The Experts below are selected from a list of 84324 Experts worldwide ranked by ideXlab platform
Jin Tae Hong - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory effect of astaxanthin in phthalic anhydride induced atopic Dermatitis animal model
Experimental Dermatology, 2018Co-Authors: Ju Ho Park, In Jun Yeo, Ji Hye Han, Jeong Won Suh, Hee Pom Lee, Jin Tae HongAbstract:In this study, we investigated anti-dermatitic effects of astaxanthin (AST) in phthalic anhydride (PA)-induced atopic Dermatitis (AD) animal model as well as in vitro model. AD-like lesion was induced by the topical application of 5% PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 1 mg/mL and 2 mg/mL of AST (10 μg or 20 μg/cm2 ) was spread on the dorsum of ear or back skin three times a week for four weeks. We evaluated Dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) activity. We also measured tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and immunoglobulin E (IgE) concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). AST treatment attenuated the development of PA-induced AD. Histological analysis showed that AST inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. AST treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as release of TNF-α, IL-1β, IL-6 and IgE. In addition, AST (5, 10 and 20 μM) potently inhibited lipopolysaccharide (LPS) (1 μg/mL)-induced nitric oxide (NO) production, expression of iNOS and COX-2 and NF-κB DNA binding activities in RAW 264.7 macrophage cells. Our data demonstrated that AST could be a promising agent for AD by inhibition of NF-κB signalling.
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anti inflammatory effect of titrated extract of centella asiatica in phthalic anhydride induced allergic Dermatitis animal model
International Journal of Molecular Sciences, 2017Co-Authors: Ju Ho Park, Ji Yeon Choi, Dong Ju Son, Eun Kyung Park, Min Jong Song, Mats Hellstrom, Jin Tae HongAbstract:Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic Dermatitis (AD) animal model as well as in vitro model. An AD-like lesion was induced by the topical application of five percent PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 0.2% and 0.4% of TECA (40 μg or 80 μg/cm²) was spread on the dorsum of the ear or back skin three times a week for four weeks. We evaluated Dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and NF-κB activity, which were determined by electromobility shift assay (EMSA). We also measured TNF-α, IL-1β, IL-6, and IgE concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). TECA treatment attenuated the development of PA-induced atopic Dermatitis. Histological analysis showed that TECA inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. TECA treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as the release of TNF-α, IL-1β, IL-6, and IgE. In addition, TECA (1, 2, 5 μg/mL) potently inhibited Lipopolysaccharide (LPS) (1 μg/mL)-induced NO production, expression of iNOS and COX-2, and NF-κB DNA binding activities in RAW264.7 macrophage cells. Our data demonstrated that TECA could be a promising agent for AD by inhibition of NF-κB signaling.
Joseph F Fowler - One of the best experts on this subject based on the ideXlab platform.
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eyelid Dermatitis in patients referred for patch testing retrospective analysis of north american contact Dermatitis group data 1994 2016
Journal of The American Academy of Dermatology, 2020Co-Authors: Erin M Warshaw, Howard I. Maibach, Lindsey M Voller, Kathryn A Zug, Joel G Dekoven, Amber Reck Atwater, Margo J Reeder, Denis Sasseville, James S Taylor, Joseph F FowlerAbstract:Abstract Background Eyelid Dermatitis is a common dermatologic complaint. Objective To characterize patients with eyelid Dermatitis. Methods Retrospective analysis (1994 – 2016) of North American Contact Dermatitis Group data. Results Of 50,795 patients, 2,332 (4.6%) had eyelid Dermatitis only (E-only), while 1,623 (3.2%) also had Dermatitis of the head/neck (E+HN). When compared to patients without eyelid involvement (NoE, n=26,130), E-only and E+HN groups were significantly more likely to be female, Caucasian, aged >40, and have a history of hay fever and/or atopic Dermatitis (p-values Limitations Lack of specific distribution patterns of eyelid Dermatitis and no long-term follow-up data. Conclusion Patch testing remains a critical tool in evaluating patients with eyelid Dermatitis.
