The Experts below are selected from a list of 256716 Experts worldwide ranked by ideXlab platform
Xuemei Wang - One of the best experts on this subject based on the ideXlab platform.
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Multifocal Interdigitating Dendritic Cell Sarcoma Demonstrated on FDG PET/CT Imaging
Clinical nuclear medicine, 2020Co-Authors: Xia Bai, Xiangcheng Wang, Xuemei WangAbstract:Interdigitating Dendritic Cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating Dendritic Cell sarcoma in a 30-year-old woman.
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multifocal interdigitating Dendritic Cell sarcoma demonstrated on fdg pet ct imaging
Clinical Nuclear Medicine, 2020Co-Authors: Xia Bai, Xiangcheng Wang, Xuemei WangAbstract:Interdigitating Dendritic Cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating Dendritic Cell sarcoma in a 30-year-old woman.
Damiana Alvarezerrico - One of the best experts on this subject based on the ideXlab platform.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
Josep M Aran - One of the best experts on this subject based on the ideXlab platform.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
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IL-4 orchestrates STAT6-mediated DNA demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Vento-tormo, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Carlos Company, Javier Rodríguez-ubreva, Josep M AranAbstract:Background The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Results Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Conclusions Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
Xia Bai - One of the best experts on this subject based on the ideXlab platform.
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Multifocal Interdigitating Dendritic Cell Sarcoma Demonstrated on FDG PET/CT Imaging
Clinical nuclear medicine, 2020Co-Authors: Xia Bai, Xiangcheng Wang, Xuemei WangAbstract:Interdigitating Dendritic Cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating Dendritic Cell sarcoma in a 30-year-old woman.
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multifocal interdigitating Dendritic Cell sarcoma demonstrated on fdg pet ct imaging
Clinical Nuclear Medicine, 2020Co-Authors: Xia Bai, Xiangcheng Wang, Xuemei WangAbstract:Interdigitating Dendritic Cell sarcoma is a very rare malignancy that more commonly occurs in one anatomic location. Surgical resection of the lesion is the mainstay of the therapy. Multiple lesions at different locations are less common at the presentation. We report FDG PET/CT findings of multifocal interdigitating Dendritic Cell sarcoma in a 30-year-old woman.
Jose M Urquiza - One of the best experts on this subject based on the ideXlab platform.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
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IL-4 orchestrates STAT6-mediated DNA demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Vento-tormo, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Carlos Company, Javier Rodríguez-ubreva, Josep M AranAbstract:Background The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Results Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Conclusions Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.
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il 4 orchestrates stat6 mediated dna demethylation leading to Dendritic Cell differentiation
Genome Biology, 2016Co-Authors: Roser Ventotormo, Javier Rodriguezubreva, Lorenzo De La Rica, Jose M Urquiza, Biola M Javierre, Radhakrishnan Sabarinathan, Ana Luque, Manel Esteller, Josep M Aran, Damiana AlvarezerricoAbstract:The role of cytokines in establishing specific transcriptional programmes in innate immune Cells has long been recognized. However, little is known about how these extraCellular factors instruct innate immune Cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector Cells with non-redundant functions, such as Dendritic Cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive Dendritic Cell differentiation, whereas GM-CSF alone leads to macrophage differentiation. Here, we investigate the role of IL-4 in directing functionally relevant Dendritic-Cell-specific DNA methylation changes. A comparison of DNA methylome dynamics during differentiation from human monocytes to Dendritic Cells and macrophages identified gene sets undergoing Dendritic-Cell-specific or macrophage-specific demethylation. Demethylation is TET2-dependent and is essential for acquiring proper Dendritic Cell and macrophage identity. Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the Dendritic-Cell-specific demethylation and expression signature, following STAT6 binding. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct Dendritic-Cell-specific functional DNA methylation changes. Our study is the first description of a cytokine-mediated sequence of events leading to direct gene-specific demethylation in innate immune Cell differentiation.