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Slawomir Gonkowski - One of the best experts on this subject based on the ideXlab platform.

  • Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon
    MDPI AG, 2019
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    Neurons of the enteric nervous system (ENS) may undergo changes during maturation and aging, but knowledge of physiological stimuli-dependent changes in the ENS is still fragmentary. On the other hand, the frequency of many ENS-related intestinal illnesses depends on age and/or sex. The double immunofluorescence technique was used to study the influence of both of these factors on calcitonin gene-related peptide (CGRP)—positive enteric nervous structures—in the Descending Colon in young and adult female and castrated male pigs. The influence of age and gender on the number and neurochemical characterization (i.e., co-localization of CGRP with substance P, nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter) of CGRP-positive nerve structures in the Colonic wall has been shown. These observations strongly suggest the participation of CGRP in adaptive processes in the ENS during GI tract maturation. Moreover, although the castration of males may mask some aspects of sex-dependent influences on the ENS, the sex-specific differences in CGRP-positive nervous structures were mainly visible in adult animals. This may suggest that the distribution and exact role of this substance in the ENS depend on the sex hormones

  • the influence of inflammation and nerve damage on the neurochemical characterization of calcitonin gene related peptide like immunoreactive cgrp li neurons in the enteric nervous system of the porcine Descending Colon
    International Journal of Molecular Sciences, 2018
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS), localized in the wall of the gastrointestinal tract, regulates the functions of the intestine using a wide range of neuronally-active substances. One of them is the calcitonin gene-related peptide (CGRP), whose participation in pathological states in the large intestine remains unclear. Therefore, the aim of this study was to investigate the influence of inflammation and nerve damage using a double immunofluorescence technique to neurochemically characterize CGRP-positive enteric nervous structures in the porcine Descending Colon. Both pathological factors caused an increase in the percentage of CGRP-positive enteric neurons, and these changes were the most visible in the myenteric plexus after nerve damage. Moreover, both pathological states change the degree of co-localization of CGRP with other neurochemical factors, including substance P, the neuronal isoform of nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter. The character and severity of these changes depended on the pathological factor and the type of enteric plexus. The obtained results show that CGRP-positive enteric neurons are varied in terms of neurochemical characterization and take part in adaptive processes in the Descending Colon during inflammation and after nerve damage.

  • The Influence of Inflammation and Nerve Damage on the Neurochemical Characterization of Calcitonin Gene-Related Peptide—Like Immunoreactive (CGRP-LI) Neurons in the Enteric Nervous System of the Porcine Descending Colon
    MDPI AG, 2018
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS), localized in the wall of the gastrointestinal tract, regulates the functions of the intestine using a wide range of neuronally-active substances. One of them is the calcitonin gene-related peptide (CGRP), whose participation in pathological states in the large intestine remains unclear. Therefore, the aim of this study was to investigate the influence of inflammation and nerve damage using a double immunofluorescence technique to neurochemically characterize CGRP-positive enteric nervous structures in the porcine Descending Colon. Both pathological factors caused an increase in the percentage of CGRP-positive enteric neurons, and these changes were the most visible in the myenteric plexus after nerve damage. Moreover, both pathological states change the degree of co-localization of CGRP with other neurochemical factors, including substance P, the neuronal isoform of nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter. The character and severity of these changes depended on the pathological factor and the type of enteric plexus. The obtained results show that CGRP-positive enteric neurons are varied in terms of neurochemical characterization and take part in adaptive processes in the Descending Colon during inflammation and after nerve damage

  • the influence of low doses of zearalenone and t 2 toxin on calcitonin gene related peptide like immunoreactive cgrp li neurons in the ens of the porcine Descending Colon
    Toxins, 2017
    Co-Authors: Krystyna Makowska, K Obremski, L Zielonka, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS) can undergo adaptive and reparative changes in response to physiological and pathological stimuli. These manifest primarily as alterations in the levels of active substances expressed by the enteric neuron. While it is known that mycotoxins can affect the function of the central and peripheral nervous systems, knowledge about their influence on the ENS is limited. Therefore, the aim of the present study was to investigate the influence of low doses of zearalenone (ZEN) and T-2 toxin on calcitonin gene related peptide-like immunoreactive (CGRP-LI) neurons in the ENS of the porcine Descending Colon using a double immunofluorescence technique. Both mycotoxins led to an increase in the percentage of CGRP-LI neurons in all types of enteric plexuses and changed the degree of co-localization of CGRP with other neuronal active substances, such as substance P, galanin, nitric oxide synthase, and cocaine- and amphetamine-regulated transcript peptide. The obtained results demonstrate that even low doses of ZEN and T-2 can affect living organisms and cause changes in the neurochemical profile of enteric neurons.

