The Experts below are selected from a list of 29799 Experts worldwide ranked by ideXlab platform
Qiang Zhang - One of the best experts on this subject based on the ideXlab platform.
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Lithiophilic Sites in Doped Graphene Guide Uniform Lithium Nucleation for Dendrite-Free Lithium Metal Anodes
Angewandte Chemie - International Edition, 2017Co-Authors: Rui Zhang, Chong Yan, Xue Qiang Zhang, Xin-bing Cheng, Xiao-ru Chen, Xiang Chen, Qiang ZhangAbstract:Lithium (Li) metal is the most promising electrode for next-generation rechargeable batteries. However, the challenges induced by Li Dendrites on a working Li metal anode hinder the practical applications of Li metal batteries. Herein, nitrogen (N) doped graphene was adopted as the Li plating matrix to regulate Li metal nucleation and suppress Dendrite growth. The N-containing functional groups, such as pyridinic and pyrrolic nitrogen in the N-doped graphene, are lithiophilic, which guide the metallic Li nucleation causing the metal to distribute uniformly on the anode surface. As a result, the N-doped graphene modified Li metal anode exhibits a Dendrite-free morphology during repeated Li plating and demonstrates a high Coulombic efficiency of 98 % for near 200 cycles.
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conductive nanostructured scaffolds render low local current density to inhibit lithium Dendrite growth
Advanced Materials, 2016Co-Authors: Rui Zhang, Xin-bing Cheng, Chenzi Zhao, Hongjie Peng, Jiale Shi, Jiaqi Huang, Jinfu Wang, Fei Wei, Qiang ZhangAbstract:A nanostructured lithium-metal anode employing an unstacked graphene "drum" and dual-salt electrolyte brings about a Dendrite-free lithium depositing morphology. On the one hand, the unstacked graphene framework with ultrahigh specific surface area guarantees an ultralow local current density that prevents the growth of lithium Dendrites. On the other hand, the stable, flexible, and compact solid electrolyte interphase layer induced by the dual-salt electrolyte protects the deposited lithium layers.
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chronic ocular hypertension induces Dendrite pathology in the lateral geniculate nucleus of the brain
Experimental Eye Research, 2007Co-Authors: Neeru Gupta, Tina Ly, Paul L Kaufman, Robert N Weinreb, Yeni H Yucel, Qiang ZhangAbstract:In glaucoma, there is atrophy and loss of retinal ganglion cells (RGC), in addition to atrophy and loss of target neurons in the lateral geniculate nucleus (LGN) of the brain. To investigate possible changes to the Dendrites of LGN neurons in glaucoma, a selective marker for Dendrites called microtubule-associated protein-2 (MAP2) was used. The LGNs from five monkeys with varying degrees of optic nerve fiber loss were compared to those from five normal control monkeys. Dendrites in magno- and parvocellular layers connected to the glaucomatous eye were evaluated. In controls, long MAP2-positive Dendrites with multiple fine branches were seen. However, chronic ocular hypertension induced striking disruption of Dendrites with a thickened and shortened appearance. Dendrite field area was significantly reduced in the glaucoma group compared to controls. Sholl analysis revealed reduced Dendrite complexity by 47% and 41% in magnocellular layer 1 and parvocellular layer 6, respectively in the glaucoma group compared to controls. The striking Dendrite changes in the LGN following chronically elevated intraocular pressure may be relevant to early visual dysfunction in glaucoma.
Junwei Qiao - One of the best experts on this subject based on the ideXlab platform.
