The Experts below are selected from a list of 129 Experts worldwide ranked by ideXlab platform

Rita Patrizia Aquino - One of the best experts on this subject based on the ideXlab platform.

  • novel co axial prilling technique for the development of core shell particles as Delayed Drug delivery systems
    European Journal of Pharmaceutics and Biopharmaceutics, 2014
    Co-Authors: Pasquale Del Gaudio, Giulia Auriemma, Paola Russo, Teresa Mencherini, Pietro Campiglia, Mariateresa Stigliani, Rita Patrizia Aquino
    Abstract:

    Abstract In this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory Drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the Release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled Release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) Released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the Drug was achieved during the next 3 h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to Release Drug in a Delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with Delayed Drug Release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation.

Pasquale Del Gaudio - One of the best experts on this subject based on the ideXlab platform.

  • novel co axial prilling technique for the development of core shell particles as Delayed Drug delivery systems
    European Journal of Pharmaceutics and Biopharmaceutics, 2014
    Co-Authors: Pasquale Del Gaudio, Giulia Auriemma, Paola Russo, Teresa Mencherini, Pietro Campiglia, Mariateresa Stigliani, Rita Patrizia Aquino
    Abstract:

    Abstract In this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory Drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the Release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled Release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) Released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the Drug was achieved during the next 3 h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to Release Drug in a Delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with Delayed Drug Release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation.

Giulia Auriemma - One of the best experts on this subject based on the ideXlab platform.

  • novel co axial prilling technique for the development of core shell particles as Delayed Drug delivery systems
    European Journal of Pharmaceutics and Biopharmaceutics, 2014
    Co-Authors: Pasquale Del Gaudio, Giulia Auriemma, Paola Russo, Teresa Mencherini, Pietro Campiglia, Mariateresa Stigliani, Rita Patrizia Aquino
    Abstract:

    Abstract In this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory Drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the Release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled Release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) Released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the Drug was achieved during the next 3 h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to Release Drug in a Delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with Delayed Drug Release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation.

Paola Russo - One of the best experts on this subject based on the ideXlab platform.

  • novel co axial prilling technique for the development of core shell particles as Delayed Drug delivery systems
    European Journal of Pharmaceutics and Biopharmaceutics, 2014
    Co-Authors: Pasquale Del Gaudio, Giulia Auriemma, Paola Russo, Teresa Mencherini, Pietro Campiglia, Mariateresa Stigliani, Rita Patrizia Aquino
    Abstract:

    Abstract In this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory Drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the Release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled Release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) Released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the Drug was achieved during the next 3 h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to Release Drug in a Delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with Delayed Drug Release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation.

Teresa Mencherini - One of the best experts on this subject based on the ideXlab platform.

  • novel co axial prilling technique for the development of core shell particles as Delayed Drug delivery systems
    European Journal of Pharmaceutics and Biopharmaceutics, 2014
    Co-Authors: Pasquale Del Gaudio, Giulia Auriemma, Paola Russo, Teresa Mencherini, Pietro Campiglia, Mariateresa Stigliani, Rita Patrizia Aquino
    Abstract:

    Abstract In this study, biocompatible double layered beads consisting of pectin core and alginate shell were prepared through a single step manufacturing process based on prilling apparatus equipped with co-axial nozzles. The core was loaded with piroxicam (PRX) as model non-steroidal anti-inflammatory Drug (NSAID). Morphology, size distribution and shape of the double layered beads varied depending on the operative conditions and polymer concentrations. Co-axial nozzles size, applied vibration frequency, gelling conditions and, mainly, polymers mass ratio were identified as critical variables. Particularly, the relative viscosity of polymeric feed solutions inside the nozzle was the key parameter to obtain homogeneous and well-formed coated particles. The produced beads were investigated for the Release kinetic in different media. Once PRX was encapsulated within the pectin core, a controlled Release pattern was observed. Particularly, beads produced with 4:1 core/shell ratio (F4) Released less than 30% of PRX in simulated gastric fluid (SGF) while total liberation of the Drug was achieved during the next 3 h in simulated intestinal fluid (SIF). More interesting, F4 tested in SIF was able to Release Drug in a Delayed and sustained manner at established time points (2h_8.2%, 3h_32.2%, 4h_70.1% and 5h_about 100%). Based on the above results, co-axial prilling approach is expected to provide success in manufacturing systems with Delayed Drug Release profiles. Such systems may be potentially useful in targeting diseases which are affected by the circadian rhythm, such as chronic inflammation.