  • immunohistochemical distribution of cocaine and amphetamine regulated transcript peptide like immunoreactive cart li nerve fibers and various degree of co localization with other neuronal factors in the circular muscle layer of human Descending Colon
    Histology and Histopathology, 2013
    Co-Authors: Slawomir Gonkowski, Barbara Kaminska, Piotr Landowski, Jaroslaw Calka
    Abstract:

    Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investigation the distribution and immunohistochemical reaction (IR) of CART - like immunoreactive (CART-LI) nerve fibers in the circular muscle layer of human Descending Colon were studied. Fragments of human Colon were processed for double labelling immunofluorescence using a mixture of anti-CART antibodies with antibodies against vesicular acetylocholine transporter (VAChT), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase - activating peptide (PACAP), substance P (SP), galanin (GAL) and nitric oxide synthase (NOS). Thick CART-LI nerve fibers formed a very dense meshwork within the Colonic circular muscle layer in all patients studied. The highest number of CART - positive nerves also contained VAChT and/or VIP. A slightly lower level of co-localisation was observed in the case of CART and PACAP or CART and NOS. Only single nerve fibers were concurrently immunoreactive to CART and SP or CART and GAL. The present study reports for the first time a detailed description of the IR of CART-LI nerve fibers in the circular muscle layer within adult human Descending Colon.

Jaroslaw Calka - One of the best experts on this subject based on the ideXlab platform.

  • immunohistochemical distribution of cocaine and amphetamine regulated transcript peptide like immunoreactive cart li nerve fibers and various degree of co localization with other neuronal factors in the circular muscle layer of human Descending Colon
    Histology and Histopathology, 2013
    Co-Authors: Slawomir Gonkowski, Barbara Kaminska, Piotr Landowski, Jaroslaw Calka
    Abstract:

    Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investigation the distribution and immunohistochemical reaction (IR) of CART - like immunoreactive (CART-LI) nerve fibers in the circular muscle layer of human Descending Colon were studied. Fragments of human Colon were processed for double labelling immunofluorescence using a mixture of anti-CART antibodies with antibodies against vesicular acetylocholine transporter (VAChT), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase - activating peptide (PACAP), substance P (SP), galanin (GAL) and nitric oxide synthase (NOS). Thick CART-LI nerve fibers formed a very dense meshwork within the Colonic circular muscle layer in all patients studied. The highest number of CART - positive nerves also contained VAChT and/or VIP. A slightly lower level of co-localisation was observed in the case of CART and PACAP or CART and NOS. Only single nerve fibers were concurrently immunoreactive to CART and SP or CART and GAL. The present study reports for the first time a detailed description of the IR of CART-LI nerve fibers in the circular muscle layer within adult human Descending Colon.

  • changes in cocaine and amphetamine regulated transcript like immunoreactive cart li nerve structures of the porcine Descending Colon during proliferative enteropathy
    Bulletin of The Veterinary Institute in Pulawy, 2012
    Co-Authors: Slawomir Gonkowski, P J Burlinski, Piotr Szwajca, Jaroslaw Calka
    Abstract:

    The distribution pattern of CART‐ like immunoreactive (CART-LI) nerve structures was studied by a double immunofluorescence technique in the circular muscle layer, myenteric (MP), outer submucous (OSP), and inner submucous plexuses (ISP), as well as in the mucosal layer of porcine d escending Colon under physiological conditions and during proliferative enteropathy (PE). In control animals, CART-LI perikar ya have been shown to constitute 3.18 ±0.51%, 3.44 ±0.6%, and 3.33 ±0.72% in MP, OSP, and ISP, respectively. PE caused a decr ease in the number of CART ‐ LI neurons in MP and ISP. In OSP, the observed changes were not statistically significant. During PE, the number of CART-LI perikarya amounted to 2.18 ±0.27%, 3.07 ±0.06%, and 0.07 ±0.02% within MP, OSP, and ISP, respectively. Moreover, PE caused an increase in the number o f CART-LI nerve fibers in the Colonic circular muscle and mucosal layers as w ell as in MP. This study describes for the first ti me changes in CART-LI nerve structures of the porcine Descending Colon during Lawsonia intracellularis infection, and suggests the participation of this neuropeptide in the regulation of gut functions, no t only under physiological conditions, but also dur ing pathological processes.

  • changes in the somatostatin som like immunoreactivity within nervous structures of the porcine Descending Colon under various pathological factors
    Experimental and Molecular Pathology, 2010
    Co-Authors: Sławomir Gonkowski, Jaroslaw Calka
    Abstract:

    Abstract This study reports on changes in the somatostatin-like immunoreactive (SOM-LI) nerve structures of the enteric nervous system (ENS) in the porcine Descending Colon, caused by chemically driven inflammation, proliferative enteropathy (PE), which is a “natural” inflammation with proliferative changes and nerve injury (axotomy). The distribution pattern of SOM-LI structures was studied using the immunofluorescence technique in the circular muscle layer, the myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP) and also in the mucosal layer. Under physiological conditions SOM-LI perikarya have been shown to constitute 1.97 ± 0.36%, 2.06 ± 0.33% and 4.23 ± 0.40% in the MP, OSP and ISP, respectively. Changes in SOM-immunoreactivity depended on the pathological factor and the part of the ENS studied. Numbers of the SOM-LI perikarya amounted 1.81 ± 0.30, 1.97 ± 0.24 and 11.15 ± 0.95 during chemically induced colitis and 3.21 ± 0.37%, 4.33 ± 0.33% and 4.42 ± 0.32% after axotomy in MP, OSP and ISP, respectively. Moreover during PE SOM-positive cell bodies were not observed at all in MP, whereas within OSP and ISP the number of SOM-LI perikarya amounted to 3.34 ± 0.36 and 10.92 ± 059, respectively. All processes studied resulted in a decrease in the number of SOM-LI nerve fibers in the mucosal layer, whereas within the circular muscle layer chemically induced inflammation and axotomy caused an increase in the number of the SOM-LI nerve fibers contrary to PE, which reduced the number of such fibers. The obtained results suggest that SOM-LI nerve structures of the ENS may participate in various pathological states within the porcine Descending Colon and their functions probably depend on the type of pathological factor.

  • inflammation and axotomy induced changes in galanin like immunoreactive gal li nerve structures in the porcine Descending Colon
    Acta Veterinaria Hungarica, 2010
    Co-Authors: Slawomir Gonkowski, P J Burlinski, Cezary Skobowiat, Mariusz Majewski, Jaroslaw Calka
    Abstract:

    This study reports on changes caused by chemically driven inflammation and axotomy in galanin-like immunoreactive (GAL-LI) nerve structures in the porcine Descending Colon. The distribution pattern of GAL-LI structures was studied using the immunofluorescence technique in the circular muscle layer, the myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP), and also in the mucosal layer. Under physiological conditions GAL-LI perikarya were shown to constitute 3.68 ± 0.32%, 7.02 ± 0.93% and 10.99 ± 0.71% in MP, OSP and ISP, respectively. Both colitis and axotomy caused an increase in GAL-like immunoreactivity, which was different in particular parts of the bowel segment studied. The numbers of GAL-LI perikarya increased to 14.16 ± 0.49%, 16.78 ± 1.09% and 37.46 ± 1.18% during colitis and 7.92 ± 0.72%, 10.44 ± 0.71% and 16.20 ± 0.96% after axotomy in MP, OSP and ISP, respectively. Both these processes caused an increase in the number of GAL-LI nerve fibres in the circular muscle and mucosal layers as well as the appearance of a population of GAL-LI cells in the mucosa.

Krystyna Makowska - One of the best experts on this subject based on the ideXlab platform.

  • Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon
    MDPI AG, 2019
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    Neurons of the enteric nervous system (ENS) may undergo changes during maturation and aging, but knowledge of physiological stimuli-dependent changes in the ENS is still fragmentary. On the other hand, the frequency of many ENS-related intestinal illnesses depends on age and/or sex. The double immunofluorescence technique was used to study the influence of both of these factors on calcitonin gene-related peptide (CGRP)—positive enteric nervous structures—in the Descending Colon in young and adult female and castrated male pigs. The influence of age and gender on the number and neurochemical characterization (i.e., co-localization of CGRP with substance P, nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter) of CGRP-positive nerve structures in the Colonic wall has been shown. These observations strongly suggest the participation of CGRP in adaptive processes in the ENS during GI tract maturation. Moreover, although the castration of males may mask some aspects of sex-dependent influences on the ENS, the sex-specific differences in CGRP-positive nervous structures were mainly visible in adult animals. This may suggest that the distribution and exact role of this substance in the ENS depend on the sex hormones

  • the influence of inflammation and nerve damage on the neurochemical characterization of calcitonin gene related peptide like immunoreactive cgrp li neurons in the enteric nervous system of the porcine Descending Colon
    International Journal of Molecular Sciences, 2018
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS), localized in the wall of the gastrointestinal tract, regulates the functions of the intestine using a wide range of neuronally-active substances. One of them is the calcitonin gene-related peptide (CGRP), whose participation in pathological states in the large intestine remains unclear. Therefore, the aim of this study was to investigate the influence of inflammation and nerve damage using a double immunofluorescence technique to neurochemically characterize CGRP-positive enteric nervous structures in the porcine Descending Colon. Both pathological factors caused an increase in the percentage of CGRP-positive enteric neurons, and these changes were the most visible in the myenteric plexus after nerve damage. Moreover, both pathological states change the degree of co-localization of CGRP with other neurochemical factors, including substance P, the neuronal isoform of nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter. The character and severity of these changes depended on the pathological factor and the type of enteric plexus. The obtained results show that CGRP-positive enteric neurons are varied in terms of neurochemical characterization and take part in adaptive processes in the Descending Colon during inflammation and after nerve damage.

  • The Influence of Inflammation and Nerve Damage on the Neurochemical Characterization of Calcitonin Gene-Related Peptide—Like Immunoreactive (CGRP-LI) Neurons in the Enteric Nervous System of the Porcine Descending Colon
    MDPI AG, 2018
    Co-Authors: Krystyna Makowska, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS), localized in the wall of the gastrointestinal tract, regulates the functions of the intestine using a wide range of neuronally-active substances. One of them is the calcitonin gene-related peptide (CGRP), whose participation in pathological states in the large intestine remains unclear. Therefore, the aim of this study was to investigate the influence of inflammation and nerve damage using a double immunofluorescence technique to neurochemically characterize CGRP-positive enteric nervous structures in the porcine Descending Colon. Both pathological factors caused an increase in the percentage of CGRP-positive enteric neurons, and these changes were the most visible in the myenteric plexus after nerve damage. Moreover, both pathological states change the degree of co-localization of CGRP with other neurochemical factors, including substance P, the neuronal isoform of nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter. The character and severity of these changes depended on the pathological factor and the type of enteric plexus. The obtained results show that CGRP-positive enteric neurons are varied in terms of neurochemical characterization and take part in adaptive processes in the Descending Colon during inflammation and after nerve damage

  • the influence of low doses of zearalenone and t 2 toxin on calcitonin gene related peptide like immunoreactive cgrp li neurons in the ens of the porcine Descending Colon
    Toxins, 2017
    Co-Authors: Krystyna Makowska, K Obremski, L Zielonka, Slawomir Gonkowski
    Abstract:

    The enteric nervous system (ENS) can undergo adaptive and reparative changes in response to physiological and pathological stimuli. These manifest primarily as alterations in the levels of active substances expressed by the enteric neuron. While it is known that mycotoxins can affect the function of the central and peripheral nervous systems, knowledge about their influence on the ENS is limited. Therefore, the aim of the present study was to investigate the influence of low doses of zearalenone (ZEN) and T-2 toxin on calcitonin gene related peptide-like immunoreactive (CGRP-LI) neurons in the ENS of the porcine Descending Colon using a double immunofluorescence technique. Both mycotoxins led to an increase in the percentage of CGRP-LI neurons in all types of enteric plexuses and changed the degree of co-localization of CGRP with other neuronal active substances, such as substance P, galanin, nitric oxide synthase, and cocaine- and amphetamine-regulated transcript peptide. The obtained results demonstrate that even low doses of ZEN and T-2 can affect living organisms and cause changes in the neurochemical profile of enteric neurons.