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tensile deformation micromechanisms for bulk metallic glass matrix composites from work hardening to softening
Acta Materialia, 2011Co-Authors: P K Liaw, Junwei Qiao, Ewen Huang, Yong Zhang, C P ChuangAbstract:Abstract A Ti-based bulk metallic glass matrix composite (BMGMC) with a homogeneous distribution of Dendrites and the composition of Ti46Zr20V12Cu5Be17 is characterized by a high tensile strength of ∼1640 MPa and a large tensile strain of ∼15.5% at room temperature. The present BMGMC exhibits the largest tensile ductility and highest fracture absorption energy under the stress–strain curve of all Dendrite-reinforced BMGMCs developed to date. Tensile deformation micromechanisms are explored through experimental visualization and theoretical analyses. After tension, fragmentation of the Dendrites, rather than crystallization within the glass matrix and/or atom debonding near the interface of dual-phase composites, is responsible for the high tensile ductility. The subdivisions within the interior of Dendrites are separated by shear bands and dense dislocation walls, and local separation of Dendrites under modes I and II prevails. The multiplication of dislocations, severe lattice distortions, and even local amorphization dominate within the Dendrites. Good structural coherency of the interface is demonstrated, despite being subjected to significant plastic deformation. Theoretical analyses reveal that the constitutive relations elastic–elastic, elastic–plastic, and plastic–plastic of dual-phase BMGMC generally correspond to the (1) elastic, (2) work-hardening, and (3) softening deformation stages, respectively. The capacity for work-hardening is highly dependent on the large plastic deformation of the Dendrites and the high yield strength of the glass matrix. The present study provides a fundamental basis for designing work-hardening dual-phase BMGMCs exhibiting remarkably homogeneous deformation.
Fengwei Yu - One of the best experts on this subject based on the ideXlab platform.
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sec71 functions as a gef for the small gtpase arf1 to govern Dendrite pruning of drosophila sensory neurons
Development, 2017Co-Authors: Yihcherng Liou, Fengwei Yu, Lei Lu, Yan Wang, Heng ZhangAbstract:Pruning, whereby neurons eliminate their excess neurites, is central for the maturation of the nervous system. In Drosophila, sensory neurons, ddaCs, selectively prune their larval Dendrites without affecting their axons during metamorphosis. However, it is unknown whether the secretory pathway plays a role in Dendrite pruning. Here, we show that the small GTPase Arf1, an important regulator of the secretory pathway, is specifically required for Dendrite pruning of ddaC/D/E sensory neurons but dispensable for apoptosis of ddaF neurons. Analyses of the GTP- and GDP-locked forms of Arf1 indicate that the cycling of Arf1 between GDP-bound and GTP-bound forms is essential for Dendrite pruning. We further identified Sec71 as a guanine nucleotide exchange factor for Arf1 that preferentially interacts with its GDP-bound form. Like Arf1, Sec71 is also important for Dendrite pruning, but not for apoptosis, of sensory neurons. Arf1 and Sec71 are interdependent for their localizations on Golgi. Finally, we show that the Sec71/Arf1-mediated trafficking process is a prerequisite for Rab5-dependent endocytosis to facilitate endocytosis and degradation of the cell-adhesion molecule Neuroglian (Nrg).
Guangshuo Ou - One of the best experts on this subject based on the ideXlab platform.
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spectrin based membrane mechanics is asymmetric and remodels during neural development
bioRxiv, 2020Co-Authors: Guangshuo Ou, Wei Li, Yongping Chai, Kaiyao HuangAbstract:Abstract Perturbation of spectrin-based membrane mechanics causes hereditary elliptocytosis and spinocerebellar ataxia, but the underlying cellular basis of pathogenesis remains unclear. Here, we introduced the conserved disease-associated spectrin mutations into the C. elegans genome and studied the contribution of spectrin to neuronal migration and Dendrite formation in developing larvae. The loss of spectrin generates an ectopic actin polymerization outside of the existing front and secondary membrane protrusions, leading to defective neuronal positioning and Dendrite morphology in adult animals. Spectrin accumulates in the lateral and the rear of migrating neuroblasts and redistributes from the soma into the newly formed Dendrites, indicating that the spectrin-based membrane skeleton is asymmetric and remodels to regulate actin assembly and cell shape during development. We affinity-purified spectrin from C. elegans and showed that its binding partner ankyrin functions with spectrin. Asymmetry and remodeling of membrane skeleton may enable spatiotemporal modulation of membrane mechanics for distinct developmental events. Significance Statement The biomechanical regulation of neural development is largely unknown. The spectrin-based membrane skeleton is essential for the structural integrity of the plasma membrane. This study addresses the function and behavior of spectrin in neuroblast migration and Dendrite formation. The loss of spectrin generates an ectopic actin polymerization outside of the existing front, leading to defective neuronal positioning and Dendrite morphology. Spectrin is absent from the leading edge but accumulates in the posterior of migrating neuroblasts and redistributes from the soma into the nascent Dendrites, indicating that the membrane skeleton is asymmetric and remodels. Asymmetry and remodeling of the membrane skeleton may enable spatiotemporal modulation of membrane mechanics for distinct developmental events.
