The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
P. Litoux - One of the best experts on this subject based on the ideXlab platform.
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local steroid therapy and bacterial skin flora in atopic dermatitis
British Journal of Dermatology, 2006Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, M. Rostin, F. Pheline, P. LitouxAbstract:Summary A double-blind, randomized trial was conducted to determine the influence of topical steroid therapy on atopic skin flora. The bacteriological and clinical effects of Desonide (Locapred®), compared with those of its excipient, were studied in 40 children. Clinical scoring and bacteriological sampling were performed before the start of the trial and after 7 days of once-daily topical treatment. Before treatment, no differences in clinical score or Staphylococcus aureus colonization were noted between the two groups. After treatment, the clinical score improved (P<0.001) in the Desonide group, and S. aureus density decreased dramatically (P<0.001). In the excipient group, no significant differences in clinical score or S. aureus density were noted. A comparison of the two groups demonstrated statistically significant differences with regard to clinical score (P<0.001) and S. aureus density (P<0.05). These results show the efficacy of topical corticosteroid treatment alone on S. aureus colonization in atopic skin, and confirm the critical role of inflammation in bacterial colonization.
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comparative effects of two topical antiseptics chlorhexidine vs kmn04 on bacterial skin flora in atopic dermatitis
Acta Dermato-venereologica, 1992Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, T Allavoine, C Chalamet, P Brosset, P. LitouxAbstract:In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (Desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S.A.) density was high and predominant in both groups. After treatment, the decrease in S.A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.
Jean-françois Stalder - One of the best experts on this subject based on the ideXlab platform.
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local steroid therapy and bacterial skin flora in atopic dermatitis
British Journal of Dermatology, 2006Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, M. Rostin, F. Pheline, P. LitouxAbstract:Summary A double-blind, randomized trial was conducted to determine the influence of topical steroid therapy on atopic skin flora. The bacteriological and clinical effects of Desonide (Locapred®), compared with those of its excipient, were studied in 40 children. Clinical scoring and bacteriological sampling were performed before the start of the trial and after 7 days of once-daily topical treatment. Before treatment, no differences in clinical score or Staphylococcus aureus colonization were noted between the two groups. After treatment, the clinical score improved (P<0.001) in the Desonide group, and S. aureus density decreased dramatically (P<0.001). In the excipient group, no significant differences in clinical score or S. aureus density were noted. A comparison of the two groups demonstrated statistically significant differences with regard to clinical score (P<0.001) and S. aureus density (P<0.05). These results show the efficacy of topical corticosteroid treatment alone on S. aureus colonization in atopic skin, and confirm the critical role of inflammation in bacterial colonization.
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comparative effects of two topical antiseptics chlorhexidine vs kmn04 on bacterial skin flora in atopic dermatitis
Acta Dermato-venereologica, 1992Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, T Allavoine, C Chalamet, P Brosset, P. LitouxAbstract:In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (Desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S.A.) density was high and predominant in both groups. After treatment, the decrease in S.A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.
Catherine Girardin Tordeur - One of the best experts on this subject based on the ideXlab platform.
