The Experts below are selected from a list of 63450 Experts worldwide ranked by ideXlab platform
Caroline M. Mills - One of the best experts on this subject based on the ideXlab platform.
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macrocephaly cutis marmorata telangiectatica congenita a case report and review of salient features
Journal of The American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
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Macrocephaly–cutis marmorata telangiectatica congenita: A case report and review of salient features
Journal of the American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
Darrell S Rigel - One of the best experts on this subject based on the ideXlab platform.
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impact of guidance provided by a multispectral digital skin lesion analysis device following dermoscopy on decisions to biopsy atypical melanocytic lesions
The Journal of clinical and aesthetic dermatology, 2015Co-Authors: Richard R Winkelmann, Natalie Tucker, Richard White, Darrell S RigelAbstract:To determine how a multispectral digital skin lesion analysis (MSDSLA) device data affects the biopsy performance of Dermatologists and non-Dermatologist practitioners following clinical and dermoscopic pigmented lesion evaluation.MSDSLA employs near infrared light to image and analyze pigmented skin lesions. MSDSLA generates a "classifier score" based on morphological disorganization. Using a logistical regression model, 1) a probability of being melanoma and, 2) a probability of being melanoma, atypical melanocytic hyperplasia, or a high grade dysplastic nevus is computed. PARTICIPANTS were shown clinical images of 12 lesions (2 melanomas in situ, 3 invasive melanomas, and 7 low grade DNs). They were asked first if they would biopsy the lesion based on clinical images, again after observing dermoscopy images, and once more when presented with MSDSLA probability information.National dermoscopy conference.Sixty-four healthcare providers; 30 Dermatologists and 34 non-Dermatologist practitioners.Sensitivity, specificity, diagnostic accuracy, biopsy rates Results: For the 30 Dermatologists, sensitivity was 65 percent after clinical evaluation (C) and 65% post-dermoscopy (D) but improved to 91% after MSDSLA. For the 34 non-Dermatologist practitioners, sensitivity improved from 66 percent (C) to 70 percent (D) to 95 percent after MSDSLA. With MSDSLA information, Dermatologist specificity increased from 40 percent (D) to 58 percent while non-Dermatologist practitioners specificity increased from 34 percent (D) to 55 percent. Diagnostic accuracy of malignant and benign lesions decreased for both groups 55 percent (C) to 51 percent (D) for Dermatologists and 54 percent (C) to 49 percent (D) for non-Dermatologist practitioners. However, diagnostic accuracy increased to 72 percent for Dermatologists and 72 percent for non-Dermatologist practitioners with MSDSLA data. Non-melanoma biopsy percentages by Dermatologists increased from 53 percent (C) to 60 percent (D), but decreased to 42 percent when provided with MSDSLA data. Similarly, non-Dermatologist practitioners' biopsy percentages of nonmelanomas increased from 55 percent (C) to 66 percent (D) and decreased to 45 percent with MSDSLA.Decisions to biopsy atypical melanocytic lesions were more sensitive and specific when MSDSLA information was provided for both Dermatologists and nonDermatologist practitioners. Both groups were also less likely to biopsy nonmelanomas after MSDSLA evaluation. The authors' results suggest providing practitioners with MSDSLA data leads to improved biopsy accuracy decreasing the number of nonessential biopsies for nonmelanocytic lesions even after dermoscopic evaluation.
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Assessment of a Diagnostic Predictive Probability Model Provided by a Multispectral Digital Skin Lesion Analysis Device for Melanoma and Other High-risk Pigmented Lesions and its Impact on Biopsy Decisions.
The Journal of clinical and aesthetic dermatology, 2014Co-Authors: Richard R Winkelmann, Natalie Tucker, Richard L. White, Darrell S RigelAbstract:Objective: Risk prediction models for primary malignant melanoma thus far have relied on qualitative patient information. The authors propose a quantitative diagnostic predictive probability model using Multispectral Digital Skin Lesion Analysis for melanoma and other high-risk pigmented lesions and evaluate its effectiveness optimizing biopsy decisions by Dermatologists. Design: Data from 1,632 pigmented lesions analyzed by a Multispectral Digital Skin Lesion Analysis device were used to perform a logistic regression analysis. This new quantitative melanoma or melanoma/atypical melanocytic hyperplasia/high-grade dysplastic nevus probability model was then evaluated to determine its impact on Dermatologist decisions to biopsy pigmented lesions clinically suggestive of melanoma. Participants were given an electronic keypad and answered “yes” or “no” if they would biopsy each of 12 pigmented lesions when presented first with patient history, clinical images, and dermoscopic images and again when subsequently shown Multispectral Digital Skin Lesion Analysis data. Setting/participants: Study of 191 Dermatologists at a medical conference. Measurements: Sensitivity, specificity, biopsy accuracy, overall biopsy rate, and percentage Dermatologists biopsying all five melanomas. Results: Dermatologists were significantly more sensitive, specific, and accurate while decreasing overall biopsy rates with Multispectral Digital Skin Lesion Analysis probability information. Conclusion: Integration of Multispectral Digital Skin Lesion Analysis probability information in the biopsy evaluation and selection process of pigmented lesions has the potential to improve melanoma sensitivity of Dermatologists without the concomitant costs associated with additional biopsies being performed.
R. P. Katugampola - One of the best experts on this subject based on the ideXlab platform.
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macrocephaly cutis marmorata telangiectatica congenita a case report and review of salient features
Journal of The American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
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Macrocephaly–cutis marmorata telangiectatica congenita: A case report and review of salient features
Journal of the American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
Richard R Winkelmann - One of the best experts on this subject based on the ideXlab platform.