Sławomir Gonkowski - One of the best experts on this subject based on the ideXlab platform.

  • substance p as a neuronal factor in the enteric nervous system of the porcine Descending Colon in physiological conditions and during selected pathogenic processes
    Biofactors, 2013
    Co-Authors: Sławomir Gonkowski
    Abstract:

    The present investigation pertains to changes in substance P-like immunoreactive (SP-LI) nerve structures of the enteric nervous system (ENS) in the porcine Descending Colon, caused by chemically-induced inflammation and nerve injury (axotomy). The distribution pattern of SP-LI structures was studied using the double immunofluorescence technique in the myenteric (MP), outer submucous (OSP) and inner submucous (ISP) plexuses, as well as in the circular muscle and mucosal layers. Under physiological conditions, SP-LI neurons have been shown to constitute 4.13 ± 0.24%, 3.36 ± 0.26%, and 7.92 ± 0.16% in the MP, OSP, and ISP, respectively. Changes in SP-immunoreactivity depended on the pathological factor studied. The numbers of the SP-LI perikarya amounted to 7.89 ± 0.34, 5.56 ± 0.30, and 19.96 ± 0.57 in chemically-induced colitis, and 4.28 ± 0.13%, 7.18 ± 20%, and 11.62 ± 0.48% after axotomy in MP, OSP, and ISP, respectively. The both studied processes generally resulted in an increase in the number of SP-LI nerve fibers in the circular muscle and mucosal layers. The obtained results suggest that SP-LI nerve structures of the ENS may participate in various pathological processes in the porcine Descending Colon and exact functions of SP probably depend on the type of the pathological factor. © 2013 BioFactors 39(5):542–551, 2013

  • Changes in Pituitary Adenylate Cyclase-Activating Peptide 27-Like Immunoreactive Nervous Structures in the Porcine Descending Colon During Selected Pathological Processes
    Journal of Molecular Neuroscience, 2012
    Co-Authors: Sławomir Gonkowski, Jarosław Całka
    Abstract:

    This study reports on changes in the pituitary adenylate cyclase-activating peptide 27-like immunoreactive (PACAP-27-LI) nerve structures of the enteric nervous system (ENS) in the porcine Descending Colon, caused by chemically induced inflammation, nerve injury, and proliferative enteropathy (PE), which is a “natural” inflammation of the porcine digestive tract. The distribution pattern of PACAP-27-LI structures was studied using the immunofluorescence technique in the circular muscle layer, enteric plexuses (i.e., myenteric plexus (MP), outer submucous plexus (OSP), and inner submucous plexus (ISP)), and in the mucosal layer. Under physiological conditions, PACAP-27-LI perikarya have been shown to constitute 4.04 ± 0.66, 6.66 ± 0.77, and 11.19 ± 0.74 % in the MP, OSP, and ISP, respectively. Changes in PACAP-27 immunoreactivity depended on the pathological factor studied. The numbers of the PACAP-27-LI perikarya amounted to 12.26 ± 1.43, 12.28 ± 0.79, and 21.13 ± 1.19 % in chemically induced colitis, 17.83 ± 0.88, 9.03 ± 1.05, and 20.72 ± 1.35 % during PE and 10.65 ± 0.82, 6.88 ± 1.04, and 14.04 ± 1.09 % after axotomy in MP, OSP, and ISP, respectively. All of the studied processes generally resulted in an increase in the number of PACAP-27-LI nerve fibers in the circular muscle and mucosal layers. The obtained results suggest that PACAP-27-LI nerve structures of ENS may participate in various pathological states within the porcine Descending Colon, and their functions probably depend on the type of pathological factor.