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the spectrin based membrane skeleton is asymmetric and remodels during neural development in c elegans
Journal of Cell Science, 2020Co-Authors: Yongping Chai, Wei Li, Kaiyao Huang, Guangshuo OuAbstract:Perturbation of spectrin-based membrane mechanics causes hereditary elliptocytosis and spinocerebellar ataxia, but the underlying cellular basis of pathogenesis remains unclear. Here, we introduced the conserved disease-associated spectrin mutations into the C. elegans genome and studied the contribution of spectrin to neuronal migration and Dendrite formation in developing larvae. The loss of spectrin generates an ectopic actin polymerization outside of the existing front and secondary membrane protrusions, leading to defective neuronal positioning and Dendrite morphology in adult animals. Spectrin accumulates in the lateral and the rear of migrating neuroblasts and redistributes from the soma into the newly formed Dendrites, indicating that the spectrin-based membrane skeleton is asymmetric and remodels to regulate actin assembly and cell shape during development. We affinity-purified spectrin from C. elegans and showed that its binding partner ankyrin functions with spectrin. Asymmetry and remodeling of membrane skeleton may enable spatiotemporal modulation of membrane mechanics for distinct developmental events.
P K Liaw - One of the best experts on this subject based on the ideXlab platform.
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a tensile deformation model for in situ Dendrite metallic glass matrix composites
Scientific Reports, 2013Co-Authors: J W Qiao, T Zhang, Fuqia Yang, P K Liaw, Simo PaulyAbstract:In-situ Dendrite/metallic glass matrix composites (MGMCs) with a composition of Ti46Zr20V12Cu5Be17 exhibit ultimate tensile strength of 1510 MPa and fracture strain of about 7.6%. A tensile deformation model is established, based on the five-stage classification: (1) elastic-elastic, (2) elastic-plastic, (3) plastic-plastic (yield platform), (4) plastic-plastic (work hardening) and (5) plastic-plastic (softening) stages, analogous to the tensile behavior of common carbon steels. The constitutive relations strongly elucidate the tensile deformation mechanism. In parallel, the simulation results by a finite-element method (FEM) are in good agreement with the experimental findings and theoretical calculations. The present study gives a mathematical model to clarify the work-hardening behavior of Dendrites and softening of the amorphous matrix. Furthermore, the model can be employed to simulate the tensile behavior of in-situ Dendrite/MGMCs.
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tensile deformation micromechanisms for bulk metallic glass matrix composites from work hardening to softening
Acta Materialia, 2011Co-Authors: P K Liaw, Junwei Qiao, Ewen Huang, Yong Zhang, C P ChuangAbstract:Abstract A Ti-based bulk metallic glass matrix composite (BMGMC) with a homogeneous distribution of Dendrites and the composition of Ti46Zr20V12Cu5Be17 is characterized by a high tensile strength of ∼1640 MPa and a large tensile strain of ∼15.5% at room temperature. The present BMGMC exhibits the largest tensile ductility and highest fracture absorption energy under the stress–strain curve of all Dendrite-reinforced BMGMCs developed to date. Tensile deformation micromechanisms are explored through experimental visualization and theoretical analyses. After tension, fragmentation of the Dendrites, rather than crystallization within the glass matrix and/or atom debonding near the interface of dual-phase composites, is responsible for the high tensile ductility. The subdivisions within the interior of Dendrites are separated by shear bands and dense dislocation walls, and local separation of Dendrites under modes I and II prevails. The multiplication of dislocations, severe lattice distortions, and even local amorphization dominate within the Dendrites. Good structural coherency of the interface is demonstrated, despite being subjected to significant plastic deformation. Theoretical analyses reveal that the constitutive relations elastic–elastic, elastic–plastic, and plastic–plastic of dual-phase BMGMC generally correspond to the (1) elastic, (2) work-hardening, and (3) softening deformation stages, respectively. The capacity for work-hardening is highly dependent on the large plastic deformation of the Dendrites and the high yield strength of the glass matrix. The present study provides a fundamental basis for designing work-hardening dual-phase BMGMCs exhibiting remarkably homogeneous deformation.