The Experts below are selected from a list of 42 Experts worldwide ranked by ideXlab platform
Saxena Varsha - One of the best experts on this subject based on the ideXlab platform.
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A Case Study on the Ayurvedic Managment of Spastic Cerebral Palsy Due to Birth Asphyxia
Journal of Natural Remedies, 2019Co-Authors: Srivastava Niraj, Saxena VarshaAbstract:Background: Cerebral palsy is a disorder of motor control due to a static lesion of the developing brain. It was described almost 150 years ago. Global incidence of Cerebral Palsy is 2 to 2.5/1000 children but in Indian scenario, incidence is 03.8% of population. In India about twenty-five Lakh children are suffering from cerebral palsy. Most common type of cerebral palsy is spastic which cover 70% to 75% of overall. There is no exact correlation found for cerebral palsy in Ayurvedic literature but may be the result of Shiromarmabhighata (injury to brain) and can be considered as Vata Vikara or Vata Vyadhi (neurological disorders). Aim: To assess the effect of certain oral medication with Purvakarma (preparatory procedures) and Panchakarma procedures (Five-fold measures of Bio-cleansing) in the management of Cerebral Palsy (CP). Material and Method: In this case study, one case of Spastic cerebral palsy was registered and treated with multiple Ayurvedic treatment modalities. Total period of treatment was 93 days in which 5 days of Abhyanga (Massage) with Nadi swedana (steam kettle Sudation), 5 days of Abhyanga (Massage) with Shashti Shali Pinda Swedana (a type of Sudation) and then 7 days of Matra Vasti (Enema by Medicated oil in small dose) by Ksheera Bala Taila; this schedule of treatment was given three times with a gap of 14 days. Vacha mula (Root of Acorus calamus ) and Samvardhana Ghrita was given as internal medication during the total course of treatment. Results were assessed by progress in Delayed Milestone, anthropometrical measurement, modified Ashworth scale, muscle power grading and Manual Ability Classification System (MACS) scale. Result: Treatment protocol of oral medication with Panchkarma delivered better result in CP patient, especially improving anthropometric data (weight, height, chest circumference), delaying Milestone (walking and language), reducing spasticity and improved Quality of Life (QOL). Conclusion: Cerebral palsy is a disorder of motor function. The cause originates from the brain sometime during its developmental period. Internal medication along with Purvakarma (preparatory procedures) and Panchakarma (Five-fold measures of Bio-cleansing) give significant improvement in all the facets of spastic CP.
Grace John-stewart - One of the best experts on this subject based on the ideXlab platform.
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Comparison of developmental Milestone attainment in early treated HIV-infected infants versus HIV-unexposed infants: a prospective cohort study
BMC Pediatrics, 2017Co-Authors: Sarah Benki-nugent, Dalton Wamalwa, Agnes Langat, Kenneth Tapia, Judith Adhiambo, Daisy Chebet, Helen Moraa Okinyi, Grace John-stewartAbstract:Background Infant HIV infection is associated with Delayed Milestone attainment. The extent to which effective antiretroviral therapy (ART) prevents these delays is not well defined.
Smruti Prava Sahoo - One of the best experts on this subject based on the ideXlab platform.
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Efficacy of supracondylar knee ankle foot orthosis for hyperextended knee and heel rise in spastic cerebral palsy: A pilot clinical trial
Indian Journal of Cerebral Palsy, 2020Co-Authors: Rajesh Kumar Mohanty, Ullas Chandra Sahoo, Smruti Prava SahooAbstract:Background: Guidelines to assist with decision making for orthotic management of gait dysfunction in individual with cerebral palsy (CP) is difficult to derive and remain controversial. The research question is whether supracondylar knee ankle foot orthosis (SKAFO) is one of best options for knee hyperextension and heel rise for spastic diaplegic Cerebral palsy. Aim: The purpose of this study was to check the efficacy of bilateral molded SKAFO for knee hyperextension and heel rise for Cerebral palsy in terms of gait parameters and energy expenditure. Materials and Methods: Five individuals (mean age 3.5 years) were diagnosed as spastic diplegic and one with hemiplegic (age 5 years old) Cerebral palsy with Delayed Milestone presented with knee hyperextension and heel rise during mid-stance and were fitted with bilateral molded SKAFO with pair of shoes. Observational gait analysis by video recording was performed and gait parameters by 10 m walk test and energy expenditure using physiological cost index was recorded in bracing and non-bracing conditions. Results: The orthosis controlled knee hyperextension by not allowing the knee to go beyond neutral position. The gait was more natural with proper heel strike and better push off. There was improvement in temporal-spatial gait parameters and gait was energy efficient. Conclusion: The SKAFO was found to be effective in controlling knee hyperextension and resulted in stable, natural, satisfactory and energy efficient gait in spastic Cerebral palsy with knee hyperextension and heel rise. Similar study involving case series can be used to set the prognosis of ambulation and the kind of orthotic interventions needed to optimize the walking ability.
Sakina Aneeb - One of the best experts on this subject based on the ideXlab platform.
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De novo reciprocal translocation t(4;20) (q28;q11) associated in a child with developmental delay: Case report
Apollo Medicine, 2014Co-Authors: Kavitha Eppa, Iravathy Goud Kalal, Pranathi Reddy Guttala, Sakina AneebAbstract:Abstract The common cause of mental impairment and the wide range of physical abnormalities is balanced chromosome rearrangement. As such, it is difficult to interpret, posing as a diagnostic challenge in human development. We present a unique case report with a denovo autosomal-balanced reciprocal translocation involving chromosomal regions 4q and 20q.The etiology of the translocation, i.e. 46,XX,t (4;20)(q28;q11) was detected by conventional high-resolution Giemsa-Trypsin-Giemsabanding technique. Parents non-consanguineous, with 2 healthy children. To the best of our knowledge this is the first case reported so far with the balanced reciprocal translocation involving 4q and 20q associated with the Delayed Milestone development. Conclusion The reason likely may be due to the rearrangement of genetic material at these breakpoints having a crucial relationship and thus manifesting developmental delay in the proband.
Lalji Singh - One of the best experts on this subject based on the ideXlab platform.
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Paternally derived translocation t(8;18)(q22.1;q22)pat associated in a patient with developmental delay: Case report and review
Journal of Pediatric Neurosciences, 2020Co-Authors: Murthy Kanakavalli, Venkata Padmalatha, Pratibha Nallari, Lalji SinghAbstract:The common cause of mental impairment and the wide range of physical abnormalities is balanced chromosome rearrangement. As such, it is difficult to interpret, posing as a diagnostic challenge in human development. We present a unique familial case report with the paternally inherited autosomal-balanced reciprocal translocation involving chromosomal regions 8q and 18q. The etiology of the translocation, i.e. 46,XX,t(8;18)(q22.1;q22) was detected by conventional high-resolution Giemsa-Trypsin-Giemsa-banding and fluorescence in situ hybridization techniques. The father was found to be the carrier of the chromosome defect and also the same was observed in the first female child referred with a history of Delayed Milestone development. However, the second female child showed normal 46, XX karyotype. This is the first report of reciprocal translocation involving 8q and 18q associated with the Delayed Milestone development. The reason likely may be due to the rearrangement of genetic material at these breakpoints having a crucial relationship and thus manifesting developmental delay in the progeny. Accordingly, this paper also shows genetic counseling discussion for the cause.