  • changes in the somatostatin som like immunoreactivity within nervous structures of the porcine Descending Colon under various pathological factors
    Experimental and Molecular Pathology, 2010
    Co-Authors: Sławomir Gonkowski, Jaroslaw Calka
    Abstract:

    Abstract This study reports on changes in the somatostatin-like immunoreactive (SOM-LI) nerve structures of the enteric nervous system (ENS) in the porcine Descending Colon, caused by chemically driven inflammation, proliferative enteropathy (PE), which is a “natural” inflammation with proliferative changes and nerve injury (axotomy). The distribution pattern of SOM-LI structures was studied using the immunofluorescence technique in the circular muscle layer, the myenteric (MP), outer submucous (OSP) and inner submucous plexuses (ISP) and also in the mucosal layer. Under physiological conditions SOM-LI perikarya have been shown to constitute 1.97 ± 0.36%, 2.06 ± 0.33% and 4.23 ± 0.40% in the MP, OSP and ISP, respectively. Changes in SOM-immunoreactivity depended on the pathological factor and the part of the ENS studied. Numbers of the SOM-LI perikarya amounted 1.81 ± 0.30, 1.97 ± 0.24 and 11.15 ± 0.95 during chemically induced colitis and 3.21 ± 0.37%, 4.33 ± 0.33% and 4.42 ± 0.32% after axotomy in MP, OSP and ISP, respectively. Moreover during PE SOM-positive cell bodies were not observed at all in MP, whereas within OSP and ISP the number of SOM-LI perikarya amounted to 3.34 ± 0.36 and 10.92 ± 059, respectively. All processes studied resulted in a decrease in the number of SOM-LI nerve fibers in the mucosal layer, whereas within the circular muscle layer chemically induced inflammation and axotomy caused an increase in the number of the SOM-LI nerve fibers contrary to PE, which reduced the number of such fibers. The obtained results suggest that SOM-LI nerve structures of the ENS may participate in various pathological states within the porcine Descending Colon and their functions probably depend on the type of pathological factor.

T. Zheng - One of the best experts on this subject based on the ideXlab platform.

  • a birth cohort analysis of the incidence of ascending and Descending Colon cancer in the united states 1973 2008
    Cancer Causes & Control, 2013
    Co-Authors: C. Zhu, B. A. Bassig, D. Zaridze, P. Boyle, M. Dai, T. Zheng
    Abstract:

    Objectives There is evidence indicating that the trends in colorectal cancer (CRC) incidence rates in the United States differ according to CRC subsites, including for ascending cancer which has shown a different pattern from the overall trends. We investigated the time trends for ascending and Descending Colon cancer in the United States by race and gender to identify the specific components that may account for the incidence trends.

  • a birth cohort analysis of the incidence of ascending and Descending Colon cancer in the united states 1973 2008
    Cancer Causes & Control, 2013
    Co-Authors: C. Zhu, B. A. Bassig, D. Zaridze, P. Boyle, M. Dai, T. Zheng
    Abstract:

    There is evidence indicating that the trends in colorectal cancer (CRC) incidence rates in the United States differ according to CRC subsites, including for ascending cancer which has shown a different pattern from the overall trends. We investigated the time trends for ascending and Descending Colon cancer in the United States by race and gender to identify the specific components that may account for the incidence trends. Using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program for 1973–2008, we conducted age–period–cohort modeling to evaluate birth cohort patterns and evaluate age–period–cohort effects on incidence trends of Colon cancer over time. A clear birth cohort pattern was observed for both ascending and Descending Colon cancer, and the incidence rates of ascending Colon cancer in the more recent birth cohorts were higher compared to earlier cohorts particularly for black males and females. This increase was most obvious in the younger age groups and appeared to accelerate, especially for black females. For Descending Colon cancer, the study suggested an increase in the birth cohort slope in the later birth cohorts for all gender and race groups, after a period of decline in earlier birth cohorts. The increase in incidence rates of both ascending and Descending Colon cancer in more recent birth cohorts for blacks suggests the need for targeted public health strategies to increase CRC screening. Further, additional etiological studies are warranted to evaluate factors responsible for the observed trends in more recent birth cohorts, including differences by subsites, race, and/or gender.