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Hsiang Ching Wang - One of the best experts on this subject based on the ideXlab platform.

  • effect of a neuropilin 1 derived virus receptor trap on enterovirus a71 infection in vitro
    Antimicrobial Agents and Chemotherapy, 2020
    Co-Authors: Hsiang Ching Wang, Pengnien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yunming Wang, Shin-ru Shih
    Abstract:

    We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the Design, Engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Shin-ru Shih - One of the best experts on this subject based on the ideXlab platform.

  • effect of a neuropilin 1 derived virus receptor trap on enterovirus a71 infection in vitro
    Antimicrobial Agents and Chemotherapy, 2020
    Co-Authors: Hsiang Ching Wang, Pengnien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yunming Wang, Shin-ru Shih
    Abstract:

    We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the Design, Engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Pengnien Huang - One of the best experts on this subject based on the ideXlab platform.

  • effect of a neuropilin 1 derived virus receptor trap on enterovirus a71 infection in vitro
    Antimicrobial Agents and Chemotherapy, 2020
    Co-Authors: Hsiang Ching Wang, Pengnien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yunming Wang, Shin-ru Shih
    Abstract:

    We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the Design, Engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

J C Diehl - One of the best experts on this subject based on the ideXlab platform.

Hui Chen Hung - One of the best experts on this subject based on the ideXlab platform.

  • effect of a neuropilin 1 derived virus receptor trap on enterovirus a71 infection in vitro
    Antimicrobial Agents and Chemotherapy, 2020
    Co-Authors: Hsiang Ching Wang, Pengnien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yunming Wang, Shin-ru Shih
    Abstract:

    We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the Design, Engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.