The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
D. Taramelli - One of the best experts on this subject based on the ideXlab platform.
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Antimalarial polyketide cycloperoxides from the marine sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess-Martin Oxidation, and by application of Mosher's method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity
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Antimalarial Polyketide Cycloperoxides from the Marine SpongePlakortis simplex
European Journal of Organic Chemistry, 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5–7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess–Martin Oxidation, and by application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
C. Campagnuolo - One of the best experts on this subject based on the ideXlab platform.
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Antimalarial polyketide cycloperoxides from the marine sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess-Martin Oxidation, and by application of Mosher's method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity
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Antimalarial Polyketide Cycloperoxides from the Marine Sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, N. Basilico, Taglialatela O. Scafati, Parapini S. D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations, including Zn-mediated reduction, Dess-Martin Oxidation, and application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules compared to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activit
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Antimalarial Polyketide Cycloperoxides from the Marine SpongePlakortis simplex
European Journal of Organic Chemistry, 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5–7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess–Martin Oxidation, and by application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Tomislav Rovis - One of the best experts on this subject based on the ideXlab platform.
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enantioselective synthesis of hydrobenzofuranones using an asymmetric desymmetrizing intramolecular stetter reaction of cyclohexadienones
Organic Process Research & Development, 2007Co-Authors: Tomislav RovisAbstract:A series of cyclohexadienones were synthesized by dearomatization of phenols followed by Dess−Martin Oxidation. Asymmetric intramolecular Stetter reactions of these substrates provide hydrobenzofuranones in good to excellent yields and excellent stereoselectivities. Up to three stereocenters as well as a quaternary stereocenter are formed from polysubstituted substrates. A scale-up experiment demonstrates the utility of this transformation.
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Enantioselective Synthesis of Hydrobenzofuranones Using an Asymmetric Desymmetrizing Intramolecular Stetter Reaction of Cyclohexadienones.
Organic process research & development, 2007Co-Authors: Qin Liu, Tomislav RovisAbstract:A series of cyclohexadienones were synthesized by dearomatization of phenols followed by Dess−Martin Oxidation. Asymmetric intramolecular Stetter reactions of these substrates provide hydrobenzofur...
N. Basilico - One of the best experts on this subject based on the ideXlab platform.
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Antimalarial polyketide cycloperoxides from the marine sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess-Martin Oxidation, and by application of Mosher's method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity
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Antimalarial Polyketide Cycloperoxides from the Marine Sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, N. Basilico, Taglialatela O. Scafati, Parapini S. D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations, including Zn-mediated reduction, Dess-Martin Oxidation, and application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules compared to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activit
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Antimalarial Polyketide Cycloperoxides from the Marine SpongePlakortis simplex
European Journal of Organic Chemistry, 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5–7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess–Martin Oxidation, and by application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
A. Romano - One of the best experts on this subject based on the ideXlab platform.
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Antimalarial polyketide cycloperoxides from the marine sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess-Martin Oxidation, and by application of Mosher's method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity
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Antimalarial Polyketide Cycloperoxides from the Marine Sponge Plakortis simplex
'Wiley', 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, N. Basilico, Taglialatela O. Scafati, Parapini S. D. TaramelliAbstract:Three new (5-7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations, including Zn-mediated reduction, Dess-Martin Oxidation, and application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules compared to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activit
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Antimalarial Polyketide Cycloperoxides from the Marine SpongePlakortis simplex
European Journal of Organic Chemistry, 2005Co-Authors: C. Campagnuolo, E. Fattorusso, A. Romano, O. Taglialatela-scafati, N. Basilico, S. Parapini, D. TaramelliAbstract:Three new (5–7) and two known (4 and 8) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex. Their stereostructures have been determined by spectroscopic methods and chemical transformations that include Zn-mediated reduction and Dess–Martin Oxidation, and by application of Mosher’s method. The cycloperoxide derivatives plakortide Q (7) and compound 8 were evaluated for their in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. The lower potency of these molecules relative to plakortin indicates that the change of configuration at C-3 exerts negative effects on the antimalarial activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)