Ju Ho Park - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory effect of astaxanthin in phthalic anhydride induced atopic Dermatitis animal model
Experimental Dermatology, 2018Co-Authors: Ju Ho Park, In Jun Yeo, Ji Hye Han, Jeong Won Suh, Hee Pom Lee, Jin Tae HongAbstract:In this study, we investigated anti-dermatitic effects of astaxanthin (AST) in phthalic anhydride (PA)-induced atopic Dermatitis (AD) animal model as well as in vitro model. AD-like lesion was induced by the topical application of 5% PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 1 mg/mL and 2 mg/mL of AST (10 μg or 20 μg/cm2 ) was spread on the dorsum of ear or back skin three times a week for four weeks. We evaluated Dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and nuclear factor-κB (NF-κB) activity. We also measured tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and immunoglobulin E (IgE) concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). AST treatment attenuated the development of PA-induced AD. Histological analysis showed that AST inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. AST treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as release of TNF-α, IL-1β, IL-6 and IgE. In addition, AST (5, 10 and 20 μM) potently inhibited lipopolysaccharide (LPS) (1 μg/mL)-induced nitric oxide (NO) production, expression of iNOS and COX-2 and NF-κB DNA binding activities in RAW 264.7 macrophage cells. Our data demonstrated that AST could be a promising agent for AD by inhibition of NF-κB signalling.
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anti inflammatory effect of titrated extract of centella asiatica in phthalic anhydride induced allergic Dermatitis animal model
International Journal of Molecular Sciences, 2017Co-Authors: Ju Ho Park, Ji Yeon Choi, Dong Ju Son, Eun Kyung Park, Min Jong Song, Mats Hellstrom, Jin Tae HongAbstract:Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported. In this study, we investigated the anti-dermatitic effects of titrated extract of Centella asiatica (TECA) in a phthalic anhydride (PA)-induced atopic Dermatitis (AD) animal model as well as in vitro model. An AD-like lesion was induced by the topical application of five percent PA to the dorsal skin or ear of Hos:HR-1 mouse. After AD induction, 100 μL of 0.2% and 0.4% of TECA (40 μg or 80 μg/cm²) was spread on the dorsum of the ear or back skin three times a week for four weeks. We evaluated Dermatitis severity, histopathological changes and changes in protein expression by Western blotting for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and NF-κB activity, which were determined by electromobility shift assay (EMSA). We also measured TNF-α, IL-1β, IL-6, and IgE concentration in the blood of AD mice by enzyme-linked immunosorbent assay (ELISA). TECA treatment attenuated the development of PA-induced atopic Dermatitis. Histological analysis showed that TECA inhibited hyperkeratosis, mast cells and infiltration of inflammatory cells. TECA treatment inhibited expression of iNOS and COX-2, and NF-κB activity as well as the release of TNF-α, IL-1β, IL-6, and IgE. In addition, TECA (1, 2, 5 μg/mL) potently inhibited Lipopolysaccharide (LPS) (1 μg/mL)-induced NO production, expression of iNOS and COX-2, and NF-κB DNA binding activities in RAW264.7 macrophage cells. Our data demonstrated that TECA could be a promising agent for AD by inhibition of NF-κB signaling.
Jan Faergemann - One of the best experts on this subject based on the ideXlab platform.
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the prevalence of malassezia yeasts in patients with atopic Dermatitis seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with seborrhoeic Dermatitis (88%) or in healthy controls (84%, pv0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, pv0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensiti
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the prevalence of malassezia yeasts in patients with atopic Dermatitis seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with seborrhoeic Dermatitis (88%) or in healthy controls (84%, p<0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, p<0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensitization to Malassezia in patients with atopic Dermatitis.
Erin M Warshaw - One of the best experts on this subject based on the ideXlab platform.
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eyelid Dermatitis in patients referred for patch testing retrospective analysis of north american contact Dermatitis group data 1994 2016
Journal of The American Academy of Dermatology, 2020Co-Authors: Erin M Warshaw, Howard I. Maibach, Lindsey M Voller, Kathryn A Zug, Joel G Dekoven, Amber Reck Atwater, Margo J Reeder, Denis Sasseville, James S Taylor, Joseph F FowlerAbstract:Abstract Background Eyelid Dermatitis is a common dermatologic complaint. Objective To characterize patients with eyelid Dermatitis. Methods Retrospective analysis (1994 – 2016) of North American Contact Dermatitis Group data. Results Of 50,795 patients, 2,332 (4.6%) had eyelid Dermatitis only (E-only), while 1,623 (3.2%) also had Dermatitis of the head/neck (E+HN). When compared to patients without eyelid involvement (NoE, n=26,130), E-only and E+HN groups were significantly more likely to be female, Caucasian, aged >40, and have a history of hay fever and/or atopic Dermatitis (p-values Limitations Lack of specific distribution patterns of eyelid Dermatitis and no long-term follow-up data. Conclusion Patch testing remains a critical tool in evaluating patients with eyelid Dermatitis.