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tacrolimus 0 1 versus ciclopiroxolamine 1 for maintenance therapy in patients with severe facial seborrheic dermatitis a multicenter double blind randomized controlled study
Journal of The American Academy of Dermatology, 2021Co-Authors: P Joly, Ines Tejedor, F Tetart, Helene Collas Cailleux, Alice Barrel, Paul Arnaud De Preville, Nathalie Mionmouton, Germaine Gabison, Sophie Baricault, Catherine Girardin TordeurAbstract:Background No long-term maintenance therapy has been tested in patients with seborrheic dermatitis (SD). Objective We sought to compare the efficacy and tolerance of tacrolimus 0.1% ointment versus ciclopiroxolamine 1% cream as maintenance therapy for severe SD. Methods This double-blind randomized controlled study was conducted from 2014 to 2017 in 5 Dermatology Departments and 15 dermatology practices in France. Consecutive patients with severe and chronic facial SD were included. Patients were initially treated with Desonide 0.05% cream twice daily for 7 days. Patients cleared after this open phase were randomized to receive tacrolimus 0.1% or ciclopiroxolamine 1% cream 2 times a week 24 weeks. The primary endpoint was disease-free-duration, defined as the time from randomization to first relapse. Results One hundred fourteen patients were randomized (tacrolimus, n = 57; ciclopiroxolamine, n = 57). Twelve patients relapsed in the tacrolimus group after a median delay of 91.5 days (range 15-195 days) versus 23 patients in the ciclopiroxolamine group (median delay, 27 days [range 13-201 days]). Comparison of disease-free duration curves showed that patients in the tacrolimus group had a longer duration of complete remission than those in the ciclopiroxolamine group (P = .018), corresponding to a hazard ratio of relapse of 0.44 (95% confidence interval 0.22-0.89; P = .022). Limitations The theoretical sample size was not reached. Conclusion Tacrolimus 0.1% is more effective than ciclopiroxolamine 1% as maintenance therapy for patients with facial SD.
M. Sourisse - One of the best experts on this subject based on the ideXlab platform.
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local steroid therapy and bacterial skin flora in atopic dermatitis
British Journal of Dermatology, 2006Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, M. Rostin, F. Pheline, P. LitouxAbstract:Summary A double-blind, randomized trial was conducted to determine the influence of topical steroid therapy on atopic skin flora. The bacteriological and clinical effects of Desonide (Locapred®), compared with those of its excipient, were studied in 40 children. Clinical scoring and bacteriological sampling were performed before the start of the trial and after 7 days of once-daily topical treatment. Before treatment, no differences in clinical score or Staphylococcus aureus colonization were noted between the two groups. After treatment, the clinical score improved (P<0.001) in the Desonide group, and S. aureus density decreased dramatically (P<0.001). In the excipient group, no significant differences in clinical score or S. aureus density were noted. A comparison of the two groups demonstrated statistically significant differences with regard to clinical score (P<0.001) and S. aureus density (P<0.05). These results show the efficacy of topical corticosteroid treatment alone on S. aureus colonization in atopic skin, and confirm the critical role of inflammation in bacterial colonization.
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comparative effects of two topical antiseptics chlorhexidine vs kmn04 on bacterial skin flora in atopic dermatitis
Acta Dermato-venereologica, 1992Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, T Allavoine, C Chalamet, P Brosset, P. LitouxAbstract:In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (Desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S.A.) density was high and predominant in both groups. After treatment, the decrease in S.A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.
M. Fleury - One of the best experts on this subject based on the ideXlab platform.
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local steroid therapy and bacterial skin flora in atopic dermatitis
British Journal of Dermatology, 2006Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, M. Rostin, F. Pheline, P. LitouxAbstract:Summary A double-blind, randomized trial was conducted to determine the influence of topical steroid therapy on atopic skin flora. The bacteriological and clinical effects of Desonide (Locapred®), compared with those of its excipient, were studied in 40 children. Clinical scoring and bacteriological sampling were performed before the start of the trial and after 7 days of once-daily topical treatment. Before treatment, no differences in clinical score or Staphylococcus aureus colonization were noted between the two groups. After treatment, the clinical score improved (P<0.001) in the Desonide group, and S. aureus density decreased dramatically (P<0.001). In the excipient group, no significant differences in clinical score or S. aureus density were noted. A comparison of the two groups demonstrated statistically significant differences with regard to clinical score (P<0.001) and S. aureus density (P<0.05). These results show the efficacy of topical corticosteroid treatment alone on S. aureus colonization in atopic skin, and confirm the critical role of inflammation in bacterial colonization.
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comparative effects of two topical antiseptics chlorhexidine vs kmn04 on bacterial skin flora in atopic dermatitis
Acta Dermato-venereologica, 1992Co-Authors: Jean-françois Stalder, M. Fleury, M. Sourisse, T Allavoine, C Chalamet, P Brosset, P. LitouxAbstract:In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (Desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S.A.) density was high and predominant in both groups. After treatment, the decrease in S.A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.