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impact of guidance provided by a multispectral digital skin lesion analysis device following dermoscopy on decisions to biopsy atypical melanocytic lesions
The Journal of clinical and aesthetic dermatology, 2015Co-Authors: Richard R Winkelmann, Natalie Tucker, Richard White, Darrell S RigelAbstract:To determine how a multispectral digital skin lesion analysis (MSDSLA) device data affects the biopsy performance of Dermatologists and non-Dermatologist practitioners following clinical and dermoscopic pigmented lesion evaluation.MSDSLA employs near infrared light to image and analyze pigmented skin lesions. MSDSLA generates a "classifier score" based on morphological disorganization. Using a logistical regression model, 1) a probability of being melanoma and, 2) a probability of being melanoma, atypical melanocytic hyperplasia, or a high grade dysplastic nevus is computed. PARTICIPANTS were shown clinical images of 12 lesions (2 melanomas in situ, 3 invasive melanomas, and 7 low grade DNs). They were asked first if they would biopsy the lesion based on clinical images, again after observing dermoscopy images, and once more when presented with MSDSLA probability information.National dermoscopy conference.Sixty-four healthcare providers; 30 Dermatologists and 34 non-Dermatologist practitioners.Sensitivity, specificity, diagnostic accuracy, biopsy rates Results: For the 30 Dermatologists, sensitivity was 65 percent after clinical evaluation (C) and 65% post-dermoscopy (D) but improved to 91% after MSDSLA. For the 34 non-Dermatologist practitioners, sensitivity improved from 66 percent (C) to 70 percent (D) to 95 percent after MSDSLA. With MSDSLA information, Dermatologist specificity increased from 40 percent (D) to 58 percent while non-Dermatologist practitioners specificity increased from 34 percent (D) to 55 percent. Diagnostic accuracy of malignant and benign lesions decreased for both groups 55 percent (C) to 51 percent (D) for Dermatologists and 54 percent (C) to 49 percent (D) for non-Dermatologist practitioners. However, diagnostic accuracy increased to 72 percent for Dermatologists and 72 percent for non-Dermatologist practitioners with MSDSLA data. Non-melanoma biopsy percentages by Dermatologists increased from 53 percent (C) to 60 percent (D), but decreased to 42 percent when provided with MSDSLA data. Similarly, non-Dermatologist practitioners' biopsy percentages of nonmelanomas increased from 55 percent (C) to 66 percent (D) and decreased to 45 percent with MSDSLA.Decisions to biopsy atypical melanocytic lesions were more sensitive and specific when MSDSLA information was provided for both Dermatologists and nonDermatologist practitioners. Both groups were also less likely to biopsy nonmelanomas after MSDSLA evaluation. The authors' results suggest providing practitioners with MSDSLA data leads to improved biopsy accuracy decreasing the number of nonessential biopsies for nonmelanocytic lesions even after dermoscopic evaluation.
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Assessment of a Diagnostic Predictive Probability Model Provided by a Multispectral Digital Skin Lesion Analysis Device for Melanoma and Other High-risk Pigmented Lesions and its Impact on Biopsy Decisions.
The Journal of clinical and aesthetic dermatology, 2014Co-Authors: Richard R Winkelmann, Natalie Tucker, Richard L. White, Darrell S RigelAbstract:Objective: Risk prediction models for primary malignant melanoma thus far have relied on qualitative patient information. The authors propose a quantitative diagnostic predictive probability model using Multispectral Digital Skin Lesion Analysis for melanoma and other high-risk pigmented lesions and evaluate its effectiveness optimizing biopsy decisions by Dermatologists. Design: Data from 1,632 pigmented lesions analyzed by a Multispectral Digital Skin Lesion Analysis device were used to perform a logistic regression analysis. This new quantitative melanoma or melanoma/atypical melanocytic hyperplasia/high-grade dysplastic nevus probability model was then evaluated to determine its impact on Dermatologist decisions to biopsy pigmented lesions clinically suggestive of melanoma. Participants were given an electronic keypad and answered “yes” or “no” if they would biopsy each of 12 pigmented lesions when presented first with patient history, clinical images, and dermoscopic images and again when subsequently shown Multispectral Digital Skin Lesion Analysis data. Setting/participants: Study of 191 Dermatologists at a medical conference. Measurements: Sensitivity, specificity, biopsy accuracy, overall biopsy rate, and percentage Dermatologists biopsying all five melanomas. Results: Dermatologists were significantly more sensitive, specific, and accurate while decreasing overall biopsy rates with Multispectral Digital Skin Lesion Analysis probability information. Conclusion: Integration of Multispectral Digital Skin Lesion Analysis probability information in the biopsy evaluation and selection process of pigmented lesions has the potential to improve melanoma sensitivity of Dermatologists without the concomitant costs associated with additional biopsies being performed.
Celia Moss - One of the best experts on this subject based on the ideXlab platform.
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macrocephaly cutis marmorata telangiectatica congenita a case report and review of salient features
Journal of The American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
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Macrocephaly–cutis marmorata telangiectatica congenita: A case report and review of salient features
Journal of the American Academy of Dermatology, 2008Co-Authors: R. P. Katugampola, Celia Moss, Caroline M. MillsAbstract:Macrocephaly–cutis marmorata telangiectatica congenita is a recently recognized syndrome described mainly in the genetics literature. However, children with macrocephaly–cutis marmorata telangiectatica congenita are likely to present first to a Dermatologist, with generalized cutis marmorata telangiectatica congenita as the main feature. These children are at risk of neurologic abnormalities and life-threatening complications. Therefore it is important for Dermatologists to recognize this syndrome to monitor these children for potential complications. We report the case of a 2-year-old boy with macrocephaly–cutis marmorata telangiectatica congenita in association with dysmorphic facies, seizures, and facial and limb asymmetry, and we review the salient features of this syndrome.
