • Relation of sex hormones and Dehydroepiandrosterone Sulfate (DHEA-so4) to cardiovascular risk factors in postmenopausal women
    American Journal of Epidemiology, 1995
    Co-Authors: Steven M Haffner, Barbara E. K. Klein, P. M. Marcus, Polly A. Newcomb, Ronald Klein
    Abstract:

    Sex hormones play a major role in determining the risk of cardiovascular disease. While several studies have shown that reduced sex hormone-binding globulin is associated with an atherogenic pattern of lipoproteins and increased glucose concentrations in premenopausal women, little data are available examining the association of sex hormone-binding globulin and sex hormones with cardiovascular risk factors in postmenopausal women, a group with high rates of cardiovascular disease. The investigators hypothesized that in postmenopausal women decreased sex hormone-binding globulin and increased testosterone would be associated with an atherogenic pattern of cardiovascular risk factors. The sex hormone-binding globulin, total and free testosterone, estrone, and Dehydroepiandrosterone Sulfate (DHEA-SO-4) in 253 postmenopausal women who were not taking hormones were measured in a population-based study, the Beaver Dam Eye Study (Beaver Dam, Wisconsin, 1988-1990). Sex hormone-binding globulin was significantly inversely correlated with body mass index (r = -0.53, p lt 0.001), glycosylated hemoglobin (r = -0.34, p lt 0.001), and diastolic blood pressure (r = -0.25, p lt 0.01), and positively correlated with high density lipoprotein cholesterol (HDL cholesterol) (r = 0.31, p lt 0.001), and HDL cholesterol/total cholesterol (r = 0.31, p lt -.001). Total (r = -0.20, p lt 0.01) and free (r = -0.14, p lt 0.05) testosterone were significantly inversely correlated with HDL cholesterol/total cholesterol ratio. Total testosterone concentrations were also significantly positively correlated with total cholesterol (r = 0.15), body mass index (r = 0.16), and systolic (r = 0.17) and diastolic (r = 0.1 8) blood pressures (all p lt 0.01). DHEA-SO-4 was not associated with any of the metabolic variables, while estrone was inversely associated only with the HDL cholesterol/total cholesterol ratio (r = 0.13, p lt 0.05). The authors conclude that increased androgenization in postmenopausal women is associated with atherogenic changes in cardiovascular risk factors

Bill L Lasley - One of the best experts on this subject based on the ideXlab platform.

  • circulating Dehydroepiandrosterone Sulfate levels in women who underwent bilateral salpingo oophorectomy during the menopausal transition
    Menopause, 2011
    Co-Authors: Bill L Lasley, Sybil L Crawford, Gail A Laughlin, Nanette Santoro, Daniel S Mcconnell, Carolyn J Crandall, Gail A Greendale, Alex J Polotsky, Marike Vuga
    Abstract:

    Background A rise in circulating Dehydroepiandrosterone Sulfate (DHEAS) concentration occurs during the menopausal transition (MT) that is ovarian-stage but not age-related. The objective of this study was to determine the source of the rise in circulating DHEAS.

  • circulating Dehydroepiandrosterone Sulfate concentrations during the menopausal transition
    The Journal of Clinical Endocrinology and Metabolism, 2009
    Co-Authors: Sybil L Crawford, Gail A Laughlin, Nanette Santoro, Daniel S Mcconnell, Marike Vuga, Maryfran Sowers, Kim Suttontyrrell, Gerson Weiss, John F Randolph, Bill L Lasley
    Abstract:

    Context: A previous report from the Study of Women Across the Nation indicated a rise in Dehydroepiandrosterone Sulfate (DHEAS) during the menopausal transition using data from three annual visits. Objective: Our objective was to examine changes in DHEAS with chronological and ovarian aging, expanding the original analyses to include 10 yr of annual data. Design: A longitudinal observational study and cross-sectional analyses of baseline data were conducted. Outcome Measures and Subjects: DHEAS, age, menopause status, ethnicity, smoking, weight, and height were assessed in 2886 women from five ethnic groups aged 42–52 yr at entry. Hysterectomy, bilateral oophorectomy, and hormone use were excluded. Results: Cross-sectional analysis at baseline showed a linear decline in circulating log-transformed DHEAS with increasing age for either the entire cohort (2.81% per year) or for individual ethnicities. A similar negative association with baseline age (2.44% decline per year) was seen in longitudinal linear mi...