The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Pancras C W Hogendoorn - One of the best experts on this subject based on the ideXlab platform.
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Desmoplastic Fibroma of bone an immunohistochemical study including beta catenin expression and mutational analysis for beta catenin
Human Pathology, 2005Co-Authors: Esther I Hauben, Gernot Jundt, Annemarie Cletonjansen, Ayse Yavas, H M Kroon, Eric Van Marck, Pancras C W HogendoornAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis.
Esther I Hauben - One of the best experts on this subject based on the ideXlab platform.
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Desmoplastic Fibroma of bone an immunohistochemical study including beta catenin expression and mutational analysis for beta catenin
Human Pathology, 2005Co-Authors: Esther I Hauben, Gernot Jundt, Annemarie Cletonjansen, Ayse Yavas, H M Kroon, Eric Van Marck, Pancras C W HogendoornAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis.
H M Kroon - One of the best experts on this subject based on the ideXlab platform.
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Desmoplastic Fibroma of bone an immunohistochemical study including beta catenin expression and mutational analysis for beta catenin
Human Pathology, 2005Co-Authors: Esther I Hauben, Gernot Jundt, Annemarie Cletonjansen, Ayse Yavas, H M Kroon, Eric Van Marck, Pancras C W HogendoornAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis.
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Desmoplastic Fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin
W.B. Saunders, 2005Co-Authors: Hauben Esther, Van Marck E, H M Kroon, Jundt G, Am Cleton-jansen, Yavas A, Hogendoorn PcwAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis. (c) 2005 Elsevier Inc. All rights reserved.status: publishe
Annemarie Cletonjansen - One of the best experts on this subject based on the ideXlab platform.
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Desmoplastic Fibroma of bone an immunohistochemical study including beta catenin expression and mutational analysis for beta catenin
Human Pathology, 2005Co-Authors: Esther I Hauben, Gernot Jundt, Annemarie Cletonjansen, Ayse Yavas, H M Kroon, Eric Van Marck, Pancras C W HogendoornAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis.
Ayse Yavas - One of the best experts on this subject based on the ideXlab platform.
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Desmoplastic Fibroma of bone an immunohistochemical study including beta catenin expression and mutational analysis for beta catenin
Human Pathology, 2005Co-Authors: Esther I Hauben, Gernot Jundt, Annemarie Cletonjansen, Ayse Yavas, H M Kroon, Eric Van Marck, Pancras C W HogendoornAbstract:Desmoplastic Fibroma of bone is a very rare primary bone tumor morphologically resembling desmoid-type Fibromatosis, its much more common counterpart of soft tissue. The aim of this study is to investigate the immunohistochemical profile and the involvement of the beta-catenin pathway in Desmoplastic Fibroma as it is known in desmoid-type Fibromatosis. Immunohistochemistry was performed on 13 cases of Desmoplastic Fibroma for muscle-specific markers, estrogen and progesterone receptors, CD117, beta-catenin, and the potential downstream target of beta-catenin, namely, cyclin D1. In all 13 cases, DNA sequencing was performed for the detection of activating beta-catenin gene mutations. There was no immunoreactivity of CD117, estrogen, and progesterone receptors. Seven cases were immunoreactive for one or more muscle-specific markers. In 6 cases, there was overexpression of beta-catenin in the cytoplasm; in one of these cases, there was also accumulation of beta-catenin in the nucleus. In 6 cases in which DNA sequencing was successful, no beta-catenin mutations were detected. Search in a national database showed that not a single case over a frame of 23 years was associated with occurrence of colon cancer in the same patient. The epidemiological, histological, and immunohistochemical findings in Desmoplastic Fibroma are suggestive of Desmoplastic Fibroma being the bony counterpart of the more common desmoid-type Fibromatosis of soft tissue. However, the beta-catenin pathway does not seem to have the same essential role in the tumorigenesis of Desmoplastic Fibroma, as it has in desmoid-type Fibromatosis.